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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PGAP3 (spascer ID:93210)

Gene summary for PGAP3

Gene summary

Gene information
	Species	Human
	Gene symbol	PGAP3
	Gene ID	93210
	Gene name	post-GPI attachment to proteins phospholipase 3
	Synonyms	AGLA546\|CAB2\|PERLD1\|PP1498\|hCOS16
	Cytomap	17q12
	Type of gene	protein-coding
	Description	post-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1post-GPI attachment to proteins 3
	Modification date	20220513
	UniProtAcc	Q96FM1

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PGAP3	GO:0006506	GPI anchor biosynthetic process	21873635	Process
PGAP3	GO:0016788	hydrolase activity, acting on ester bonds	21873635	Function
PGAP3	GO:0031227	intrinsic component of endoplasmic reticulum membrane	21873635	Component

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Spatial pattern events for PGAP3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PGAP3	Human	Intestine	rep_colon1	34417225	2.48e-11
PGAP3	Human	Intestine	rep_colon4	34417225	2.06e-15
PGAP3	Human	Liver	rep_liver2	34417225	5.17e-07
PGAP3	Human	Breast	A6	34650042	1.76e-07
PGAP3	Human	Breast	B5	34650042	1.22e-06
PGAP3	Human	Breast	E1	34650042	2.67e-07
PGAP3	Human	Breast	E2	34650042	1.44e-12
PGAP3	Human	Breast	E3	34650042	1.47e-06
PGAP3	Human	Breast	1160920F	34493872	1.48e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver2_H&E
Breast_A6_H&E
Breast_B5_H&E
Breast_E1_H&E
Breast_E2_H&E
Breast_E3_H&E
Breast_1160920F_H&E

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Spatial pattern pathway has PGAP3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PGAP3	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
PGAP3	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Bladder	rep_4	3.0e-06
PGAP3	GOBP_Organophosphate_Biosynthetic_Process	Human	Bladder	rep_4	3.2e-09
PGAP3	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
PGAP3	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Intestine	A3	1.8e-09
PGAP3	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
PGAP3	GOBP_Glycerophospholipid_Metabolic_Process	Human	Intestine	A3	7.7e-12
PGAP3	GOBP_Lipid_Biosynthetic_Process	Human	Intestine	A3	5.0e-07
PGAP3	GOBP_Organophosphate_Biosynthetic_Process	Human	Intestine	A3	2.2e-07
PGAP3	GOBP_Organophosphate_Metabolic_Process	Human	Intestine	A3	4.4e-13
PGAP3	GOBP_Phospholipid_Metabolic_Process	Human	Intestine	A3	3.0e-11
PGAP3	GOBP_Cellular_Lipid_Metabolic_Process	Human	Intestine	A8	3.8e-13
PGAP3	GOBP_Glycerolipid_Biosynthetic_Process	Human	Intestine	A8	1.4e-11
PGAP3	GOBP_Glycerolipid_Metabolic_Process	Human	Intestine	A8	1.2e-09
PGAP3	GOBP_Glycolipid_Biosynthetic_Process	Human	Intestine	A8	2.5e-21
PGAP3	GOBP_Gpi_Anchor_Metabolic_Process	Human	Intestine	A8	9.6e-11
PGAP3	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
PGAP3	GOBP_Membrane_Lipid_Biosynthetic_Process	Human	Intestine	A8	4.7e-19
PGAP3	GOBP_Membrane_Lipid_Metabolic_Process	Human	Intestine	A8	1.9e-14
PGAP3	GOBP_Phosphatidylinositol_Biosynthetic_Process	Human	Intestine	A8	1.8e-16
PGAP3	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Intestine	A8	1.1e-15
PGAP3	GOBP_Phospholipid_Biosynthetic_Process	Human	Intestine	A8	2.2e-17
PGAP3	GOBP_Gpi_Anchor_Metabolic_Process	Human	Pancreas	PDAC-A-st2	1.4e-07
PGAP3	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Uterus	rep_26	3.5e-11
PGAP3	GOBP_Glycerolipid_Biosynthetic_Process	Human	Uterus	rep_26	9.1e-06
PGAP3	GOBP_Glycolipid_Biosynthetic_Process	Human	Uterus	rep_26	5.0e-07
PGAP3	GOBP_Liposaccharide_Metabolic_Process	Human	Uterus	rep_26	7.7e-10
PGAP3	GOBP_Organophosphate_Biosynthetic_Process	Human	Uterus	rep_26	8.0e-07
PGAP3	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Uterus	rep_26	6.7e-06
PGAP3	GOBP_Glycerolipid_Metabolic_Process	Human	Uterus	rep_29	5.7e-07
PGAP3	GOBP_Phospholipid_Biosynthetic_Process	Human	Uterus	rep_29	6.7e-09
PGAP3	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Breast	rep_1	2.1e-06
PGAP3	GOBP_Glycerolipid_Biosynthetic_Process	Human	Breast	rep_1	2.0e-10
PGAP3	GOBP_Membrane_Lipid_Biosynthetic_Process	Human	Breast	rep_1	2.0e-05
PGAP3	GOBP_Organophosphate_Biosynthetic_Process	Human	Breast	rep_1	1.4e-07
PGAP3	GOBP_Phosphatidylinositol_Biosynthetic_Process	Human	Breast	rep_1	2.2e-19
PGAP3	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Breast	rep_1	1.8e-27
PGAP3	GOBP_Cellular_Lipid_Metabolic_Process	Human	Breast	rep_5	2.6e-07
PGAP3	GOBP_Lipid_Biosynthetic_Process	Human	Breast	rep_5	7.0e-04
PGAP3	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
PGAP3	GOBP_Liposaccharide_Metabolic_Process	Human	Breast	rep_5	1.8e-11
PGAP3	GOBP_Membrane_Lipid_Metabolic_Process	Human	Breast	rep_5	1.9e-17
PGAP3	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
PGAP3	GOBP_Glycerolipid_Metabolic_Process	Human	Breast	rep_6	9.2e-09
PGAP3	GOBP_Glycerophospholipid_Metabolic_Process	Human	Breast	rep_6	3.2e-05
PGAP3	GOBP_Glycolipid_Biosynthetic_Process	Human	Breast	rep_6	2.2e-04
PGAP3	GOBP_Lipoprotein_Biosynthetic_Process	Human	Breast	rep_6	4.1e-08
PGAP3	GOBP_Lipoprotein_Metabolic_Process	Human	Breast	rep_6	1.4e-05
PGAP3	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
PGAP3	GOBP_Organophosphate_Metabolic_Process	Human	Breast	rep_6	1.0e-12
PGAP3	GOBP_Phospholipid_Biosynthetic_Process	Human	Breast	rep_6	5.0e-10
PGAP3	GOBP_Phospholipid_Metabolic_Process	Human	Breast	rep_6	4.1e-09
PGAP3	GOBP_Phosphatidylinositol_Biosynthetic_Process	Human	Skin	P5_rep1	1.1e-10
PGAP3	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Skin	P5_rep1	2.8e-09
PGAP3	GOBP_Glycolipid_Biosynthetic_Process	Human	Skin	P10_rep1	6.7e-17
PGAP3	GOBP_Gpi_Anchor_Metabolic_Process	Human	Skin	P10_rep2	4.9e-15

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PGAP3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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PGAP3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for PGAP3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for PGAP3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PGAP3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PGAP3	C1855923	Hyperphosphatasia with Mental Retardation	1	CTD_human;ORPHANET
PGAP3	C3810354	HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 4	1	GENOMICS_ENGLAND;UNIPROT