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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PIGM (spascer ID:93183)

Gene summary for PIGM

Gene summary

Gene information
	Species	Human
	Gene symbol	PIGM
	Gene ID	93183
	Gene name	phosphatidylinositol glycan anchor biosynthesis class M
	Synonyms	GPI-MT-I
	Cytomap	1q23.2
	Type of gene	protein-coding
	Description	GPI mannosyltransferase 1DPM:GlcN-(acyl-)PI mannosyltransferaseGPI mannosyltransferase IPIG-M mannosyltransferasedol-P-Man dependent GPI mannosyltransferasephosphatidylinositol-glycan biosynthesis class M protein
	Modification date	20220513
	UniProtAcc	Q9H3S5

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PIGM	GO:0000030	mannosyltransferase activity	21873635	Function
PIGM	GO:0006506	GPI anchor biosynthetic process	21873635	Process
PIGM	GO:1990529	glycosylphosphatidylinositol-mannosyltransferase I complex	21873635	Component

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Spatial pattern events for PIGM

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PIGM	Human	Liver	rep_liver2	34417225	6.98e-16

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E

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Spatial pattern pathway has PIGM envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PIGM	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
PIGM	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Bladder	rep_4	3.0e-06
PIGM	GOBP_Organophosphate_Biosynthetic_Process	Human	Bladder	rep_4	3.2e-09
PIGM	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
PIGM	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Intestine	A3	1.8e-09
PIGM	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
PIGM	GOBP_Glycerophospholipid_Metabolic_Process	Human	Intestine	A3	7.7e-12
PIGM	GOBP_Lipid_Biosynthetic_Process	Human	Intestine	A3	5.0e-07
PIGM	GOBP_Mannosylation	Human	Intestine	A3	3.0e-08
PIGM	GOBP_Organophosphate_Biosynthetic_Process	Human	Intestine	A3	2.2e-07
PIGM	GOBP_Organophosphate_Metabolic_Process	Human	Intestine	A3	4.4e-13
PIGM	GOBP_Phospholipid_Metabolic_Process	Human	Intestine	A3	3.0e-11
PIGM	GOBP_Cellular_Lipid_Metabolic_Process	Human	Intestine	A8	3.8e-13
PIGM	GOBP_Glycerolipid_Biosynthetic_Process	Human	Intestine	A8	1.4e-11
PIGM	GOBP_Glycerolipid_Metabolic_Process	Human	Intestine	A8	1.2e-09
PIGM	GOBP_Glycolipid_Biosynthetic_Process	Human	Intestine	A8	2.5e-21
PIGM	GOBP_Glycosylation	Human	Intestine	A8	1.2e-17
PIGM	GOBP_Gpi_Anchor_Metabolic_Process	Human	Intestine	A8	9.6e-11
PIGM	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
PIGM	GOBP_Membrane_Lipid_Biosynthetic_Process	Human	Intestine	A8	4.7e-19
PIGM	GOBP_Membrane_Lipid_Metabolic_Process	Human	Intestine	A8	1.9e-14
PIGM	GOBP_Phosphatidylinositol_Biosynthetic_Process	Human	Intestine	A8	1.8e-16
PIGM	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Intestine	A8	1.1e-15
PIGM	GOBP_Phospholipid_Biosynthetic_Process	Human	Intestine	A8	2.2e-17
PIGM	GOBP_Preassembly_Of_Gpi_Anchor_In_Er_Membrane	Human	Intestine	A8	3.9e-08
PIGM	GOBP_Gpi_Anchor_Metabolic_Process	Human	Pancreas	PDAC-A-st2	1.4e-07
PIGM	GOBP_Mannosylation	Human	Pancreas	PDAC-A-st2	5.0e-05
PIGM	GOBP_Preassembly_Of_Gpi_Anchor_In_Er_Membrane	Human	Uterus	rep_25	8.1e-06
PIGM	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Uterus	rep_26	3.5e-11
PIGM	GOBP_Glycerolipid_Biosynthetic_Process	Human	Uterus	rep_26	9.1e-06
PIGM	GOBP_Glycolipid_Biosynthetic_Process	Human	Uterus	rep_26	5.0e-07
PIGM	GOBP_Liposaccharide_Metabolic_Process	Human	Uterus	rep_26	7.7e-10
PIGM	GOBP_Organophosphate_Biosynthetic_Process	Human	Uterus	rep_26	8.0e-07
PIGM	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Uterus	rep_26	6.7e-06
PIGM	GOBP_Glycerolipid_Metabolic_Process	Human	Uterus	rep_29	5.7e-07
PIGM	GOBP_Phospholipid_Biosynthetic_Process	Human	Uterus	rep_29	6.7e-09
PIGM	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Breast	rep_1	2.1e-06
PIGM	GOBP_Glycerolipid_Biosynthetic_Process	Human	Breast	rep_1	2.0e-10
PIGM	GOBP_Membrane_Lipid_Biosynthetic_Process	Human	Breast	rep_1	2.0e-05
PIGM	GOBP_Organophosphate_Biosynthetic_Process	Human	Breast	rep_1	1.4e-07
PIGM	GOBP_Phosphatidylinositol_Biosynthetic_Process	Human	Breast	rep_1	2.2e-19
PIGM	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Breast	rep_1	1.8e-27
PIGM	GOBP_Cellular_Lipid_Metabolic_Process	Human	Breast	rep_5	2.6e-07
PIGM	GOBP_Lipid_Biosynthetic_Process	Human	Breast	rep_5	7.0e-04
PIGM	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
PIGM	GOBP_Liposaccharide_Metabolic_Process	Human	Breast	rep_5	1.8e-11
PIGM	GOBP_Membrane_Lipid_Metabolic_Process	Human	Breast	rep_5	1.9e-17
PIGM	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
PIGM	GOBP_Glycerolipid_Metabolic_Process	Human	Breast	rep_6	9.2e-09
PIGM	GOBP_Glycerophospholipid_Metabolic_Process	Human	Breast	rep_6	3.2e-05
PIGM	GOBP_Glycolipid_Biosynthetic_Process	Human	Breast	rep_6	2.2e-04
PIGM	GOBP_Glycosylation	Human	Breast	rep_6	5.3e-04
PIGM	GOBP_Lipoprotein_Biosynthetic_Process	Human	Breast	rep_6	4.1e-08
PIGM	GOBP_Lipoprotein_Metabolic_Process	Human	Breast	rep_6	1.4e-05
PIGM	GOBP_Mannosylation	Human	Breast	rep_6	2.8e-05
PIGM	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
PIGM	GOBP_Organophosphate_Metabolic_Process	Human	Breast	rep_6	1.0e-12
PIGM	GOBP_Phospholipid_Biosynthetic_Process	Human	Breast	rep_6	5.0e-10
PIGM	GOBP_Phospholipid_Metabolic_Process	Human	Breast	rep_6	4.1e-09
PIGM	GOBP_Phosphatidylinositol_Biosynthetic_Process	Human	Skin	P5_rep1	1.1e-10
PIGM	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Skin	P5_rep1	2.8e-09
PIGM	GOBP_Glycolipid_Biosynthetic_Process	Human	Skin	P10_rep1	6.7e-17
PIGM	GOBP_Preassembly_Of_Gpi_Anchor_In_Er_Membrane	Human	Skin	P10_rep1	2.8e-14
PIGM	GOBP_Gpi_Anchor_Metabolic_Process	Human	Skin	P10_rep2	4.9e-15

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PIGM function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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PIGM function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for PIGM envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for PIGM

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PIGM

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PIGM	C1853205	Glycosylphosphatidylinositol deficiency	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
PIGM	C0022333	Jacksonian Seizure	1	CTD_human
PIGM	C0036572	Seizures	1	CTD_human
PIGM	C0042487	Venous Thrombosis	1	CTD_human
PIGM	C0149871	Deep Vein Thrombosis	1	CTD_human
PIGM	C0149958	Complex partial seizures	1	CTD_human
PIGM	C0234533	Generalized seizures	1	CTD_human
PIGM	C0234535	Clonic Seizures	1	CTD_human
PIGM	C0270824	Visual seizure	1	CTD_human
PIGM	C0270844	Tonic Seizures	1	CTD_human
PIGM	C0270846	Epileptic drop attack	1	CTD_human
PIGM	C0422850	Seizures, Somatosensory	1	CTD_human
PIGM	C0422852	Seizures, Auditory	1	CTD_human
PIGM	C0422853	Olfactory seizure	1	CTD_human
PIGM	C0422854	Gustatory seizure	1	CTD_human
PIGM	C0422855	Vertiginous seizure	1	CTD_human
PIGM	C0494475	Tonic - clonic seizures	1	CTD_human
PIGM	C0751056	Non-epileptic convulsion	1	CTD_human
PIGM	C0751110	Single Seizure	1	CTD_human
PIGM	C0751123	Atonic Absence Seizures	1	CTD_human
PIGM	C0751494	Convulsive Seizures	1	CTD_human
PIGM	C0751495	Seizures, Focal	1	CTD_human
PIGM	C0751496	Seizures, Sensory	1	CTD_human
PIGM	C3495874	Nonepileptic Seizures	1	CTD_human
PIGM	C4048158	Convulsions	1	CTD_human
PIGM	C4316903	Absence Seizures	1	CTD_human
PIGM	C4317109	Epileptic Seizures	1	CTD_human
PIGM	C4317123	Myoclonic Seizures	1	CTD_human
PIGM	C4505436	Generalized Absence Seizures	1	CTD_human
PIGM	C4510605	Hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency	1	GENOMICS_ENGLAND