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Spatial pattern gene: DPH6 (spascer ID:89978) |
Gene summary for DPH6 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | DPH6 | Gene ID | 89978 |
| Gene name | diphthamine biosynthesis 6 |
| Synonyms | ATPBD4 |
| Cytomap | 15q14 |
| Type of gene | protein-coding |
| Description | diphthine--ammonia ligaseATP binding domain 4ATP-binding domain-containing protein 4DPH6 homologdiphthamide synthasediphthamide synthetaseprotein DPH6 homolog |
| Modification date | 20220513 |
| UniProtAcc | Q7L8W6 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| DPH6 | GO:0017178 | diphthine-ammonia ligase activity | 21873635 | Function |
| DPH6 | GO:0017183 | peptidyl-diphthamide biosynthetic process from peptidyl-histidine | 21873635 | Process |
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Spatial pattern events for DPH6 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| DPH6 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
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Spatial pattern pathway has DPH6 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| DPH6 | GOBP_Amide_Biosynthetic_Process | Human | Intestine | A1 | 6.4e-07 |
| DPH6 | GOBP_Cytoplasmic_Translation | Human | Intestine | A1 | 5.4e-14 |
| DPH6 | GOBP_Cytoplasmic_Translational_Elongation | Human | Intestine | A1 | 7.6e-07 |
| DPH6 | GOBP_Peptide_Biosynthetic_Process | Human | Intestine | A1 | 4.6e-10 |
| DPH6 | GOBP_Translational_Elongation | Human | Intestine | A1 | 6.7e-08 |
| DPH6 | GOBP_Peptidyl_Amino_Acid_Modification | Human | Intestine | A3 | 2.7e-09 |
| DPH6 | GOBP_Posttranscriptional_Regulation_Of_Gene_Expression | Human | Intestine | A3 | 4.2e-08 |
| DPH6 | GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process | Human | Intestine | A3 | 2.1e-07 |
| DPH6 | GOBP_Peptidyl_Diphthamide_Biosynthetic_Process_From_Peptidyl_Histidine | Human | Intestine | A8 | 3.0e-44 |
| DPH6 | GOBP_Peptidyl_Histidine_Modification | Human | Intestine | A8 | 1.2e-17 |
| DPH6 | GOBP_Regulation_Of_Translational_Elongation | Human | Uterus | rep_1 | 5.1e-08 |
| DPH6 | GOBP_Cytoplasmic_Translational_Elongation | Human | Uterus | rep_25 | 1.0e-12 |
| DPH6 | GOBP_Peptidyl_Diphthamide_Biosynthetic_Process_From_Peptidyl_Histidine | Human | Uterus | rep_25 | 2.5e-09 |
| DPH6 | GOBP_Translational_Elongation | Human | Uterus | rep_25 | 9.9e-08 |
| DPH6 | GOBP_Peptidyl_Histidine_Modification | Human | Uterus | rep_26 | 2.1e-06 |
| DPH6 | GOBP_Regulation_Of_Translational_Elongation | Human | Breast | rep_1 | 1.3e-09 |
| DPH6 | GOBP_Amide_Biosynthetic_Process | Human | Breast | rep_6 | 8.7e-05 |
| DPH6 | GOBP_Cellular_Amide_Metabolic_Process | Human | Breast | rep_6 | 5.6e-05 |
| DPH6 | GOBP_Cytoplasmic_Translation | Human | Breast | rep_6 | 2.4e-06 |
| DPH6 | GOBP_Organonitrogen_Compound_Biosynthetic_Process | Human | Breast | rep_6 | 1.2e-09 |
| DPH6 | GOBP_Peptide_Biosynthetic_Process | Human | Breast | rep_6 | 1.6e-05 |
| DPH6 | GOBP_Peptide_Metabolic_Process | Human | Breast | rep_6 | 8.7e-05 |
| DPH6 | GOBP_Peptidyl_Amino_Acid_Modification | Human | Breast | rep_6 | 3.8e-05 |
| DPH6 | GOBP_Peptidyl_Diphthamide_Biosynthetic_Process_From_Peptidyl_Histidine | Human | Breast | rep_6 | 4.5e-05 |
| DPH6 | GOBP_Regulation_Of_Translational_Elongation | Human | Skin | P10_rep1 | 9.0e-18 |
| DPH6 | GOBP_Cytoplasmic_Translational_Elongation | Human | Skin | P10_rep2 | 7.8e-19 |
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DPH6 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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DPH6 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for DPH6 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for DPH6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DPH6 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
