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Spatial pattern gene: UBE3B (spascer ID:89910) |
Gene summary for UBE3B |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | UBE3B | Gene ID | 89910 |
| Gene name | ubiquitin protein ligase E3B |
| Synonyms | BPIDS|KOS |
| Cytomap | 12q24.11 |
| Type of gene | protein-coding |
| Description | ubiquitin-protein ligase E3BHECT-type ubiquitin transferase E3B |
| Modification date | 20220513 |
| UniProtAcc | Q7Z3V4 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| UBE3B | GO:0000209 | protein polyubiquitination | 21873635 | Process |
| UBE3B | GO:0006511 | ubiquitin-dependent protein catabolic process | 21873635 | Process |
| UBE3B | GO:0061630 | ubiquitin protein ligase activity | 21873635 | Function |
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Spatial pattern events for UBE3B |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| UBE3B | Human | Liver | rep_liver2 | 34417225 | 1.27e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver2_H&E  |  |
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Spatial pattern pathway has UBE3B envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| UBE3B | GOBP_Proteolysis | Human | Brain | rep_4 | 1.6e-22 |
| UBE3B | GOBP_Proteolysis | Human | Liver | rep_1 | 4.2e-73 |
| UBE3B | GOBP_Proteolysis | Human | Intestine | rep_colon4 | 2.4e-90 |
| UBE3B | GOBP_Cellular_Protein_Catabolic_Process | Human | Intestine | A3 | 2.9e-12 |
| UBE3B | GOBP_Macromolecule_Catabolic_Process | Human | Intestine | A3 | 2.2e-16 |
| UBE3B | GOBP_Modification_Dependent_Macromolecule_Catabolic_Process | Human | Intestine | A3 | 7.7e-11 |
| UBE3B | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Intestine | A3 | 4.5e-13 |
| UBE3B | GOBP_Protein_Catabolic_Process | Human | Intestine | A3 | 2.9e-14 |
| UBE3B | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Human | Intestine | A3 | 1.2e-13 |
| UBE3B | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Human | Intestine | A3 | 1.8e-12 |
| UBE3B | GOBP_Protein_Polyubiquitination | Human | Intestine | A3 | 2.1e-10 |
| UBE3B | GOBP_Proteolysis | Human | Intestine | A3 | 7.3e-12 |
| UBE3B | GOBP_Protein_Polyubiquitination | Human | Uterus | rep_25 | 1.1e-17 |
| UBE3B | GOBP_Cellular_Protein_Catabolic_Process | Human | Uterus | rep_26 | 8.2e-11 |
| UBE3B | GOBP_Macromolecule_Catabolic_Process | Human | Uterus | rep_26 | 5.0e-08 |
| UBE3B | GOBP_Modification_Dependent_Macromolecule_Catabolic_Process | Human | Uterus | rep_26 | 1.1e-07 |
| UBE3B | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Uterus | rep_26 | 1.0e-08 |
| UBE3B | GOBP_Protein_Catabolic_Process | Human | Uterus | rep_26 | 3.6e-10 |
| UBE3B | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Human | Uterus | rep_26 | 2.1e-08 |
| UBE3B | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Human | Uterus | rep_26 | 5.7e-08 |
| UBE3B | GOBP_Cellular_Protein_Catabolic_Process | Human | Breast | rep_5 | 4.4e-04 |
| UBE3B | GOBP_Proteolysis | Human | Breast | rep_5 | 1.8e-07 |
| UBE3B | GOBP_Macromolecule_Catabolic_Process | Human | Breast | rep_6 | 1.3e-05 |
| UBE3B | GOBP_Modification_Dependent_Macromolecule_Catabolic_Process | Human | Breast | rep_6 | 2.2e-09 |
| UBE3B | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Breast | rep_6 | 9.5e-06 |
| UBE3B | GOBP_Protein_Catabolic_Process | Human | Breast | rep_6 | 5.3e-06 |
| UBE3B | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Human | Breast | rep_6 | 3.6e-10 |
| UBE3B | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Human | Breast | rep_6 | 2.7e-09 |
| UBE3B | GOBP_Protein_Polyubiquitination | Human | Breast | rep_6 | 6.3e-04 |
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UBE3B function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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UBE3B function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for UBE3B envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for UBE3B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for UBE3B |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| UBE3B | C1855663 | Kaufman oculocerebrofacial syndrome | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| UBE3B | C0152427 | Polydactyly | 1 | GENOMICS_ENGLAND |
