|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
|
Spatial pattern gene: P4HA2 (spascer ID:8974) |
Gene summary for P4HA2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | P4HA2 | Gene ID | 8974 |
| Gene name | prolyl 4-hydroxylase subunit alpha 2 |
| Synonyms | MYP25|lncRNA-PE |
| Cytomap | 5q31.1 |
| Type of gene | protein-coding |
| Description | prolyl 4-hydroxylase subunit alpha-24-PH alpha 2C-P4Halpha(II)collagen prolyl 4-hydroxylase alpha(II)lncRNA promotes epithelial-mesenchymal transitionprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide IIproc |
| Modification date | 20220513 |
| UniProtAcc | O15460 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| P4HA2 | GO:0004656 | procollagen-proline 4-dioxygenase activity | 21873635 | Function |
| P4HA2 | GO:0005783 | endoplasmic reticulum | 21873635 | Component |
| P4HA2 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 21873635 | Process |
Top |
Spatial pattern events for P4HA2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| P4HA2 | Human | Bladder | rep_1 | 34385456 | 3.14e-06 |
| P4HA2 | Human | Intestine | rep_colon1 | 34417225 | 6.27e-08 |
| P4HA2 | Human | Intestine | rep_colon2 | 34417225 | 1.48e-15 |
| P4HA2 | Human | Intestine | rep_colon4 | 34417225 | 4.83e-08 |
| P4HA2 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| P4HA2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| P4HA2 | Human | Intestine | A1 | 33406409 | 1.61e-09 |
| P4HA2 | Human | Intestine | A2 | 33406409 | 2.43e-14 |
| P4HA2 | Human | Uterus | rep_1 | 34857954 | 5.13e-15 |
| P4HA2 | Human | Uterus | rep_2 | 34857954 | 3.80e-10 |
| P4HA2 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| P4HA2 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| P4HA2 | Human | Breast | CID4465 | 34493872 | 7.74e-10 |
| P4HA2 | Human | Breast | CID44971 | 34493872 | 1.50e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID4465_H&E  |  |
Breast_CID44971_H&E  |  |
Top |
Spatial pattern pathway has P4HA2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| P4HA2 | GOBP_Electron_Transport_Chain | Human | Bladder | rep_4 | 1.0e-20 |
| P4HA2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Bladder | rep_4 | 3.4e-12 |
| P4HA2 | GOBP_Electron_Transport_Chain | Human | Intestine | A3 | 1.4e-19 |
| P4HA2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Intestine | A3 | 4.3e-14 |
| P4HA2 | GOBP_Peptidyl_Amino_Acid_Modification | Human | Intestine | A3 | 2.7e-09 |
| P4HA2 | GOBP_Peptidyl_Proline_Modification | Human | Intestine | A3 | 1.2e-12 |
| P4HA2 | GOBP_Peptidyl_Proline_Hydroxylation | Human | Intestine | A8 | 9.8e-08 |
| P4HA2 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Human | Intestine | A8 | 1.2e-13 |
| P4HA2 | GOBP_Electron_Transport_Chain | Human | Uterus | rep_26 | 1.9e-08 |
| P4HA2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Uterus | rep_26 | 1.8e-06 |
| P4HA2 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Human | Uterus | rep_29 | 7.0e-07 |
| P4HA2 | GOBP_Electron_Transport_Chain | Human | Breast | rep_5 | 6.2e-04 |
| P4HA2 | GOBP_Peptidyl_Proline_Hydroxylation | Human | Breast | rep_5 | 2.4e-06 |
| P4HA2 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Human | Breast | rep_5 | 2.7e-09 |
| P4HA2 | GOBP_Peptidyl_Proline_Modification | Human | Breast | rep_5 | 9.7e-05 |
| P4HA2 | GOBP_Protein_Hydroxylation | Human | Breast | rep_5 | 3.0e-12 |
| P4HA2 | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Breast | rep_6 | 7.1e-09 |
| P4HA2 | GOBP_Peptidyl_Amino_Acid_Modification | Human | Breast | rep_6 | 3.8e-05 |
| P4HA2 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Human | Skin | P10_rep3 | 1.8e-10 |
Top |
P4HA2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
Top |
P4HA2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
Top |
Transcription factor for P4HA2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
Top |
Related Drugs for P4HA2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for P4HA2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| P4HA2 | C4310655 | MYOPIA 25, AUTOSOMAL DOMINANT | 1 | CTD_human;UNIPROT |
