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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: KYNU (spascer ID:8942)

Gene summary for KYNU

Gene summary

Gene information
	Species	Human
	Gene symbol	KYNU
	Gene ID	8942
	Gene name	kynureninase
	Synonyms	KYNUU\|VCRL2
	Cytomap	2q22.2
	Type of gene	protein-coding
	Description	kynureninase
	Modification date	20220513
	UniProtAcc	Q16719

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
KYNU	GO:0005737	cytoplasm	21873635	Component
KYNU	GO:0019441	tryptophan catabolic process to kynurenine	21873635	Process
KYNU	GO:0030429	kynureninase activity	21873635	Function
KYNU	GO:0043420	anthranilate metabolic process	21873635	Process

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Spatial pattern events for KYNU

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
KYNU	Human	Liver	rep_liver1	34417225	1.08e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E

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Spatial pattern pathway has KYNU envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
KYNU	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
KYNU	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
KYNU	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
KYNU	GOBP_Response_To_Extracellular_Stimulus	Human	Brain	rep_11	2.5e-12
KYNU	GOBP_Response_To_Nutrient	Human	Brain	rep_11	2.5e-12
KYNU	GOBP_Response_To_Vitamin	Human	Brain	rep_11	2.5e-12
KYNU	GOBP_Response_To_Nutrient	Human	Bladder	rep_2	9.6e-14
KYNU	GOBP_Response_To_Vitamin	Human	Bladder	rep_2	3.3e-13
KYNU	GOBP_L_Kynurenine_Metabolic_Process	Human	Bladder	rep_3	1.0e-05
KYNU	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Bladder	rep_4	1.4e-09
KYNU	GOBP_Organophosphate_Biosynthetic_Process	Human	Bladder	rep_4	3.2e-09
KYNU	GOBP_Quinolinate_Metabolic_Process	Human	Bladder	rep_4	2.0e-06
KYNU	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
KYNU	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
KYNU	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
KYNU	GOBP_Response_To_Extracellular_Stimulus	Human	Liver	rep_1	1.7e-73
KYNU	GOBP_Response_To_Nutrient	Human	Liver	rep_1	1.7e-73
KYNU	GOBP_Response_To_Vitamin	Human	Liver	rep_1	1.7e-73
KYNU	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
KYNU	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
KYNU	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
KYNU	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	rep_liver2	8.9e-16
KYNU	GOBP_Response_To_Nutrient	Human	Intestine	rep_liver2	8.9e-16
KYNU	GOBP_Response_To_Vitamin	Human	Intestine	rep_liver2	8.9e-16
KYNU	GOBP_Aging	Human	Intestine	A3	9.0e-18
KYNU	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
KYNU	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
KYNU	GOBP_Ketone_Catabolic_Process	Human	Intestine	A3	2.3e-11
KYNU	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Human	Intestine	A3	9.9e-10
KYNU	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Intestine	A3	1.6e-10
KYNU	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
KYNU	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
KYNU	GOBP_Organophosphate_Biosynthetic_Process	Human	Intestine	A3	2.2e-07
KYNU	GOBP_Organophosphate_Metabolic_Process	Human	Intestine	A3	4.4e-13
KYNU	GOBP_Purine_Containing_Compound_Metabolic_Process	Human	Intestine	A3	7.9e-07
KYNU	GOBP_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	3.2e-15
KYNU	GOBP_Acetyl_Coa_Metabolic_Process	Human	Intestine	A8	3.0e-23
KYNU	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Intestine	A8	7.0e-13
KYNU	GOBP_Amine_Catabolic_Process	Human	Intestine	A8	3.4e-19
KYNU	GOBP_Amine_Metabolic_Process	Human	Intestine	A8	7.2e-16
KYNU	GOBP_Aromatic_Amino_Acid_Family_Catabolic_Process	Human	Intestine	A8	3.7e-11
KYNU	GOBP_Aromatic_Amino_Acid_Family_Metabolic_Process	Human	Intestine	A8	6.9e-12
KYNU	GOBP_Benzene_Containing_Compound_Metabolic_Process	Human	Intestine	A8	6.1e-26
KYNU	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Intestine	A8	2.5e-14
KYNU	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Intestine	A8	5.3e-13
KYNU	GOBP_Cellular_Ketone_Metabolic_Process	Human	Intestine	A8	1.2e-11
KYNU	GOBP_De_Novo_Nad_Biosynthetic_Process	Human	Intestine	A8	3.3e-15
KYNU	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
KYNU	GOBP_Dicarboxylic_Acid_Metabolic_Process	Human	Intestine	A8	2.6e-15
KYNU	GOBP_Indolalkylamine_Metabolic_Process	Human	Intestine	A8	6.4e-26
KYNU	GOBP_Indole_Containing_Compound_Metabolic_Process	Human	Intestine	A8	7.6e-27
KYNU	GOBP_Monocarboxylic_Acid_Metabolic_Process	Human	Intestine	A8	7.3e-16
KYNU	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Human	Intestine	A8	3.8e-09
KYNU	GOBP_Organic_Acid_Biosynthetic_Process	Human	Intestine	A8	2.1e-08
KYNU	GOBP_Organic_Acid_Catabolic_Process	Human	Intestine	A8	1.6e-12
KYNU	GOBP_Organic_Acid_Metabolic_Process	Human	Intestine	A8	2.5e-18
KYNU	GOBP_Pyridine_Containing_Compound_Biosynthetic_Process	Human	Intestine	A8	8.0e-18
KYNU	GOBP_Pyridine_Containing_Compound_Metabolic_Process	Human	Intestine	A8	7.1e-14
KYNU	GOBP_Quinolinate_Metabolic_Process	Human	Intestine	A8	2.7e-24
KYNU	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
KYNU	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	A8	2.1e-23
KYNU	GOBP_Response_To_Nitrogen_Compound	Human	Intestine	A8	1.3e-12
KYNU	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
KYNU	GOBP_Small_Molecule_Catabolic_Process	Human	Intestine	A8	2.2e-13
KYNU	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
KYNU	GOBP_Sulfur_Compound_Metabolic_Process	Human	Intestine	A8	2.5e-14
KYNU	GOBP_Thioester_Metabolic_Process	Human	Intestine	A8	4.0e-09
KYNU	GOBP_Tryptophan_Catabolic_Process	Human	Intestine	A8	8.9e-11
KYNU	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Pancreas	PDAC-A-st2	9.6e-05
KYNU	GOBP_De_Novo_Nad_Biosynthetic_Process	Human	Pancreas	PDAC-A-st2	3.9e-05
KYNU	GOBP_Indolalkylamine_Metabolic_Process	Human	Pancreas	PDAC-A-st2	1.0e-08
KYNU	GOBP_Quinolinate_Metabolic_Process	Human	Pancreas	PDAC-G-st1	3.3e-06
KYNU	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
KYNU	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
KYNU	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
KYNU	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Uterus	rep_25	1.2e-11
KYNU	GOBP_Amine_Catabolic_Process	Human	Uterus	rep_25	1.9e-13
KYNU	GOBP_Aromatic_Amino_Acid_Family_Catabolic_Process	Human	Uterus	rep_25	1.6e-11
KYNU	GOBP_Aromatic_Amino_Acid_Family_Metabolic_Process	Human	Uterus	rep_25	1.1e-07
KYNU	GOBP_Benzene_Containing_Compound_Metabolic_Process	Human	Uterus	rep_25	1.2e-08
KYNU	GOBP_De_Novo_Nad_Biosynthetic_Process	Human	Uterus	rep_25	4.7e-07
KYNU	GOBP_Dicarboxylic_Acid_Biosynthetic_Process	Human	Uterus	rep_25	8.4e-15
KYNU	GOBP_Indolalkylamine_Metabolic_Process	Human	Uterus	rep_25	7.6e-06
KYNU	GOBP_Indole_Containing_Compound_Metabolic_Process	Human	Uterus	rep_25	5.6e-09
KYNU	GOBP_Ketone_Catabolic_Process	Human	Uterus	rep_25	7.0e-09
KYNU	GOBP_Kynurenine_Metabolic_Process	Human	Uterus	rep_25	1.3e-08
KYNU	GOBP_L_Kynurenine_Metabolic_Process	Human	Uterus	rep_25	6.5e-08
KYNU	GOBP_Pyridine_Containing_Compound_Biosynthetic_Process	Human	Uterus	rep_25	3.3e-08
KYNU	GOBP_Pyridine_Containing_Compound_Metabolic_Process	Human	Uterus	rep_25	1.9e-11
KYNU	GOBP_Quinolinate_Metabolic_Process	Human	Uterus	rep_25	8.2e-23
KYNU	GOBP_Tryptophan_Catabolic_Process	Human	Uterus	rep_25	1.8e-09
KYNU	GOBP_Tryptophan_Catabolic_Process_To_Kynurenine	Human	Uterus	rep_25	6.3e-28
KYNU	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Uterus	rep_26	1.6e-06
KYNU	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Uterus	rep_26	3.2e-12
KYNU	GOBP_Cellular_Ketone_Metabolic_Process	Human	Uterus	rep_26	3.2e-13
KYNU	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Human	Uterus	rep_26	2.4e-06
KYNU	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Human	Uterus	rep_26	9.1e-11
KYNU	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Uterus	rep_26	3.4e-15
KYNU	GOBP_Organic_Acid_Biosynthetic_Process	Human	Uterus	rep_26	2.3e-06
KYNU	GOBP_Organic_Acid_Catabolic_Process	Human	Uterus	rep_26	6.9e-09
KYNU	GOBP_Organic_Acid_Metabolic_Process	Human	Uterus	rep_26	4.9e-06
KYNU	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
KYNU	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
KYNU	GOBP_Organophosphate_Biosynthetic_Process	Human	Uterus	rep_26	8.0e-07
KYNU	GOBP_Purine_Containing_Compound_Metabolic_Process	Human	Uterus	rep_26	2.0e-06
KYNU	GOBP_Response_To_Extracellular_Stimulus	Human	Uterus	rep_26	1.1e-14
KYNU	GOBP_Response_To_Interferon_Gamma	Human	Uterus	rep_26	5.5e-07
KYNU	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
KYNU	GOBP_Small_Molecule_Catabolic_Process	Human	Uterus	rep_26	9.1e-13
KYNU	GOBP_Sulfur_Compound_Metabolic_Process	Human	Uterus	rep_26	8.8e-08
KYNU	GOBP_Thioester_Metabolic_Process	Human	Uterus	rep_26	2.5e-14
KYNU	GOBP_Response_To_Nutrient	Human	Uterus	rep_31	3.9e-06
KYNU	GOBP_Aging	Human	Breast	rep_1	1.7e-60
KYNU	GOBP_Amine_Catabolic_Process	Human	Breast	rep_1	3.8e-15
KYNU	GOBP_Amine_Metabolic_Process	Human	Breast	rep_1	4.2e-96
KYNU	GOBP_Aromatic_Amino_Acid_Family_Catabolic_Process	Human	Breast	rep_1	4.5e-36
KYNU	GOBP_Benzene_Containing_Compound_Metabolic_Process	Human	Breast	rep_1	1.5e-21
KYNU	GOBP_Cellular_Ketone_Metabolic_Process	Human	Breast	rep_1	6.1e-19
KYNU	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
KYNU	GOBP_Indolalkylamine_Metabolic_Process	Human	Breast	rep_1	1.2e-06
KYNU	GOBP_Indole_Containing_Compound_Metabolic_Process	Human	Breast	rep_1	3.8e-65
KYNU	GOBP_Kynurenine_Metabolic_Process	Human	Breast	rep_1	6.1e-04
KYNU	GOBP_Organophosphate_Biosynthetic_Process	Human	Breast	rep_1	1.4e-07
KYNU	GOBP_Pyridine_Containing_Compound_Biosynthetic_Process	Human	Breast	rep_1	1.6e-38
KYNU	GOBP_Pyridine_Containing_Compound_Metabolic_Process	Human	Breast	rep_1	1.3e-34
KYNU	GOBP_Quinolinate_Metabolic_Process	Human	Breast	rep_1	9.6e-17
KYNU	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
KYNU	GOBP_Response_To_Interferon_Gamma	Human	Breast	rep_1	1.1e-10
KYNU	GOBP_Response_To_Nutrient	Human	Breast	rep_1	1.4e-05
KYNU	GOBP_Response_To_Vitamin	Human	Breast	rep_1	4.5e-26
KYNU	GOBP_Tryptophan_Catabolic_Process	Human	Breast	rep_1	5.6e-28
KYNU	GOBP_Tryptophan_Catabolic_Process_To_Kynurenine	Human	Breast	rep_1	4.6e-05
KYNU	GOBP_De_Novo_Nad_Biosynthetic_Process	Human	Breast	rep_5	1.6e-14
KYNU	GOBP_L_Kynurenine_Metabolic_Process	Human	Breast	rep_5	6.2e-04
KYNU	GOBP_Organic_Acid_Biosynthetic_Process	Human	Breast	rep_5	3.5e-09
KYNU	GOBP_Response_To_Extracellular_Stimulus	Human	Breast	rep_5	2.9e-12
KYNU	GOBP_Response_To_Nitrogen_Compound	Human	Breast	rep_5	1.1e-11
KYNU	GOBP_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	7.5e-14
KYNU	GOBP_Acetyl_Coa_Metabolic_Process	Human	Breast	rep_6	4.2e-09
KYNU	GOBP_Alpha_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	2.6e-05
KYNU	GOBP_Alpha_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.7e-08
KYNU	GOBP_Aromatic_Amino_Acid_Family_Metabolic_Process	Human	Breast	rep_6	4.0e-10
KYNU	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
KYNU	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
KYNU	GOBP_Cellular_Amino_Acid_Catabolic_Process	Human	Breast	rep_6	1.6e-05
KYNU	GOBP_Cellular_Amino_Acid_Metabolic_Process	Human	Breast	rep_6	1.0e-10
KYNU	GOBP_Ketone_Catabolic_Process	Human	Breast	rep_6	1.8e-07
KYNU	GOBP_Monocarboxylic_Acid_Metabolic_Process	Human	Breast	rep_6	6.1e-07
KYNU	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	1.7e-10
KYNU	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Human	Breast	rep_6	1.6e-07
KYNU	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Breast	rep_6	6.2e-07
KYNU	GOBP_Organic_Acid_Catabolic_Process	Human	Breast	rep_6	1.5e-11
KYNU	GOBP_Organic_Acid_Metabolic_Process	Human	Breast	rep_6	6.7e-05
KYNU	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
KYNU	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
KYNU	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
KYNU	GOBP_Organophosphate_Metabolic_Process	Human	Breast	rep_6	1.0e-12
KYNU	GOBP_Purine_Containing_Compound_Metabolic_Process	Human	Breast	rep_6	2.5e-09
KYNU	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
KYNU	GOBP_Small_Molecule_Catabolic_Process	Human	Breast	rep_6	4.7e-07
KYNU	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
KYNU	GOBP_Sulfur_Compound_Metabolic_Process	Human	Breast	rep_6	3.0e-10
KYNU	GOBP_Thioester_Metabolic_Process	Human	Breast	rep_6	2.5e-07
KYNU	GOBP_Amine_Catabolic_Process	Human	Skin	P10_rep1	1.5e-15
KYNU	GOBP_Indolalkylamine_Metabolic_Process	Human	Skin	P10_rep2	1.1e-10
KYNU	GOBP_Indole_Containing_Compound_Metabolic_Process	Human	Skin	P10_rep2	6.3e-08
KYNU	GOBP_Response_To_Vitamin	Human	Skin	P10_rep2	2.3e-21
KYNU	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
KYNU	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
KYNU	GOBP_Pyridine_Containing_Compound_Biosynthetic_Process	Human	Lung	rep_1	3.2e-07
KYNU	GOBP_Pyridine_Containing_Compound_Metabolic_Process	Human	Lung	rep_1	4.3e-07
KYNU	GOBP_Quinolinate_Metabolic_Process	Human	Lung	rep_1	1.4e-15
KYNU	GOBP_Cellular_Ketone_Metabolic_Process	Human	Lung	rep_2	2.1e-09

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KYNU function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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KYNU function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for KYNU envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for KYNU

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
KYNU	Q16719	DB00114	Pyridoxal phosphate	Kynureninase	SmallMoleculeDrug	approved\|investigational\|nutraceutical

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Related Diseases for KYNU

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
KYNU	C0268474	Hydroxykynureninuria	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
KYNU	C0000772	Multiple congenital anomalies	1	GENOMICS_ENGLAND
KYNU	C0021368	Inflammation	1	CTD_human
KYNU	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
KYNU	C0270715	Degenerative Diseases, Central Nervous System	1	CTD_human
KYNU	C0524851	Neurodegenerative Disorders	1	CTD_human
KYNU	C0751733	Degenerative Diseases, Spinal Cord	1	CTD_human
KYNU	C1302790	Congenital malformation syndrome	1	GENOMICS_ENGLAND
KYNU	C4540004	VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 1	1	ORPHANET
KYNU	C4540014	VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 2	1	GENOMICS_ENGLAND;ORPHANET