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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: MBD2 (spascer ID:8932)

Gene summary for MBD2

Gene summary

Gene information
	Species	Human
	Gene symbol	MBD2
	Gene ID	8932
	Gene name	methyl-CpG binding domain protein 2
	Synonyms	DMTase\|NY-CO-41
	Cytomap	18q21.2
	Type of gene	protein-coding
	Description	methyl-CpG-binding domain protein 2demethylase
	Modification date	20220513
	UniProtAcc	Q9UBB5

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for MBD2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
MBD2	Human	Intestine	rep_colon2	34417225	2.85e-15
MBD2	Human	Liver	rep_liver1	34417225	1.08e-15
MBD2	Human	Uterus	rep_2	34857954	3.15e-08
MBD2	Human	Uterus	rep_3	34857954	1.57e-07
MBD2	Human	Breast	1142243F	34493872	1.47e-07
MBD2	Human	Breast	CID44971	34493872	3.29e-15
MBD2	Human	Skin	P2_rep2	32946785	6.72e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon2_H&E
Liver_rep_liver1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Breast_1142243F_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has MBD2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
MBD2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
MBD2	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
MBD2	GOBP_Circulatory_System_Development	Human	Brain	rep_4	4.1e-17
MBD2	GOBP_Response_To_Lipid	Human	Brain	rep_10	2.8e-23
MBD2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
MBD2	GOBP_Response_To_Extracellular_Stimulus	Human	Brain	rep_11	2.5e-12
MBD2	GOBP_Circulatory_System_Development	Human	Bladder	rep_2	1.0e-16
MBD2	GOBP_Response_To_Estradiol	Human	Bladder	rep_2	1.6e-18
MBD2	GOBP_Circulatory_System_Development	Human	Liver	rep_1	6.0e-76
MBD2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
MBD2	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
MBD2	GOBP_Response_To_Extracellular_Stimulus	Human	Liver	rep_1	1.7e-73
MBD2	GOBP_Response_To_Lipid	Human	Liver	rep_1	3.0e-55
MBD2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
MBD2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
MBD2	GOBP_Circulatory_System_Development	Human	Intestine	rep_colon4	1.9e-09
MBD2	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
MBD2	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	rep_liver2	8.9e-16
MBD2	GOBP_Response_To_Lipid	Human	Intestine	rep_liver2	3.7e-39
MBD2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
MBD2	GOBP_Aging	Human	Intestine	A3	9.0e-18
MBD2	GOBP_Behavior	Human	Intestine	A3	1.8e-11
MBD2	GOBP_Cell_Cell_Signaling	Human	Intestine	A3	6.4e-08
MBD2	GOBP_Cell_Cell_Signaling_By_Wnt	Human	Intestine	A3	3.1e-07
MBD2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Human	Intestine	A3	7.0e-07
MBD2	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	2.5e-14
MBD2	GOBP_Chromatin_Assembly_Or_Disassembly	Human	Intestine	A3	1.7e-09
MBD2	GOBP_Chromatin_Organization	Human	Intestine	A3	3.2e-11
MBD2	GOBP_Chromosome_Organization	Human	Intestine	A3	2.5e-13
MBD2	GOBP_Circulatory_System_Development	Human	Intestine	A3	5.9e-08
MBD2	GOBP_Dna_Conformation_Change	Human	Intestine	A3	9.8e-12
MBD2	GOBP_Dna_Metabolic_Process	Human	Intestine	A3	1.2e-09
MBD2	GOBP_Dna_Methylation_Or_Demethylation	Human	Intestine	A3	2.7e-07
MBD2	GOBP_Dna_Packaging	Human	Intestine	A3	6.2e-08
MBD2	GOBP_Embryo_Development	Human	Intestine	A3	2.4e-07
MBD2	GOBP_Embryonic_Organ_Development	Human	Intestine	A3	1.4e-10
MBD2	GOBP_Heart_Development	Human	Intestine	A3	3.2e-07
MBD2	GOBP_Methylation	Human	Intestine	A3	5.9e-09
MBD2	GOBP_Multicellular_Organism_Reproduction	Human	Intestine	A3	4.1e-15
MBD2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Intestine	A3	5.9e-17
MBD2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	7.7e-14
MBD2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Intestine	A3	1.9e-15
MBD2	GOBP_Positive_Regulation_Of_Binding	Human	Intestine	A3	1.3e-09
MBD2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
MBD2	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
MBD2	GOBP_Regulation_Of_Binding	Human	Intestine	A3	4.9e-11
MBD2	GOBP_Regulation_Of_Dna_Metabolic_Process	Human	Intestine	A3	2.8e-10
MBD2	GOBP_Reproduction	Human	Intestine	A3	4.6e-19
MBD2	GOBP_Response_To_Abiotic_Stimulus	Human	Intestine	A3	5.3e-18
MBD2	GOBP_Response_To_Lipid	Human	Intestine	A3	1.7e-09
MBD2	GOBP_Response_To_Mechanical_Stimulus	Human	Intestine	A3	6.3e-07
MBD2	GOBP_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	3.2e-15
MBD2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
MBD2	GOBP_Dna_Methylation	Human	Intestine	A8	9.1e-32
MBD2	GOBP_Dna_Methylation_Dependent_Heterochromatin_Assembly	Human	Intestine	A8	1.8e-14
MBD2	GOBP_Dna_Modification	Human	Intestine	A8	2.2e-26
MBD2	GOBP_Heterochromatin_Organization	Human	Intestine	A8	6.1e-09
MBD2	GOBP_Parental_Behavior	Human	Intestine	A8	2.2e-15
MBD2	GOBP_Regulation_Of_Dna_Methylation	Human	Intestine	A8	6.1e-08
MBD2	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	A8	2.1e-23
MBD2	GOBP_Dna_Methylation_Or_Demethylation	Human	Pancreas	PDAC-B-st1	4.1e-05
MBD2	GOBP_Dna_Modification	Human	Pancreas	PDAC-B-st1	2.6e-05
MBD2	GOBP_Parental_Behavior	Human	Pancreas	PDAC-B-st1	6.7e-07
MBD2	GOBP_Dna_Methylation	Human	Pancreas	PDAC-A-st2	7.3e-05
MBD2	GOBP_Positive_Regulation_Of_Chromatin_Binding	Human	Pancreas	PDAC-A-st2	2.0e-06
MBD2	GOBP_Regulation_Of_Dna_Methylation	Human	Pancreas	PDAC-A-st2	2.2e-06
MBD2	GOBP_Chromatin_Organization	Human	Uterus	rep_1	1.9e-06
MBD2	GOBP_Positive_Regulation_Of_Binding	Human	Uterus	rep_1	6.3e-06
MBD2	GOBP_Dna_Methylation	Human	Uterus	rep_25	1.1e-09
MBD2	GOBP_Dna_Methylation_Or_Demethylation	Human	Uterus	rep_25	4.5e-16
MBD2	GOBP_Dna_Modification	Human	Uterus	rep_25	8.2e-07
MBD2	GOBP_Dna_Packaging	Human	Uterus	rep_25	9.6e-06
MBD2	GOBP_Positive_Regulation_Of_Chromatin_Binding	Human	Uterus	rep_25	8.2e-12
MBD2	GOBP_Regulation_Of_Dna_Methylation	Human	Uterus	rep_25	2.9e-10
MBD2	GOBP_Cell_Cell_Signaling_By_Wnt	Human	Uterus	rep_26	5.5e-06
MBD2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Human	Uterus	rep_26	9.2e-08
MBD2	GOBP_Chromatin_Assembly_Or_Disassembly	Human	Uterus	rep_26	4.8e-09
MBD2	GOBP_Chromosome_Organization	Human	Uterus	rep_26	1.2e-09
MBD2	GOBP_Dna_Conformation_Change	Human	Uterus	rep_26	1.2e-14
MBD2	GOBP_Dna_Methylation_Dependent_Heterochromatin_Assembly	Human	Uterus	rep_26	8.2e-06
MBD2	GOBP_Heterochromatin_Organization	Human	Uterus	rep_26	2.1e-10
MBD2	GOBP_Methylation	Human	Uterus	rep_26	1.9e-06
MBD2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Uterus	rep_26	2.1e-06
MBD2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Uterus	rep_26	6.2e-13
MBD2	GOBP_Regulation_Of_Chromatin_Binding	Human	Uterus	rep_26	7.2e-12
MBD2	GOBP_Regulation_Of_Dna_Metabolic_Process	Human	Uterus	rep_26	2.1e-06
MBD2	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Human	Uterus	rep_26	9.9e-10
MBD2	GOBP_Response_To_Extracellular_Stimulus	Human	Uterus	rep_26	1.1e-14
MBD2	GOBP_Aging	Human	Breast	rep_1	1.7e-60
MBD2	GOBP_Chromatin_Remodeling	Human	Breast	rep_1	1.7e-06
MBD2	GOBP_Circulatory_System_Development	Human	Breast	rep_1	3.8e-70
MBD2	GOBP_Heart_Development	Human	Breast	rep_1	4.1e-08
MBD2	GOBP_Parental_Behavior	Human	Breast	rep_1	5.3e-60
MBD2	GOBP_Regulation_Of_Binding	Human	Breast	rep_1	6.1e-11
MBD2	GOBP_Regulation_Of_Chromatin_Binding	Human	Breast	rep_1	2.5e-11
MBD2	GOBP_Regulation_Of_Dna_Methylation	Human	Breast	rep_1	4.3e-12
MBD2	GOBP_Response_To_Abiotic_Stimulus	Human	Breast	rep_1	2.6e-19
MBD2	GOBP_Response_To_Mechanical_Stimulus	Human	Breast	rep_1	1.2e-38
MBD2	GOBP_Behavior	Human	Breast	rep_5	3.9e-08
MBD2	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	5.1e-18
MBD2	GOBP_Embryo_Development	Human	Breast	rep_5	5.5e-08
MBD2	GOBP_Embryonic_Organ_Development	Human	Breast	rep_5	3.3e-05
MBD2	GOBP_Multicellular_Organism_Reproduction	Human	Breast	rep_5	8.1e-07
MBD2	GOBP_Positive_Regulation_Of_Binding	Human	Breast	rep_5	2.1e-11
MBD2	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
MBD2	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
MBD2	GOBP_Reproduction	Human	Breast	rep_5	8.1e-06
MBD2	GOBP_Response_To_Estradiol	Human	Breast	rep_5	6.9e-16
MBD2	GOBP_Response_To_Extracellular_Stimulus	Human	Breast	rep_5	2.9e-12
MBD2	GOBP_Response_To_Lipid	Human	Breast	rep_5	1.6e-10
MBD2	GOBP_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	7.5e-14
MBD2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
MBD2	GOBP_Cell_Cell_Signaling	Human	Breast	rep_6	5.0e-05
MBD2	GOBP_Cell_Cell_Signaling_By_Wnt	Human	Breast	rep_6	4.2e-06
MBD2	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Human	Breast	rep_6	1.5e-06
MBD2	GOBP_Chromatin_Assembly_Or_Disassembly	Human	Breast	rep_6	8.1e-05
MBD2	GOBP_Chromatin_Organization	Human	Breast	rep_6	4.3e-07
MBD2	GOBP_Chromosome_Organization	Human	Breast	rep_6	1.1e-06
MBD2	GOBP_Dna_Conformation_Change	Human	Breast	rep_6	1.4e-05
MBD2	GOBP_Dna_Metabolic_Process	Human	Breast	rep_6	1.4e-10
MBD2	GOBP_Dna_Methylation_Or_Demethylation	Human	Breast	rep_6	1.8e-05
MBD2	GOBP_Dna_Modification	Human	Breast	rep_6	6.8e-08
MBD2	GOBP_Dna_Packaging	Human	Breast	rep_6	1.9e-04
MBD2	GOBP_Heterochromatin_Organization	Human	Breast	rep_6	1.0e-04
MBD2	GOBP_Methylation	Human	Breast	rep_6	1.7e-06
MBD2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Breast	rep_6	2.6e-08
MBD2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_6	3.5e-08
MBD2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Breast	rep_6	8.2e-08
MBD2	GOBP_Positive_Regulation_Of_Chromatin_Binding	Human	Breast	rep_6	2.9e-09
MBD2	GOBP_Regulation_Of_Dna_Metabolic_Process	Human	Breast	rep_6	9.5e-08
MBD2	GOBP_Reproductive_Behavior	Human	Breast	rep_6	2.4e-04
MBD2	GOBP_Dna_Conformation_Change	Human	Skin	P5_rep1	1.8e-15
MBD2	GOBP_Dna_Methylation	Human	Skin	P10_rep1	1.7e-12
MBD2	GOBP_Positive_Regulation_Of_Chromatin_Binding	Human	Skin	P10_rep1	1.7e-18
MBD2	GOBP_Regulation_Of_Chromatin_Binding	Human	Skin	P10_rep1	4.4e-09
MBD2	GOBP_Dna_Methylation_Or_Demethylation	Human	Skin	P10_rep2	2.6e-11
MBD2	GOBP_Regulation_Of_Dna_Methylation	Human	Skin	P10_rep2	1.2e-08
MBD2	GOBP_Reproductive_Behavior	Human	Skin	P10_rep3	7.2e-22
MBD2	GOBP_Response_To_Lipid	Human	Lung	rep_1	1.8e-09
MBD2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08

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MBD2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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MBD2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for MBD2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for MBD2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MBD2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
MBD2	C0033578	Prostatic Neoplasms	1	CTD_human
MBD2	C0036341	Schizophrenia	1	PSYGENET
MBD2	C0376358	Malignant neoplasm of prostate	1	CTD_human
MBD2	C2931456	Prostate cancer, familial	1	CTD_human
MBD2	C4722327	PROSTATE CANCER, HEREDITARY, 1	1	CTD_human