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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: HERC1 (spascer ID:8925)

Gene summary for HERC1

Gene summary

Gene information
	Species	Human
	Gene symbol	HERC1
	Gene ID	8925
	Gene name	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
	Synonyms	MDFPMR\|p532\|p619
	Cytomap	15q22.31
	Type of gene	protein-coding
	Description	probable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC
	Modification date	20220513
	UniProtAcc	Q15751

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for HERC1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
HERC1	Human	Brain	rep_6	33558695	2.17e-06
HERC1	Human	Brain	rep_9	33558695	2.75e-06
HERC1	Human	Liver	rep_liver2	34417225	2.46e-06
HERC1	Human	Breast	1160920F	34493872	2.01e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_6_H&E
Brain_rep_9_H&E
Liver_rep_liver2_H&E
Breast_1160920F_H&E

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Spatial pattern pathway has HERC1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
HERC1	GOBP_Central_Nervous_System_Development	Human	Brain	rep_1	2.8e-23
HERC1	GOBP_Neurogenesis	Human	Brain	rep_1	7.4e-34
HERC1	GOBP_Neuron_Development	Human	Brain	rep_1	7.4e-34
HERC1	GOBP_Neuron_Differentiation	Human	Brain	rep_1	7.4e-34
HERC1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Brain	rep_4	4.1e-17
HERC1	GOBP_Hindbrain_Development	Human	Bladder	rep_4	3.9e-13
HERC1	GOBP_Metencephalon_Development	Human	Bladder	rep_4	5.7e-16
HERC1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Liver	rep_1	6.0e-76
HERC1	GOBP_Central_Nervous_System_Development	Human	Liver	rep_1	1.0e-70
HERC1	GOBP_Neurogenesis	Human	Liver	rep_1	1.0e-70
HERC1	GOBP_Neuron_Development	Human	Liver	rep_1	1.5e-73
HERC1	GOBP_Neuron_Differentiation	Human	Liver	rep_1	1.5e-73
HERC1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
HERC1	GOBP_Cell_Projection_Organization	Human	Intestine	A3	1.1e-09
HERC1	GOBP_Central_Nervous_System_Development	Human	Intestine	A3	7.1e-11
HERC1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Intestine	A3	8.6e-07
HERC1	GOBP_Cerebellar_Cortex_Development	Human	Intestine	A3	4.8e-07
HERC1	GOBP_Head_Development	Human	Intestine	A3	3.8e-09
HERC1	GOBP_Hindbrain_Development	Human	Intestine	A3	1.6e-15
HERC1	GOBP_Metencephalon_Development	Human	Intestine	A3	4.9e-20
HERC1	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Intestine	A3	5.0e-10
HERC1	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Intestine	A3	9.0e-12
HERC1	GOBP_Nervous_System_Process	Human	Intestine	A3	9.7e-07
HERC1	GOBP_Neurogenesis	Human	Intestine	A3	6.4e-14
HERC1	GOBP_Neuromuscular_Process	Human	Intestine	A3	1.3e-09
HERC1	GOBP_Neuron_Development	Human	Intestine	A3	1.3e-12
HERC1	GOBP_Neuron_Differentiation	Human	Intestine	A3	1.4e-11
HERC1	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Intestine	A3	4.7e-11
HERC1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
HERC1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
HERC1	GOBP_Regulation_Of_Autophagy	Human	Intestine	A3	1.5e-09
HERC1	GOBP_Regulation_Of_Catabolic_Process	Human	Intestine	A3	3.5e-16
HERC1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	A8	3.3e-08
HERC1	GOBP_Cerebellar_Cortex_Formation	Human	Intestine	A8	8.1e-07
HERC1	GOBP_Cerebellar_Cortex_Morphogenesis	Human	Intestine	A8	1.7e-08
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Development	Human	Intestine	A8	3.6e-07
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Morphogenesis	Human	Intestine	A8	2.7e-17
HERC1	GOBP_Hindbrain_Morphogenesis	Human	Intestine	A8	4.3e-09
HERC1	GOBP_Cerebellar_Cortex_Development	Human	Pancreas	PDAC-B-st1	3.5e-05
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Development	Human	Pancreas	PDAC-B-st1	4.5e-05
HERC1	GOBP_Head_Development	Human	Pancreas	PDAC-B-st1	2.0e-05
HERC1	GOBP_Cell_Differentiation_In_Hindbrain	Human	Uterus	rep_26	5.6e-17
HERC1	GOBP_Cerebellar_Cortex_Development	Human	Uterus	rep_26	6.1e-10
HERC1	GOBP_Cerebellar_Cortex_Formation	Human	Uterus	rep_26	2.7e-13
HERC1	GOBP_Cerebellar_Cortex_Morphogenesis	Human	Uterus	rep_26	6.1e-06
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Formation	Human	Uterus	rep_26	2.4e-06
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Morphogenesis	Human	Uterus	rep_26	1.8e-19
HERC1	GOBP_Hindbrain_Development	Human	Uterus	rep_26	3.2e-18
HERC1	GOBP_Metencephalon_Development	Human	Uterus	rep_26	1.7e-11
HERC1	GOBP_Negative_Regulation_Of_Autophagy	Human	Uterus	rep_26	8.0e-10
HERC1	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Uterus	rep_26	4.0e-09
HERC1	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Uterus	rep_26	4.4e-10
HERC1	GOBP_Nervous_System_Process	Human	Uterus	rep_26	2.3e-07
HERC1	GOBP_Neuromuscular_Process	Human	Uterus	rep_26	3.9e-09
HERC1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
HERC1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
HERC1	GOBP_Regulation_Of_Autophagy	Human	Uterus	rep_26	3.2e-06
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Development	Human	Uterus	rep_27	4.7e-06
HERC1	GOBP_Hindbrain_Morphogenesis	Human	Uterus	rep_28	2.1e-06
HERC1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Uterus	rep_29	2.3e-07
HERC1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Breast	rep_1	1.9e-98
HERC1	GOBP_Cell_Projection_Organization	Human	Breast	rep_1	1.8e-20
HERC1	GOBP_Central_Nervous_System_Development	Human	Breast	rep_1	5.1e-04
HERC1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Breast	rep_1	6.0e-26
HERC1	GOBP_Cerebellar_Cortex_Formation	Human	Breast	rep_1	6.2e-04
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Formation	Human	Breast	rep_1	2.5e-08
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Morphogenesis	Human	Breast	rep_1	2.7e-04
HERC1	GOBP_Head_Development	Human	Breast	rep_1	1.0e-09
HERC1	GOBP_Hindbrain_Development	Human	Breast	rep_1	9.5e-34
HERC1	GOBP_Metencephalon_Development	Human	Breast	rep_1	3.6e-23
HERC1	GOBP_Nervous_System_Process	Human	Breast	rep_1	1.2e-04
HERC1	GOBP_Neurogenesis	Human	Breast	rep_1	8.0e-11
HERC1	GOBP_Neuromuscular_Process	Human	Breast	rep_1	4.3e-06
HERC1	GOBP_Neuron_Development	Human	Breast	rep_1	2.5e-26
HERC1	GOBP_Neuron_Differentiation	Human	Breast	rep_1	1.1e-16
HERC1	GOBP_Negative_Regulation_Of_Autophagy	Human	Breast	rep_5	2.0e-05
HERC1	GOBP_Neuromuscular_Process_Controlling_Balance	Human	Breast	rep_5	1.5e-10
HERC1	GOBP_Cerebellar_Cortex_Development	Human	Breast	rep_6	3.9e-06
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Development	Human	Breast	rep_6	2.2e-07
HERC1	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	2.0e-06
HERC1	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Breast	rep_6	1.0e-06
HERC1	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Breast	rep_6	1.9e-08
HERC1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
HERC1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
HERC1	GOBP_Regulation_Of_Autophagy	Human	Breast	rep_6	7.8e-04
HERC1	GOBP_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	3.3e-04
HERC1	GOBP_Cell_Differentiation_In_Hindbrain	Human	Skin	P2_rep2	1.3e-11
HERC1	GOBP_Cerebellar_Cortex_Development	Human	Skin	P2_rep2	5.5e-10
HERC1	GOBP_Cerebellar_Cortex_Formation	Human	Skin	P2_rep2	6.7e-14
HERC1	GOBP_Cerebellar_Cortex_Morphogenesis	Human	Skin	P2_rep2	1.7e-15
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Formation	Human	Skin	P2_rep2	6.4e-16
HERC1	GOBP_Cerebellar_Purkinje_Cell_Layer_Morphogenesis	Human	Skin	P2_rep2	8.6e-31
HERC1	GOBP_Hindbrain_Morphogenesis	Human	Skin	P5_rep1	5.1e-12
HERC1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Skin	P10_rep1	5.0e-08
HERC1	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Lung	rep_2	3.4e-07

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HERC1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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HERC1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for HERC1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for HERC1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for HERC1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
HERC1	C4310766	MACROCEPHALY, DYSMORPHIC FACIES, AND PSYCHOMOTOR RETARDATION	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
HERC1	C0004238	Atrial Fibrillation	1	CTD_human
HERC1	C0235480	Paroxysmal atrial fibrillation	1	CTD_human
HERC1	C2585653	Persistent atrial fibrillation	1	CTD_human
HERC1	C3468561	familial atrial fibrillation	1	CTD_human