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Spatial pattern gene: HERC2 (spascer ID:8924) |
Gene summary for HERC2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | HERC2 | Gene ID | 8924 |
| Gene name | HECT and RLD domain containing E3 ubiquitin protein ligase 2 |
| Synonyms | D15F37S1|MRT38|SHEP1|jdf2|p528 |
| Cytomap | 15q13.1 |
| Type of gene | protein-coding |
| Description | E3 ubiquitin-protein ligase HERC2HECT-type E3 ubiquitin transferase HERC2hect domain and RCC1-like domain-containing protein 2hect domain and RLD 2probable E3 ubiquitin-protein ligase HERC2 |
| Modification date | 20220513 |
| UniProtAcc | O95714 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| HERC2 | GO:0005737 | cytoplasm | 21873635 | Component |
| HERC2 | GO:0016020 | membrane | 21873635 | Component |
| HERC2 | GO:0016567 | protein ubiquitination | 21873635 | Process |
| HERC2 | GO:0061630 | ubiquitin protein ligase activity | 21873635 | Function |
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Spatial pattern events for HERC2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| HERC2 | Human | Bladder | rep_2 | 34385456 | 5.01e-07 |
| HERC2 | Human | Intestine | rep_colon1 | 34417225 | 1.56e-07 |
| HERC2 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| HERC2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| HERC2 | Human | Heart | w6_s3 | 31835037 | 5.93e-04 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_2_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
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Spatial pattern pathway has HERC2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| HERC2 | GOBP_Cellular_Macromolecule_Localization | Human | Intestine | A3 | 1.7e-09 |
| HERC2 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Human | Intestine | A3 | 6.6e-16 |
| HERC2 | GOBP_Dna_Metabolic_Process | Human | Intestine | A3 | 1.2e-09 |
| HERC2 | GOBP_Dna_Repair | Human | Intestine | A3 | 4.4e-09 |
| HERC2 | GOBP_Double_Strand_Break_Repair | Human | Intestine | A3 | 3.1e-09 |
| HERC2 | GOBP_Establishment_Of_Protein_Localization | Human | Intestine | A3 | 5.0e-10 |
| HERC2 | GOBP_Intracellular_Protein_Transport | Human | Intestine | A3 | 4.8e-12 |
| HERC2 | GOBP_Intracellular_Transport | Human | Intestine | A3 | 7.6e-15 |
| HERC2 | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Human | Intestine | A3 | 1.2e-13 |
| HERC2 | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Human | Intestine | A3 | 1.8e-12 |
| HERC2 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Human | Uterus | rep_26 | 2.4e-07 |
| HERC2 | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Human | Uterus | rep_26 | 2.1e-08 |
| HERC2 | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Human | Uterus | rep_26 | 5.7e-08 |
| HERC2 | GOBP_Cellular_Macromolecule_Localization | Human | Breast | rep_1 | 3.7e-09 |
| HERC2 | GOBP_Establishment_Of_Protein_Localization | Human | Breast | rep_1 | 7.2e-05 |
| HERC2 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Human | Breast | rep_6 | 6.0e-06 |
| HERC2 | GOBP_Dna_Metabolic_Process | Human | Breast | rep_6 | 1.4e-10 |
| HERC2 | GOBP_Dna_Repair | Human | Breast | rep_6 | 1.0e-09 |
| HERC2 | GOBP_Double_Strand_Break_Repair | Human | Breast | rep_6 | 2.0e-09 |
| HERC2 | GOBP_Intracellular_Protein_Transport | Human | Breast | rep_6 | 6.4e-12 |
| HERC2 | GOBP_Intracellular_Transport | Human | Breast | rep_6 | 1.3e-08 |
| HERC2 | GOBP_Protein_Modification_By_Small_Protein_Conjugation | Human | Breast | rep_6 | 3.6e-10 |
| HERC2 | GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal | Human | Breast | rep_6 | 2.7e-09 |
| HERC2 | GOBP_Dna_Repair | Human | Skin | P5_rep1 | 1.7e-08 |
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HERC2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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HERC2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for HERC2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for HERC2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for HERC2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| HERC2 | C3809753 | MENTAL RETARDATION, AUTOSOMAL RECESSIVE 38 | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| HERC2 | C0009324 | Ulcerative Colitis | 1 | CTD_human |
| HERC2 | C0264423 | Asthma, Occupational | 1 | CTD_human |
