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Spatial pattern gene: EIF2S2 (spascer ID:8894) |
Gene summary for EIF2S2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | EIF2S2 | Gene ID | 8894 |
| Gene name | eukaryotic translation initiation factor 2 subunit beta |
| Synonyms | EIF2|EIF2B|EIF2beta|PPP1R67|eIF-2-beta |
| Cytomap | 20q11.22 |
| Type of gene | protein-coding |
| Description | eukaryotic translation initiation factor 2 subunit 2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDaprotein phosphatase 1, regulatory subunit 67 |
| Modification date | 20220513 |
| UniProtAcc | P20042 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| EIF2S2 | GO:0001731 | formation of translation preinitiation complex | 21873635 | Process |
| EIF2S2 | GO:0001732 | formation of cytoplasmic translation initiation complex | 21873635 | Process |
| EIF2S2 | GO:0003729 | mRNA binding | 21873635 | Function |
| EIF2S2 | GO:0003743 | translation initiation factor activity | 21873635 | Function |
| EIF2S2 | GO:0005850 | eukaryotic translation initiation factor 2 complex | 21873635 | Component |
| EIF2S2 | GO:0031369 | translation initiation factor binding | 21873635 | Function |
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Spatial pattern events for EIF2S2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| EIF2S2 | Human | Bladder | rep_1 | 34385456 | 8.93e-15 |
| EIF2S2 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| EIF2S2 | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| EIF2S2 | Human | Intestine | rep_colon3 | 34417225 | 2.39e-07 |
| EIF2S2 | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| EIF2S2 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| EIF2S2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| EIF2S2 | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| EIF2S2 | Human | Uterus | rep_2 | 34857954 | 2.55e-15 |
| EIF2S2 | Human | Uterus | rep_3 | 34857954 | 2.01e-14 |
| EIF2S2 | Human | Breast | 1142243F | 34493872 | 2.30e-15 |
| EIF2S2 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| EIF2S2 | Human | Skin | P2_rep2 | 32946785 | 5.63e-11 |
| EIF2S2 | Human | Lung | rep_1 | 35355018 | 6.67e-07 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Bladder_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Lung_rep_1_H&E  |  |
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Spatial pattern pathway has EIF2S2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| EIF2S2 | GOBP_Transmembrane_Transport | Human | Brain | rep_1 | 2.8e-23 |
| EIF2S2 | GOBP_Germ_Cell_Proliferation | Human | Bladder | rep_2 | 1.1e-06 |
| EIF2S2 | GOBP_Transmembrane_Transport | Human | Liver | rep_1 | 1.0e-70 |
| EIF2S2 | GOBP_Amide_Biosynthetic_Process | Human | Intestine | A1 | 6.4e-07 |
| EIF2S2 | GOBP_Cytoplasmic_Translation | Human | Intestine | A1 | 5.4e-14 |
| EIF2S2 | GOBP_Peptide_Biosynthetic_Process | Human | Intestine | A1 | 4.6e-10 |
| EIF2S2 | GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism | Human | Intestine | A3 | 2.5e-12 |
| EIF2S2 | GOBP_Development_Of_Primary_Sexual_Characteristics | Human | Intestine | A3 | 5.0e-13 |
| EIF2S2 | GOBP_Developmental_Process_Involved_In_Reproduction | Human | Intestine | A3 | 2.7e-15 |
| EIF2S2 | GOBP_Embryo_Development | Human | Intestine | A3 | 2.4e-07 |
| EIF2S2 | GOBP_Gamete_Generation | Human | Intestine | A3 | 4.2e-13 |
| EIF2S2 | GOBP_Male_Sex_Differentiation | Human | Intestine | A3 | 2.6e-16 |
| EIF2S2 | GOBP_Multicellular_Organism_Reproduction | Human | Intestine | A3 | 4.1e-15 |
| EIF2S2 | GOBP_Reproduction | Human | Intestine | A3 | 4.6e-19 |
| EIF2S2 | GOBP_Reproductive_System_Development | Human | Intestine | A3 | 2.9e-14 |
| EIF2S2 | GOBP_Ribonucleoprotein_Complex_Subunit_Organization | Human | Intestine | A3 | 1.6e-07 |
| EIF2S2 | GOBP_Sex_Differentiation | Human | Intestine | A3 | 6.1e-18 |
| EIF2S2 | GOBP_Translational_Initiation | Human | Intestine | A3 | 5.0e-09 |
| EIF2S2 | GOBP_Transmembrane_Transport | Human | Intestine | A3 | 1.4e-10 |
| EIF2S2 | GOBP_Formation_Of_Translation_Preinitiation_Complex | Human | Intestine | A8 | 3.3e-13 |
| EIF2S2 | GOBP_Germ_Cell_Proliferation | Human | Intestine | A8 | 2.7e-11 |
| EIF2S2 | GOBP_Developmental_Process_Involved_In_Reproduction | Human | Uterus | rep_1 | 1.6e-06 |
| EIF2S2 | GOBP_Formation_Of_Translation_Preinitiation_Complex | Human | Uterus | rep_25 | 4.0e-10 |
| EIF2S2 | GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism | Human | Uterus | rep_26 | 6.1e-12 |
| EIF2S2 | GOBP_Cytoplasmic_Translational_Initiation | Human | Uterus | rep_26 | 2.8e-10 |
| EIF2S2 | GOBP_Gamete_Generation | Human | Uterus | rep_26 | 3.8e-10 |
| EIF2S2 | GOBP_Germ_Cell_Proliferation | Human | Uterus | rep_26 | 2.6e-08 |
| EIF2S2 | GOBP_Ribonucleoprotein_Complex_Subunit_Organization | Human | Uterus | rep_26 | 4.6e-06 |
| EIF2S2 | GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching | Human | Breast | rep_1 | 7.7e-07 |
| EIF2S2 | GOBP_In_Utero_Embryonic_Development | Human | Breast | rep_1 | 1.5e-18 |
| EIF2S2 | GOBP_Transmembrane_Transport | Human | Breast | rep_1 | 3.2e-56 |
| EIF2S2 | GOBP_Development_Of_Primary_Sexual_Characteristics | Human | Breast | rep_5 | 3.0e-05 |
| EIF2S2 | GOBP_Developmental_Process_Involved_In_Reproduction | Human | Breast | rep_5 | 1.5e-12 |
| EIF2S2 | GOBP_Embryo_Development | Human | Breast | rep_5 | 5.5e-08 |
| EIF2S2 | GOBP_Multicellular_Organism_Reproduction | Human | Breast | rep_5 | 8.1e-07 |
| EIF2S2 | GOBP_Reproduction | Human | Breast | rep_5 | 8.1e-06 |
| EIF2S2 | GOBP_Reproductive_System_Development | Human | Breast | rep_5 | 3.6e-15 |
| EIF2S2 | GOBP_Amide_Biosynthetic_Process | Human | Breast | rep_6 | 8.7e-05 |
| EIF2S2 | GOBP_Cellular_Amide_Metabolic_Process | Human | Breast | rep_6 | 5.6e-05 |
| EIF2S2 | GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism | Human | Breast | rep_6 | 4.4e-11 |
| EIF2S2 | GOBP_Cytoplasmic_Translation | Human | Breast | rep_6 | 2.4e-06 |
| EIF2S2 | GOBP_Cytoplasmic_Translational_Initiation | Human | Breast | rep_6 | 3.6e-11 |
| EIF2S2 | GOBP_Formation_Of_Translation_Preinitiation_Complex | Human | Breast | rep_6 | 1.3e-10 |
| EIF2S2 | GOBP_Gamete_Generation | Human | Breast | rep_6 | 7.3e-08 |
| EIF2S2 | GOBP_Male_Sex_Differentiation | Human | Breast | rep_6 | 2.0e-08 |
| EIF2S2 | GOBP_Organonitrogen_Compound_Biosynthetic_Process | Human | Breast | rep_6 | 1.2e-09 |
| EIF2S2 | GOBP_Peptide_Biosynthetic_Process | Human | Breast | rep_6 | 1.6e-05 |
| EIF2S2 | GOBP_Peptide_Metabolic_Process | Human | Breast | rep_6 | 8.7e-05 |
| EIF2S2 | GOBP_Ribonucleoprotein_Complex_Biogenesis | Human | Breast | rep_6 | 1.3e-07 |
| EIF2S2 | GOBP_Ribonucleoprotein_Complex_Subunit_Organization | Human | Breast | rep_6 | 1.4e-08 |
| EIF2S2 | GOBP_Sex_Differentiation | Human | Breast | rep_6 | 4.2e-05 |
| EIF2S2 | GOBP_Translational_Initiation | Human | Breast | rep_6 | 2.2e-09 |
| EIF2S2 | GOBP_Formation_Of_Translation_Preinitiation_Complex | Human | Skin | P10_rep1 | 2.6e-08 |
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EIF2S2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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EIF2S2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for EIF2S2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for EIF2S2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EIF2S2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| EIF2S2 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| EIF2S2 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| EIF2S2 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| EIF2S2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| EIF2S2 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
