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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: EIF2B5 (spascer ID:8893)

Gene summary for EIF2B5

Gene summary

Gene information
	Species	Human
	Gene symbol	EIF2B5
	Gene ID	8893
	Gene name	eukaryotic translation initiation factor 2B subunit epsilon
	Synonyms	CACH\|CLE\|EIF-2B\|EIF2Bepsilon\|LVWM
	Cytomap	3q27.1
	Type of gene	protein-coding
	Description	translation initiation factor eIF-2B subunit epsiloneIF-2B GDP-GTP exchange factor subunit epsiloneukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
	Modification date	20220513
	UniProtAcc	Q13144

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
EIF2B5	GO:0005085	guanyl-nucleotide exchange factor activity	21873635	Function
EIF2B5	GO:0005851	eukaryotic translation initiation factor 2B complex	21873635	Component
EIF2B5	GO:0031369	translation initiation factor binding	21873635	Function

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Spatial pattern events for EIF2B5

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
EIF2B5	Human	Intestine	rep_colon4	34417225	1.14e-15
EIF2B5	Human	Liver	rep_liver1	34417225	1.08e-15
EIF2B5	Human	Liver	rep_liver2	34417225	6.98e-16
EIF2B5	Human	Intestine	A2	33406409	2.96e-11
EIF2B5	Human	Breast	1142243F	34493872	8.62e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Intestine_A2_H&E
Breast_1142243F_H&E

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Spatial pattern pathway has EIF2B5 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
EIF2B5	GOBP_Activation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
EIF2B5	GOBP_Central_Nervous_System_Development	Human	Brain	rep_1	2.8e-23
EIF2B5	GOBP_Neurogenesis	Human	Brain	rep_1	7.4e-34
EIF2B5	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Brain	rep_1	4.4e-07
EIF2B5	GOBP_Positive_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
EIF2B5	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
EIF2B5	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
EIF2B5	GOBP_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
EIF2B5	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
EIF2B5	GOBP_Response_To_Endogenous_Stimulus	Human	Brain	rep_10	2.8e-23
EIF2B5	GOBP_Response_To_Hormone	Human	Brain	rep_10	2.8e-23
EIF2B5	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
EIF2B5	GOBP_Response_To_Peptide	Human	Bladder	rep_2	2.3e-11
EIF2B5	GOBP_Response_To_Peptide_Hormone	Human	Bladder	rep_2	2.9e-13
EIF2B5	GOBP_Activation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
EIF2B5	GOBP_Central_Nervous_System_Development	Human	Liver	rep_1	1.0e-70
EIF2B5	GOBP_Neurogenesis	Human	Liver	rep_1	1.0e-70
EIF2B5	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Liver	rep_1	3.7e-85
EIF2B5	GOBP_Positive_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
EIF2B5	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
EIF2B5	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
EIF2B5	GOBP_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
EIF2B5	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
EIF2B5	GOBP_Response_To_Endogenous_Stimulus	Human	Liver	rep_1	3.0e-55
EIF2B5	GOBP_Response_To_Hormone	Human	Liver	rep_1	3.0e-55
EIF2B5	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
EIF2B5	GOBP_Activation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
EIF2B5	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Intestine	rep_colon4	6.4e-48
EIF2B5	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
EIF2B5	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
EIF2B5	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
EIF2B5	GOBP_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
EIF2B5	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
EIF2B5	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	rep_liver2	3.7e-39
EIF2B5	GOBP_Response_To_Hormone	Human	Intestine	rep_liver2	3.7e-39
EIF2B5	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
EIF2B5	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
EIF2B5	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
EIF2B5	GOBP_Positive_Regulation_Of_Translation	Human	Intestine	A1	7.9e-07
EIF2B5	GOBP_Activation_Of_Immune_Response	Human	Intestine	A3	5.7e-11
EIF2B5	GOBP_Central_Nervous_System_Development	Human	Intestine	A3	7.1e-11
EIF2B5	GOBP_Development_Of_Primary_Female_Sexual_Characteristics	Human	Intestine	A3	7.5e-10
EIF2B5	GOBP_Development_Of_Primary_Sexual_Characteristics	Human	Intestine	A3	5.0e-13
EIF2B5	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Intestine	A3	2.7e-15
EIF2B5	GOBP_Female_Sex_Differentiation	Human	Intestine	A3	1.1e-15
EIF2B5	GOBP_Glial_Cell_Differentiation	Human	Intestine	A3	2.9e-07
EIF2B5	GOBP_Gliogenesis	Human	Intestine	A3	9.7e-09
EIF2B5	GOBP_Immune_Response_Regulating_Signaling_Pathway	Human	Intestine	A3	2.2e-11
EIF2B5	GOBP_Neurogenesis	Human	Intestine	A3	6.4e-14
EIF2B5	GOBP_Oligodendrocyte_Differentiation	Human	Intestine	A3	2.1e-16
EIF2B5	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Intestine	A3	3.7e-11
EIF2B5	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	A3	2.4e-07
EIF2B5	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	A3	6.8e-15
EIF2B5	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
EIF2B5	GOBP_Positive_Regulation_Of_Translational_Initiation	Human	Intestine	A3	2.1e-07
EIF2B5	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
EIF2B5	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
EIF2B5	GOBP_Regulation_Of_Immune_Response	Human	Intestine	A3	1.6e-12
EIF2B5	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
EIF2B5	GOBP_Regulation_Of_Translational_Initiation	Human	Intestine	A3	9.4e-12
EIF2B5	GOBP_Reproduction	Human	Intestine	A3	4.6e-19
EIF2B5	GOBP_Reproductive_System_Development	Human	Intestine	A3	2.9e-14
EIF2B5	GOBP_Response_To_Abiotic_Stimulus	Human	Intestine	A3	5.3e-18
EIF2B5	GOBP_Response_To_Carbohydrate	Human	Intestine	A3	1.8e-07
EIF2B5	GOBP_Response_To_Endogenous_Stimulus	Human	Intestine	A3	5.2e-09
EIF2B5	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Human	Intestine	A3	2.1e-18
EIF2B5	GOBP_Response_To_Heat	Human	Intestine	A3	7.0e-22
EIF2B5	GOBP_Response_To_Monosaccharide	Human	Intestine	A3	1.4e-09
EIF2B5	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
EIF2B5	GOBP_Response_To_Temperature_Stimulus	Human	Intestine	A3	4.2e-20
EIF2B5	GOBP_Sex_Differentiation	Human	Intestine	A3	6.1e-18
EIF2B5	GOBP_T_Cell_Receptor_Signaling_Pathway	Human	Intestine	A3	1.2e-07
EIF2B5	GOBP_Translational_Initiation	Human	Intestine	A3	5.0e-09
EIF2B5	GOBP_Antigen_Receptor_Mediated_Signaling_Pathway	Human	Intestine	A8	1.0e-17
EIF2B5	GOBP_Ensheathment_Of_Neurons	Human	Intestine	A8	1.4e-08
EIF2B5	GOBP_Response_To_Hormone	Human	Intestine	A8	2.3e-13
EIF2B5	GOBP_Response_To_Nitrogen_Compound	Human	Intestine	A8	1.3e-12
EIF2B5	GOBP_Response_To_Peptide	Human	Intestine	A8	2.0e-09
EIF2B5	GOBP_Response_To_Peptide_Hormone	Human	Intestine	A8	3.4e-09
EIF2B5	GOBP_Gliogenesis	Human	Pancreas	PDAC-B-st1	8.6e-05
EIF2B5	GOBP_Positive_Regulation_Of_Translational_Initiation	Human	Pancreas	PDAC-A-st2	5.3e-08
EIF2B5	GOBP_Activation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
EIF2B5	GOBP_Positive_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
EIF2B5	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
EIF2B5	GOBP_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
EIF2B5	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
EIF2B5	GOBP_Astrocyte_Differentiation	Human	Uterus	rep_1	6.2e-07
EIF2B5	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Uterus	rep_1	1.6e-06
EIF2B5	GOBP_Oligodendrocyte_Development	Human	Uterus	rep_25	8.5e-06
EIF2B5	GOBP_Response_To_Temperature_Stimulus	Human	Uterus	rep_25	8.0e-06
EIF2B5	GOBP_Ovarian_Follicle_Development	Human	Uterus	rep_26	1.6e-07
EIF2B5	GOBP_Response_To_Heat	Human	Uterus	rep_26	3.4e-07
EIF2B5	GOBP_Response_To_Monosaccharide	Human	Uterus	rep_26	2.0e-06
EIF2B5	GOBP_Astrocyte_Development	Human	Uterus	rep_29	3.3e-11
EIF2B5	GOBP_Positive_Regulation_Of_Translational_Initiation	Human	Uterus	rep_29	7.6e-06
EIF2B5	GOBP_Central_Nervous_System_Development	Human	Breast	rep_1	5.1e-04
EIF2B5	GOBP_Ensheathment_Of_Neurons	Human	Breast	rep_1	8.5e-22
EIF2B5	GOBP_Neurogenesis	Human	Breast	rep_1	8.0e-11
EIF2B5	GOBP_Positive_Regulation_Of_Gene_Expression	Human	Breast	rep_1	7.3e-07
EIF2B5	GOBP_Positive_Regulation_Of_Translational_Initiation	Human	Breast	rep_1	8.7e-45
EIF2B5	GOBP_Response_To_Abiotic_Stimulus	Human	Breast	rep_1	2.6e-19
EIF2B5	GOBP_Response_To_Carbohydrate	Human	Breast	rep_1	3.1e-80
EIF2B5	GOBP_Response_To_Monosaccharide	Human	Breast	rep_1	3.0e-61
EIF2B5	GOBP_Response_To_Peptide_Hormone	Human	Breast	rep_1	2.0e-36
EIF2B5	GOBP_Response_To_Temperature_Stimulus	Human	Breast	rep_1	1.2e-34
EIF2B5	GOBP_Development_Of_Primary_Female_Sexual_Characteristics	Human	Breast	rep_5	3.2e-09
EIF2B5	GOBP_Development_Of_Primary_Sexual_Characteristics	Human	Breast	rep_5	3.0e-05
EIF2B5	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Breast	rep_5	1.5e-12
EIF2B5	GOBP_Female_Sex_Differentiation	Human	Breast	rep_5	4.1e-09
EIF2B5	GOBP_Oligodendrocyte_Development	Human	Breast	rep_5	1.5e-06
EIF2B5	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
EIF2B5	GOBP_Reproduction	Human	Breast	rep_5	8.1e-06
EIF2B5	GOBP_Reproductive_System_Development	Human	Breast	rep_5	3.6e-15
EIF2B5	GOBP_Response_To_Endogenous_Stimulus	Human	Breast	rep_5	3.6e-09
EIF2B5	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Human	Breast	rep_5	4.4e-06
EIF2B5	GOBP_Response_To_Hormone	Human	Breast	rep_5	2.9e-13
EIF2B5	GOBP_Response_To_Nitrogen_Compound	Human	Breast	rep_5	1.1e-11
EIF2B5	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
EIF2B5	GOBP_Response_To_Peptide	Human	Breast	rep_5	1.2e-15
EIF2B5	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
EIF2B5	GOBP_Astrocyte_Differentiation	Human	Breast	rep_6	5.8e-05
EIF2B5	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
EIF2B5	GOBP_Gliogenesis	Human	Breast	rep_6	2.3e-05
EIF2B5	GOBP_Oligodendrocyte_Differentiation	Human	Breast	rep_6	4.8e-06
EIF2B5	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
EIF2B5	GOBP_Ovarian_Follicle_Development	Human	Breast	rep_6	1.6e-09
EIF2B5	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
EIF2B5	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
EIF2B5	GOBP_Positive_Regulation_Of_Translation	Human	Breast	rep_6	3.8e-04
EIF2B5	GOBP_Regulation_Of_Translational_Initiation	Human	Breast	rep_6	6.5e-06
EIF2B5	GOBP_Sex_Differentiation	Human	Breast	rep_6	4.2e-05
EIF2B5	GOBP_Translational_Initiation	Human	Breast	rep_6	2.2e-09
EIF2B5	GOBP_Astrocyte_Development	Human	Skin	P2_rep1	1.5e-10
EIF2B5	GOBP_Astrocyte_Differentiation	Human	Skin	P2_rep1	1.1e-10
EIF2B5	GOBP_Glial_Cell_Development	Human	Skin	P2_rep1	7.8e-09
EIF2B5	GOBP_Gliogenesis	Human	Skin	P2_rep1	1.8e-10
EIF2B5	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	3.1e-08
EIF2B5	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07
EIF2B5	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08
EIF2B5	GOBP_Immune_Response_Regulating_Signaling_Pathway	Human	Lung	rep_2	1.2e-08

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EIF2B5 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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EIF2B5 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for EIF2B5 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for EIF2B5

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EIF2B5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
EIF2B5	C1858991	Childhood Ataxia with Central Nervous System Hypomyelinization	8	GENOMICS_ENGLAND;ORPHANET;UNIPROT
EIF2B5	C1847967	OVARIOLEUKODYSTROPHY	2	CTD_human;ORPHANET
EIF2B5	C0026838	Muscle Spasticity	1	GENOMICS_ENGLAND
EIF2B5	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
EIF2B5	C0338656	Impaired cognition	1	GENOMICS_ENGLAND
EIF2B5	C0393525	Progressive cerebellar ataxia	1	GENOMICS_ENGLAND
EIF2B5	C4553743	Spasticity, CTCAE	1	GENOMICS_ENGLAND