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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: DDX18 (spascer ID:8886)

Gene summary for DDX18

Gene summary

Gene information
	Species	Human
	Gene symbol	DDX18
	Gene ID	8886
	Gene name	DEAD-box helicase 18
	Synonyms	Has1\|MrDb
	Cytomap	2q14.1
	Type of gene	protein-coding
	Description	ATP-dependent RNA helicase DDX18DEAD (Asp-Glu-Ala-Asp) box polypeptide 18DEAD box protein 18DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated)Myc-regulated DEAD box protein
	Modification date	20220513
	UniProtAcc	Q9NVP1

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
DDX18	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635	Process
DDX18	GO:0005730	nucleolus	21873635	Component

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Spatial pattern events for DDX18

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
DDX18	Human	Intestine	rep_colon1	34417225	1.95e-15
DDX18	Human	Intestine	rep_colon4	34417225	8.32e-11
DDX18	Human	Liver	rep_liver1	34417225	1.08e-15
DDX18	Human	Liver	rep_liver2	34417225	6.98e-16
DDX18	Human	Liver	rep_liver4	34417225	7.71e-16
DDX18	Human	Skin	P9_rep1	32946785	3.92e-06
DDX18	Human	Skin	P9_rep2	32946785	5.77e-15
DDX18	Human	Skin	P9_rep3	32946785	2.16e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Skin_P9_rep1_H&E
Skin_P9_rep2_H&E
Skin_P9_rep3_H&E

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Spatial pattern pathway has DDX18 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
DDX18	GOBP_Response_To_Lipid	Human	Brain	rep_10	2.8e-23
DDX18	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
DDX18	GOBP_Response_To_Estradiol	Human	Bladder	rep_2	1.6e-18
DDX18	GOBP_Response_To_Lipid	Human	Liver	rep_1	3.0e-55
DDX18	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
DDX18	GOBP_Response_To_Lipid	Human	Intestine	rep_liver2	3.7e-39
DDX18	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
DDX18	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Intestine	A1	4.4e-09
DDX18	GOBP_Ribosome_Biogenesis	Human	Intestine	A1	6.5e-08
DDX18	GOBP_Cellular_Response_To_Lipid	Human	Intestine	A3	7.7e-08
DDX18	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	2.5e-14
DDX18	GOBP_Ncrna_Metabolic_Process	Human	Intestine	A3	8.6e-07
DDX18	GOBP_Response_To_Lipid	Human	Intestine	A3	1.7e-09
DDX18	GOBP_Response_To_Organic_Cyclic_Compound	Human	Intestine	A3	3.2e-15
DDX18	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
DDX18	GOBP_Rna_Processing	Human	Intestine	A3	3.9e-09
DDX18	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Intestine	A8	1.4e-09
DDX18	GOBP_Cellular_Response_To_Estradiol_Stimulus	Human	Pancreas	PDAC-B-st1	5.1e-05
DDX18	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Pancreas	PDAC-B-st1	5.3e-05
DDX18	GOBP_Maturation_Of_Lsu_Rrna	Human	Uterus	rep_1	2.4e-08
DDX18	GOBP_Ncrna_Processing	Human	Uterus	rep_1	4.5e-06
DDX18	GOBP_Ribosome_Biogenesis	Human	Uterus	rep_1	9.5e-06
DDX18	GOBP_Rrna_Metabolic_Process	Human	Uterus	rep_1	2.4e-07
DDX18	GOBP_Maturation_Of_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Uterus	rep_25	4.5e-06
DDX18	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Uterus	rep_26	1.5e-07
DDX18	GOBP_Cellular_Response_To_Lipid	Human	Breast	rep_5	3.3e-11
DDX18	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	5.1e-18
DDX18	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.9e-11
DDX18	GOBP_Response_To_Estradiol	Human	Breast	rep_5	6.9e-16
DDX18	GOBP_Response_To_Lipid	Human	Breast	rep_5	1.6e-10
DDX18	GOBP_Response_To_Organic_Cyclic_Compound	Human	Breast	rep_5	7.5e-14
DDX18	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
DDX18	GOBP_Cellular_Response_To_Estradiol_Stimulus	Human	Breast	rep_6	5.9e-11
DDX18	GOBP_Maturation_Of_Lsu_Rrna	Human	Breast	rep_6	1.0e-04
DDX18	GOBP_Maturation_Of_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Breast	rep_6	7.2e-06
DDX18	GOBP_Ncrna_Metabolic_Process	Human	Breast	rep_6	1.9e-04
DDX18	GOBP_Ncrna_Processing	Human	Breast	rep_6	1.3e-05
DDX18	GOBP_Ribonucleoprotein_Complex_Biogenesis	Human	Breast	rep_6	1.3e-07
DDX18	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Breast	rep_6	2.7e-06
DDX18	GOBP_Ribosome_Biogenesis	Human	Breast	rep_6	2.0e-06
DDX18	GOBP_Rna_Processing	Human	Breast	rep_6	3.5e-06
DDX18	GOBP_Rrna_Metabolic_Process	Human	Breast	rep_6	4.0e-06
DDX18	GOBP_Ribosomal_Large_Subunit_Biogenesis	Human	Skin	P10_rep1	1.5e-10
DDX18	GOBP_Cellular_Response_To_Estradiol_Stimulus	Human	Skin	P10_rep2	1.6e-16
DDX18	GOBP_Maturation_Of_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Skin	P10_rep2	3.9e-08
DDX18	GOBP_Cellular_Response_To_Lipid	Human	Lung	rep_1	1.3e-10
DDX18	GOBP_Response_To_Lipid	Human	Lung	rep_1	1.8e-09
DDX18	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08

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DDX18 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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DDX18 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for DDX18 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for DDX18

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DDX18

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source