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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: SQSTM1 (spascer ID:8878)

Gene summary for SQSTM1

Gene summary

Gene information
	Species	Human
	Gene symbol	SQSTM1
	Gene ID	8878
	Gene name	sequestosome 1
	Synonyms	A170\|DMRV\|FTDALS3\|NADGP\|OSIL\|PDB3\|ZIP3\|p60\|p62\|p62B
	Cytomap	5q35.3
	Type of gene	protein-coding
	Description	sequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domain
	Modification date	20220515
	UniProtAcc	Q13501

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
SQSTM1	GO:0000423	mitophagy	21873635	Process
SQSTM1	GO:0005080	protein kinase C binding	21873635	Function
SQSTM1	GO:0007032	endosome organization	21873635	Process
SQSTM1	GO:0016235	aggresome	21873635	Component
SQSTM1	GO:0035973	aggrephagy	21873635	Process
SQSTM1	GO:0044753	amphisome	21873635	Component
SQSTM1	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	21873635	Function

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Spatial pattern events for SQSTM1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
SQSTM1	Human	Brain	rep_9	33558695	3.01e-15
SQSTM1	Human	Brain	rep_10	33558695	3.23e-15
SQSTM1	Human	Brain	rep_11	33558695	5.51e-12
SQSTM1	Human	Intestine	rep_colon1	34417225	1.95e-15
SQSTM1	Human	Intestine	rep_colon2	34417225	1.48e-15
SQSTM1	Human	Intestine	rep_colon3	34417225	6.38e-07
SQSTM1	Human	Intestine	rep_colon4	34417225	1.14e-15
SQSTM1	Human	Liver	rep_liver1	34417225	1.08e-15
SQSTM1	Human	Liver	rep_liver2	34417225	6.98e-16
SQSTM1	Human	Liver	rep_liver3	34417225	1.54e-06
SQSTM1	Human	Liver	rep_liver4	34417225	7.71e-16
SQSTM1	Human	Intestine	A1	33406409	2.09e-15
SQSTM1	Human	Intestine	A2	33406409	2.47e-15
SQSTM1	Human	Uterus	rep_2	34857954	2.55e-15
SQSTM1	Human	Uterus	rep_3	34857954	1.66e-15
SQSTM1	Human	Uterus	rep_4	34857954	1.82e-15
SQSTM1	Human	Breast	G1	34650042	2.55e-09
SQSTM1	Human	Breast	G2	34650042	5.71e-13
SQSTM1	Human	Breast	1142243F	34493872	9.03e-11
SQSTM1	Human	Breast	1160920F	34493872	1.48e-15
SQSTM1	Human	Breast	CID4290	34493872	1.53e-14
SQSTM1	Human	Breast	CID44971	34493872	1.76e-15
SQSTM1	Human	Breast	CID4535	34493872	6.37e-15
SQSTM1	Human	Skin	P2_rep1	32946785	5.84e-10
SQSTM1	Human	Skin	P2_rep2	32946785	3.68e-07
SQSTM1	Human	Lung	rep_1	35355018	2.54e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_9_H&E
Brain_rep_10_H&E
Brain_rep_11_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Breast_G1_H&E
Breast_G2_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has SQSTM1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
SQSTM1	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Brain	rep_1	2.8e-23
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	4.4e-07
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Brain	rep_1	2.8e-23
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Brain	rep_1	2.8e-23
SQSTM1	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
SQSTM1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
SQSTM1	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Brain	rep_1	7.4e-34
SQSTM1	GOBP_Regulation_Of_Protein_Modification_Process	Human	Brain	rep_1	7.4e-34
SQSTM1	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Brain	rep_1	7.4e-34
SQSTM1	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
SQSTM1	GOBP_Regulation_Of_Protein_Localization	Human	Brain	rep_4	1.0e-14
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.1e-67
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
SQSTM1	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
SQSTM1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
SQSTM1	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Regulation_Of_Protein_Localization	Human	Liver	rep_1	2.1e-52
SQSTM1	GOBP_Regulation_Of_Protein_Modification_Process	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Liver	rep_1	1.0e-70
SQSTM1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
SQSTM1	GOBP_Regulation_Of_Protein_Localization	Human	Intestine	rep_colon2	1.5e-57
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	rep_colon4	1.2e-51
SQSTM1	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
SQSTM1	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
SQSTM1	GOBP_Cell_Cell_Signaling	Human	Intestine	A3	6.4e-08
SQSTM1	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
SQSTM1	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
SQSTM1	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
SQSTM1	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Intestine	A3	2.6e-09
SQSTM1	GOBP_Endomembrane_System_Organization	Human	Intestine	A3	1.6e-16
SQSTM1	GOBP_Endosomal_Transport	Human	Intestine	A3	1.9e-09
SQSTM1	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
SQSTM1	GOBP_Macroautophagy	Human	Intestine	A3	2.3e-07
SQSTM1	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
SQSTM1	GOBP_Mitochondrion_Organization	Human	Intestine	A3	2.3e-19
SQSTM1	GOBP_Mitophagy	Human	Intestine	A3	4.5e-11
SQSTM1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Intestine	A3	7.7e-11
SQSTM1	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Intestine	A3	5.9e-17
SQSTM1	GOBP_Negative_Regulation_Of_Cell_Death	Human	Intestine	A3	5.8e-14
SQSTM1	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	7.7e-14
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	2.0e-08
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	3.2e-14
SQSTM1	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Intestine	A3	1.9e-15
SQSTM1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
SQSTM1	GOBP_Positive_Regulation_Of_Cell_Death	Human	Intestine	A3	4.5e-11
SQSTM1	GOBP_Positive_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Intestine	A3	8.0e-08
SQSTM1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	5.1e-13
SQSTM1	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Intestine	A3	7.8e-15
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	5.0e-14
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	9.1e-12
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Intestine	A3	2.0e-08
SQSTM1	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
SQSTM1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Intestine	A3	9.4e-13
SQSTM1	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Intestine	A3	4.7e-11
SQSTM1	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
SQSTM1	GOBP_Protein_Localization_To_Cell_Periphery	Human	Intestine	A3	4.6e-14
SQSTM1	GOBP_Protein_Localization_To_Plasma_Membrane	Human	Intestine	A3	4.0e-10
SQSTM1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
SQSTM1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
SQSTM1	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
SQSTM1	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
SQSTM1	GOBP_Regulation_Of_Cellular_Localization	Human	Intestine	A3	4.5e-11
SQSTM1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
SQSTM1	GOBP_Regulation_Of_Mitochondrion_Organization	Human	Intestine	A3	1.6e-17
SQSTM1	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
SQSTM1	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Intestine	A3	1.5e-11
SQSTM1	GOBP_Regulation_Of_Protein_Localization	Human	Intestine	A3	7.5e-08
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Cell_Periphery	Human	Intestine	A3	2.1e-07
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Membrane	Human	Intestine	A3	6.6e-10
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Plasma_Membrane	Human	Intestine	A3	2.9e-07
SQSTM1	GOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	3.0e-12
SQSTM1	GOBP_Regulation_Of_Protein_Modification_Process	Human	Intestine	A3	1.1e-14
SQSTM1	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Intestine	A3	8.8e-11
SQSTM1	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Intestine	A3	4.7e-08
SQSTM1	GOBP_Selective_Autophagy	Human	Intestine	A3	3.5e-11
SQSTM1	GOBP_Synaptic_Signaling	Human	Intestine	A3	5.0e-10
SQSTM1	GOBP_Vesicle_Organization	Human	Intestine	A3	3.0e-15
SQSTM1	GOBP_Aggrephagy	Human	Intestine	A8	1.4e-17
SQSTM1	GOBP_Autophagy_Of_Mitochondrion	Human	Intestine	A8	8.5e-14
SQSTM1	GOBP_Endosome_Organization	Human	Intestine	A8	1.9e-13
SQSTM1	GOBP_Interleukin_1_Mediated_Signaling_Pathway	Human	Intestine	A8	1.1e-27
SQSTM1	GOBP_Long_Term_Synaptic_Potentiation	Human	Intestine	A8	3.2e-09
SQSTM1	GOBP_Organelle_Disassembly	Human	Intestine	A8	3.1e-16
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Localization_To_Cell_Periphery	Human	Intestine	A8	2.7e-20
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Localization_To_Membrane	Human	Intestine	A8	6.9e-19
SQSTM1	GOBP_Positive_Regulation_Of_Synaptic_Transmission	Human	Intestine	A8	1.7e-08
SQSTM1	GOBP_Ras_Protein_Signal_Transduction	Human	Intestine	A8	6.4e-07
SQSTM1	GOBP_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Intestine	A8	6.4e-08
SQSTM1	GOBP_Regulation_Of_Protein_Complex_Stability	Human	Intestine	A8	7.8e-24
SQSTM1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Human	Intestine	A8	3.1e-07
SQSTM1	GOBP_Regulation_Of_Synaptic_Plasticity	Human	Intestine	A8	3.7e-08
SQSTM1	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
SQSTM1	GOBP_Response_To_Interleukin_1	Human	Intestine	A8	2.2e-14
SQSTM1	GOBP_Response_To_Ischemia	Human	Intestine	A8	1.5e-30
SQSTM1	GOBP_Response_To_Mitochondrial_Depolarisation	Human	Intestine	A8	2.0e-12
SQSTM1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Human	Intestine	A8	7.1e-10
SQSTM1	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Pancreas	PDAC-B-st1	8.9e-05
SQSTM1	GOBP_Ras_Protein_Signal_Transduction	Human	Pancreas	PDAC-B-st1	9.4e-05
SQSTM1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Human	Pancreas	PDAC-B-st1	4.8e-05
SQSTM1	GOBP_Regulation_Of_Synaptic_Plasticity	Human	Pancreas	PDAC-B-st1	6.0e-05
SQSTM1	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Pancreas	PDAC-B-st1	5.9e-05
SQSTM1	GOBP_Aggrephagy	Human	Pancreas	PDAC-A-st2	3.0e-05
SQSTM1	GOBP_Endosomal_Transport	Human	Pancreas	PDAC-A-st2	9.1e-05
SQSTM1	GOBP_Mitophagy	Human	Pancreas	PDAC-A-st2	6.7e-05
SQSTM1	GOBP_Selective_Autophagy	Human	Pancreas	PDAC-A-st2	1.9e-06
SQSTM1	GOBP_Interleukin_1_Mediated_Signaling_Pathway	Human	Uterus	rep_25	8.0e-20
SQSTM1	GOBP_Mitophagy	Human	Uterus	rep_25	1.0e-09
SQSTM1	GOBP_Positive_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Uterus	rep_25	2.6e-07
SQSTM1	GOBP_Response_To_Mitochondrial_Depolarisation	Human	Uterus	rep_25	8.8e-11
SQSTM1	GOBP_Aggrephagy	Human	Uterus	rep_26	4.0e-07
SQSTM1	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
SQSTM1	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
SQSTM1	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Uterus	rep_26	2.0e-10
SQSTM1	GOBP_Endosomal_Transport	Human	Uterus	rep_26	1.1e-06
SQSTM1	GOBP_Endosome_Organization	Human	Uterus	rep_26	5.1e-07
SQSTM1	GOBP_Macroautophagy	Human	Uterus	rep_26	1.7e-06
SQSTM1	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
SQSTM1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	1.1e-07
SQSTM1	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Uterus	rep_26	2.1e-06
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	2.2e-08
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Modification_Process	Human	Uterus	rep_26	2.3e-14
SQSTM1	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Uterus	rep_26	6.2e-13
SQSTM1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Localization_To_Cell_Periphery	Human	Uterus	rep_26	4.6e-10
SQSTM1	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
SQSTM1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
SQSTM1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
SQSTM1	GOBP_Ras_Protein_Signal_Transduction	Human	Uterus	rep_26	7.0e-12
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Cell_Periphery	Human	Uterus	rep_26	3.9e-06
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Plasma_Membrane	Human	Uterus	rep_26	3.0e-06
SQSTM1	GOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	2.9e-09
SQSTM1	GOBP_Regulation_Of_Ras_Protein_Signal_Transduction	Human	Uterus	rep_26	1.0e-06
SQSTM1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Human	Uterus	rep_26	9.8e-09
SQSTM1	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Uterus	rep_26	1.2e-08
SQSTM1	GOBP_Response_To_Interleukin_1	Human	Uterus	rep_26	1.5e-07
SQSTM1	GOBP_Response_To_Ischemia	Human	Uterus	rep_26	9.9e-09
SQSTM1	GOBP_Selective_Autophagy	Human	Uterus	rep_26	1.1e-06
SQSTM1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Human	Uterus	rep_26	4.7e-08
SQSTM1	GOBP_Synaptic_Signaling	Human	Uterus	rep_26	3.3e-08
SQSTM1	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Uterus	rep_29	2.8e-06
SQSTM1	GOBP_Regulation_Of_Protein_Complex_Stability	Human	Uterus	rep_29	2.6e-10
SQSTM1	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
SQSTM1	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.5e-144
SQSTM1	GOBP_Endomembrane_System_Organization	Human	Breast	rep_1	2.2e-04
SQSTM1	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Breast	rep_1	1.2e-47
SQSTM1	GOBP_Interleukin_1_Mediated_Signaling_Pathway	Human	Breast	rep_1	5.2e-44
SQSTM1	GOBP_Positive_Regulation_Of_Cell_Death	Human	Breast	rep_1	2.2e-15
SQSTM1	GOBP_Protein_Localization_To_Cell_Periphery	Human	Breast	rep_1	7.2e-19
SQSTM1	GOBP_Protein_Localization_To_Plasma_Membrane	Human	Breast	rep_1	1.9e-28
SQSTM1	GOBP_Regulation_Of_Cellular_Localization	Human	Breast	rep_1	5.5e-07
SQSTM1	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
SQSTM1	GOBP_Regulation_Of_Protein_Complex_Stability	Human	Breast	rep_1	5.1e-05
SQSTM1	GOBP_Regulation_Of_Protein_Localization	Human	Breast	rep_1	2.8e-21
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Membrane	Human	Breast	rep_1	5.4e-18
SQSTM1	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
SQSTM1	GOBP_Response_To_Interleukin_1	Human	Breast	rep_1	3.2e-51
SQSTM1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Human	Breast	rep_1	3.4e-04
SQSTM1	GOBP_Synaptic_Signaling	Human	Breast	rep_1	3.5e-04
SQSTM1	GOBP_Vesicle_Organization	Human	Breast	rep_1	8.3e-15
SQSTM1	GOBP_Aggrephagy	Human	Breast	rep_5	1.7e-13
SQSTM1	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
SQSTM1	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
SQSTM1	GOBP_Endosome_Organization	Human	Breast	rep_5	4.4e-04
SQSTM1	GOBP_Long_Term_Synaptic_Potentiation	Human	Breast	rep_5	1.2e-07
SQSTM1	GOBP_Negative_Regulation_Of_Cell_Death	Human	Breast	rep_5	1.9e-07
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
SQSTM1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_5	8.0e-09
SQSTM1	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Human	Breast	rep_5	5.9e-12
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	2.6e-04
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_5	3.0e-10
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Human	Breast	rep_5	1.0e-15
SQSTM1	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
SQSTM1	GOBP_Positive_Regulation_Of_Synaptic_Transmission	Human	Breast	rep_5	2.7e-12
SQSTM1	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
SQSTM1	GOBP_Ras_Protein_Signal_Transduction	Human	Breast	rep_5	2.7e-06
SQSTM1	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
SQSTM1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
SQSTM1	GOBP_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Breast	rep_5	4.7e-05
SQSTM1	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Human	Breast	rep_5	2.5e-06
SQSTM1	GOBP_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_5	9.1e-07
SQSTM1	GOBP_Regulation_Of_Protein_Phosphorylation	Human	Breast	rep_5	5.8e-14
SQSTM1	GOBP_Regulation_Of_Small_Gtpase_Mediated_Signal_Transduction	Human	Breast	rep_5	2.0e-07
SQSTM1	GOBP_Regulation_Of_Synaptic_Plasticity	Human	Breast	rep_5	4.7e-13
SQSTM1	GOBP_Response_To_Ischemia	Human	Breast	rep_5	5.2e-10
SQSTM1	GOBP_Response_To_Mitochondrial_Depolarisation	Human	Breast	rep_5	1.0e-07
SQSTM1	GOBP_Autophagy_Of_Mitochondrion	Human	Breast	rep_6	1.7e-09
SQSTM1	GOBP_Cell_Cell_Signaling	Human	Breast	rep_6	5.0e-05
SQSTM1	GOBP_Endosomal_Transport	Human	Breast	rep_6	1.7e-13
SQSTM1	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
SQSTM1	GOBP_Macroautophagy	Human	Breast	rep_6	6.1e-10
SQSTM1	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
SQSTM1	GOBP_Mitochondrion_Organization	Human	Breast	rep_6	2.0e-05
SQSTM1	GOBP_Mitophagy	Human	Breast	rep_6	5.8e-09
SQSTM1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Breast	rep_6	2.2e-09
SQSTM1	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Breast	rep_6	2.6e-08
SQSTM1	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_6	3.5e-08
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	1.1e-09
SQSTM1	GOBP_Negative_Regulation_Of_Protein_Modification_Process	Human	Breast	rep_6	6.2e-08
SQSTM1	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Breast	rep_6	8.2e-08
SQSTM1	GOBP_Organelle_Disassembly	Human	Breast	rep_6	2.0e-07
SQSTM1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
SQSTM1	GOBP_Positive_Regulation_Of_Long_Term_Synaptic_Potentiation	Human	Breast	rep_6	1.2e-04
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Localization_To_Cell_Periphery	Human	Breast	rep_6	1.5e-05
SQSTM1	GOBP_Positive_Regulation_Of_Protein_Localization_To_Membrane	Human	Breast	rep_6	1.9e-09
SQSTM1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Breast	rep_6	4.2e-06
SQSTM1	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Breast	rep_6	1.9e-08
SQSTM1	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
SQSTM1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
SQSTM1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
SQSTM1	GOBP_Regulation_Of_Mitochondrion_Organization	Human	Breast	rep_6	1.3e-06
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Cell_Periphery	Human	Breast	rep_6	1.2e-06
SQSTM1	GOBP_Regulation_Of_Protein_Localization_To_Plasma_Membrane	Human	Breast	rep_6	1.9e-05
SQSTM1	GOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	1.0e-10
SQSTM1	GOBP_Regulation_Of_Trans_Synaptic_Signaling	Human	Breast	rep_6	1.3e-06
SQSTM1	GOBP_Selective_Autophagy	Human	Breast	rep_6	5.2e-08
SQSTM1	GOBP_Protein_Localization_To_Cell_Periphery	Human	Skin	P5_rep1	2.4e-09
SQSTM1	GOBP_Vesicle_Organization	Human	Skin	P5_rep1	2.3e-09
SQSTM1	GOBP_Response_To_Ischemia	Human	Skin	P9_rep2	2.3e-08
SQSTM1	GOBP_Interleukin_1_Mediated_Signaling_Pathway	Human	Lung	rep_1	1.4e-07
SQSTM1	GOBP_Long_Term_Synaptic_Potentiation	Human	Lung	rep_1	7.4e-07
SQSTM1	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07
SQSTM1	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Human	Lung	rep_2	6.0e-08
SQSTM1	GOBP_Positive_Regulation_Of_Cell_Death	Human	Lung	rep_2	3.0e-07

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SQSTM1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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SQSTM1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for SQSTM1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for SQSTM1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SQSTM1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
SQSTM1	C4085252	PAGET DISEASE OF BONE 3	9	GENOMICS_ENGLAND;UNIPROT
SQSTM1	C0002736	Amyotrophic Lateral Sclerosis	5	CTD_human;ORPHANET
SQSTM1	C4225326	FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3	4	CTD_human;UNIPROT
SQSTM1	C0029463	Osteosarcoma	2	GENOMICS_ENGLAND
SQSTM1	C0221054	Welander Distal Myopathy	1	ORPHANET
SQSTM1	C0242383	Age related macular degeneration	1	CTD_human
SQSTM1	C0393554	Amyotrophic Lateral Sclerosis With Dementia	1	CTD_human
SQSTM1	C0543859	Amyotrophic Lateral Sclerosis, Guam Form	1	CTD_human
SQSTM1	C1853926	NONAKA MYOPATHY	1	CTD_human;GENOMICS_ENGLAND
SQSTM1	C2931290	Welander distal myopathy, Swedish type	1	ORPHANET
SQSTM1	C3888102	Frontotemporal Dementia With Motor Neuron Disease	1	ORPHANET
SQSTM1	C4011788	Behavioral variant of frontotemporal dementia	1	ORPHANET