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Spatial pattern gene: ESPN (spascer ID:83715) |
Gene summary for ESPN |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | ESPN | Gene ID | 83715 |
| Gene name | espin |
| Synonyms | DFNB36|LP2654|USH1M |
| Cytomap | 1p36.31 |
| Type of gene | protein-coding |
| Description | espinautosomal recessive deafness type 36 proteinectoplasmic specialization protein |
| Modification date | 20220513 |
| UniProtAcc | B1AK53 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| ESPN | GO:0005737 | cytoplasm | 21873635 | Component |
| ESPN | GO:0051015 | actin filament binding | 21873635 | Function |
| ESPN | GO:0051017 | actin filament bundle assembly | 21873635 | Process |
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Spatial pattern events for ESPN |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| ESPN | Human | Intestine | rep_colon1 | 34417225 | 7.99e-14 |
| ESPN | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| ESPN | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| ESPN | Human | Intestine | A4 | 33406409 | 7.35e-15 |
| ESPN | Human | Intestine | A6 | 33406409 | 8.60e-14 |
| ESPN | Human | Intestine | A7 | 33406409 | 1.91e-09 |
| ESPN | Human | Intestine | A8 | 33406409 | 4.60e-14 |
| ESPN | Human | Intestine | A9 | 33406409 | 3.55e-14 |
| ESPN | Human | Breast | CID4290 | 34493872 | 4.15e-11 |
| ESPN | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| ESPN | Human | Heart | w6_s4 | 31835037 | 5.99e-03 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Intestine_A4_H&E  |  |
Intestine_A6_H&E  |  |
Intestine_A7_H&E  |  |
Intestine_A8_H&E  |  |
Intestine_A9_H&E  |  |
Breast_CID4290_H&E  |  |
Breast_CID44971_H&E  |  |
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Spatial pattern pathway has ESPN envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| ESPN | GOBP_Sensory_Perception_Of_Mechanical_Stimulus | Human | Bladder | rep_2 | 1.4e-23 |
| ESPN | GOBP_Cell_Projection_Assembly | Human | Intestine | A3 | 4.9e-09 |
| ESPN | GOBP_Cell_Projection_Organization | Human | Intestine | A3 | 1.1e-09 |
| ESPN | GOBP_Nervous_System_Process | Human | Intestine | A3 | 9.7e-07 |
| ESPN | GOBP_Sensory_Perception_Of_Mechanical_Stimulus | Human | Intestine | A3 | 1.6e-07 |
| ESPN | GOBP_Microvillus_Assembly | Human | Intestine | A8 | 1.9e-12 |
| ESPN | GOBP_Parallel_Actin_Filament_Bundle_Assembly | Human | Intestine | A8 | 4.4e-13 |
| ESPN | GOBP_Sensory_Perception | Human | Intestine | A8 | 2.1e-09 |
| ESPN | GOBP_Nervous_System_Process | Human | Uterus | rep_26 | 2.3e-07 |
| ESPN | GOBP_Parallel_Actin_Filament_Bundle_Assembly | Human | Uterus | rep_26 | 3.2e-09 |
| ESPN | GOBP_Sensory_Perception_Of_Mechanical_Stimulus | Human | Uterus | rep_26 | 1.1e-09 |
| ESPN | GOBP_Actin_Filament_Based_Process | Human | Breast | rep_1 | 1.8e-86 |
| ESPN | GOBP_Actin_Filament_Bundle_Organization | Human | Breast | rep_1 | 4.8e-140 |
| ESPN | GOBP_Actin_Filament_Organization | Human | Breast | rep_1 | 4.0e-75 |
| ESPN | GOBP_Cell_Projection_Assembly | Human | Breast | rep_1 | 1.9e-26 |
| ESPN | GOBP_Cell_Projection_Organization | Human | Breast | rep_1 | 1.8e-20 |
| ESPN | GOBP_Cytoskeleton_Organization | Human | Breast | rep_1 | 1.3e-22 |
| ESPN | GOBP_Microvillus_Assembly | Human | Breast | rep_1 | 3.0e-54 |
| ESPN | GOBP_Microvillus_Organization | Human | Breast | rep_1 | 1.9e-36 |
| ESPN | GOBP_Nervous_System_Process | Human | Breast | rep_1 | 1.2e-04 |
| ESPN | GOBP_Supramolecular_Fiber_Organization | Human | Breast | rep_1 | 2.8e-72 |
| ESPN | GOBP_Sensory_Perception_Of_Mechanical_Stimulus | Human | Breast | rep_5 | 1.4e-10 |
| ESPN | GOBP_Cytoskeleton_Organization | Human | Skin | P9_rep3 | 3.1e-12 |
| ESPN | GOBP_Parallel_Actin_Filament_Bundle_Assembly | Human | Skin | P10_rep2 | 2.4e-11 |
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ESPN function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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ESPN function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for ESPN envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for ESPN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ESPN |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| ESPN | C3711374 | Nonsyndromic Deafness | 11 | CLINGEN |
| ESPN | C1837007 | DEAFNESS, AUTOSOMAL RECESSIVE 36, WITH OR WITHOUT VESTIBULAR INVOLVEMENT | 3 | CTD_human;UNIPROT |
| ESPN | C0011052 | Prelingual Deafness | 2 | CTD_human |
| ESPN | C0011053 | Deafness | 2 | CTD_human |
| ESPN | C0086395 | Hearing Loss, Extreme | 2 | CTD_human |
| ESPN | C0581883 | Complete Hearing Loss | 2 | CTD_human |
| ESPN | C0751068 | Deafness, Acquired | 2 | CTD_human |
| ESPN | C3665473 | Bilateral Deafness | 2 | CTD_human |
| ESPN | C4082305 | Deaf Mutism | 2 | CTD_human |
| ESPN | C0042594 | Vestibular Diseases | 1 | CTD_human |
