Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CA12 (spascer ID:771)

Gene summary for CA12

Gene summary

Gene information
	Species	Human
	Gene symbol	CA12
	Gene ID	771
	Gene name	carbonic anhydrase 12
	Synonyms	CA-XII\|CAXII\|HsT18816\|T18816
	Cytomap	15q22.2
	Type of gene	protein-coding
	Description	carbonic anhydrase 12carbonate dehydratase XIIcarbonic anhydrase XIIcarbonic dehydratasetumor antigen HOM-RCC-3.1.3
	Modification date	20220513
	UniProtAcc	O43570

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CA12	GO:0004089	carbonate dehydratase activity	21873635	Function
CA12	GO:0005886	plasma membrane	21873635	Component
CA12	GO:0006730	one-carbon metabolic process	21873635	Process
CA12	GO:0016836	hydro-lyase activity	21873635	Function

Top

Spatial pattern events for CA12

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CA12	Human	Brain	rep_10	33558695	3.03e-12
CA12	Human	Intestine	rep_colon1	34417225	1.95e-15
CA12	Human	Intestine	rep_colon4	34417225	1.14e-15
CA12	Human	Liver	rep_liver1	34417225	1.08e-15
CA12	Human	Intestine	A2	33406409	5.79e-09
CA12	Human	Intestine	A4	33406409	9.63e-15
CA12	Human	Uterus	rep_1	34857954	5.13e-15
CA12	Human	Uterus	rep_2	34857954	4.63e-15
CA12	Human	Uterus	rep_3	34857954	1.66e-15
CA12	Human	Breast	A1	34650042	5.43e-10
CA12	Human	Breast	A2	34650042	2.61e-11
CA12	Human	Breast	A3	34650042	8.02e-10
CA12	Human	Breast	A4	34650042	2.70e-13
CA12	Human	Breast	A5	34650042	1.69e-11
CA12	Human	Breast	D4	34650042	9.28e-06
CA12	Human	Breast	D5	34650042	2.67e-06
CA12	Human	Breast	CID4290	34493872	4.68e-15
CA12	Human	Breast	CID4535	34493872	2.87e-08
CA12	Human	Lung	rep_1	35355018	1.37e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_10_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Intestine_A2_H&E
Intestine_A4_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Breast_A1_H&E
Breast_A2_H&E
Breast_A3_H&E
Breast_A4_H&E
Breast_A5_H&E
Breast_D4_H&E
Breast_D5_H&E
Breast_CID4290_H&E
Breast_CID4535_H&E
Lung_rep_1_H&E

Top

Spatial pattern pathway has CA12 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CA12	GOBP_Monovalent_Inorganic_Anion_Homeostasis	Human	Bladder	rep_2	3.6e-06
CA12	GOBP_Bicarbonate_Transport	Human	Bladder	rep_4	1.1e-05
CA12	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
CA12	GOBP_Anion_Homeostasis	Human	Intestine	A8	4.2e-11
CA12	GOBP_Chemical_Homeostasis	Human	Intestine	A8	1.3e-12
CA12	GOBP_Ion_Homeostasis	Human	Intestine	A8	6.1e-15
CA12	GOBP_Monovalent_Inorganic_Anion_Homeostasis	Human	Intestine	A8	1.6e-13
CA12	GOBP_One_Carbon_Metabolic_Process	Human	Intestine	A8	4.4e-16
CA12	GOBP_Organic_Anion_Transport	Human	Intestine	A8	3.5e-15
CA12	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
CA12	GOBP_Bicarbonate_Transport	Human	Pancreas	PDAC-A-st2	5.1e-07
CA12	GOBP_Bicarbonate_Transport	Human	Uterus	rep_25	4.1e-06
CA12	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
CA12	GOBP_Monovalent_Inorganic_Anion_Homeostasis	Human	Uterus	rep_26	1.9e-06
CA12	GOBP_Chemical_Homeostasis	Human	Breast	rep_1	4.8e-18
CA12	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
CA12	GOBP_Ion_Homeostasis	Human	Breast	rep_1	1.4e-53
CA12	GOBP_Anion_Homeostasis	Human	Breast	rep_4	3.6e-07
CA12	GOBP_Monovalent_Inorganic_Anion_Homeostasis	Human	Breast	rep_4	4.8e-05
CA12	GOBP_Organic_Anion_Transport	Human	Breast	rep_5	9.5e-10
CA12	GOBP_One_Carbon_Metabolic_Process	Human	Breast	rep_6	7.1e-06
CA12	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
CA12	GOBP_Monovalent_Inorganic_Anion_Homeostasis	Human	Skin	P10_rep1	1.6e-12
CA12	GOBP_Bicarbonate_Transport	Human	Skin	P10_rep2	4.9e-09
CA12	GOBP_Ion_Homeostasis	Human	Lung	rep_1	6.1e-07

Top

CA12 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

CA12 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for CA12 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for CA12

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CA12	O43570	DB00562	Benzthiazide	Carbonic anhydrase 12	SmallMoleculeDrug	approved
CA12	O43570	DB00909	Zonisamide	Carbonic anhydrase 12	SmallMoleculeDrug	approved\|investigational
CA12	O43570	DB00774	Hydroflumethiazide	Carbonic anhydrase 12	SmallMoleculeDrug	approved\|investigational\|withdrawn
CA12	O43570	DB00819	Acetazolamide	Carbonic anhydrase 12	SmallMoleculeDrug	approved\|vet_approved

Top

Related Diseases for CA12

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
CA12	C1840437	Isolated hyperchlorhidrosis	3	CTD_human;ORPHANET;UNIPROT
CA12	C0024121	Lung Neoplasms	1	CTD_human
CA12	C0242379	Malignant neoplasm of lung	1	CTD_human