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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: PCGF2 (spascer ID:7703)

Gene summary for PCGF2

Gene summary

Gene information
	Species	Human
	Gene symbol	PCGF2
	Gene ID	7703
	Gene name	polycomb group ring finger 2
	Synonyms	MEL-18\|RNF110\|TPFS\|ZNF144
	Cytomap	17q12
	Type of gene	protein-coding
	Description	polycomb group RING finger protein 2DNA-binding protein Mel-18ring finger protein 110zinc finger protein 144
	Modification date	20220513
	UniProtAcc	P35227

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
PCGF2	GO:0000122	negative regulation of transcription by RNA polymerase II	21873635	Process
PCGF2	GO:0035102	PRC1 complex	21873635	Component
PCGF2	GO:0036353	histone H2A-K119 monoubiquitination	21873635	Process
PCGF2	GO:1990841	promoter-specific chromatin binding	21873635	Function

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Spatial pattern events for PCGF2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
PCGF2	Human	Intestine	rep_colon1	34417225	5.44e-06
PCGF2	Human	Liver	rep_liver1	34417225	1.08e-15
PCGF2	Human	Breast	A3	34650042	4.75e-14
PCGF2	Human	Breast	A4	34650042	1.22e-09
PCGF2	Human	Breast	A5	34650042	4.62e-14
PCGF2	Human	Breast	E3	34650042	4.61e-07
PCGF2	Human	Breast	H2	34650042	7.23e-06
PCGF2	Human	Breast	CID4535	34493872	5.70e-07
PCGF2	Human	Heart	w6_s3	31835037	3.91e-05

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Breast_A3_H&E
Breast_A4_H&E
Breast_A5_H&E
Breast_E3_H&E
Breast_H2_H&E
Breast_CID4535_H&E

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Spatial pattern pathway has PCGF2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
PCGF2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
PCGF2	GOBP_Skeletal_System_Development	Human	Bladder	rep_2	2.5e-15
PCGF2	GOBP_Skeletal_System_Morphogenesis	Human	Bladder	rep_2	7.5e-11
PCGF2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Liver	rep_1	2.8e-53
PCGF2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
PCGF2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
PCGF2	GOBP_Anterior_Posterior_Pattern_Specification	Human	Intestine	A3	4.1e-08
PCGF2	GOBP_Apoptotic_Signaling_Pathway	Human	Intestine	A3	7.0e-12
PCGF2	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
PCGF2	GOBP_Cell_Cycle_Process	Human	Intestine	A3	2.7e-14
PCGF2	GOBP_Cellular_Response_To_Chemical_Stress	Human	Intestine	A3	1.1e-11
PCGF2	GOBP_Chromatin_Organization	Human	Intestine	A3	3.2e-11
PCGF2	GOBP_Chromosome_Organization	Human	Intestine	A3	2.5e-13
PCGF2	GOBP_Embryo_Development	Human	Intestine	A3	2.4e-07
PCGF2	GOBP_Embryonic_Morphogenesis	Human	Intestine	A3	1.3e-11
PCGF2	GOBP_Embryonic_Organ_Development	Human	Intestine	A3	1.4e-10
PCGF2	GOBP_Embryonic_Organ_Morphogenesis	Human	Intestine	A3	1.5e-09
PCGF2	GOBP_Histone_Ubiquitination	Human	Intestine	A3	1.9e-07
PCGF2	GOBP_Negative_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Intestine	A3	5.6e-14
PCGF2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Intestine	A3	5.9e-17
PCGF2	GOBP_Negative_Regulation_Of_Cell_Death	Human	Intestine	A3	5.8e-14
PCGF2	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
PCGF2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	7.7e-14
PCGF2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Intestine	A3	6.0e-11
PCGF2	GOBP_Negative_Regulation_Of_Signaling	Human	Intestine	A3	4.9e-15
PCGF2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Intestine	A3	1.9e-15
PCGF2	GOBP_Pattern_Specification_Process	Human	Intestine	A3	4.9e-07
PCGF2	GOBP_Peptidyl_Amino_Acid_Modification	Human	Intestine	A3	2.7e-09
PCGF2	GOBP_Peptidyl_Lysine_Modification	Human	Intestine	A3	2.8e-09
PCGF2	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
PCGF2	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
PCGF2	GOBP_Regionalization	Human	Intestine	A3	1.1e-10
PCGF2	GOBP_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Intestine	A3	1.3e-15
PCGF2	GOBP_Regulation_Of_Cell_Cycle	Human	Intestine	A3	1.6e-08
PCGF2	GOBP_Regulation_Of_Cell_Cycle_Process	Human	Intestine	A3	1.1e-15
PCGF2	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
PCGF2	GOBP_Response_To_Inorganic_Substance	Human	Intestine	A3	6.8e-07
PCGF2	GOBP_Response_To_Oxidative_Stress	Human	Intestine	A3	5.4e-18
PCGF2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
PCGF2	GOBP_Cellular_Response_To_Hydrogen_Peroxide	Human	Intestine	A8	5.2e-21
PCGF2	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Intestine	A8	1.4e-09
PCGF2	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Human	Intestine	A8	4.8e-25
PCGF2	GOBP_Embryonic_Skeletal_System_Development	Human	Intestine	A8	1.1e-07
PCGF2	GOBP_Embryonic_Skeletal_System_Morphogenesis	Human	Intestine	A8	5.9e-08
PCGF2	GOBP_G0_To_G1_Transition	Human	Intestine	A8	1.1e-12
PCGF2	GOBP_Histone_H2a_K119_Monoubiquitination	Human	Intestine	A8	3.8e-14
PCGF2	GOBP_Histone_H2a_Monoubiquitination	Human	Intestine	A8	4.2e-10
PCGF2	GOBP_Histone_H2a_Ubiquitination	Human	Intestine	A8	9.7e-14
PCGF2	GOBP_Histone_Monoubiquitination	Human	Intestine	A8	3.2e-09
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Intestine	A8	3.1e-14
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Intestine	A8	6.5e-12
PCGF2	GOBP_Peptidyl_Lysine_Acetylation	Human	Intestine	A8	1.9e-08
PCGF2	GOBP_Protein_Acetylation	Human	Intestine	A8	6.7e-07
PCGF2	GOBP_Protein_Monoubiquitination	Human	Intestine	A8	9.4e-12
PCGF2	GOBP_Regulation_Of_Gene_Expression_Epigenetic	Human	Intestine	A8	7.4e-16
PCGF2	GOBP_Response_To_Hydrogen_Peroxide	Human	Intestine	A8	7.1e-08
PCGF2	GOBP_Response_To_Reactive_Oxygen_Species	Human	Intestine	A8	1.4e-28
PCGF2	GOBP_Histone_H2a_Monoubiquitination	Human	Pancreas	PDAC-B-st1	2.6e-06
PCGF2	GOBP_Histone_H2a_Ubiquitination	Human	Pancreas	PDAC-B-st1	1.2e-05
PCGF2	GOBP_Histone_Monoubiquitination	Human	Pancreas	PDAC-B-st1	2.4e-06
PCGF2	GOBP_Negative_Regulation_Of_Signaling	Human	Pancreas	PDAC-B-st1	1.7e-05
PCGF2	GOBP_Response_To_Hydrogen_Peroxide	Human	Pancreas	PDAC-B-st1	7.1e-05
PCGF2	GOBP_Chromatin_Organization	Human	Uterus	rep_1	1.9e-06
PCGF2	GOBP_Chromosome_Organization	Human	Uterus	rep_26	1.2e-09
PCGF2	GOBP_G0_To_G1_Transition	Human	Uterus	rep_26	8.3e-06
PCGF2	GOBP_Histone_H2a_Monoubiquitination	Human	Uterus	rep_26	1.4e-12
PCGF2	GOBP_Histone_H2a_Ubiquitination	Human	Uterus	rep_26	4.7e-07
PCGF2	GOBP_Histone_Monoubiquitination	Human	Uterus	rep_26	5.9e-09
PCGF2	GOBP_Histone_Ubiquitination	Human	Uterus	rep_26	8.7e-07
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Uterus	rep_26	1.0e-08
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Uterus	rep_26	2.4e-12
PCGF2	GOBP_Negative_Regulation_Of_Gene_Expression_Epigenetic	Human	Uterus	rep_26	1.9e-10
PCGF2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Uterus	rep_26	2.1e-06
PCGF2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Uterus	rep_26	6.2e-13
PCGF2	GOBP_Pattern_Specification_Process	Human	Uterus	rep_26	3.6e-06
PCGF2	GOBP_Peptidyl_Lysine_Modification	Human	Uterus	rep_26	2.3e-09
PCGF2	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
PCGF2	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
PCGF2	GOBP_Protein_Monoubiquitination	Human	Uterus	rep_26	5.5e-08
PCGF2	GOBP_Regionalization	Human	Uterus	rep_26	2.0e-06
PCGF2	GOBP_Regulation_Of_Gene_Expression_Epigenetic	Human	Uterus	rep_26	4.4e-12
PCGF2	GOBP_Response_To_Reactive_Oxygen_Species	Human	Uterus	rep_26	2.1e-12
PCGF2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Uterus	rep_29	1.2e-06
PCGF2	GOBP_Negative_Regulation_Of_Signaling	Human	Uterus	rep_29	5.3e-06
PCGF2	GOBP_Peptidyl_Lysine_Acetylation	Human	Uterus	rep_29	6.7e-06
PCGF2	GOBP_Animal_Organ_Morphogenesis	Human	Breast	rep_1	5.4e-25
PCGF2	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Human	Breast	rep_1	7.7e-07
PCGF2	GOBP_G0_To_G1_Transition	Human	Breast	rep_1	1.3e-66
PCGF2	GOBP_Histone_H2a_K119_Monoubiquitination	Human	Breast	rep_1	1.4e-10
PCGF2	GOBP_In_Utero_Embryonic_Development	Human	Breast	rep_1	1.5e-18
PCGF2	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Human	Breast	rep_1	2.4e-07
PCGF2	GOBP_Peptidyl_Lysine_Acetylation	Human	Breast	rep_1	4.3e-46
PCGF2	GOBP_Protein_Acetylation	Human	Breast	rep_1	3.7e-29
PCGF2	GOBP_Protein_Acylation	Human	Breast	rep_1	1.9e-23
PCGF2	GOBP_Skeletal_System_Morphogenesis	Human	Breast	rep_1	6.7e-20
PCGF2	GOBP_Anterior_Posterior_Pattern_Specification	Human	Breast	rep_5	1.5e-08
PCGF2	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.9e-11
PCGF2	GOBP_Embryo_Development	Human	Breast	rep_5	5.5e-08
PCGF2	GOBP_Embryonic_Morphogenesis	Human	Breast	rep_5	2.0e-06
PCGF2	GOBP_Embryonic_Organ_Development	Human	Breast	rep_5	3.3e-05
PCGF2	GOBP_Negative_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Breast	rep_5	2.5e-09
PCGF2	GOBP_Negative_Regulation_Of_Cell_Death	Human	Breast	rep_5	1.9e-07
PCGF2	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
PCGF2	GOBP_Negative_Regulation_Of_Signaling	Human	Breast	rep_5	8.6e-14
PCGF2	GOBP_Pattern_Specification_Process	Human	Breast	rep_5	3.7e-14
PCGF2	GOBP_Regionalization	Human	Breast	rep_5	5.8e-16
PCGF2	GOBP_Regulation_Of_Cell_Cycle	Human	Breast	rep_5	3.7e-04
PCGF2	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
PCGF2	GOBP_Response_To_Inorganic_Substance	Human	Breast	rep_5	1.8e-10
PCGF2	GOBP_Response_To_Oxidative_Stress	Human	Breast	rep_5	1.0e-04
PCGF2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
PCGF2	GOBP_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	4.8e-09
PCGF2	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
PCGF2	GOBP_Cell_Cycle_Process	Human	Breast	rep_6	6.7e-09
PCGF2	GOBP_Cellular_Response_To_Chemical_Stress	Human	Breast	rep_6	3.6e-05
PCGF2	GOBP_Cellular_Response_To_Hydrogen_Peroxide	Human	Breast	rep_6	2.8e-05
PCGF2	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Human	Breast	rep_6	1.3e-05
PCGF2	GOBP_Chromatin_Organization	Human	Breast	rep_6	4.3e-07
PCGF2	GOBP_Chromosome_Organization	Human	Breast	rep_6	1.1e-06
PCGF2	GOBP_Embryonic_Organ_Morphogenesis	Human	Breast	rep_6	1.8e-08
PCGF2	GOBP_Histone_H2a_Monoubiquitination	Human	Breast	rep_6	2.7e-09
PCGF2	GOBP_Histone_H2a_Ubiquitination	Human	Breast	rep_6	6.5e-09
PCGF2	GOBP_Histone_Monoubiquitination	Human	Breast	rep_6	5.1e-06
PCGF2	GOBP_Histone_Ubiquitination	Human	Breast	rep_6	3.5e-07
PCGF2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Human	Breast	rep_6	2.6e-08
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Breast	rep_6	5.3e-11
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Breast	rep_6	2.3e-13
PCGF2	GOBP_Negative_Regulation_Of_Gene_Expression_Epigenetic	Human	Breast	rep_6	4.6e-06
PCGF2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_6	3.5e-08
PCGF2	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Human	Breast	rep_6	8.2e-08
PCGF2	GOBP_Peptidyl_Amino_Acid_Modification	Human	Breast	rep_6	3.8e-05
PCGF2	GOBP_Peptidyl_Lysine_Modification	Human	Breast	rep_6	4.5e-08
PCGF2	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
PCGF2	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
PCGF2	GOBP_Protein_Monoubiquitination	Human	Breast	rep_6	2.7e-05
PCGF2	GOBP_Regulation_Of_Apoptotic_Signaling_Pathway	Human	Breast	rep_6	1.6e-07
PCGF2	GOBP_Regulation_Of_Cell_Cycle_Process	Human	Breast	rep_6	6.1e-08
PCGF2	GOBP_Response_To_Hydrogen_Peroxide	Human	Breast	rep_6	6.6e-04
PCGF2	GOBP_Peptidyl_Lysine_Acetylation	Human	Skin	P5_rep1	1.5e-08
PCGF2	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Skin	P5_rep3	1.1e-11
PCGF2	GOBP_Histone_H2a_K119_Monoubiquitination	Human	Skin	P10_rep2	9.8e-28
PCGF2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08

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PCGF2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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PCGF2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for PCGF2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for PCGF2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PCGF2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
PCGF2	C3714756	Intellectual Disability	2	GENOMICS_ENGLAND
PCGF2	C0243050	Cardiovascular Abnormalities	1	GENOMICS_ENGLAND
PCGF2	C0432072	Dysmorphic features	1	GENOMICS_ENGLAND
PCGF2	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
PCGF2	C4021762	Abnormality of the cerebrum	1	GENOMICS_ENGLAND
PCGF2	C4021790	Abnormality of the skeletal system	1	GENOMICS_ENGLAND