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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: PTTG1IP (spascer ID:754)

Gene summary for PTTG1IP

check button Gene summary
Gene information
SpeciesHuman
Gene symbol

PTTG1IP

Gene ID

754

Gene namePTTG1 interacting protein
SynonymsC21orf1|C21orf3|PBF|PTTG1IP1
Cytomap21q22.3
Type of geneprotein-coding
Descriptionpituitary tumor-transforming gene 1 protein-interacting proteinPTTG-binding factorpituitary tumor-transforming 1 interacting proteinpituitary tumor-transforming gene protein-binding factor
Modification date20220513
UniProtAcc

P53801


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
PTTG1IP

GO:0005634

nucleus

21873635

Component
PTTG1IP

GO:0005737

cytoplasm

21873635

Component
PTTG1IP

GO:0006606

protein import into nucleus

21873635

Process

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Spatial pattern events for PTTG1IP

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
PTTG1IPHumanBrainrep_1 335586953.74e-08
PTTG1IPHumanBrainrep_3 335586952.47e-08
PTTG1IPHumanBrainrep_9 335586953.01e-15
PTTG1IPHumanBrainrep_10 335586953.23e-15
PTTG1IPHumanBrainrep_11 335586953.36e-15
PTTG1IPHumanBrainrep_12 335586953.65e-15
PTTG1IPHumanProstaterep_3 299258781.72e-11
PTTG1IPHumanIntestinerep_colon1 344172251.95e-15
PTTG1IPHumanIntestinerep_colon2 344172258.12e-16
PTTG1IPHumanIntestinerep_colon4 344172251.14e-15
PTTG1IPHumanLiverrep_liver1 344172251.55e-13
PTTG1IPHumanLiverrep_liver2 344172256.98e-16
PTTG1IPHumanLiverrep_liver4 344172257.71e-16
PTTG1IPHumanIntestineA1 334064092.09e-15
PTTG1IPHumanIntestineA2 334064092.47e-15
PTTG1IPHumanIntestineA3 334064091.94e-14
PTTG1IPHumanIntestineA8 334064094.28e-07
PTTG1IPHumanUterusrep_1 348579541.35e-08
PTTG1IPHumanUterusrep_2 348579542.55e-15
PTTG1IPHumanUterusrep_3 348579544.99e-11
PTTG1IPHumanUterusrep_4 348579541.82e-15
PTTG1IPHumanBreastD2 346500421.23e-06
PTTG1IPHumanBreastD3 346500429.94e-09
PTTG1IPHumanBreastD4 346500426.23e-07
PTTG1IPHumanBreastD5 346500425.62e-07
PTTG1IPHumanBreast1142243F 344938722.30e-15
PTTG1IPHumanBreast1160920F 344938721.48e-15
PTTG1IPHumanBreastCID4465 344938724.85e-15
PTTG1IPHumanBreastCID44971 344938721.76e-15
PTTG1IPHumanHeartw9_s3 318350371.97e-03
PTTG1IPHumanHeartw9_s5 318350372.45e-04
PTTG1IPHumanHeartw9_s6 318350377.58e-06
PTTG1IPHumanSkinmel1_rep1 301541482.81e-14
PTTG1IPHumanSkinmel1_rep2 301541482.48e-14
PTTG1IPHumanSkinmel2_rep1 301541481.85e-09
PTTG1IPHumanSkinmel2_rep2 301541481.30e-11

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
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Brain_rep_3_H&E
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Brain_rep_9_H&E
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Brain_rep_10_H&E
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Brain_rep_11_H&E
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Brain_rep_12_H&E
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Intestine_rep_colon1_H&E
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Intestine_rep_colon2_H&E
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Intestine_rep_colon4_H&E
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Liver_rep_liver1_H&E
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Liver_rep_liver2_H&E
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Liver_rep_liver4_H&E
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Intestine_A1_H&E
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Intestine_A2_H&E
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Intestine_A3_H&E
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Intestine_A8_H&E
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Uterus_rep_1_H&E
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Uterus_rep_2_H&E
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Uterus_rep_3_H&E
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Uterus_rep_4_H&E
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Breast_D2_H&E
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Breast_D3_H&E
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Breast_D4_H&E
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Breast_D5_H&E
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Breast_1142243F_H&E
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Breast_1160920F_H&E
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Breast_CID4465_H&E
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Breast_CID44971_H&E
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Spatial pattern pathway has PTTG1IP envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanBrainrep_1 4.4e-07
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_ProcessHumanBrainrep_1 2.8e-23
PTTG1IPGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanBrainrep_1 1.2e-64
PTTG1IPGOBP_Regulation_Of_Protein_Modification_ProcessHumanBrainrep_1 7.4e-34
PTTG1IPGOBP_Regulation_Of_Response_To_StressHumanBrainrep_1 4.6e-05
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_StimulusHumanLiverrep_1 2.8e-53
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanLiverrep_1 1.1e-67
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_ProcessHumanLiverrep_1 1.0e-70
PTTG1IPGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanLiverrep_1 6.9e-47
PTTG1IPGOBP_Regulation_Of_Protein_Modification_ProcessHumanLiverrep_1 1.0e-70
PTTG1IPGOBP_Regulation_Of_Response_To_StressHumanLiverrep_1 5.3e-67
PTTG1IPGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanIntestinerep_colon2 2.4e-25
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanIntestinerep_colon4 1.2e-51
PTTG1IPGOBP_Regulation_Of_Response_To_StressHumanIntestinerep_colon4 2.2e-52
PTTG1IPGOBP_Apoptotic_Signaling_PathwayHumanIntestineA3 7.0e-12
PTTG1IPGOBP_Cellular_Macromolecule_LocalizationHumanIntestineA3 1.7e-09
PTTG1IPGOBP_Cellular_Protein_Catabolic_ProcessHumanIntestineA3 2.9e-12
PTTG1IPGOBP_Cellular_Response_To_Dna_Damage_StimulusHumanIntestineA3 6.6e-16
PTTG1IPGOBP_Establishment_Of_Protein_LocalizationHumanIntestineA3 5.0e-10
PTTG1IPGOBP_Establishment_Of_Protein_Localization_To_OrganelleHumanIntestineA3 3.8e-08
PTTG1IPGOBP_Intracellular_Protein_TransportHumanIntestineA3 4.8e-12
PTTG1IPGOBP_Intracellular_TransportHumanIntestineA3 7.6e-15
PTTG1IPGOBP_Intrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 2.5e-16
PTTG1IPGOBP_Macromolecule_Catabolic_ProcessHumanIntestineA3 2.2e-16
PTTG1IPGOBP_Negative_Regulation_Of_Apoptotic_Signaling_PathwayHumanIntestineA3 5.6e-14
PTTG1IPGOBP_Negative_Regulation_Of_Cell_DeathHumanIntestineA3 5.8e-14
PTTG1IPGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionHumanIntestineA3 2.6e-18
PTTG1IPGOBP_Negative_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 1.0e-10
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_StimulusHumanIntestineA3 6.0e-11
PTTG1IPGOBP_Negative_Regulation_Of_SignalingHumanIntestineA3 4.9e-15
PTTG1IPGOBP_Nuclear_TransportHumanIntestineA3 5.6e-10
PTTG1IPGOBP_Organonitrogen_Compound_Catabolic_ProcessHumanIntestineA3 4.5e-13
PTTG1IPGOBP_Positive_Regulation_Of_Catabolic_ProcessHumanIntestineA3 2.8e-16
PTTG1IPGOBP_Positive_Regulation_Of_Cellular_Protein_Catabolic_ProcessHumanIntestineA3 8.5e-19
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanIntestineA3 7.7e-21
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanIntestineA3 5.0e-14
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanIntestineA3 4.9e-09
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_ProcessHumanIntestineA3 9.1e-12
PTTG1IPGOBP_Protein_Catabolic_ProcessHumanIntestineA3 2.9e-14
PTTG1IPGOBP_Protein_Localization_To_NucleusHumanIntestineA3 7.7e-09
PTTG1IPGOBP_Protein_Localization_To_OrganelleHumanIntestineA3 1.5e-12
PTTG1IPGOBP_Protein_Modification_By_Small_Protein_ConjugationHumanIntestineA3 1.2e-13
PTTG1IPGOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanIntestineA3 1.8e-12
PTTG1IPGOBP_Regulation_Of_Apoptotic_Signaling_PathwayHumanIntestineA3 1.3e-15
PTTG1IPGOBP_Regulation_Of_Catabolic_ProcessHumanIntestineA3 3.5e-16
PTTG1IPGOBP_Regulation_Of_Cell_DeathHumanIntestineA3 7.1e-10
PTTG1IPGOBP_Regulation_Of_Cellular_Protein_Catabolic_ProcessHumanIntestineA3 7.2e-15
PTTG1IPGOBP_Regulation_Of_Cellular_Response_To_StressHumanIntestineA3 7.7e-17
PTTG1IPGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanIntestineA3 7.5e-12
PTTG1IPGOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 1.3e-16
PTTG1IPGOBP_Regulation_Of_Protein_Catabolic_ProcessHumanIntestineA3 1.2e-14
PTTG1IPGOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanIntestineA3 3.0e-12
PTTG1IPGOBP_Regulation_Of_Protein_Modification_ProcessHumanIntestineA3 1.1e-14
PTTG1IPGOBP_Regulation_Of_Response_To_Dna_Damage_StimulusHumanIntestineA3 1.1e-13
PTTG1IPGOBP_Regulation_Of_Response_To_StressHumanIntestineA3 1.1e-10
PTTG1IPGOBP_Dna_Damage_Response_Signal_Transduction_By_P53_Class_MediatorHumanIntestineA8 2.8e-10
PTTG1IPGOBP_Negative_Regulation_Of_Dna_Damage_Response_Signal_Transduction_By_P53_Class_MediatorHumanIntestineA8 1.7e-07
PTTG1IPGOBP_Negative_Regulation_Of_SignalingHumanPancreasPDAC-B-st1 1.7e-05
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanPancreasPDAC-B-st1 6.7e-05
PTTG1IPGOBP_Regulation_Of_Dna_Damage_Response_Signal_Transduction_By_P53_Class_MediatorHumanPancreasPDAC-B-st1 1.4e-06
PTTG1IPGOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanUterusrep_1 2.6e-06
PTTG1IPGOBP_Signal_Transduction_By_P53_Class_MediatorHumanUterusrep_1 3.7e-07
PTTG1IPGOBP_Nuclear_TransportHumanUterusrep_25 2.3e-13
PTTG1IPGOBP_Cellular_Protein_Catabolic_ProcessHumanUterusrep_26 8.2e-11
PTTG1IPGOBP_Cellular_Response_To_Dna_Damage_StimulusHumanUterusrep_26 2.4e-07
PTTG1IPGOBP_Macromolecule_Catabolic_ProcessHumanUterusrep_26 5.0e-08
PTTG1IPGOBP_Negative_Regulation_Of_Dna_Damage_Response_Signal_Transduction_By_P53_Class_MediatorHumanUterusrep_26 8.7e-09
PTTG1IPGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionHumanUterusrep_26 2.7e-06
PTTG1IPGOBP_Negative_Regulation_Of_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanUterusrep_26 8.2e-10
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_Dna_Damage_StimulusHumanUterusrep_26 3.9e-08
PTTG1IPGOBP_Organonitrogen_Compound_Catabolic_ProcessHumanUterusrep_26 1.0e-08
PTTG1IPGOBP_Positive_Regulation_Of_Cellular_Protein_Catabolic_ProcessHumanUterusrep_26 1.3e-07
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanUterusrep_26 2.4e-09
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanUterusrep_26 2.2e-08
PTTG1IPGOBP_Protein_Catabolic_ProcessHumanUterusrep_26 3.6e-10
PTTG1IPGOBP_Protein_ImportHumanUterusrep_26 5.4e-13
PTTG1IPGOBP_Protein_Modification_By_Small_Protein_ConjugationHumanUterusrep_26 2.1e-08
PTTG1IPGOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanUterusrep_26 5.7e-08
PTTG1IPGOBP_Regulation_Of_Cellular_Protein_Catabolic_ProcessHumanUterusrep_26 2.7e-10
PTTG1IPGOBP_Regulation_Of_Protein_Catabolic_ProcessHumanUterusrep_26 7.3e-06
PTTG1IPGOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanUterusrep_26 2.9e-09
PTTG1IPGOBP_Signal_Transduction_In_Response_To_Dna_DamageHumanUterusrep_26 6.1e-08
PTTG1IPGOBP_Negative_Regulation_Of_Signal_Transduction_By_P53_Class_MediatorHumanUterusrep_28 5.3e-10
PTTG1IPGOBP_Negative_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanUterusrep_29 4.2e-06
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_StimulusHumanUterusrep_29 1.2e-06
PTTG1IPGOBP_Negative_Regulation_Of_SignalingHumanUterusrep_29 5.3e-06
PTTG1IPGOBP_Regulation_Of_Response_To_Dna_Damage_StimulusHumanUterusrep_29 9.2e-06
PTTG1IPGOBP_Cellular_Macromolecule_LocalizationHumanBreastrep_1 3.7e-09
PTTG1IPGOBP_Establishment_Of_Protein_LocalizationHumanBreastrep_1 7.2e-05
PTTG1IPGOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionHumanBreastrep_1 3.6e-04
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_StimulusHumanBreastrep_1 2.4e-07
PTTG1IPGOBP_Positive_Regulation_Of_Cellular_Protein_Catabolic_ProcessHumanBreastrep_1 4.1e-24
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanBreastrep_1 2.2e-13
PTTG1IPGOBP_Regulation_Of_Response_To_StressHumanBreastrep_1 3.4e-19
PTTG1IPGOBP_Cellular_Protein_Catabolic_ProcessHumanBreastrep_5 4.4e-04
PTTG1IPGOBP_Negative_Regulation_Of_Apoptotic_Signaling_PathwayHumanBreastrep_5 2.5e-09
PTTG1IPGOBP_Negative_Regulation_Of_Cell_DeathHumanBreastrep_5 1.9e-07
PTTG1IPGOBP_Negative_Regulation_Of_SignalingHumanBreastrep_5 8.6e-14
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanBreastrep_5 2.6e-04
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_ProcessHumanBreastrep_5 3.0e-10
PTTG1IPGOBP_Protein_Localization_To_NucleusHumanBreastrep_5 1.3e-04
PTTG1IPGOBP_Regulation_Of_Cell_DeathHumanBreastrep_5 9.8e-08
PTTG1IPGOBP_Regulation_Of_Cellular_Response_To_StressHumanBreastrep_5 8.1e-10
PTTG1IPGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanBreastrep_5 8.7e-11
PTTG1IPGOBP_Regulation_Of_Protein_Modification_ProcessHumanBreastrep_5 9.1e-07
PTTG1IPGOBP_Apoptotic_Signaling_PathwayHumanBreastrep_6 4.8e-09
PTTG1IPGOBP_Cellular_Response_To_Dna_Damage_StimulusHumanBreastrep_6 6.0e-06
PTTG1IPGOBP_Establishment_Of_Protein_Localization_To_OrganelleHumanBreastrep_6 8.5e-11
PTTG1IPGOBP_Import_Into_NucleusHumanBreastrep_6 4.5e-08
PTTG1IPGOBP_Intracellular_Protein_TransportHumanBreastrep_6 6.4e-12
PTTG1IPGOBP_Intracellular_TransportHumanBreastrep_6 1.3e-08
PTTG1IPGOBP_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 2.7e-08
PTTG1IPGOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanBreastrep_6 2.9e-05
PTTG1IPGOBP_Macromolecule_Catabolic_ProcessHumanBreastrep_6 1.3e-05
PTTG1IPGOBP_Negative_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 2.1e-09
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_Dna_Damage_StimulusHumanBreastrep_6 8.2e-04
PTTG1IPGOBP_Nuclear_TransportHumanBreastrep_6 3.1e-08
PTTG1IPGOBP_Organonitrogen_Compound_Catabolic_ProcessHumanBreastrep_6 9.5e-06
PTTG1IPGOBP_Positive_Regulation_Of_Catabolic_ProcessHumanBreastrep_6 9.2e-08
PTTG1IPGOBP_Positive_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanBreastrep_6 1.5e-06
PTTG1IPGOBP_Protein_Catabolic_ProcessHumanBreastrep_6 5.3e-06
PTTG1IPGOBP_Protein_ImportHumanBreastrep_6 3.9e-08
PTTG1IPGOBP_Protein_Localization_To_OrganelleHumanBreastrep_6 1.1e-07
PTTG1IPGOBP_Protein_Modification_By_Small_Protein_ConjugationHumanBreastrep_6 3.6e-10
PTTG1IPGOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanBreastrep_6 2.7e-09
PTTG1IPGOBP_Regulation_Of_Apoptotic_Signaling_PathwayHumanBreastrep_6 1.6e-07
PTTG1IPGOBP_Regulation_Of_Catabolic_ProcessHumanBreastrep_6 3.3e-04
PTTG1IPGOBP_Regulation_Of_Cellular_Protein_Catabolic_ProcessHumanBreastrep_6 6.2e-07
PTTG1IPGOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 3.3e-09
PTTG1IPGOBP_Regulation_Of_Protein_Catabolic_ProcessHumanBreastrep_6 4.3e-04
PTTG1IPGOBP_Regulation_Of_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalHumanBreastrep_6 1.0e-10
PTTG1IPGOBP_Regulation_Of_Response_To_Dna_Damage_StimulusHumanBreastrep_6 7.4e-06
PTTG1IPGOBP_Regulation_Of_Signal_Transduction_By_P53_Class_MediatorHumanBreastrep_6 1.6e-04
PTTG1IPGOBP_Signal_Transduction_By_P53_Class_MediatorHumanBreastrep_6 7.7e-05
PTTG1IPGOBP_Signal_Transduction_In_Response_To_Dna_DamageHumanBreastrep_6 1.7e-07
PTTG1IPGOBP_Import_Into_NucleusHumanSkinP5_rep1 3.8e-09
PTTG1IPGOBP_Nuclear_TransportHumanSkinP5_rep1 5.0e-19
PTTG1IPGOBP_Intrinsic_Apoptotic_Signaling_PathwayHumanSkinP9_rep3 4.3e-09
PTTG1IPGOBP_Negative_Regulation_Of_Dna_Damage_Response_Signal_Transduction_By_P53_Class_MediatorHumanSkinP10_rep1 6.3e-10
PTTG1IPGOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanSkinP10_rep1 1.8e-12
PTTG1IPGOBP_Negative_Regulation_Of_Signal_Transduction_By_P53_Class_MediatorHumanSkinP10_rep2 1.5e-09
PTTG1IPGOBP_Regulation_Of_Signal_Transduction_By_P53_Class_MediatorHumanSkinP10_rep2 7.3e-12
PTTG1IPGOBP_Negative_Regulation_Of_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanSkinP10_rep3 1.4e-08
PTTG1IPGOBP_Negative_Regulation_Of_Response_To_Dna_Damage_StimulusHumanSkinP10_rep3 2.1e-09

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PTTG1IP function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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PTTG1IP function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for PTTG1IP envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for PTTG1IP

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTTG1IP

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource