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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: C9 (spascer ID:735)

Gene summary for C9

Gene summary

Gene information
	Species	Human
	Gene symbol	C9
	Gene ID	735
	Gene name	complement C9
	Synonyms	ARMD15\|C9D
	Cytomap	5p13.1
	Type of gene	protein-coding
	Description	complement component C9complement component 9
	Modification date	20220513
	UniProtAcc	P02748

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for C9

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
C9	Human	Liver	rep_liver1	34417225	1.89e-15
C9	Human	Liver	rep_liver2	34417225	1.27e-15
C9	Human	Liver	rep_liver3	34417225	3.51e-15
C9	Human	Liver	rep_liver4	34417225	7.71e-16

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E

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Spatial pattern pathway has C9 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
C9	GOBP_Activation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C9	GOBP_Adaptive_Immune_Response	Human	Brain	rep_1	8.1e-16
C9	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Brain	rep_1	8.1e-16
C9	GOBP_B_Cell_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C9	GOBP_Cell_Killing	Human	Brain	rep_1	2.8e-23
C9	GOBP_Complement_Activation	Human	Brain	rep_1	8.1e-16
C9	GOBP_Complement_Activation_Alternative_Pathway	Human	Brain	rep_1	1.1e-26
C9	GOBP_Humoral_Immune_Response	Human	Brain	rep_1	8.1e-16
C9	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Brain	rep_1	8.1e-16
C9	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
C9	GOBP_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C9	GOBP_Lymphocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C9	GOBP_Positive_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C9	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
C9	GOBP_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C9	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
C9	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
C9	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
C9	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
C9	GOBP_Cytolysis	Human	Brain	rep_12	4.0e-05
C9	GOBP_Activation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C9	GOBP_Adaptive_Immune_Response	Human	Liver	rep_1	2.3e-76
C9	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Liver	rep_1	2.3e-76
C9	GOBP_B_Cell_Mediated_Immunity	Human	Liver	rep_1	2.3e-76
C9	GOBP_Cell_Killing	Human	Liver	rep_1	6.5e-65
C9	GOBP_Complement_Activation	Human	Liver	rep_1	2.3e-76
C9	GOBP_Complement_Activation_Alternative_Pathway	Human	Liver	rep_1	1.3e-69
C9	GOBP_Cytolysis	Human	Liver	rep_1	2.8e-62
C9	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
C9	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
C9	GOBP_Humoral_Immune_Response	Human	Liver	rep_1	9.0e-62
C9	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Liver	rep_1	2.3e-76
C9	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
C9	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
C9	GOBP_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	9.0e-62
C9	GOBP_Lymphocyte_Mediated_Immunity	Human	Liver	rep_1	2.3e-76
C9	GOBP_Positive_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C9	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
C9	GOBP_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C9	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
C9	GOBP_Activation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Adaptive_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_B_Cell_Mediated_Immunity	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Complement_Activation	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
C9	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
C9	GOBP_Humoral_Immune_Response	Human	Intestine	rep_colon4	1.3e-27
C9	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
C9	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
C9	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	rep_colon4	1.3e-27
C9	GOBP_Lymphocyte_Mediated_Immunity	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
C9	GOBP_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C9	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
C9	GOBP_Complement_Activation_Alternative_Pathway	Human	Intestine	rep_liver3	9.5e-14
C9	GOBP_Cytolysis	Human	Intestine	rep_liver3	1.5e-08
C9	GOBP_Cell_Killing	Human	Intestine	rep_liver4	3.1e-11
C9	GOBP_Activation_Of_Immune_Response	Human	Intestine	A3	5.7e-11
C9	GOBP_Cell_Killing	Human	Intestine	A3	8.0e-07
C9	GOBP_Complement_Activation	Human	Intestine	A3	5.9e-07
C9	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
C9	GOBP_Humoral_Immune_Response	Human	Intestine	A3	1.4e-08
C9	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
C9	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	A3	8.2e-10
C9	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	A3	2.4e-07
C9	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	A3	6.8e-15
C9	GOBP_Regulation_Of_Immune_Response	Human	Intestine	A3	1.6e-12
C9	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
C9	GOBP_Adaptive_Immune_Response	Human	Intestine	A8	2.4e-10
C9	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Intestine	A8	1.3e-09
C9	GOBP_B_Cell_Mediated_Immunity	Human	Intestine	A8	9.3e-10
C9	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
C9	GOBP_Regulation_Of_Complement_Activation	Human	Intestine	A8	1.6e-14
C9	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Intestine	A8	2.6e-12
C9	GOBP_Regulation_Of_Immune_Effector_Process	Human	Intestine	A8	2.4e-12
C9	GOBP_Protein_Complex_Oligomerization	Human	Pancreas	PDAC-B-st1	8.7e-05
C9	GOBP_Cytolysis	Human	Uterus	rep_2	1.2e-27
C9	GOBP_Activation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Adaptive_Immune_Response	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Uterus	rep_4	6.1e-31
C9	GOBP_B_Cell_Mediated_Immunity	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Complement_Activation	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Complement_Activation_Alternative_Pathway	Human	Uterus	rep_4	1.0e-36
C9	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
C9	GOBP_Humoral_Immune_Response	Human	Uterus	rep_4	2.0e-31
C9	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
C9	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Leukocyte_Mediated_Immunity	Human	Uterus	rep_4	2.0e-31
C9	GOBP_Lymphocyte_Mediated_Immunity	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Positive_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
C9	GOBP_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C9	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
C9	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
C9	GOBP_Cell_Killing	Human	Uterus	rep_28	1.6e-06
C9	GOBP_Regulation_Of_Immune_Effector_Process	Human	Uterus	rep_28	5.1e-07
C9	GOBP_Regulation_Of_Complement_Activation	Human	Uterus	rep_29	1.3e-08
C9	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Uterus	rep_29	3.7e-10
C9	GOBP_Complement_Activation_Alternative_Pathway	Human	Breast	rep_1	3.0e-236
C9	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
C9	GOBP_Protein_Complex_Oligomerization	Human	Breast	rep_1	1.7e-04
C9	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Breast	rep_1	2.0e-67
C9	GOBP_Cytolysis	Human	Breast	rep_3	2.2e-06
C9	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Skin	P10_rep1	3.5e-08
C9	GOBP_Protein_Homooligomerization	Human	Skin	P10_rep1	9.8e-09
C9	GOBP_Regulation_Of_Complement_Activation	Human	Skin	P10_rep1	7.7e-16
C9	GOBP_Complement_Activation_Alternative_Pathway	Human	Skin	P10_rep2	1.3e-09
C9	GOBP_Cell_Killing	Human	Lung	rep_1	7.5e-18
C9	GOBP_Cytolysis	Human	Lung	rep_1	6.9e-08
C9	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
C9	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
C9	GOBP_Humoral_Immune_Response	Human	Lung	rep_1	1.7e-10
C9	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	3.1e-08
C9	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07
C9	GOBP_Lymphocyte_Mediated_Immunity	Human	Lung	rep_2	3.7e-07

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C9 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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C9 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for C9 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for C9

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
C9	P02748	DB09130	Copper	Complement component C9	SmallMoleculeDrug	approved\|investigational

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Related Diseases for C9

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
C9	C0003257	Antibody Deficiency Syndrome	2	CTD_human
C9	C0021051	Immunologic Deficiency Syndromes	2	CTD_human
C9	C2239176	Liver carcinoma	2	CTD_human
C9	C3151189	C9 Deficiency	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
C9	C0011633	Dermatomyositis	1	CTD_human
C9	C0015456	Facial Dermatoses	1	CTD_human
C9	C0015704	Favre-Racouchot Syndrome	1	CTD_human
C9	C0025294	Meningococcal meningitis	1	CTD_human
C9	C0027412	Opioid-Related Disorders	1	CTD_human
C9	C0029095	Opioid abuse	1	CTD_human
C9	C0041834	Erythema	1	CTD_human
C9	C0221056	Adult type dermatomyositis	1	CTD_human
C9	C0242383	Age related macular degeneration	1	CTD_human
C9	C0263666	Dermatomyositis, Childhood Type	1	CTD_human
C9	C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
C9	C0343097	Nodular Elastoidosis	1	CTD_human
C9	C0345967	Malignant mesothelioma	1	CTD_human
C9	C0524661	Narcotic Abuse	1	CTD_human
C9	C0524662	Opiate Addiction	1	CTD_human
C9	C1135745	Meningitis, Meningococcal, Serogroup A	1	CTD_human
C9	C1135746	Meningitis, Meningococcal, Serogroup B	1	CTD_human
C9	C1135747	Meningitis, Meningococcal, Serogroup C	1	CTD_human
C9	C1136209	Meningitis, Meningococcal, Serogroup Y	1	CTD_human
C9	C1136210	Meningitis, Meningococcal, Serogroup W-135	1	CTD_human
C9	C1527402	Narcotic Dependence	1	CTD_human
C9	C3810042	MACULAR DEGENERATION, AGE-RELATED, 15	1	CTD_human;UNIPROT
C9	C4551628	Opiate Abuse	1	CTD_human