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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: C4BPA (spascer ID:722)

Gene summary for C4BPA

check button Gene summary
Gene information
SpeciesHuman
Gene symbol

C4BPA

Gene ID

722

Gene namecomplement component 4 binding protein alpha
SynonymsC4BP|PRP
Cytomap1q32.2
Type of geneprotein-coding
DescriptionC4b-binding protein alpha chainproline-rich protein
Modification date20220513
UniProtAcc

P04003


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
C4BPA

GO:0005615

extracellular space

21873635

Component
C4BPA

GO:0045959

negative regulation of complement activation, classical pathway

21873635

Process

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Spatial pattern events for C4BPA

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
C4BPAHumanLiverrep_1 347922893.43e-14
C4BPAHumanLiverrep_liver1 344172251.89e-15
C4BPAHumanLiverrep_liver2 344172251.27e-15
C4BPAHumanLiverrep_liver3 344172253.51e-15
C4BPAHumanLiverrep_liver4 344172257.71e-16
C4BPAHumanUterusrep_2 348579542.55e-15
C4BPAHumanUterusrep_4 348579541.82e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Liver_rep_1_H&E
boxplot

boxplot
Liver_rep_liver1_H&E
boxplot

boxplot
Liver_rep_liver2_H&E
boxplot

boxplot
Liver_rep_liver3_H&E
boxplot

boxplot
Liver_rep_liver4_H&E
boxplot

boxplot
Uterus_rep_2_H&E
boxplot

boxplot
Uterus_rep_4_H&E
boxplot

boxplot


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Spatial pattern pathway has C4BPA envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
C4BPAGOBP_Activation_Of_Immune_ResponseHumanBrainrep_1 8.1e-16
C4BPAGOBP_Adaptive_Immune_ResponseHumanBrainrep_1 8.1e-16
C4BPAGOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_DomainsHumanBrainrep_1 8.1e-16
C4BPAGOBP_B_Cell_Mediated_ImmunityHumanBrainrep_1 8.1e-16
C4BPAGOBP_Complement_ActivationHumanBrainrep_1 8.1e-16
C4BPAGOBP_EndocytosisHumanBrainrep_1 7.4e-34
C4BPAGOBP_Humoral_Immune_ResponseHumanBrainrep_1 8.1e-16
C4BPAGOBP_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanBrainrep_1 8.1e-16
C4BPAGOBP_Immune_Effector_ProcessHumanBrainrep_1 8.1e-16
C4BPAGOBP_Leukocyte_Mediated_ImmunityHumanBrainrep_1 8.1e-16
C4BPAGOBP_Lymphocyte_Mediated_ImmunityHumanBrainrep_1 8.1e-16
C4BPAGOBP_PhagocytosisHumanBrainrep_1 3.1e-16
C4BPAGOBP_Positive_Regulation_Of_Immune_ResponseHumanBrainrep_1 8.1e-16
C4BPAGOBP_Positive_Regulation_Of_Immune_System_ProcessHumanBrainrep_1 1.1e-18
C4BPAGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanBrainrep_1 4.4e-07
C4BPAGOBP_Regulation_Of_Immune_ResponseHumanBrainrep_1 8.1e-16
C4BPAGOBP_Regulation_Of_Immune_System_ProcessHumanBrainrep_1 1.1e-18
C4BPAGOBP_Response_To_BacteriumHumanBrainrep_1 3.1e-16
C4BPAGOBP_Defense_ResponseHumanBrainrep_4 2.2e-20
C4BPAGOBP_Defense_Response_To_Other_OrganismHumanBrainrep_4 1.2e-64
C4BPAGOBP_Innate_Immune_ResponseHumanBrainrep_4 1.2e-64
C4BPAGOBP_OpsonizationHumanBladderrep_2 2.0e-09
C4BPAGOBP_Response_To_SymbiontHumanBladderrep_3 3.4e-05
C4BPAGOBP_Activation_Of_Immune_ResponseHumanLiverrep_1 2.3e-76
C4BPAGOBP_Adaptive_Immune_ResponseHumanLiverrep_1 2.3e-76
C4BPAGOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_DomainsHumanLiverrep_1 2.3e-76
C4BPAGOBP_B_Cell_Mediated_ImmunityHumanLiverrep_1 2.3e-76
C4BPAGOBP_Complement_ActivationHumanLiverrep_1 2.3e-76
C4BPAGOBP_Defense_ResponseHumanLiverrep_1 1.3e-59
C4BPAGOBP_Defense_Response_To_Other_OrganismHumanLiverrep_1 4.3e-69
C4BPAGOBP_EndocytosisHumanLiverrep_1 1.5e-73
C4BPAGOBP_Humoral_Immune_ResponseHumanLiverrep_1 9.0e-62
C4BPAGOBP_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanLiverrep_1 2.3e-76
C4BPAGOBP_Immune_Effector_ProcessHumanLiverrep_1 9.0e-62
C4BPAGOBP_Innate_Immune_ResponseHumanLiverrep_1 7.3e-68
C4BPAGOBP_Leukocyte_Mediated_ImmunityHumanLiverrep_1 9.0e-62
C4BPAGOBP_Lymphocyte_Mediated_ImmunityHumanLiverrep_1 2.3e-76
C4BPAGOBP_Negative_Regulation_Of_Response_To_StimulusHumanLiverrep_1 2.8e-53
C4BPAGOBP_PhagocytosisHumanLiverrep_1 3.2e-72
C4BPAGOBP_Positive_Regulation_Of_Immune_ResponseHumanLiverrep_1 2.3e-76
C4BPAGOBP_Positive_Regulation_Of_Immune_System_ProcessHumanLiverrep_1 1.4e-67
C4BPAGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanLiverrep_1 1.1e-67
C4BPAGOBP_Regulation_Of_Immune_ResponseHumanLiverrep_1 2.3e-76
C4BPAGOBP_Regulation_Of_Immune_System_ProcessHumanLiverrep_1 1.4e-67
C4BPAGOBP_Response_To_BacteriumHumanLiverrep_1 9.4e-68
C4BPAGOBP_Activation_Of_Immune_ResponseHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Adaptive_Immune_ResponseHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_DomainsHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_B_Cell_Mediated_ImmunityHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Complement_ActivationHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Defense_ResponseHumanIntestinerep_colon4 2.5e-86
C4BPAGOBP_Defense_Response_To_Other_OrganismHumanIntestinerep_colon4 1.2e-82
C4BPAGOBP_Humoral_Immune_ResponseHumanIntestinerep_colon4 1.3e-27
C4BPAGOBP_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Immune_Effector_ProcessHumanIntestinerep_colon4 1.3e-27
C4BPAGOBP_Innate_Immune_ResponseHumanIntestinerep_colon4 3.4e-69
C4BPAGOBP_Leukocyte_Mediated_ImmunityHumanIntestinerep_colon4 1.3e-27
C4BPAGOBP_Lymphocyte_Mediated_ImmunityHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_PhagocytosisHumanIntestinerep_colon4 7.4e-22
C4BPAGOBP_Positive_Regulation_Of_Immune_ResponseHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Positive_Regulation_Of_Immune_System_ProcessHumanIntestinerep_colon4 4.8e-23
C4BPAGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanIntestinerep_colon4 1.2e-51
C4BPAGOBP_Regulation_Of_Immune_ResponseHumanIntestinerep_colon4 7.2e-20
C4BPAGOBP_Regulation_Of_Immune_System_ProcessHumanIntestinerep_colon4 4.8e-23
C4BPAGOBP_Response_To_BacteriumHumanIntestinerep_colon4 1.0e-26
C4BPAGOBP_Activation_Of_Immune_ResponseHumanIntestineA3 5.7e-11
C4BPAGOBP_Complement_ActivationHumanIntestineA3 5.9e-07
C4BPAGOBP_Defense_ResponseHumanIntestineA3 6.3e-13
C4BPAGOBP_EndocytosisHumanIntestineA3 9.3e-10
C4BPAGOBP_Humoral_Immune_ResponseHumanIntestineA3 1.4e-08
C4BPAGOBP_Immune_Effector_ProcessHumanIntestineA3 3.9e-14
C4BPAGOBP_Leukocyte_Mediated_ImmunityHumanIntestineA3 8.2e-10
C4BPAGOBP_Macromolecule_Catabolic_ProcessHumanIntestineA3 2.2e-16
C4BPAGOBP_Negative_Regulation_Of_Response_To_StimulusHumanIntestineA3 6.0e-11
C4BPAGOBP_Organonitrogen_Compound_Catabolic_ProcessHumanIntestineA3 4.5e-13
C4BPAGOBP_PhagocytosisHumanIntestineA3 2.4e-07
C4BPAGOBP_Positive_Regulation_Of_Catabolic_ProcessHumanIntestineA3 2.8e-16
C4BPAGOBP_Positive_Regulation_Of_Immune_ResponseHumanIntestineA3 2.4e-07
C4BPAGOBP_Positive_Regulation_Of_Immune_System_ProcessHumanIntestineA3 6.8e-15
C4BPAGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanIntestineA3 7.7e-21
C4BPAGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanIntestineA3 5.0e-14
C4BPAGOBP_Protein_Catabolic_ProcessHumanIntestineA3 2.9e-14
C4BPAGOBP_Regulation_Of_Catabolic_ProcessHumanIntestineA3 3.5e-16
C4BPAGOBP_Regulation_Of_Immune_ResponseHumanIntestineA3 1.6e-12
C4BPAGOBP_Regulation_Of_Immune_System_ProcessHumanIntestineA3 1.5e-15
C4BPAGOBP_Regulation_Of_Protein_Catabolic_ProcessHumanIntestineA3 1.2e-14
C4BPAGOBP_Adaptive_Immune_ResponseHumanIntestineA8 2.4e-10
C4BPAGOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_DomainsHumanIntestineA8 1.3e-09
C4BPAGOBP_B_Cell_Mediated_ImmunityHumanIntestineA8 9.3e-10
C4BPAGOBP_Cell_RecognitionHumanIntestineA8 4.6e-18
C4BPAGOBP_Defense_Response_To_Other_OrganismHumanIntestineA8 5.3e-08
C4BPAGOBP_Negative_Regulation_Of_Adaptive_Immune_ResponseHumanIntestineA8 9.9e-14
C4BPAGOBP_Negative_Regulation_Of_B_Cell_Mediated_ImmunityHumanIntestineA8 1.3e-07
C4BPAGOBP_Negative_Regulation_Of_Complement_ActivationHumanIntestineA8 1.9e-07
C4BPAGOBP_Negative_Regulation_Of_Humoral_Immune_ResponseHumanIntestineA8 2.3e-11
C4BPAGOBP_Negative_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanIntestineA8 1.9e-24
C4BPAGOBP_Negative_Regulation_Of_Immune_Effector_ProcessHumanIntestineA8 3.2e-09
C4BPAGOBP_Negative_Regulation_Of_Immune_System_ProcessHumanIntestineA8 1.6e-09
C4BPAGOBP_Negative_Regulation_Of_Leukocyte_Mediated_ImmunityHumanIntestineA8 2.1e-18
C4BPAGOBP_Negative_Regulation_Of_Lymphocyte_Mediated_ImmunityHumanIntestineA8 1.0e-14
C4BPAGOBP_OpsonizationHumanIntestineA8 1.1e-09
C4BPAGOBP_Phagocytosis_RecognitionHumanIntestineA8 1.2e-08
C4BPAGOBP_Regulation_Of_Adaptive_Immune_ResponseHumanIntestineA8 1.1e-12
C4BPAGOBP_Regulation_Of_Complement_ActivationHumanIntestineA8 1.6e-14
C4BPAGOBP_Regulation_Of_Humoral_Immune_ResponseHumanIntestineA8 2.6e-12
C4BPAGOBP_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanIntestineA8 7.7e-12
C4BPAGOBP_Regulation_Of_Immune_Effector_ProcessHumanIntestineA8 2.4e-12
C4BPAGOBP_Regulation_Of_Leukocyte_Mediated_ImmunityHumanIntestineA8 7.6e-11
C4BPAGOBP_Regulation_Of_Lymphocyte_Mediated_ImmunityHumanIntestineA8 5.2e-12
C4BPAGOBP_Response_To_BacteriumHumanIntestineA8 3.3e-17
C4BPAGOBP_Response_To_SymbiontHumanIntestineA8 1.3e-31
C4BPAGOBP_Negative_Regulation_Of_Complement_ActivationHumanPancreasPDAC-B-st1 2.4e-06
C4BPAGOBP_Negative_Regulation_Of_Humoral_Immune_ResponseHumanPancreasPDAC-B-st1 4.2e-05
C4BPAGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanPancreasPDAC-B-st1 6.7e-05
C4BPAGOBP_Activation_Of_Immune_ResponseHumanUterusrep_4 6.1e-31
C4BPAGOBP_Adaptive_Immune_ResponseHumanUterusrep_4 6.1e-31
C4BPAGOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_DomainsHumanUterusrep_4 6.1e-31
C4BPAGOBP_B_Cell_Mediated_ImmunityHumanUterusrep_4 6.1e-31
C4BPAGOBP_Complement_ActivationHumanUterusrep_4 6.1e-31
C4BPAGOBP_Defense_Response_To_Other_OrganismHumanUterusrep_4 2.0e-31
C4BPAGOBP_Humoral_Immune_ResponseHumanUterusrep_4 2.0e-31
C4BPAGOBP_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanUterusrep_4 6.1e-31
C4BPAGOBP_Immune_Effector_ProcessHumanUterusrep_4 2.0e-31
C4BPAGOBP_Innate_Immune_ResponseHumanUterusrep_4 6.1e-31
C4BPAGOBP_Leukocyte_Mediated_ImmunityHumanUterusrep_4 2.0e-31
C4BPAGOBP_Lymphocyte_Mediated_ImmunityHumanUterusrep_4 6.1e-31
C4BPAGOBP_Positive_Regulation_Of_Immune_ResponseHumanUterusrep_4 6.1e-31
C4BPAGOBP_Positive_Regulation_Of_Immune_System_ProcessHumanUterusrep_4 5.1e-31
C4BPAGOBP_Regulation_Of_Immune_ResponseHumanUterusrep_4 6.1e-31
C4BPAGOBP_Regulation_Of_Immune_System_ProcessHumanUterusrep_4 5.1e-31
C4BPAGOBP_Defense_ResponseHumanUterusrep_1 3.0e-06
C4BPAGOBP_OpsonizationHumanUterusrep_1 1.4e-10
C4BPAGOBP_Negative_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanUterusrep_25 1.7e-15
C4BPAGOBP_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanUterusrep_25 2.1e-14
C4BPAGOBP_Response_To_SymbiontHumanUterusrep_25 8.4e-24
C4BPAGOBP_Macromolecule_Catabolic_ProcessHumanUterusrep_26 5.0e-08
C4BPAGOBP_Negative_Regulation_Of_B_Cell_Mediated_ImmunityHumanUterusrep_26 4.8e-08
C4BPAGOBP_Organonitrogen_Compound_Catabolic_ProcessHumanUterusrep_26 1.0e-08
C4BPAGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanUterusrep_26 2.4e-09
C4BPAGOBP_Protein_Catabolic_ProcessHumanUterusrep_26 3.6e-10
C4BPAGOBP_Regulation_Of_Protein_Catabolic_ProcessHumanUterusrep_26 7.3e-06
C4BPAGOBP_Regulation_Of_Immune_Effector_ProcessHumanUterusrep_28 5.1e-07
C4BPAGOBP_Response_To_BacteriumHumanUterusrep_28 3.0e-06
C4BPAGOBP_Negative_Regulation_Of_Response_To_StimulusHumanUterusrep_29 1.2e-06
C4BPAGOBP_Regulation_Of_Complement_ActivationHumanUterusrep_29 1.3e-08
C4BPAGOBP_Regulation_Of_Humoral_Immune_ResponseHumanUterusrep_29 3.7e-10
C4BPAGOBP_Defense_ResponseHumanBreastrep_1 1.0e-09
C4BPAGOBP_Negative_Regulation_Of_Adaptive_Immune_ResponseHumanBreastrep_1 7.8e-12
C4BPAGOBP_Negative_Regulation_Of_Leukocyte_Mediated_ImmunityHumanBreastrep_1 5.2e-04
C4BPAGOBP_Negative_Regulation_Of_Response_To_StimulusHumanBreastrep_1 2.4e-07
C4BPAGOBP_OpsonizationHumanBreastrep_1 1.3e-04
C4BPAGOBP_Positive_Regulation_Of_Protein_Catabolic_ProcessHumanBreastrep_1 2.2e-13
C4BPAGOBP_Regulation_Of_Humoral_Immune_ResponseHumanBreastrep_1 2.0e-67
C4BPAGOBP_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanBreastrep_1 1.8e-16
C4BPAGOBP_Response_To_SymbiontHumanBreastrep_1 1.9e-24
C4BPAGOBP_Negative_Regulation_Of_Lymphocyte_Mediated_ImmunityHumanBreastrep_3 9.5e-18
C4BPAGOBP_Negative_Regulation_Of_B_Cell_Mediated_ImmunityHumanBreastrep_4 1.8e-06
C4BPAGOBP_Negative_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanBreastrep_4 4.3e-21
C4BPAGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanBreastrep_5 2.6e-04
C4BPAGOBP_Macromolecule_Catabolic_ProcessHumanBreastrep_6 1.3e-05
C4BPAGOBP_Organonitrogen_Compound_Catabolic_ProcessHumanBreastrep_6 9.5e-06
C4BPAGOBP_Positive_Regulation_Of_Catabolic_ProcessHumanBreastrep_6 9.2e-08
C4BPAGOBP_Protein_Catabolic_ProcessHumanBreastrep_6 5.3e-06
C4BPAGOBP_Regulation_Of_Catabolic_ProcessHumanBreastrep_6 3.3e-04
C4BPAGOBP_Regulation_Of_Protein_Catabolic_ProcessHumanBreastrep_6 4.3e-04
C4BPAGOBP_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanSkinP10_rep1 3.5e-08
C4BPAGOBP_Negative_Regulation_Of_B_Cell_Mediated_ImmunityHumanSkinP10_rep1 3.0e-13
C4BPAGOBP_Negative_Regulation_Of_Complement_ActivationHumanSkinP10_rep1 8.7e-20
C4BPAGOBP_Negative_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanSkinP10_rep1 1.3e-16
C4BPAGOBP_Regulation_Of_Complement_ActivationHumanSkinP10_rep1 7.7e-16
C4BPAGOBP_Regulation_Of_Humoral_Immune_Response_Mediated_By_Circulating_ImmunoglobulinHumanSkinP10_rep1 4.0e-10
C4BPAGOBP_Response_To_SymbiontHumanSkinP10_rep2 5.4e-08
C4BPAGOBP_Defense_ResponseHumanLungrep_1 9.9e-12
C4BPAGOBP_Defense_Response_To_Other_OrganismHumanLungrep_1 1.5e-09
C4BPAGOBP_Humoral_Immune_ResponseHumanLungrep_1 1.7e-10
C4BPAGOBP_Negative_Regulation_Of_Immune_System_ProcessHumanLungrep_1 2.3e-08
C4BPAGOBP_Positive_Regulation_Of_Immune_System_ProcessHumanLungrep_1 3.1e-08
C4BPAGOBP_Regulation_Of_Immune_System_ProcessHumanLungrep_1 5.9e-07
C4BPAGOBP_Response_To_BacteriumHumanLungrep_1 1.1e-09
C4BPAGOBP_Lymphocyte_Mediated_ImmunityHumanLungrep_2 3.7e-07

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C4BPA function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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C4BPA function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication
C4BPALRP1C4BPA_LRP1IntestineA1

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Transcription factor for C4BPA envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for C4BPA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
C4BPAP04003DB14548Zinc sulfate, unspecified formC4b-binding protein alpha chain SmallMoleculeDrugapproved|experimental
C4BPAP04003DB01593ZincC4b-binding protein alpha chain SmallMoleculeDrugapproved|investigational
C4BPAP04003DB09130CopperC4b-binding protein alpha chain SmallMoleculeDrugapproved|investigational
C4BPAP04003DB14487Zinc acetateC4b-binding protein alpha chain SmallMoleculeDrugapproved|investigational
C4BPAP04003DB14533Zinc chlorideC4b-binding protein alpha chain SmallMoleculeDrugapproved|investigational

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Related Diseases for C4BPA

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource