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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: C2 (spascer ID:717)

Gene summary for C2

Gene summary

Gene information
	Species	Human
	Gene symbol	C2
	Gene ID	717
	Gene name	complement C2
	Synonyms	ARMD14\|CO2
	Cytomap	6p21.33
	Type of gene	protein-coding
	Description	complement C2C3/C5 convertasecomplement component 2complement component C2
	Modification date	20220513
	UniProtAcc	P06681

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for C2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
C2	Human	Intestine	rep_colon1	34417225	1.95e-15
C2	Human	Intestine	rep_colon2	34417225	8.12e-16
C2	Human	Intestine	rep_colon4	34417225	1.14e-15
C2	Human	Liver	rep_liver1	34417225	1.89e-15
C2	Human	Liver	rep_liver2	34417225	1.27e-15
C2	Human	Liver	rep_liver3	34417225	3.51e-15
C2	Human	Liver	rep_liver4	34417225	7.71e-16
C2	Human	Uterus	rep_2	34857954	2.55e-15
C2	Human	Breast	1160920F	34493872	1.48e-15
C2	Human	Breast	CID4465	34493872	1.43e-07
C2	Human	Breast	CID44971	34493872	1.76e-15
C2	Human	Breast	CID4535	34493872	4.15e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Uterus_rep_2_H&E
Breast_1160920F_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E

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Spatial pattern pathway has C2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
C2	GOBP_Activation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C2	GOBP_Adaptive_Immune_Response	Human	Brain	rep_1	8.1e-16
C2	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Brain	rep_1	8.1e-16
C2	GOBP_Apoptotic_Cell_Clearance	Human	Brain	rep_1	3.1e-16
C2	GOBP_B_Cell_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C2	GOBP_Complement_Activation	Human	Brain	rep_1	8.1e-16
C2	GOBP_Humoral_Immune_Response	Human	Brain	rep_1	8.1e-16
C2	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Brain	rep_1	8.1e-16
C2	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
C2	GOBP_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C2	GOBP_Lymphocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C2	GOBP_Phagocytosis	Human	Brain	rep_1	3.1e-16
C2	GOBP_Positive_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C2	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
C2	GOBP_Positive_Regulation_Of_Phagocytosis	Human	Brain	rep_1	3.1e-16
C2	GOBP_Positive_Regulation_Of_Transport	Human	Brain	rep_1	3.1e-16
C2	GOBP_Regulation_Of_Apoptotic_Cell_Clearance	Human	Brain	rep_1	3.1e-16
C2	GOBP_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C2	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
C2	GOBP_Regulation_Of_Phagocytosis	Human	Brain	rep_1	3.1e-16
C2	GOBP_Regulation_Of_Transport	Human	Brain	rep_1	3.1e-16
C2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Brain	rep_1	3.1e-16
C2	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
C2	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
C2	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
C2	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
C2	GOBP_Response_To_Extracellular_Stimulus	Human	Brain	rep_11	2.5e-12
C2	GOBP_Response_To_Nutrient	Human	Brain	rep_11	2.5e-12
C2	GOBP_Response_To_Nutrient	Human	Bladder	rep_2	9.6e-14
C2	GOBP_Activation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C2	GOBP_Adaptive_Immune_Response	Human	Liver	rep_1	2.3e-76
C2	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Liver	rep_1	2.3e-76
C2	GOBP_Apoptotic_Cell_Clearance	Human	Liver	rep_1	3.2e-72
C2	GOBP_B_Cell_Mediated_Immunity	Human	Liver	rep_1	2.3e-76
C2	GOBP_Complement_Activation	Human	Liver	rep_1	2.3e-76
C2	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
C2	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
C2	GOBP_Humoral_Immune_Response	Human	Liver	rep_1	9.0e-62
C2	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Liver	rep_1	2.3e-76
C2	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
C2	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
C2	GOBP_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	9.0e-62
C2	GOBP_Lymphocyte_Mediated_Immunity	Human	Liver	rep_1	2.3e-76
C2	GOBP_Phagocytosis	Human	Liver	rep_1	3.2e-72
C2	GOBP_Positive_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C2	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
C2	GOBP_Positive_Regulation_Of_Phagocytosis	Human	Liver	rep_1	3.2e-72
C2	GOBP_Positive_Regulation_Of_Transport	Human	Liver	rep_1	9.4e-68
C2	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
C2	GOBP_Regulation_Of_Apoptotic_Cell_Clearance	Human	Liver	rep_1	3.2e-72
C2	GOBP_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C2	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
C2	GOBP_Regulation_Of_Phagocytosis	Human	Liver	rep_1	3.2e-72
C2	GOBP_Regulation_Of_Transport	Human	Liver	rep_1	9.4e-68
C2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Liver	rep_1	3.2e-72
C2	GOBP_Response_To_Extracellular_Stimulus	Human	Liver	rep_1	1.7e-73
C2	GOBP_Response_To_Nutrient	Human	Liver	rep_1	1.7e-73
C2	GOBP_Activation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Adaptive_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Apoptotic_Cell_Clearance	Human	Intestine	rep_colon4	7.4e-22
C2	GOBP_B_Cell_Mediated_Immunity	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Complement_Activation	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
C2	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
C2	GOBP_Humoral_Immune_Response	Human	Intestine	rep_colon4	1.3e-27
C2	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
C2	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
C2	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	rep_colon4	1.3e-27
C2	GOBP_Lymphocyte_Mediated_Immunity	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Phagocytosis	Human	Intestine	rep_colon4	7.4e-22
C2	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
C2	GOBP_Positive_Regulation_Of_Phagocytosis	Human	Intestine	rep_colon4	7.4e-22
C2	GOBP_Positive_Regulation_Of_Transport	Human	Intestine	rep_colon4	1.0e-26
C2	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
C2	GOBP_Regulation_Of_Apoptotic_Cell_Clearance	Human	Intestine	rep_colon4	7.4e-22
C2	GOBP_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C2	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
C2	GOBP_Regulation_Of_Phagocytosis	Human	Intestine	rep_colon4	7.4e-22
C2	GOBP_Regulation_Of_Transport	Human	Intestine	rep_colon4	1.0e-26
C2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Intestine	rep_colon4	7.4e-22
C2	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	rep_liver2	8.9e-16
C2	GOBP_Response_To_Nutrient	Human	Intestine	rep_liver2	8.9e-16
C2	GOBP_Regulation_Of_Apoptotic_Cell_Clearance	Human	Intestine	A1	3.0e-25
C2	GOBP_Activation_Of_Immune_Response	Human	Intestine	A3	5.7e-11
C2	GOBP_Complement_Activation	Human	Intestine	A3	5.9e-07
C2	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
C2	GOBP_Humoral_Immune_Response	Human	Intestine	A3	1.4e-08
C2	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
C2	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	A3	8.2e-10
C2	GOBP_Phagocytosis	Human	Intestine	A3	2.4e-07
C2	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	A3	2.4e-07
C2	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	A3	6.8e-15
C2	GOBP_Positive_Regulation_Of_Transport	Human	Intestine	A3	9.5e-08
C2	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
C2	GOBP_Regulation_Of_Immune_Response	Human	Intestine	A3	1.6e-12
C2	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
C2	GOBP_Regulation_Of_Transport	Human	Intestine	A3	4.4e-11
C2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Intestine	A3	1.3e-11
C2	GOBP_Adaptive_Immune_Response	Human	Intestine	A8	2.4e-10
C2	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Intestine	A8	1.3e-09
C2	GOBP_Apoptotic_Cell_Clearance	Human	Intestine	A8	3.0e-07
C2	GOBP_B_Cell_Mediated_Immunity	Human	Intestine	A8	9.3e-10
C2	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
C2	GOBP_Positive_Regulation_Of_Phagocytosis	Human	Intestine	A8	4.2e-10
C2	GOBP_Regulation_Of_Complement_Activation	Human	Intestine	A8	1.6e-14
C2	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Intestine	A8	2.6e-12
C2	GOBP_Regulation_Of_Immune_Effector_Process	Human	Intestine	A8	2.4e-12
C2	GOBP_Regulation_Of_Phagocytosis	Human	Intestine	A8	8.7e-10
C2	GOBP_Response_To_Extracellular_Stimulus	Human	Intestine	A8	2.1e-23
C2	GOBP_Apoptotic_Cell_Clearance	Human	Pancreas	PDAC-A-st2	3.5e-05
C2	GOBP_Activation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Adaptive_Immune_Response	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Uterus	rep_4	6.1e-31
C2	GOBP_B_Cell_Mediated_Immunity	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Complement_Activation	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
C2	GOBP_Humoral_Immune_Response	Human	Uterus	rep_4	2.0e-31
C2	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
C2	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Leukocyte_Mediated_Immunity	Human	Uterus	rep_4	2.0e-31
C2	GOBP_Lymphocyte_Mediated_Immunity	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Positive_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
C2	GOBP_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C2	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
C2	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
C2	GOBP_Positive_Regulation_Of_Phagocytosis	Human	Uterus	rep_26	1.3e-08
C2	GOBP_Regulation_Of_Apoptotic_Cell_Clearance	Human	Uterus	rep_26	1.4e-06
C2	GOBP_Regulation_Of_Phagocytosis	Human	Uterus	rep_26	2.8e-11
C2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Uterus	rep_26	3.4e-11
C2	GOBP_Response_To_Extracellular_Stimulus	Human	Uterus	rep_26	1.1e-14
C2	GOBP_Regulation_Of_Immune_Effector_Process	Human	Uterus	rep_28	5.1e-07
C2	GOBP_Regulation_Of_Complement_Activation	Human	Uterus	rep_29	1.3e-08
C2	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Uterus	rep_29	3.7e-10
C2	GOBP_Response_To_Nutrient	Human	Uterus	rep_31	3.9e-06
C2	GOBP_Apoptotic_Cell_Clearance	Human	Breast	rep_1	1.9e-218
C2	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
C2	GOBP_Positive_Regulation_Of_Phagocytosis	Human	Breast	rep_1	4.3e-175
C2	GOBP_Positive_Regulation_Of_Transport	Human	Breast	rep_1	3.1e-10
C2	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Breast	rep_1	2.0e-67
C2	GOBP_Regulation_Of_Phagocytosis	Human	Breast	rep_1	6.9e-38
C2	GOBP_Regulation_Of_Transport	Human	Breast	rep_1	3.7e-17
C2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Breast	rep_1	4.9e-41
C2	GOBP_Response_To_Nutrient	Human	Breast	rep_1	1.4e-05
C2	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
C2	GOBP_Response_To_Extracellular_Stimulus	Human	Breast	rep_5	2.9e-12
C2	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Skin	P10_rep1	3.5e-08
C2	GOBP_Regulation_Of_Complement_Activation	Human	Skin	P10_rep1	7.7e-16
C2	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
C2	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
C2	GOBP_Humoral_Immune_Response	Human	Lung	rep_1	1.7e-10
C2	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	3.1e-08
C2	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07
C2	GOBP_Lymphocyte_Mediated_Immunity	Human	Lung	rep_2	3.7e-07

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C2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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C2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for C2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for C2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
C2	C3150275	COMPLEMENT COMPONENT 2 DEFICIENCY	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
C2	C0024138	Lupus Erythematosus, Discoid	2	GENOMICS_ENGLAND
C2	C0011633	Dermatomyositis	1	CTD_human
C2	C0017661	IGA Glomerulonephritis	1	CTD_human
C2	C0024131	Lupus Vulgaris	1	GENOMICS_ENGLAND
C2	C0024141	Lupus Erythematosus, Systemic	1	GENOMICS_ENGLAND
C2	C0162823	Dermatitis, Irritant	1	CTD_human
C2	C0221056	Adult type dermatomyositis	1	CTD_human
C2	C0242383	Age related macular degeneration	1	CTD_human;GENOMICS_ENGLAND
C2	C0263666	Dermatomyositis, Childhood Type	1	CTD_human
C2	C0272242	Complement deficiency disease	1	GENOMICS_ENGLAND
C2	C0409974	Lupus Erythematosus	1	GENOMICS_ENGLAND