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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: BOK (spascer ID:666)

Gene summary for BOK

check button Gene summary
Gene information
SpeciesHuman
Gene symbol

BOK

Gene ID

666

Gene nameBCL2 family apoptosis regulator BOK
SynonymsBCL2L9|BOKL
Cytomap2q37.3
Type of geneprotein-coding
Descriptionbcl-2-related ovarian killer proteinBCL2 related ovarian killerBOK, BCL2 family apoptosis regulatorbcl-2-like protein 9bcl2-L-9hBOK
Modification date20220513
UniProtAcc

Q9UMX3


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
BOK

GO:0005741

mitochondrial outer membrane

21873635

Component
BOK

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

21873635

Process
BOK

GO:0042803

protein homodimerization activity

21873635

Function
BOK

GO:0046982

protein heterodimerization activity

21873635

Function
BOK

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

21873635

Process

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Spatial pattern events for BOK

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
BOKHumanBrainrep_9 335586953.01e-15
BOKHumanBrainrep_10 335586953.23e-15
BOKHumanBrainrep_11 335586953.36e-15
BOKHumanBrainrep_12 335586953.65e-15
BOKHumanBladderrep_1 343854561.74e-06
BOKHumanIntestinerep_colon1 344172256.48e-15
BOKHumanIntestinerep_colon2 344172258.12e-16
BOKHumanIntestinerep_colon3 344172251.01e-15
BOKHumanLiverrep_liver1 344172251.08e-15
BOKHumanLiverrep_liver2 344172256.98e-16
BOKHumanIntestineA1 334064092.09e-15
BOKHumanIntestineA2 334064093.85e-15
BOKHumanIntestineA4 334064091.50e-06
BOKHumanUterusrep_1 348579546.60e-14
BOKHumanUterusrep_2 348579542.55e-15
BOKHumanUterusrep_3 348579545.81e-15
BOKHumanUterusrep_4 348579542.93e-06
BOKHumanBreastA3 346500421.30e-09
BOKHumanBreast1142243F 344938726.82e-07
BOKHumanBreastCID44971 344938721.76e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_9_H&E
boxplot

boxplot
Brain_rep_10_H&E
boxplot

boxplot
Brain_rep_11_H&E
boxplot

boxplot
Brain_rep_12_H&E
boxplot

boxplot
Bladder_rep_1_H&E
boxplot

boxplot
Intestine_rep_colon1_H&E
boxplot

boxplot
Intestine_rep_colon2_H&E
boxplot

boxplot
Intestine_rep_colon3_H&E
boxplot

boxplot
Liver_rep_liver1_H&E
boxplot

boxplot
Liver_rep_liver2_H&E
boxplot

boxplot
Intestine_A1_H&E
boxplot

boxplot
Intestine_A2_H&E
boxplot

boxplot
Intestine_A4_H&E
boxplot

boxplot
Uterus_rep_1_H&E
boxplot

boxplot
Uterus_rep_2_H&E
boxplot

boxplot
Uterus_rep_3_H&E
boxplot

boxplot
Uterus_rep_4_H&E
boxplot

boxplot
Breast_A3_H&E
boxplot

boxplot
Breast_1142243F_H&E
boxplot

boxplot
Breast_CID44971_H&E
boxplot

boxplot


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Spatial pattern pathway has BOK envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
BOKGOBP_Central_Nervous_System_DevelopmentHumanBrainrep_1 2.8e-23
BOKGOBP_NeurogenesisHumanBrainrep_1 7.4e-34
BOKGOBP_Positive_Regulation_Of_Catalytic_ActivityHumanBrainrep_1 8.7e-71
BOKGOBP_Positive_Regulation_Of_Hydrolase_ActivityHumanBrainrep_1 8.7e-71
BOKGOBP_Positive_Regulation_Of_Intracellular_Signal_TransductionHumanBrainrep_1 3.1e-68
BOKGOBP_Positive_Regulation_Of_Molecular_FunctionHumanBrainrep_1 8.7e-71
BOKGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanBrainrep_1 4.4e-07
BOKGOBP_Positive_Regulation_Of_ProteolysisHumanBrainrep_11.2e-161
BOKGOBP_Positive_Regulation_Of_SignalingHumanBrainrep_1 6.4e-05
BOKGOBP_Positive_Regulation_Of_TransportHumanBrainrep_1 3.1e-16
BOKGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanBrainrep_1 1.2e-64
BOKGOBP_Regulation_Of_ProteolysisHumanBrainrep_1 4.4e-07
BOKGOBP_Regulation_Of_Response_To_StressHumanBrainrep_1 4.6e-05
BOKGOBP_Regulation_Of_TransportHumanBrainrep_1 3.1e-16
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanBrainrep_2 2.1e-15
BOKGOBP_ProteolysisHumanBrainrep_4 1.6e-22
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanBrainrep_4 4.1e-17
BOKGOBP_Negative_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanBladderrep_2 9.0e-06
BOKGOBP_Regulation_Of_Epithelial_Cell_Apoptotic_ProcessHumanBladderrep_2 5.5e-04
BOKGOBP_Necrotic_Cell_DeathHumanBladderrep_4 8.2e-15
BOKGOBP_Regulation_Of_Necrotic_Cell_DeathHumanBladderrep_4 6.8e-16
BOKGOBP_Central_Nervous_System_DevelopmentHumanLiverrep_1 1.0e-70
BOKGOBP_Negative_Regulation_Of_Response_To_StimulusHumanLiverrep_1 2.8e-53
BOKGOBP_NeurogenesisHumanLiverrep_1 1.0e-70
BOKGOBP_Positive_Regulation_Of_Catalytic_ActivityHumanLiverrep_1 2.1e-52
BOKGOBP_Positive_Regulation_Of_Hydrolase_ActivityHumanLiverrep_1 4.9e-46
BOKGOBP_Positive_Regulation_Of_Intracellular_Signal_TransductionHumanLiverrep_1 6.9e-47
BOKGOBP_Positive_Regulation_Of_Molecular_FunctionHumanLiverrep_1 2.1e-52
BOKGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanLiverrep_1 1.1e-67
BOKGOBP_Positive_Regulation_Of_ProteolysisHumanLiverrep_1 2.0e-70
BOKGOBP_Positive_Regulation_Of_SignalingHumanLiverrep_1 2.9e-73
BOKGOBP_Positive_Regulation_Of_TransportHumanLiverrep_1 9.4e-68
BOKGOBP_ProteolysisHumanLiverrep_1 4.2e-73
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanLiverrep_1 6.0e-76
BOKGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanLiverrep_1 6.9e-47
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanLiverrep_1 6.0e-76
BOKGOBP_Regulation_Of_ProteolysisHumanLiverrep_1 1.1e-67
BOKGOBP_Regulation_Of_Response_To_StressHumanLiverrep_1 5.3e-67
BOKGOBP_Regulation_Of_TransportHumanLiverrep_1 9.4e-68
BOKGOBP_Positive_Regulation_Of_Catalytic_ActivityHumanIntestinerep_colon2 2.3e-37
BOKGOBP_Positive_Regulation_Of_Hydrolase_ActivityHumanIntestinerep_colon2 4.1e-22
BOKGOBP_Positive_Regulation_Of_Intracellular_Signal_TransductionHumanIntestinerep_colon2 3.4e-10
BOKGOBP_Positive_Regulation_Of_Molecular_FunctionHumanIntestinerep_colon2 2.3e-37
BOKGOBP_Positive_Regulation_Of_ProteolysisHumanIntestinerep_colon2 1.6e-21
BOKGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanIntestinerep_colon2 2.4e-25
BOKGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanIntestinerep_colon4 1.2e-51
BOKGOBP_Positive_Regulation_Of_SignalingHumanIntestinerep_colon4 2.0e-10
BOKGOBP_Positive_Regulation_Of_TransportHumanIntestinerep_colon4 1.0e-26
BOKGOBP_ProteolysisHumanIntestinerep_colon4 2.4e-90
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanIntestinerep_colon4 3.7e-11
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanIntestinerep_colon4 1.9e-09
BOKGOBP_Regulation_Of_ProteolysisHumanIntestinerep_colon4 1.2e-51
BOKGOBP_Regulation_Of_Response_To_StressHumanIntestinerep_colon4 2.2e-52
BOKGOBP_Regulation_Of_TransportHumanIntestinerep_colon4 1.0e-26
BOKGOBP_Activation_Of_Cysteine_Type_Endopeptidase_Activity_Involved_In_Apoptotic_ProcessHumanIntestineA3 2.9e-13
BOKGOBP_Apoptotic_Mitochondrial_ChangesHumanIntestineA3 1.6e-16
BOKGOBP_Apoptotic_Signaling_PathwayHumanIntestineA3 7.0e-12
BOKGOBP_Cellular_Component_DisassemblyHumanIntestineA3 1.0e-14
BOKGOBP_Cellular_Component_Disassembly_Involved_In_Execution_Phase_Of_ApoptosisHumanIntestineA3 8.5e-10
BOKGOBP_Cellular_Response_To_Dna_Damage_StimulusHumanIntestineA3 6.6e-16
BOKGOBP_Cellular_Response_To_Topologically_Incorrect_ProteinHumanIntestineA3 3.0e-16
BOKGOBP_Central_Nervous_System_DevelopmentHumanIntestineA3 7.1e-11
BOKGOBP_Development_Of_Primary_Sexual_CharacteristicsHumanIntestineA3 5.0e-13
BOKGOBP_Developmental_Process_Involved_In_ReproductionHumanIntestineA3 2.7e-15
BOKGOBP_Epithelial_Cell_Apoptotic_ProcessHumanIntestineA3 2.9e-09
BOKGOBP_Extrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 3.4e-16
BOKGOBP_Glial_Cell_DifferentiationHumanIntestineA3 2.9e-07
BOKGOBP_GliogenesisHumanIntestineA3 9.7e-09
BOKGOBP_Head_DevelopmentHumanIntestineA3 3.8e-09
BOKGOBP_Homeostatic_ProcessHumanIntestineA3 8.7e-10
BOKGOBP_Intrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 2.5e-16
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_StressHumanIntestineA3 4.4e-20
BOKGOBP_Male_Sex_DifferentiationHumanIntestineA3 2.6e-16
BOKGOBP_Membrane_OrganizationHumanIntestineA3 2.7e-18
BOKGOBP_Mitochondrial_Membrane_OrganizationHumanIntestineA3 1.0e-17
BOKGOBP_Mitochondrial_Outer_Membrane_PermeabilizationHumanIntestineA3 1.1e-15
BOKGOBP_Mitochondrial_TransportHumanIntestineA3 9.8e-16
BOKGOBP_Mitochondrion_OrganizationHumanIntestineA3 2.3e-19
BOKGOBP_Negative_Regulation_Of_Apoptotic_Signaling_PathwayHumanIntestineA3 5.6e-14
BOKGOBP_Negative_Regulation_Of_Cell_DeathHumanIntestineA3 5.8e-14
BOKGOBP_Negative_Regulation_Of_Cellular_Component_OrganizationHumanIntestineA3 9.1e-10
BOKGOBP_Negative_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanIntestineA3 2.1e-19
BOKGOBP_Negative_Regulation_Of_Mitochondrion_OrganizationHumanIntestineA3 4.8e-24
BOKGOBP_Negative_Regulation_Of_Neuron_Apoptotic_ProcessHumanIntestineA3 2.9e-13
BOKGOBP_Negative_Regulation_Of_Neuron_DeathHumanIntestineA3 9.1e-14
BOKGOBP_Negative_Regulation_Of_Organelle_OrganizationHumanIntestineA3 3.5e-11
BOKGOBP_Negative_Regulation_Of_Response_To_StimulusHumanIntestineA3 6.0e-11
BOKGOBP_Negative_Regulation_Of_SignalingHumanIntestineA3 4.9e-15
BOKGOBP_NeurogenesisHumanIntestineA3 6.4e-14
BOKGOBP_Neuron_Apoptotic_ProcessHumanIntestineA3 7.8e-11
BOKGOBP_Neuron_DeathHumanIntestineA3 2.4e-14
BOKGOBP_Oligodendrocyte_DifferentiationHumanIntestineA3 2.1e-16
BOKGOBP_Positive_Regulation_Of_Apoptotic_Signaling_PathwayHumanIntestineA3 1.8e-07
BOKGOBP_Positive_Regulation_Of_Catalytic_ActivityHumanIntestineA3 7.7e-16
BOKGOBP_Positive_Regulation_Of_Cell_DeathHumanIntestineA3 4.5e-11
BOKGOBP_Positive_Regulation_Of_Cellular_Component_OrganizationHumanIntestineA3 3.8e-12
BOKGOBP_Positive_Regulation_Of_Cysteine_Type_Endopeptidase_ActivityHumanIntestineA3 3.1e-08
BOKGOBP_Positive_Regulation_Of_Hydrolase_ActivityHumanIntestineA3 2.8e-16
BOKGOBP_Positive_Regulation_Of_Intracellular_Signal_TransductionHumanIntestineA3 2.6e-10
BOKGOBP_Positive_Regulation_Of_Membrane_PermeabilityHumanIntestineA3 4.2e-15
BOKGOBP_Positive_Regulation_Of_Molecular_FunctionHumanIntestineA3 2.1e-13
BOKGOBP_Positive_Regulation_Of_Organelle_OrganizationHumanIntestineA3 1.7e-13
BOKGOBP_Positive_Regulation_Of_Peptidase_ActivityHumanIntestineA3 2.8e-12
BOKGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanIntestineA3 5.0e-14
BOKGOBP_Positive_Regulation_Of_ProteolysisHumanIntestineA3 5.2e-21
BOKGOBP_Positive_Regulation_Of_SignalingHumanIntestineA3 3.3e-14
BOKGOBP_Positive_Regulation_Of_TransportHumanIntestineA3 9.5e-08
BOKGOBP_Process_Utilizing_Autophagic_MechanismHumanIntestineA3 4.7e-11
BOKGOBP_ProteolysisHumanIntestineA3 7.3e-12
BOKGOBP_Regulation_Of_Apoptotic_Signaling_PathwayHumanIntestineA3 1.3e-15
BOKGOBP_Regulation_Of_AutophagyHumanIntestineA3 1.5e-09
BOKGOBP_Regulation_Of_Catabolic_ProcessHumanIntestineA3 3.5e-16
BOKGOBP_Regulation_Of_Cell_DeathHumanIntestineA3 7.1e-10
BOKGOBP_Regulation_Of_Cellular_Response_To_StressHumanIntestineA3 7.7e-17
BOKGOBP_Regulation_Of_Cysteine_Type_Endopeptidase_ActivityHumanIntestineA3 2.9e-10
BOKGOBP_Regulation_Of_Cytosolic_Calcium_Ion_ConcentrationHumanIntestineA3 1.2e-08
BOKGOBP_Regulation_Of_Endoplasmic_Reticulum_Stress_Induced_Intrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 1.2e-18
BOKGOBP_Regulation_Of_Epithelial_Cell_Apoptotic_ProcessHumanIntestineA3 1.3e-10
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanIntestineA3 7.3e-16
BOKGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanIntestineA3 7.5e-12
BOKGOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanIntestineA3 1.3e-16
BOKGOBP_Regulation_Of_Membrane_PermeabilityHumanIntestineA3 6.7e-12
BOKGOBP_Regulation_Of_Membrane_PotentialHumanIntestineA3 5.6e-08
BOKGOBP_Regulation_Of_Mitochondrial_Membrane_PermeabilityHumanIntestineA3 2.1e-12
BOKGOBP_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanIntestineA3 2.0e-07
BOKGOBP_Regulation_Of_Mitochondrion_OrganizationHumanIntestineA3 1.6e-17
BOKGOBP_Regulation_Of_Necrotic_Cell_DeathHumanIntestineA3 2.9e-07
BOKGOBP_Regulation_Of_Organelle_OrganizationHumanIntestineA3 1.1e-11
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanIntestineA3 9.8e-13
BOKGOBP_Regulation_Of_ProteolysisHumanIntestineA3 9.5e-13
BOKGOBP_Regulation_Of_Response_To_Endoplasmic_Reticulum_StressHumanIntestineA3 1.6e-16
BOKGOBP_Regulation_Of_Response_To_StressHumanIntestineA3 1.1e-10
BOKGOBP_Regulation_Of_TransportHumanIntestineA3 4.4e-11
BOKGOBP_Release_Of_Cytochrome_C_From_MitochondriaHumanIntestineA3 2.6e-09
BOKGOBP_ReproductionHumanIntestineA3 4.6e-19
BOKGOBP_Reproductive_System_DevelopmentHumanIntestineA3 2.9e-14
BOKGOBP_Response_To_Endoplasmic_Reticulum_StressHumanIntestineA3 2.1e-18
BOKGOBP_Response_To_Topologically_Incorrect_ProteinHumanIntestineA3 1.7e-15
BOKGOBP_Sex_DifferentiationHumanIntestineA3 6.1e-18
BOKGOBP_Signal_Transduction_In_Absence_Of_LigandHumanIntestineA3 3.6e-11
BOKGOBP_Cellular_HomeostasisHumanIntestineA8 2.1e-11
BOKGOBP_Cellular_Ion_HomeostasisHumanIntestineA8 4.3e-12
BOKGOBP_Chemical_HomeostasisHumanIntestineA8 1.3e-12
BOKGOBP_Chorionic_Trophoblast_Cell_ProliferationHumanIntestineA8 5.4e-11
BOKGOBP_Divalent_Inorganic_Cation_HomeostasisHumanIntestineA8 1.0e-12
BOKGOBP_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanIntestineA8 6.5e-14
BOKGOBP_Er_Nucleus_Signaling_PathwayHumanIntestineA8 1.4e-21
BOKGOBP_Execution_Phase_Of_ApoptosisHumanIntestineA8 2.3e-12
BOKGOBP_Integrated_Stress_Response_SignalingHumanIntestineA8 8.6e-20
BOKGOBP_Ion_HomeostasisHumanIntestineA8 6.1e-15
BOKGOBP_Metal_Ion_HomeostasisHumanIntestineA8 2.2e-10
BOKGOBP_Necrotic_Cell_DeathHumanIntestineA8 9.0e-13
BOKGOBP_Negative_Regulation_Of_Necrotic_Cell_DeathHumanIntestineA8 5.1e-12
BOKGOBP_Negative_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanIntestineA8 2.2e-08
BOKGOBP_Positive_Regulation_Of_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanIntestineA8 3.2e-16
BOKGOBP_Positive_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanIntestineA8 1.1e-15
BOKGOBP_Positive_Regulation_Of_Response_To_Endoplasmic_Reticulum_StressHumanIntestineA8 2.7e-20
BOKGOBP_Programmed_Necrotic_Cell_DeathHumanIntestineA8 2.5e-10
BOKGOBP_Regulation_Of_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanIntestineA8 2.8e-14
BOKGOBP_Regulation_Of_Perk_Mediated_Unfolded_Protein_ResponseHumanIntestineA8 9.0e-19
BOKGOBP_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanIntestineA8 5.0e-14
BOKGOBP_GliogenesisHumanPancreasPDAC-B-st1 8.6e-05
BOKGOBP_Head_DevelopmentHumanPancreasPDAC-B-st1 2.0e-05
BOKGOBP_Mitochondrial_DepolarizationHumanPancreasPDAC-B-st1 8.9e-05
BOKGOBP_Negative_Regulation_Of_Organelle_OrganizationHumanPancreasPDAC-B-st1 6.2e-05
BOKGOBP_Negative_Regulation_Of_SignalingHumanPancreasPDAC-B-st1 1.7e-05
BOKGOBP_Programmed_Necrotic_Cell_DeathHumanPancreasPDAC-B-st1 9.1e-05
BOKGOBP_Protein_Complex_OligomerizationHumanPancreasPDAC-B-st1 8.7e-05
BOKGOBP_Cellular_Component_Disassembly_Involved_In_Execution_Phase_Of_ApoptosisHumanPancreasPDAC-A-st2 2.4e-05
BOKGOBP_Er_Nucleus_Signaling_PathwayHumanPancreasPDAC-A-st2 1.0e-06
BOKGOBP_Execution_Phase_Of_ApoptosisHumanPancreasPDAC-A-st2 7.5e-08
BOKGOBP_Negative_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanPancreasPDAC-A-st2 7.2e-06
BOKGOBP_Chorionic_Trophoblast_Cell_ProliferationHumanUterusrep_1 2.1e-07
BOKGOBP_Developmental_Process_Involved_In_ReproductionHumanUterusrep_1 1.6e-06
BOKGOBP_Epithelial_Cell_Apoptotic_ProcessHumanUterusrep_1 3.7e-07
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanUterusrep_1 2.6e-06
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_DamageHumanUterusrep_1 5.1e-06
BOKGOBP_Positive_Regulation_Of_Response_To_Endoplasmic_Reticulum_StressHumanUterusrep_1 3.7e-07
BOKGOBP_Signal_Transduction_By_P53_Class_MediatorHumanUterusrep_1 3.7e-07
BOKGOBP_Cellular_Component_Disassembly_Involved_In_Execution_Phase_Of_ApoptosisHumanUterusrep_25 1.6e-06
BOKGOBP_Mitochondrial_DepolarizationHumanUterusrep_25 3.4e-06
BOKGOBP_Negative_Regulation_Of_Membrane_DepolarizationHumanUterusrep_25 2.6e-22
BOKGOBP_Negative_Regulation_Of_Necrotic_Cell_DeathHumanUterusrep_25 6.2e-09
BOKGOBP_Negative_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanUterusrep_25 9.5e-11
BOKGOBP_Positive_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanUterusrep_25 4.3e-13
BOKGOBP_Regulation_Of_Mitochondrial_Membrane_PotentialHumanUterusrep_25 9.0e-11
BOKGOBP_Cellular_Component_DisassemblyHumanUterusrep_26 2.7e-06
BOKGOBP_Cellular_Response_To_Dna_Damage_StimulusHumanUterusrep_26 2.4e-07
BOKGOBP_Cellular_Response_To_Topologically_Incorrect_ProteinHumanUterusrep_26 4.9e-11
BOKGOBP_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanUterusrep_26 5.9e-07
BOKGOBP_Extrinsic_Apoptotic_Signaling_PathwayHumanUterusrep_26 1.2e-09
BOKGOBP_Homeostatic_ProcessHumanUterusrep_26 1.9e-07
BOKGOBP_Integrated_Stress_Response_SignalingHumanUterusrep_26 3.6e-11
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_StressHumanUterusrep_26 3.2e-07
BOKGOBP_Membrane_DepolarizationHumanUterusrep_26 1.9e-07
BOKGOBP_Mitochondrial_Membrane_OrganizationHumanUterusrep_26 1.5e-06
BOKGOBP_Negative_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanUterusrep_26 8.9e-06
BOKGOBP_Negative_Regulation_Of_Mitochondrion_OrganizationHumanUterusrep_26 6.7e-08
BOKGOBP_Negative_Regulation_Of_Neuron_Apoptotic_ProcessHumanUterusrep_26 6.4e-11
BOKGOBP_Negative_Regulation_Of_Neuron_DeathHumanUterusrep_26 3.7e-10
BOKGOBP_Neuron_Apoptotic_ProcessHumanUterusrep_26 4.5e-12
BOKGOBP_Neuron_DeathHumanUterusrep_26 4.0e-13
BOKGOBP_Positive_Regulation_Of_Membrane_PermeabilityHumanUterusrep_26 9.7e-06
BOKGOBP_Positive_Regulation_Of_Organelle_OrganizationHumanUterusrep_26 1.2e-06
BOKGOBP_Programmed_Necrotic_Cell_DeathHumanUterusrep_26 4.5e-08
BOKGOBP_Regulation_Of_AutophagyHumanUterusrep_26 3.2e-06
BOKGOBP_Regulation_Of_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanUterusrep_26 2.1e-09
BOKGOBP_Regulation_Of_Membrane_DepolarizationHumanUterusrep_26 1.9e-07
BOKGOBP_Regulation_Of_Necrotic_Cell_DeathHumanUterusrep_26 1.5e-08
BOKGOBP_Regulation_Of_Perk_Mediated_Unfolded_Protein_ResponseHumanUterusrep_26 1.0e-08
BOKGOBP_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanUterusrep_26 1.4e-14
BOKGOBP_Regulation_Of_ProteolysisHumanUterusrep_26 2.1e-07
BOKGOBP_Regulation_Of_Response_To_Endoplasmic_Reticulum_StressHumanUterusrep_26 6.4e-06
BOKGOBP_Response_To_Topologically_Incorrect_ProteinHumanUterusrep_26 1.0e-06
BOKGOBP_Signal_Transduction_In_Absence_Of_LigandHumanUterusrep_26 2.6e-08
BOKGOBP_Release_Of_Cytochrome_C_From_MitochondriaHumanUterusrep_27 1.5e-06
BOKGOBP_Activation_Of_Cysteine_Type_Endopeptidase_Activity_Involved_In_Apoptotic_Process_By_Cytochrome_CHumanUterusrep_29 1.3e-08
BOKGOBP_Negative_Regulation_Of_Response_To_StimulusHumanUterusrep_29 1.2e-06
BOKGOBP_Negative_Regulation_Of_SignalingHumanUterusrep_29 5.3e-06
BOKGOBP_Positive_Regulation_Of_Intracellular_Signal_TransductionHumanUterusrep_29 5.5e-06
BOKGOBP_Regulation_Of_Cytosolic_Calcium_Ion_ConcentrationHumanUterusrep_29 4.5e-07
BOKGOBP_Regulation_Of_Execution_Phase_Of_ApoptosisHumanUterusrep_29 2.0e-06
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanUterusrep_29 6.6e-10
BOKGOBP_Regulation_Of_Membrane_PotentialHumanUterusrep_29 4.3e-06
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanUterusrep_29 1.4e-10
BOKGOBP_Apoptotic_Mitochondrial_ChangesHumanBreastrep_1 9.3e-30
BOKGOBP_Cellular_HomeostasisHumanBreastrep_1 2.8e-10
BOKGOBP_Cellular_Ion_HomeostasisHumanBreastrep_1 7.6e-24
BOKGOBP_Central_Nervous_System_DevelopmentHumanBreastrep_1 5.1e-04
BOKGOBP_Chemical_HomeostasisHumanBreastrep_1 4.8e-18
BOKGOBP_Chorionic_Trophoblast_Cell_ProliferationHumanBreastrep_1 2.0e-07
BOKGOBP_Divalent_Inorganic_Cation_HomeostasisHumanBreastrep_1 1.2e-25
BOKGOBP_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanBreastrep_1 9.4e-14
BOKGOBP_Epithelial_Cell_Apoptotic_ProcessHumanBreastrep_12.1e-112
BOKGOBP_Execution_Phase_Of_ApoptosisHumanBreastrep_1 5.1e-04
BOKGOBP_Head_DevelopmentHumanBreastrep_1 1.0e-09
BOKGOBP_Homeostatic_ProcessHumanBreastrep_1 9.0e-53
BOKGOBP_Integrated_Stress_Response_SignalingHumanBreastrep_1 7.4e-07
BOKGOBP_Ion_HomeostasisHumanBreastrep_1 1.4e-53
BOKGOBP_Membrane_DepolarizationHumanBreastrep_1 4.7e-47
BOKGOBP_Metal_Ion_HomeostasisHumanBreastrep_1 6.8e-70
BOKGOBP_Mitochondrial_DepolarizationHumanBreastrep_1 2.9e-43
BOKGOBP_Necrotic_Cell_DeathHumanBreastrep_1 1.3e-71
BOKGOBP_Negative_Regulation_Of_Cellular_Component_OrganizationHumanBreastrep_1 7.3e-14
BOKGOBP_Negative_Regulation_Of_Membrane_DepolarizationHumanBreastrep_1 8.3e-78
BOKGOBP_Negative_Regulation_Of_Neuron_Apoptotic_ProcessHumanBreastrep_1 1.2e-11
BOKGOBP_Negative_Regulation_Of_Organelle_OrganizationHumanBreastrep_1 2.9e-09
BOKGOBP_Negative_Regulation_Of_Response_To_StimulusHumanBreastrep_1 2.4e-07
BOKGOBP_NeurogenesisHumanBreastrep_1 8.0e-11
BOKGOBP_Positive_Regulation_Of_Cell_DeathHumanBreastrep_1 2.2e-15
BOKGOBP_Positive_Regulation_Of_Cellular_Component_OrganizationHumanBreastrep_1 1.3e-17
BOKGOBP_Positive_Regulation_Of_Cysteine_Type_Endopeptidase_ActivityHumanBreastrep_1 3.7e-11
BOKGOBP_Positive_Regulation_Of_Endoplasmic_Reticulum_Stress_Induced_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_1 8.5e-08
BOKGOBP_Positive_Regulation_Of_Execution_Phase_Of_ApoptosisHumanBreastrep_1 2.2e-37
BOKGOBP_Positive_Regulation_Of_Hydrolase_ActivityHumanBreastrep_1 7.8e-04
BOKGOBP_Positive_Regulation_Of_Peptidase_ActivityHumanBreastrep_1 5.6e-24
BOKGOBP_Positive_Regulation_Of_ProteolysisHumanBreastrep_1 1.7e-07
BOKGOBP_Positive_Regulation_Of_Response_To_Endoplasmic_Reticulum_StressHumanBreastrep_1 3.4e-14
BOKGOBP_Positive_Regulation_Of_TransportHumanBreastrep_1 3.1e-10
BOKGOBP_Protein_Complex_OligomerizationHumanBreastrep_1 1.7e-04
BOKGOBP_Regulation_Of_Cysteine_Type_Endopeptidase_ActivityHumanBreastrep_1 3.8e-05
BOKGOBP_Regulation_Of_Cytosolic_Calcium_Ion_ConcentrationHumanBreastrep_12.9e-140
BOKGOBP_Regulation_Of_Epithelial_Cell_Apoptotic_ProcessHumanBreastrep_19.2e-147
BOKGOBP_Regulation_Of_Membrane_DepolarizationHumanBreastrep_1 3.2e-49
BOKGOBP_Regulation_Of_Membrane_PotentialHumanBreastrep_1 5.7e-09
BOKGOBP_Regulation_Of_Necrotic_Cell_DeathHumanBreastrep_1 3.7e-53
BOKGOBP_Regulation_Of_Organelle_OrganizationHumanBreastrep_1 8.7e-11
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanBreastrep_1 2.2e-33
BOKGOBP_Regulation_Of_Perk_Mediated_Unfolded_Protein_ResponseHumanBreastrep_1 3.1e-26
BOKGOBP_Regulation_Of_ProteolysisHumanBreastrep_1 6.4e-05
BOKGOBP_Regulation_Of_Response_To_StressHumanBreastrep_1 3.4e-19
BOKGOBP_Regulation_Of_TransportHumanBreastrep_1 3.7e-17
BOKGOBP_Release_Of_Cytochrome_C_From_MitochondriaHumanBreastrep_1 2.9e-49
BOKGOBP_Activation_Of_Cysteine_Type_Endopeptidase_Activity_Involved_In_Apoptotic_ProcessHumanBreastrep_5 4.6e-05
BOKGOBP_Cellular_Component_DisassemblyHumanBreastrep_5 2.0e-06
BOKGOBP_Cellular_Component_Disassembly_Involved_In_Execution_Phase_Of_ApoptosisHumanBreastrep_5 7.2e-04
BOKGOBP_Cellular_Response_To_Topologically_Incorrect_ProteinHumanBreastrep_5 3.5e-04
BOKGOBP_Development_Of_Primary_Sexual_CharacteristicsHumanBreastrep_5 3.0e-05
BOKGOBP_Developmental_Process_Involved_In_ReproductionHumanBreastrep_5 1.5e-12
BOKGOBP_Er_Nucleus_Signaling_PathwayHumanBreastrep_5 5.9e-05
BOKGOBP_Extrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_5 7.1e-11
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Endoplasmic_Reticulum_StressHumanBreastrep_5 1.3e-04
BOKGOBP_Negative_Regulation_Of_Apoptotic_Signaling_PathwayHumanBreastrep_5 2.5e-09
BOKGOBP_Negative_Regulation_Of_Cell_DeathHumanBreastrep_5 1.9e-07
BOKGOBP_Negative_Regulation_Of_Necrotic_Cell_DeathHumanBreastrep_5 5.4e-08
BOKGOBP_Negative_Regulation_Of_Neuron_DeathHumanBreastrep_5 9.9e-10
BOKGOBP_Negative_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanBreastrep_5 1.6e-09
BOKGOBP_Negative_Regulation_Of_SignalingHumanBreastrep_5 8.6e-14
BOKGOBP_Neuron_DeathHumanBreastrep_5 6.5e-07
BOKGOBP_Positive_Regulation_Of_Catalytic_ActivityHumanBreastrep_5 1.9e-12
BOKGOBP_Positive_Regulation_Of_Intracellular_Signal_TransductionHumanBreastrep_5 5.3e-08
BOKGOBP_Positive_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanBreastrep_5 8.6e-15
BOKGOBP_Positive_Regulation_Of_Mitochondrion_OrganizationHumanBreastrep_5 1.3e-04
BOKGOBP_Positive_Regulation_Of_Molecular_FunctionHumanBreastrep_5 7.4e-10
BOKGOBP_Positive_Regulation_Of_Protein_Metabolic_ProcessHumanBreastrep_5 2.6e-04
BOKGOBP_Positive_Regulation_Of_SignalingHumanBreastrep_5 1.3e-06
BOKGOBP_Programmed_Necrotic_Cell_DeathHumanBreastrep_5 2.5e-09
BOKGOBP_ProteolysisHumanBreastrep_5 1.8e-07
BOKGOBP_Regulation_Of_Cell_DeathHumanBreastrep_5 9.8e-08
BOKGOBP_Regulation_Of_Cellular_Response_To_StressHumanBreastrep_5 8.1e-10
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanBreastrep_5 3.2e-13
BOKGOBP_Regulation_Of_Intracellular_Signal_TransductionHumanBreastrep_5 8.7e-11
BOKGOBP_Regulation_Of_Mitochondrial_Membrane_PotentialHumanBreastrep_5 3.6e-04
BOKGOBP_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanBreastrep_5 7.1e-17
BOKGOBP_ReproductionHumanBreastrep_5 8.1e-06
BOKGOBP_Reproductive_System_DevelopmentHumanBreastrep_5 3.6e-15
BOKGOBP_Response_To_Endoplasmic_Reticulum_StressHumanBreastrep_5 4.4e-06
BOKGOBP_Response_To_Topologically_Incorrect_ProteinHumanBreastrep_5 3.6e-05
BOKGOBP_Apoptotic_Signaling_PathwayHumanBreastrep_6 4.8e-09
BOKGOBP_Cellular_Response_To_Dna_Damage_StimulusHumanBreastrep_6 6.0e-06
BOKGOBP_GliogenesisHumanBreastrep_6 2.3e-05
BOKGOBP_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 2.7e-08
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_By_P53_Class_MediatorHumanBreastrep_6 2.9e-05
BOKGOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Dna_DamageHumanBreastrep_6 9.9e-04
BOKGOBP_Male_Sex_DifferentiationHumanBreastrep_6 2.0e-08
BOKGOBP_Mitochondrial_Membrane_OrganizationHumanBreastrep_6 3.7e-05
BOKGOBP_Mitochondrial_Outer_Membrane_PermeabilizationHumanBreastrep_6 2.3e-09
BOKGOBP_Mitochondrial_TransportHumanBreastrep_6 6.5e-10
BOKGOBP_Mitochondrion_OrganizationHumanBreastrep_6 2.0e-05
BOKGOBP_Negative_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanBreastrep_6 2.5e-04
BOKGOBP_Negative_Regulation_Of_Mitochondrion_OrganizationHumanBreastrep_6 5.2e-08
BOKGOBP_Neuron_Apoptotic_ProcessHumanBreastrep_6 1.3e-06
BOKGOBP_Oligodendrocyte_DifferentiationHumanBreastrep_6 4.8e-06
BOKGOBP_Positive_Regulation_Of_Apoptotic_Signaling_PathwayHumanBreastrep_6 2.5e-08
BOKGOBP_Positive_Regulation_Of_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanBreastrep_6 2.6e-06
BOKGOBP_Positive_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 5.0e-06
BOKGOBP_Positive_Regulation_Of_Membrane_PermeabilityHumanBreastrep_6 2.9e-09
BOKGOBP_Positive_Regulation_Of_Organelle_OrganizationHumanBreastrep_6 7.3e-09
BOKGOBP_Process_Utilizing_Autophagic_MechanismHumanBreastrep_6 1.9e-08
BOKGOBP_Regulation_Of_Apoptotic_Signaling_PathwayHumanBreastrep_6 1.6e-07
BOKGOBP_Regulation_Of_AutophagyHumanBreastrep_6 7.8e-04
BOKGOBP_Regulation_Of_Catabolic_ProcessHumanBreastrep_6 3.3e-04
BOKGOBP_Regulation_Of_Endoplasmic_Reticulum_Stress_Induced_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 1.7e-07
BOKGOBP_Regulation_Of_Endoplasmic_Reticulum_Unfolded_Protein_ResponseHumanBreastrep_6 8.9e-07
BOKGOBP_Regulation_Of_Intrinsic_Apoptotic_Signaling_PathwayHumanBreastrep_6 3.3e-09
BOKGOBP_Regulation_Of_Membrane_PermeabilityHumanBreastrep_6 1.8e-09
BOKGOBP_Regulation_Of_Mitochondrial_Membrane_PermeabilityHumanBreastrep_6 2.3e-08
BOKGOBP_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanBreastrep_6 1.5e-08
BOKGOBP_Regulation_Of_Mitochondrion_OrganizationHumanBreastrep_6 1.3e-06
BOKGOBP_Regulation_Of_Response_To_Endoplasmic_Reticulum_StressHumanBreastrep_6 6.4e-06
BOKGOBP_Sex_DifferentiationHumanBreastrep_6 4.2e-05
BOKGOBP_Signal_Transduction_By_P53_Class_MediatorHumanBreastrep_6 7.7e-05
BOKGOBP_Signal_Transduction_In_Absence_Of_LigandHumanBreastrep_6 1.2e-05
BOKGOBP_GliogenesisHumanSkinP2_rep1 1.8e-10
BOKGOBP_Positive_Regulation_Of_Endoplasmic_Reticulum_Stress_Induced_Intrinsic_Apoptotic_Signaling_PathwayHumanSkinP2_rep2 5.5e-16
BOKGOBP_Divalent_Inorganic_Cation_HomeostasisHumanSkinP2_rep3 1.3e-08
BOKGOBP_Regulation_Of_Execution_Phase_Of_ApoptosisHumanSkinP5_rep2 4.0e-08
BOKGOBP_Chorionic_Trophoblast_Cell_ProliferationHumanSkinP5_rep3 3.8e-13
BOKGOBP_Mitochondrial_Membrane_OrganizationHumanSkinP5_rep3 2.4e-11
BOKGOBP_Positive_Regulation_Of_Organelle_OrganizationHumanSkinP5_rep3 4.1e-08
BOKGOBP_Regulation_Of_Membrane_PotentialHumanSkinP5_rep3 3.6e-10
BOKGOBP_Intrinsic_Apoptotic_Signaling_PathwayHumanSkinP9_rep3 4.3e-09
BOKGOBP_Cellular_Component_Disassembly_Involved_In_Execution_Phase_Of_ApoptosisHumanSkinP10_rep2 2.6e-08
BOKGOBP_Negative_Regulation_Of_Necrotic_Cell_DeathHumanSkinP10_rep2 2.3e-08
BOKGOBP_Programmed_Necrotic_Cell_DeathHumanSkinP10_rep2 4.3e-17
BOKGOBP_Regulation_Of_Programmed_Necrotic_Cell_DeathHumanSkinP10_rep2 3.0e-18
BOKGOBP_Activation_Of_Cysteine_Type_Endopeptidase_Activity_Involved_In_Apoptotic_Process_By_Cytochrome_CHumanSkinP10_rep3 5.5e-11
BOKGOBP_Positive_Regulation_Of_Mitochondrial_Outer_Membrane_Permeabilization_Involved_In_Apoptotic_Signaling_PathwayHumanSkinP10_rep3 3.7e-22
BOKGOBP_Ion_HomeostasisHumanLungrep_1 6.1e-07
BOKGOBP_Positive_Regulation_Of_Execution_Phase_Of_ApoptosisHumanLungrep_1 4.3e-09
BOKGOBP_Regulation_Of_Cysteine_Type_Endopeptidase_ActivityHumanLungrep_1 9.0e-08
BOKGOBP_Regulation_Of_Execution_Phase_Of_ApoptosisHumanLungrep_1 7.1e-09
BOKGOBP_Regulation_Of_Hydrolase_ActivityHumanLungrep_1 4.1e-07
BOKGOBP_Regulation_Of_Peptidase_ActivityHumanLungrep_1 4.6e-11
BOKGOBP_Regulation_Of_ProteolysisHumanLungrep_1 3.2e-08
BOKGOBP_Cellular_Component_DisassemblyHumanLungrep_2 5.6e-07
BOKGOBP_Cellular_HomeostasisHumanLungrep_2 7.3e-07
BOKGOBP_Negative_Regulation_Of_Neuron_Apoptotic_ProcessHumanLungrep_2 7.1e-08
BOKGOBP_Negative_Regulation_Of_Neuron_DeathHumanLungrep_2 8.1e-08
BOKGOBP_Neuron_Apoptotic_ProcessHumanLungrep_2 7.1e-08
BOKGOBP_Neuron_DeathHumanLungrep_2 3.5e-08
BOKGOBP_Positive_Regulation_Of_Cell_DeathHumanLungrep_2 3.0e-07
BOKGOBP_Positive_Regulation_Of_Hydrolase_ActivityHumanLungrep_2 7.9e-07

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BOK function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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BOK function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for BOK envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for BOK

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BOK

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource