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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: VPS16 (spascer ID:64601)

Gene summary for VPS16

Gene summary

Gene information
	Species	Human
	Gene symbol	VPS16
	Gene ID	64601
	Gene name	VPS16 core subunit of CORVET and HOPS complexes
	Synonyms	DYT30\|hVPS16
	Cytomap	20p13
	Type of gene	protein-coding
	Description	vacuolar protein sorting-associated protein 16 homologVPS16, CORVET/HOPS core subunitvacuolar protein sorting 16 homologvacuolar protein sorting protein 16
	Modification date	20220513
	UniProtAcc	Q9H269

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
VPS16	GO:0003779	actin binding	21873635	Function
VPS16	GO:0005768	endosome	21873635	Component
VPS16	GO:0016197	endosomal transport	21873635	Process
VPS16	GO:0030897	HOPS complex	21873635	Component
VPS16	GO:0042144	vacuole fusion, non-autophagic	21873635	Process

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Spatial pattern events for VPS16

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
VPS16	Human	Liver	rep_liver2	34417225	6.98e-16

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E

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Spatial pattern pathway has VPS16 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
VPS16	GOBP_Cellular_Component_Disassembly	Human	Intestine	A3	1.0e-14
VPS16	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
VPS16	GOBP_Endosomal_Transport	Human	Intestine	A3	1.9e-09
VPS16	GOBP_Endosome_To_Lysosome_Transport	Human	Intestine	A3	2.6e-09
VPS16	GOBP_Establishment_Of_Protein_Localization	Human	Intestine	A3	5.0e-10
VPS16	GOBP_Intracellular_Protein_Transport	Human	Intestine	A3	4.8e-12
VPS16	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
VPS16	GOBP_Lysosomal_Transport	Human	Intestine	A3	7.2e-12
VPS16	GOBP_Macroautophagy	Human	Intestine	A3	2.3e-07
VPS16	GOBP_Organelle_Fusion	Human	Intestine	A3	9.7e-08
VPS16	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Intestine	A3	4.7e-11
VPS16	GOBP_Vacuolar_Transport	Human	Intestine	A3	4.3e-14
VPS16	GOBP_Autophagosome_Maturation	Human	Intestine	A8	2.5e-22
VPS16	GOBP_Vacuole_Organization	Human	Intestine	A8	2.4e-07
VPS16	GOBP_Endosome_To_Lysosome_Transport	Human	Pancreas	PDAC-B-st1	4.8e-06
VPS16	GOBP_Endosomal_Transport	Human	Pancreas	PDAC-A-st2	9.1e-05
VPS16	GOBP_Endosome_To_Lysosome_Transport	Human	Uterus	rep_25	2.2e-06
VPS16	GOBP_Cellular_Component_Disassembly	Human	Uterus	rep_26	2.7e-06
VPS16	GOBP_Endosomal_Transport	Human	Uterus	rep_26	1.1e-06
VPS16	GOBP_Lysosomal_Transport	Human	Uterus	rep_26	1.3e-08
VPS16	GOBP_Macroautophagy	Human	Uterus	rep_26	1.7e-06
VPS16	GOBP_Vacuolar_Transport	Human	Uterus	rep_26	2.2e-09
VPS16	GOBP_Vacuole_Organization	Human	Uterus	rep_26	3.0e-12
VPS16	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
VPS16	GOBP_Endosome_To_Lysosome_Transport	Human	Breast	rep_1	1.9e-06
VPS16	GOBP_Establishment_Of_Protein_Localization	Human	Breast	rep_1	7.2e-05
VPS16	GOBP_Organelle_Fusion	Human	Breast	rep_1	1.0e-07
VPS16	GOBP_Vacuole_Organization	Human	Breast	rep_1	6.9e-10
VPS16	GOBP_Autophagosome_Maturation	Human	Breast	rep_5	1.5e-06
VPS16	GOBP_Cellular_Component_Disassembly	Human	Breast	rep_5	2.0e-06
VPS16	GOBP_Lysosomal_Transport	Human	Breast	rep_5	9.9e-17
VPS16	GOBP_Vacuolar_Transport	Human	Breast	rep_5	6.0e-13
VPS16	GOBP_Endosomal_Transport	Human	Breast	rep_6	1.7e-13
VPS16	GOBP_Intracellular_Protein_Transport	Human	Breast	rep_6	6.4e-12
VPS16	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
VPS16	GOBP_Macroautophagy	Human	Breast	rep_6	6.1e-10
VPS16	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Breast	rep_6	1.9e-08
VPS16	GOBP_Protein_Containing_Complex_Disassembly	Human	Breast	rep_6	1.0e-13
VPS16	GOBP_Organelle_Fusion	Human	Skin	P5_rep1	3.3e-08
VPS16	GOBP_Cellular_Component_Disassembly	Human	Lung	rep_2	5.6e-07
VPS16	GOBP_Lysosomal_Transport	Human	Lung	rep_2	4.5e-09
VPS16	GOBP_Vacuolar_Transport	Human	Lung	rep_2	8.0e-08

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VPS16 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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VPS16 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for VPS16 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for VPS16

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for VPS16

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source