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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: BLVRB (spascer ID:645)

Gene summary for BLVRB

Gene summary

Gene information
	Species	Human
	Gene symbol	BLVRB
	Gene ID	645
	Gene name	biliverdin reductase B
	Synonyms	BVRB\|FLR\|HEL-S-10\|SDR43U1
	Cytomap	19q13.2
	Type of gene	protein-coding
	Description	flavin reductase (NADPH)BVR-BFRGHBPNADPH-dependent diaphoraseNADPH-flavin reductasebiliverdin-IX beta-reductaseepididymis secretory protein Li 10green heme-binding proteinshort chain dehydrogenase/reductase family 43U, member 1
	Modification date	20220513
	UniProtAcc	P30043

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for BLVRB

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
BLVRB	Human	Brain	rep_10	33558695	5.46e-11
BLVRB	Human	Intestine	rep_colon1	34417225	1.64e-08
BLVRB	Human	Intestine	rep_colon2	34417225	8.12e-16
BLVRB	Human	Intestine	rep_colon3	34417225	3.51e-15
BLVRB	Human	Intestine	rep_colon4	34417225	7.05e-09
BLVRB	Human	Liver	rep_liver1	34417225	1.08e-15
BLVRB	Human	Liver	rep_liver2	34417225	6.98e-16
BLVRB	Human	Liver	rep_liver3	34417225	1.96e-06
BLVRB	Human	Liver	rep_liver4	34417225	7.71e-16
BLVRB	Human	Intestine	A1	33406409	6.31e-15
BLVRB	Human	Intestine	A2	33406409	8.13e-14
BLVRB	Human	Intestine	A4	33406409	3.57e-08
BLVRB	Human	Uterus	rep_2	34857954	2.55e-15
BLVRB	Human	Uterus	rep_3	34857954	1.66e-15
BLVRB	Human	Uterus	rep_4	34857954	1.82e-15
BLVRB	Human	Breast	1142243F	34493872	2.66e-07
BLVRB	Human	Breast	1160920F	34493872	5.08e-15
BLVRB	Human	Breast	CID44971	34493872	3.29e-15
BLVRB	Human	Breast	CID4535	34493872	1.17e-07
BLVRB	Human	Heart	w6_s4	31835037	8.15e-03
BLVRB	Human	Heart	w6_s5	31835037	1.46e-06
BLVRB	Human	Heart	w6_s6	31835037	7.08e-06
BLVRB	Human	Heart	w6_s7	31835037	5.50e-03

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_10_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Intestine_A4_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E

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Spatial pattern pathway has BLVRB envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
BLVRB	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
BLVRB	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
BLVRB	GOBP_Pigment_Metabolic_Process	Human	Intestine	A8	1.0e-13
BLVRB	GOBP_Porphyrin_Containing_Compound_Metabolic_Process	Human	Intestine	A8	2.0e-11
BLVRB	GOBP_Tetrapyrrole_Metabolic_Process	Human	Intestine	A8	2.2e-10
BLVRB	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
BLVRB	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
BLVRB	GOBP_Pigment_Metabolic_Process	Human	Uterus	rep_26	1.3e-09
BLVRB	GOBP_Porphyrin_Containing_Compound_Metabolic_Process	Human	Breast	rep_5	7.6e-07
BLVRB	GOBP_Tetrapyrrole_Metabolic_Process	Human	Breast	rep_5	1.1e-05
BLVRB	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
BLVRB	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
BLVRB	GOBP_Pigment_Metabolic_Process	Human	Breast	rep_6	1.2e-05
BLVRB	GOBP_Pigment_Metabolic_Process	Human	Skin	P5_rep2	4.2e-10

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BLVRB function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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BLVRB function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for BLVRB envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for BLVRB

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
BLVRB	P30043	DB03247	Flavin mononucleotide	Flavin reductase (NADPH)	SmallMoleculeDrug	approved\|investigational
BLVRB	P30043	DB00140	Riboflavin	Flavin reductase (NADPH)	SmallMoleculeDrug	approved\|investigational\|nutraceutical\|vet_approved
BLVRB	P30043	DB00157	NADH	Flavin reductase (NADPH)	SmallMoleculeDrug	approved\|nutraceutical

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Related Diseases for BLVRB

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
BLVRB	C0019193	Hepatitis, Toxic	1	CTD_human
BLVRB	C0024623	Malignant neoplasm of stomach	1	CTD_human
BLVRB	C0038356	Stomach Neoplasms	1	CTD_human
BLVRB	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
BLVRB	C0860207	Drug-Induced Liver Disease	1	CTD_human
BLVRB	C1262760	Hepatitis, Drug-Induced	1	CTD_human
BLVRB	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
BLVRB	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
BLVRB	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
BLVRB	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human