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Spatial pattern gene: SGCB (spascer ID:6443) |
Gene summary for SGCB |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | SGCB | Gene ID | 6443 |
| Gene name | sarcoglycan beta |
| Synonyms | A3b|LGMD2E|LGMDR4|SGC |
| Cytomap | 4q12 |
| Type of gene | protein-coding |
| Description | beta-sarcoglycan43 kDa dystrophin-associated glycoprotein43DAGbeta-SGbeta-sarcoglycan(43kD dystrophin-associated glycoprotein)limb girdle muscular dystrophy 2E (non-linked families)sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) |
| Modification date | 20220513 |
| UniProtAcc | Q16585 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| SGCB | GO:0016012 | sarcoglycan complex | 21873635 | Component |
| SGCB | GO:0042383 | sarcolemma | 21873635 | Component |
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Spatial pattern events for SGCB |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| SGCB | Human | Brain | rep_9 | 33558695 | 1.74e-12 |
| SGCB | Human | Brain | rep_10 | 33558695 | 1.11e-14 |
| SGCB | Human | Brain | rep_11 | 33558695 | 2.22e-07 |
| SGCB | Human | Brain | rep_12 | 33558695 | 3.65e-15 |
| SGCB | Human | Intestine | rep_colon1 | 34417225 | 6.48e-15 |
| SGCB | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| SGCB | Human | Liver | rep_liver1 | 34417225 | 3.57e-15 |
| SGCB | Human | Intestine | A4 | 33406409 | 3.08e-08 |
| SGCB | Human | Lung | rep_1 | 35355018 | 7.80e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Brain_rep_11_H&E  |  |
Brain_rep_12_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Liver_rep_liver1_H&E  |  |
Intestine_A4_H&E  |  |
Lung_rep_1_H&E  |  |
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Spatial pattern pathway has SGCB envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| SGCB | GOBP_Circulatory_System_Development | Human | Brain | rep_4 | 4.1e-17 |
| SGCB | GOBP_Vasculature_Development | Human | Brain | rep_4 | 4.1e-17 |
| SGCB | GOBP_Circulatory_System_Development | Human | Bladder | rep_2 | 1.0e-16 |
| SGCB | GOBP_Vasculature_Development | Human | Bladder | rep_2 | 2.0e-14 |
| SGCB | GOBP_Circulatory_System_Development | Human | Liver | rep_1 | 6.0e-76 |
| SGCB | GOBP_Vasculature_Development | Human | Liver | rep_1 | 6.0e-76 |
| SGCB | GOBP_Circulatory_System_Development | Human | Intestine | rep_colon4 | 1.9e-09 |
| SGCB | GOBP_Vasculature_Development | Human | Intestine | rep_colon4 | 1.9e-09 |
| SGCB | GOBP_Circulatory_System_Development | Human | Intestine | A3 | 5.9e-08 |
| SGCB | GOBP_Heart_Development | Human | Intestine | A3 | 3.2e-07 |
| SGCB | GOBP_Smooth_Muscle_Cell_Differentiation | Human | Intestine | A3 | 7.5e-10 |
| SGCB | GOBP_Vasculature_Development | Human | Intestine | A8 | 9.3e-07 |
| SGCB | GOBP_Vascular_Associated_Smooth_Muscle_Cell_Development | Human | Uterus | rep_1 | 3.8e-07 |
| SGCB | GOBP_Vascular_Associated_Smooth_Muscle_Cell_Differentiation | Human | Uterus | rep_1 | 6.1e-06 |
| SGCB | GOBP_Cardiac_Cell_Development | Human | Uterus | rep_25 | 1.6e-10 |
| SGCB | GOBP_Cardiac_Muscle_Cell_Differentiation | Human | Uterus | rep_26 | 6.2e-10 |
| SGCB | GOBP_Cardiac_Muscle_Tissue_Development | Human | Uterus | rep_26 | 1.3e-08 |
| SGCB | GOBP_Cardiocyte_Differentiation | Human | Uterus | rep_26 | 1.6e-13 |
| SGCB | GOBP_Muscle_Organ_Development | Human | Uterus | rep_26 | 6.5e-08 |
| SGCB | GOBP_Muscle_Tissue_Development | Human | Uterus | rep_26 | 1.2e-10 |
| SGCB | GOBP_Cardiac_Cell_Development | Human | Breast | rep_1 | 5.6e-04 |
| SGCB | GOBP_Cardiac_Muscle_Tissue_Development | Human | Breast | rep_1 | 2.2e-42 |
| SGCB | GOBP_Circulatory_System_Development | Human | Breast | rep_1 | 3.8e-70 |
| SGCB | GOBP_Heart_Development | Human | Breast | rep_1 | 4.1e-08 |
| SGCB | GOBP_Muscle_Cell_Development | Human | Breast | rep_1 | 3.0e-85 |
| SGCB | GOBP_Muscle_Cell_Differentiation | Human | Breast | rep_1 | 2.9e-50 |
| SGCB | GOBP_Muscle_Organ_Development | Human | Breast | rep_1 | 1.5e-42 |
| SGCB | GOBP_Muscle_Structure_Development | Human | Breast | rep_1 | 6.8e-61 |
| SGCB | GOBP_Muscle_Tissue_Development | Human | Breast | rep_1 | 1.0e-09 |
| SGCB | GOBP_Smooth_Muscle_Cell_Differentiation | Human | Breast | rep_1 | 1.7e-14 |
| SGCB | GOBP_Striated_Muscle_Cell_Development | Human | Breast | rep_1 | 2.5e-221 |
| SGCB | GOBP_Striated_Muscle_Cell_Differentiation | Human | Breast | rep_1 | 2.1e-49 |
| SGCB | GOBP_Vascular_Associated_Smooth_Muscle_Cell_Differentiation | Human | Breast | rep_1 | 1.4e-14 |
| SGCB | GOBP_Vasculature_Development | Human | Breast | rep_1 | 9.1e-95 |
| SGCB | GOBP_Vascular_Associated_Smooth_Muscle_Cell_Development | Human | Breast | rep_4 | 4.1e-04 |
| SGCB | GOBP_Cardiac_Muscle_Cell_Differentiation | Human | Breast | rep_5 | 7.0e-14 |
| SGCB | GOBP_Cardiocyte_Differentiation | Human | Breast | rep_5 | 4.0e-11 |
| SGCB | GOBP_Cardiac_Muscle_Tissue_Development | Human | Skin | P2_rep2 | 2.7e-12 |
| SGCB | GOBP_Muscle_Cell_Development | Human | Skin | P5_rep1 | 1.0e-13 |
| SGCB | GOBP_Striated_Muscle_Cell_Development | Human | Skin | P5_rep1 | 3.8e-10 |
| SGCB | GOBP_Smooth_Muscle_Cell_Differentiation | Human | Lung | rep_1 | 2.6e-09 |
| SGCB | GOBP_Vascular_Associated_Smooth_Muscle_Cell_Differentiation | Human | Lung | rep_1 | 2.1e-07 |
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SGCB function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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SGCB function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for SGCB envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for SGCB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SGCB |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| SGCB | C1858593 | Limb-girdle muscular dystrophy, type 2E | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| SGCB | C0007193 | Cardiomyopathy, Dilated | 1 | GENOMICS_ENGLAND |
| SGCB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| SGCB | C0033141 | Cardiomyopathies, Primary | 1 | CTD_human |
| SGCB | C0036529 | Myocardial Diseases, Secondary | 1 | CTD_human |
| SGCB | C0878544 | Cardiomyopathies | 1 | CTD_human |
