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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: SEL1L (spascer ID:6400)

Gene summary for SEL1L

Gene summary

Gene information
	Species	Human
	Gene symbol	SEL1L
	Gene ID	6400
	Gene name	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
	Synonyms	Hrd3\|PRO1063\|SEL1-LIKE\|SEL1L1
	Cytomap	14q31.1
	Type of gene	protein-coding
	Description	protein sel-1 homolog 1SEL1L, ERAD E3 ligase adaptor subunitSuppressor of lin 12 (sel-1), C. elegans, homolog ofsel-1 suppressor of lin-12-like 1suppressor of lin-12-like protein 1
	Modification date	20220513
	UniProtAcc	Q9UBV2

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
SEL1L	GO:0005789	endoplasmic reticulum membrane	21873635	Component
SEL1L	GO:0036503	ERAD pathway	21873635	Process

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Spatial pattern events for SEL1L

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
SEL1L	Human	Bladder	rep_2	34385456	6.29e-15
SEL1L	Human	Intestine	rep_colon1	34417225	1.95e-15
SEL1L	Human	Intestine	rep_colon2	34417225	8.12e-16
SEL1L	Human	Intestine	rep_colon3	34417225	5.43e-07
SEL1L	Human	Intestine	rep_colon4	34417225	1.14e-15
SEL1L	Human	Liver	rep_liver1	34417225	1.08e-15
SEL1L	Human	Liver	rep_liver2	34417225	6.98e-16
SEL1L	Human	Liver	rep_liver3	34417225	1.12e-07
SEL1L	Human	Liver	rep_liver4	34417225	6.63e-06
SEL1L	Human	Breast	1160920F	34493872	2.05e-11
SEL1L	Human	Breast	CID4290	34493872	2.20e-08
SEL1L	Human	Breast	CID4465	34493872	4.85e-15
SEL1L	Human	Breast	CID44971	34493872	1.21e-08

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has SEL1L envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
SEL1L	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
SEL1L	GOBP_Transmembrane_Transport	Human	Brain	rep_1	2.8e-23
SEL1L	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
SEL1L	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SEL1L	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
SEL1L	GOBP_Transmembrane_Transport	Human	Liver	rep_1	1.0e-70
SEL1L	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
SEL1L	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
SEL1L	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
SEL1L	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
SEL1L	GOBP_Endoplasmic_Reticulum_To_Cytosol_Transport	Human	Intestine	A3	7.4e-07
SEL1L	GOBP_Erad_Pathway	Human	Intestine	A3	1.8e-09
SEL1L	GOBP_Establishment_Of_Protein_Localization	Human	Intestine	A3	5.0e-10
SEL1L	GOBP_Intracellular_Protein_Transport	Human	Intestine	A3	4.8e-12
SEL1L	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
SEL1L	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
SEL1L	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Intestine	A3	7.7e-11
SEL1L	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
SEL1L	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Intestine	A3	4.6e-13
SEL1L	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
SEL1L	GOBP_Protein_Exit_From_Endoplasmic_Reticulum	Human	Intestine	A3	1.3e-13
SEL1L	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
SEL1L	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
SEL1L	GOBP_Protein_Stabilization	Human	Intestine	A3	5.9e-13
SEL1L	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
SEL1L	GOBP_Regulation_Of_Protein_Stability	Human	Intestine	A3	9.7e-11
SEL1L	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Human	Intestine	A3	2.1e-18
SEL1L	GOBP_Secretion	Human	Intestine	A3	1.8e-13
SEL1L	GOBP_Transmembrane_Transport	Human	Intestine	A3	1.4e-10
SEL1L	GOBP_Ubiquitin_Dependent_Erad_Pathway	Human	Intestine	A3	8.8e-14
SEL1L	GOBP_Cellular_Lipid_Metabolic_Process	Human	Intestine	A8	3.8e-13
SEL1L	GOBP_Endoplasmic_Reticulum_Mannose_Trimming	Human	Intestine	A8	6.1e-07
SEL1L	GOBP_Glycerolipid_Metabolic_Process	Human	Intestine	A8	1.2e-09
SEL1L	GOBP_Glycoprotein_Metabolic_Process	Human	Intestine	A8	5.3e-08
SEL1L	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
SEL1L	GOBP_Notch_Signaling_Pathway	Human	Intestine	A8	5.3e-07
SEL1L	GOBP_Response_To_Nitrogen_Compound	Human	Intestine	A8	1.3e-12
SEL1L	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
SEL1L	GOBP_Endoplasmic_Reticulum_Mannose_Trimming	Human	Uterus	rep_26	5.0e-06
SEL1L	GOBP_Endoplasmic_Reticulum_To_Cytosol_Transport	Human	Uterus	rep_26	8.5e-11
SEL1L	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
SEL1L	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	1.1e-07
SEL1L	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
SEL1L	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Uterus	rep_26	2.2e-12
SEL1L	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
SEL1L	GOBP_Protein_Exit_From_Endoplasmic_Reticulum	Human	Uterus	rep_26	1.7e-06
SEL1L	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
SEL1L	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
SEL1L	GOBP_Glycerolipid_Metabolic_Process	Human	Uterus	rep_29	5.7e-07
SEL1L	GOBP_Neutral_Lipid_Metabolic_Process	Human	Uterus	rep_29	2.0e-09
SEL1L	GOBP_Triglyceride_Metabolic_Process	Human	Uterus	rep_29	1.9e-07
SEL1L	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
SEL1L	GOBP_Erad_Pathway	Human	Breast	rep_1	4.4e-06
SEL1L	GOBP_Establishment_Of_Protein_Localization	Human	Breast	rep_1	7.2e-05
SEL1L	GOBP_Neutral_Lipid_Metabolic_Process	Human	Breast	rep_1	3.3e-15
SEL1L	GOBP_Notch_Signaling_Pathway	Human	Breast	rep_1	2.7e-27
SEL1L	GOBP_Secretion	Human	Breast	rep_1	9.7e-57
SEL1L	GOBP_Transmembrane_Transport	Human	Breast	rep_1	3.2e-56
SEL1L	GOBP_Triglyceride_Metabolic_Process	Human	Breast	rep_1	2.4e-04
SEL1L	GOBP_Cellular_Lipid_Metabolic_Process	Human	Breast	rep_5	2.6e-07
SEL1L	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
SEL1L	GOBP_Endoplasmic_Reticulum_Mannose_Trimming	Human	Breast	rep_5	4.8e-09
SEL1L	GOBP_Endoplasmic_Reticulum_To_Cytosol_Transport	Human	Breast	rep_5	1.2e-05
SEL1L	GOBP_Glycoprotein_Metabolic_Process	Human	Breast	rep_5	1.5e-14
SEL1L	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
SEL1L	GOBP_Protein_Demannosylation	Human	Breast	rep_5	7.3e-15
SEL1L	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
SEL1L	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Human	Breast	rep_5	4.4e-06
SEL1L	GOBP_Response_To_Nitrogen_Compound	Human	Breast	rep_5	1.1e-11
SEL1L	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
SEL1L	GOBP_Glycerolipid_Metabolic_Process	Human	Breast	rep_6	9.2e-09
SEL1L	GOBP_Intracellular_Protein_Transport	Human	Breast	rep_6	6.4e-12
SEL1L	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
SEL1L	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
SEL1L	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Breast	rep_6	2.2e-09
SEL1L	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
SEL1L	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Breast	rep_6	6.8e-09
SEL1L	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
SEL1L	GOBP_Protein_Deglycosylation	Human	Breast	rep_6	6.2e-07
SEL1L	GOBP_Protein_Exit_From_Endoplasmic_Reticulum	Human	Breast	rep_6	1.9e-08
SEL1L	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
SEL1L	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
SEL1L	GOBP_Protein_Stabilization	Human	Breast	rep_6	1.8e-07
SEL1L	GOBP_Regulation_Of_Protein_Stability	Human	Breast	rep_6	1.6e-08
SEL1L	GOBP_Ubiquitin_Dependent_Erad_Pathway	Human	Breast	rep_6	3.4e-10
SEL1L	GOBP_Protein_Stabilization	Human	Skin	P5_rep1	2.1e-11
SEL1L	GOBP_Regulation_Of_Protein_Stability	Human	Skin	P5_rep2	5.8e-08
SEL1L	GOBP_Neutral_Lipid_Metabolic_Process	Human	Lung	rep_2	2.7e-09

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SEL1L function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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SEL1L function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for SEL1L envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for SEL1L

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SEL1L

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source