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Spatial pattern gene: SDHD (spascer ID:6392) |
Gene summary for SDHD |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | SDHD | Gene ID | 6392 |
| Gene name | succinate dehydrogenase complex subunit D |
| Synonyms | CBT1|CII-4|CWS3|MC2DN3|PGL|PGL1|QPs3|SDH4|cybS |
| Cytomap | 11q23.1 |
| Type of gene | protein-coding |
| Description | succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialsuccinate dehydrogenase complex subunit D integral membrane proteinsuccinate-ubiquinone oxidoreductase cytochrome b small subunitsuccinate-ubiquinone reductase membrane ancho |
| Modification date | 20220513 |
| UniProtAcc | O14521 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| SDHD | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | 21873635 | Component |
| SDHD | GO:0006099 | tricarboxylic acid cycle | 21873635 | Process |
| SDHD | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone | 21873635 | Process |
| SDHD | GO:0020037 | heme binding | 21873635 | Function |
| SDHD | GO:0048039 | ubiquinone binding | 21873635 | Function |
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Spatial pattern events for SDHD |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| SDHD | Human | Intestine | rep_colon2 | 34417225 | 1.33e-06 |
| SDHD | Human | Intestine | rep_colon4 | 34417225 | 5.07e-10 |
| SDHD | Human | Liver | rep_liver1 | 34417225 | 2.66e-10 |
| SDHD | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| SDHD | Human | Liver | rep_liver4 | 34417225 | 1.84e-14 |
| SDHD | Human | Intestine | A1 | 33406409 | 3.49e-15 |
| SDHD | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| SDHD | Human | Uterus | rep_2 | 34857954 | 2.93e-09 |
| SDHD | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| SDHD | Human | Uterus | rep_4 | 34857954 | 1.59e-11 |
| SDHD | Human | Breast | 1142243F | 34493872 | 7.88e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Uterus_rep_4_H&E  |  |
Breast_1142243F_H&E  |  |
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Spatial pattern pathway has SDHD envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| SDHD | GOBP_Aerobic_Respiration | Human | Bladder | rep_4 | 5.9e-17 |
| SDHD | GOBP_Atp_Metabolic_Process | Human | Bladder | rep_4 | 3.6e-11 |
| SDHD | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Human | Bladder | rep_4 | 7.2e-24 |
| SDHD | GOBP_Cellular_Respiration | Human | Bladder | rep_4 | 2.0e-15 |
| SDHD | GOBP_Electron_Transport_Chain | Human | Bladder | rep_4 | 1.0e-20 |
| SDHD | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Bladder | rep_4 | 1.5e-12 |
| SDHD | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Bladder | rep_4 | 3.4e-12 |
| SDHD | GOBP_Oxidative_Phosphorylation | Human | Bladder | rep_4 | 4.6e-17 |
| SDHD | GOBP_Respiratory_Electron_Transport_Chain | Human | Bladder | rep_4 | 4.7e-21 |
| SDHD | GOBP_Aerobic_Respiration | Human | Intestine | A3 | 1.5e-15 |
| SDHD | GOBP_Atp_Metabolic_Process | Human | Intestine | A3 | 7.9e-14 |
| SDHD | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Human | Intestine | A3 | 2.3e-18 |
| SDHD | GOBP_Cellular_Respiration | Human | Intestine | A3 | 6.2e-15 |
| SDHD | GOBP_Electron_Transport_Chain | Human | Intestine | A3 | 1.4e-19 |
| SDHD | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Intestine | A3 | 2.5e-12 |
| SDHD | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Intestine | A3 | 4.3e-14 |
| SDHD | GOBP_Oxidative_Phosphorylation | Human | Intestine | A3 | 1.2e-13 |
| SDHD | GOBP_Respiratory_Electron_Transport_Chain | Human | Intestine | A3 | 7.5e-17 |
| SDHD | GOBP_Tricarboxylic_Acid_Cycle | Human | Intestine | A8 | 5.7e-09 |
| SDHD | GOBP_Aerobic_Respiration | Human | Uterus | rep_26 | 3.1e-08 |
| SDHD | GOBP_Atp_Metabolic_Process | Human | Uterus | rep_26 | 3.2e-08 |
| SDHD | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Human | Uterus | rep_26 | 2.1e-08 |
| SDHD | GOBP_Cellular_Respiration | Human | Uterus | rep_26 | 3.7e-07 |
| SDHD | GOBP_Electron_Transport_Chain | Human | Uterus | rep_26 | 1.9e-08 |
| SDHD | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Uterus | rep_26 | 7.2e-06 |
| SDHD | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Uterus | rep_26 | 1.8e-06 |
| SDHD | GOBP_Oxidative_Phosphorylation | Human | Uterus | rep_26 | 2.6e-09 |
| SDHD | GOBP_Respiratory_Electron_Transport_Chain | Human | Uterus | rep_26 | 2.1e-08 |
| SDHD | GOBP_Tricarboxylic_Acid_Cycle | Human | Uterus | rep_26 | 5.7e-11 |
| SDHD | GOBP_Atp_Synthesis_Coupled_Electron_Transport | Human | Breast | rep_5 | 3.1e-04 |
| SDHD | GOBP_Electron_Transport_Chain | Human | Breast | rep_5 | 6.2e-04 |
| SDHD | GOBP_Oxidative_Phosphorylation | Human | Breast | rep_5 | 1.1e-04 |
| SDHD | GOBP_Respiratory_Electron_Transport_Chain | Human | Breast | rep_5 | 3.1e-04 |
| SDHD | GOBP_Aerobic_Respiration | Human | Breast | rep_6 | 2.2e-06 |
| SDHD | GOBP_Atp_Metabolic_Process | Human | Breast | rep_6 | 1.3e-06 |
| SDHD | GOBP_Cellular_Respiration | Human | Breast | rep_6 | 2.2e-06 |
| SDHD | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Breast | rep_6 | 5.2e-08 |
| SDHD | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Breast | rep_6 | 7.1e-09 |
| SDHD | GOBP_Tricarboxylic_Acid_Cycle | Human | Breast | rep_6 | 8.0e-06 |
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SDHD function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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SDHD function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for SDHD envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for SDHD |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| SDHD | O14521 | DB00756 | Hexachlorophene | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | SmallMoleculeDrug | approved|withdrawn |
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Related Diseases for SDHD |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| SDHD | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 9 | CLINGEN;GENOMICS_ENGLAND |
| SDHD | C0030421 | Paraganglioma | 6 | CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT |
| SDHD | C0031511 | Pheochromocytoma | 3 | CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT |
| SDHD | C1855008 | Mitochondrial Complex II Deficiency | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| SDHD | C0024586 | Malignant Carcinoid Syndrome | 1 | ORPHANET |
| SDHD | C0025202 | melanoma | 1 | CTD_human |
| SDHD | C0751651 | Mitochondrial Diseases | 1 | GENOMICS_ENGLAND |
| SDHD | C1847319 | PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
