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Spatial pattern gene: SDHB (spascer ID:6390) |
Gene summary for SDHB |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | SDHB | Gene ID | 6390 |
| Gene name | succinate dehydrogenase complex iron sulfur subunit B |
| Synonyms | CWS2|IP|MC2DN4|PGL4|SDH|SDH1|SDH2|SDHIP |
| Cytomap | 1p36.13 |
| Type of gene | protein-coding |
| Description | succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialiron-sulfur subunit of complex IIsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| Modification date | 20220513 |
| UniProtAcc | P21912 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| SDHB | GO:0009060 | aerobic respiration | 21873635 | Process |
| SDHB | GO:0022904 | respiratory electron transport chain | 21873635 | Process |
| SDHB | GO:0031966 | mitochondrial membrane | 21873635 | Component |
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Spatial pattern events for SDHB |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| SDHB | Human | Intestine | rep_colon1 | 34417225 | 4.08e-10 |
| SDHB | Human | Intestine | rep_colon4 | 34417225 | 3.79e-08 |
| SDHB | Human | Liver | rep_liver1 | 34417225 | 2.16e-11 |
| SDHB | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| SDHB | Human | Intestine | A1 | 33406409 | 1.79e-07 |
| SDHB | Human | Intestine | A2 | 33406409 | 5.98e-08 |
| SDHB | Human | Uterus | rep_3 | 34857954 | 3.53e-09 |
| SDHB | Human | Breast | 1160920F | 34493872 | 8.18e-13 |
| SDHB | Human | Breast | CID44971 | 34493872 | 5.89e-07 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID44971_H&E  |  |
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Spatial pattern pathway has SDHB envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| SDHB | GOBP_Aerobic_Respiration | Human | Bladder | rep_4 | 5.9e-17 |
| SDHB | GOBP_Cellular_Respiration | Human | Bladder | rep_4 | 2.0e-15 |
| SDHB | GOBP_Electron_Transport_Chain | Human | Bladder | rep_4 | 1.0e-20 |
| SDHB | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Bladder | rep_4 | 1.5e-12 |
| SDHB | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Bladder | rep_4 | 3.4e-12 |
| SDHB | GOBP_Respiratory_Electron_Transport_Chain | Human | Bladder | rep_4 | 4.7e-21 |
| SDHB | GOBP_Aerobic_Respiration | Human | Intestine | A3 | 1.5e-15 |
| SDHB | GOBP_Cellular_Respiration | Human | Intestine | A3 | 6.2e-15 |
| SDHB | GOBP_Electron_Transport_Chain | Human | Intestine | A3 | 1.4e-19 |
| SDHB | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Intestine | A3 | 2.5e-12 |
| SDHB | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Intestine | A3 | 4.3e-14 |
| SDHB | GOBP_Respiratory_Electron_Transport_Chain | Human | Intestine | A3 | 7.5e-17 |
| SDHB | GOBP_Dicarboxylic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.6e-15 |
| SDHB | GOBP_Organic_Acid_Metabolic_Process | Human | Intestine | A8 | 2.5e-18 |
| SDHB | GOBP_Small_Molecule_Metabolic_Process | Human | Intestine | A8 | 2.1e-15 |
| SDHB | GOBP_Succinate_Metabolic_Process | Human | Intestine | A8 | 5.0e-10 |
| SDHB | GOBP_Tricarboxylic_Acid_Cycle | Human | Intestine | A8 | 5.7e-09 |
| SDHB | GOBP_Aerobic_Respiration | Human | Uterus | rep_26 | 3.1e-08 |
| SDHB | GOBP_Cellular_Respiration | Human | Uterus | rep_26 | 3.7e-07 |
| SDHB | GOBP_Electron_Transport_Chain | Human | Uterus | rep_26 | 1.9e-08 |
| SDHB | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Uterus | rep_26 | 7.2e-06 |
| SDHB | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Uterus | rep_26 | 1.8e-06 |
| SDHB | GOBP_Organic_Acid_Metabolic_Process | Human | Uterus | rep_26 | 4.9e-06 |
| SDHB | GOBP_Respiratory_Electron_Transport_Chain | Human | Uterus | rep_26 | 2.1e-08 |
| SDHB | GOBP_Succinate_Metabolic_Process | Human | Uterus | rep_26 | 1.3e-09 |
| SDHB | GOBP_Tricarboxylic_Acid_Cycle | Human | Uterus | rep_26 | 5.7e-11 |
| SDHB | GOBP_Electron_Transport_Chain | Human | Breast | rep_5 | 6.2e-04 |
| SDHB | GOBP_Respiratory_Electron_Transport_Chain | Human | Breast | rep_5 | 3.1e-04 |
| SDHB | GOBP_Succinate_Metabolic_Process | Human | Breast | rep_5 | 7.1e-04 |
| SDHB | GOBP_Aerobic_Respiration | Human | Breast | rep_6 | 2.2e-06 |
| SDHB | GOBP_Cellular_Respiration | Human | Breast | rep_6 | 2.2e-06 |
| SDHB | GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds | Human | Breast | rep_6 | 5.2e-08 |
| SDHB | GOBP_Generation_Of_Precursor_Metabolites_And_Energy | Human | Breast | rep_6 | 7.1e-09 |
| SDHB | GOBP_Organic_Acid_Metabolic_Process | Human | Breast | rep_6 | 6.7e-05 |
| SDHB | GOBP_Small_Molecule_Metabolic_Process | Human | Breast | rep_6 | 5.5e-09 |
| SDHB | GOBP_Tricarboxylic_Acid_Cycle | Human | Breast | rep_6 | 8.0e-06 |
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SDHB function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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SDHB function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for SDHB envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for SDHB |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SDHB |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| SDHB | C0031511 | Pheochromocytoma | 9 | CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT |
| SDHB | C1708353 | Hereditary Paraganglioma-Pheochromocytoma Syndrome | 8 | CLINGEN |
| SDHB | C1861848 | PARAGANGLIOMAS 4 | 8 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| SDHB | C0238198 | Gastrointestinal Stromal Tumors | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| SDHB | C1847319 | PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA | 4 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
| SDHB | C0030421 | Paraganglioma | 2 | CGI;CTD_human |
| SDHB | C0342777 | Succinate-coenzyme Q reductase deficiency | 2 | GENOMICS_ENGLAND |
| SDHB | C0751651 | Mitochondrial Diseases | 2 | GENOMICS_ENGLAND |
| SDHB | C1855008 | Mitochondrial Complex II Deficiency | 1 | ORPHANET |
| SDHB | C3179349 | Gastrointestinal Stromal Sarcoma | 1 | CTD_human;ORPHANET |
