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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CCL14 (spascer ID:6358)

Gene summary for CCL14

Gene summary

Gene information
	Species	Human
	Gene symbol	CCL14
	Gene ID	6358
	Gene name	C-C motif chemokine ligand 14
	Synonyms	CC-1\|CC-3\|CKB1\|HCC-1\|HCC-1(1-74)\|HCC-1/HCC-3\|HCC-3\|MCIF\|NCC-2\|NCC2\|SCYA14\|SCYL2\|SY14
	Cytomap	17q12
	Type of gene	protein-coding
	Description	C-C motif chemokine 14chemokine (C-C motif) ligand 14chemokine CC-1/CC-3chemokine CC-3hemofiltrate CC chemokine 1new CC chemokine 2small inducible cytokine subfamily A (Cys-Cys), member 14small-inducible cytokine A14
	Modification date	20220513
	UniProtAcc	Q16627

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CCL14	GO:0002548	monocyte chemotaxis	21873635	Process
CCL14	GO:0005615	extracellular space	21873635	Component
CCL14	GO:0006954	inflammatory response	21873635	Process
CCL14	GO:0007186	G protein-coupled receptor signaling pathway	21873635	Process
CCL14	GO:0008009	chemokine activity	21873635	Function
CCL14	GO:0030593	neutrophil chemotaxis	21873635	Process
CCL14	GO:0043547	positive regulation of GTPase activity	21873635	Process
CCL14	GO:0048020	CCR chemokine receptor binding	21873635	Function
CCL14	GO:0048247	lymphocyte chemotaxis	21873635	Process
CCL14	GO:0070098	chemokine-mediated signaling pathway	21873635	Process
CCL14	GO:0070374	positive regulation of ERK1 and ERK2 cascade	21873635	Process
CCL14	GO:0071346	cellular response to interferon-gamma	21873635	Process
CCL14	GO:0071347	cellular response to interleukin-1	21873635	Process
CCL14	GO:0071356	cellular response to tumor necrosis factor	21873635	Process

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Spatial pattern events for CCL14

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CCL14	Human	Liver	rep_1	34792289	5.95e-14
CCL14	Human	Intestine	rep_colon2	34417225	8.12e-16
CCL14	Human	Intestine	rep_colon3	34417225	1.01e-15
CCL14	Human	Liver	rep_liver1	34417225	3.57e-15
CCL14	Human	Liver	rep_liver2	34417225	1.27e-15
CCL14	Human	Liver	rep_liver3	34417225	3.51e-15
CCL14	Human	Uterus	rep_2	34857954	2.55e-15
CCL14	Human	Lung	rep_1	35355018	4.99e-15
CCL14	Human	Lung	rep_2	35355018	1.83e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Uterus_rep_2_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E

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Spatial pattern pathway has CCL14 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CCL14	GOBP_Cell_Migration	Human	Brain	rep_1	3.1e-68
CCL14	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Brain	rep_1	2.8e-23
CCL14	GOBP_Locomotion	Human	Brain	rep_1	3.1e-68
CCL14	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Brain	rep_1	8.7e-71
CCL14	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Brain	rep_1	1.3e-60
CCL14	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_1	8.7e-71
CCL14	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	3.1e-68
CCL14	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Brain	rep_1	8.7e-71
CCL14	GOBP_Positive_Regulation_Of_Signaling	Human	Brain	rep_1	6.4e-05
CCL14	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Brain	rep_1	1.2e-64
CCL14	GOBP_Taxis	Human	Brain	rep_1	2.3e-68
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Brain	rep_2	2.1e-15
CCL14	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
CCL14	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
CCL14	GOBP_Inflammatory_Response	Human	Brain	rep_4	5.6e-28
CCL14	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
CCL14	GOBP_Monocyte_Chemotaxis	Human	Bladder	rep_2	6.4e-05
CCL14	GOBP_Cell_Migration	Human	Liver	rep_1	1.9e-71
CCL14	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
CCL14	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
CCL14	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Liver	rep_1	1.0e-70
CCL14	GOBP_Inflammatory_Response	Human	Liver	rep_1	1.1e-67
CCL14	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
CCL14	GOBP_Locomotion	Human	Liver	rep_1	1.9e-71
CCL14	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Liver	rep_1	2.1e-52
CCL14	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Liver	rep_1	2.0e-49
CCL14	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	4.9e-46
CCL14	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
CCL14	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Liver	rep_1	2.1e-52
CCL14	GOBP_Positive_Regulation_Of_Signaling	Human	Liver	rep_1	2.9e-73
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Liver	rep_1	6.0e-76
CCL14	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Liver	rep_1	6.9e-47
CCL14	GOBP_Taxis	Human	Liver	rep_1	8.8e-90
CCL14	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	rep_colon2	2.3e-37
CCL14	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Intestine	rep_colon2	2.9e-50
CCL14	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon2	4.1e-22
CCL14	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	3.4e-10
CCL14	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	rep_colon2	2.3e-37
CCL14	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	rep_colon2	2.4e-25
CCL14	GOBP_Taxis	Human	Intestine	rep_colon2	5.0e-29
CCL14	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
CCL14	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
CCL14	GOBP_Inflammatory_Response	Human	Intestine	rep_colon4	3.1e-51
CCL14	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
CCL14	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	rep_colon4	2.0e-10
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	rep_colon4	3.7e-11
CCL14	GOBP_Cell_Migration	Human	Intestine	rep_liver2	1.0e-64
CCL14	GOBP_Locomotion	Human	Intestine	rep_liver2	1.0e-64
CCL14	GOBP_Cell_Migration	Human	Intestine	A3	1.6e-10
CCL14	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Intestine	A3	2.6e-09
CCL14	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
CCL14	GOBP_Erk1_And_Erk2_Cascade	Human	Intestine	A3	2.6e-07
CCL14	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
CCL14	GOBP_Inflammatory_Response	Human	Intestine	A3	2.9e-09
CCL14	GOBP_Leukocyte_Migration	Human	Intestine	A3	1.5e-08
CCL14	GOBP_Locomotion	Human	Intestine	A3	1.9e-08
CCL14	GOBP_Mapk_Cascade	Human	Intestine	A3	1.1e-12
CCL14	GOBP_Myeloid_Leukocyte_Migration	Human	Intestine	A3	1.3e-07
CCL14	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Intestine	A3	7.7e-16
CCL14	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Intestine	A3	3.5e-07
CCL14	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.8e-12
CCL14	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	2.8e-16
CCL14	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	2.6e-10
CCL14	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Intestine	A3	2.1e-13
CCL14	GOBP_Positive_Regulation_Of_Signaling	Human	Intestine	A3	3.3e-14
CCL14	GOBP_Regulation_Of_Gtpase_Activity	Human	Intestine	A3	1.0e-12
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Intestine	A3	7.3e-16
CCL14	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Intestine	A3	7.5e-12
CCL14	GOBP_Response_To_Tumor_Necrosis_Factor	Human	Intestine	A3	2.5e-09
CCL14	GOBP_Taxis	Human	Intestine	A3	5.0e-08
CCL14	GOBP_Cellular_Homeostasis	Human	Intestine	A8	2.1e-11
CCL14	GOBP_Cellular_Ion_Homeostasis	Human	Intestine	A8	4.3e-12
CCL14	GOBP_Chemical_Homeostasis	Human	Intestine	A8	1.3e-12
CCL14	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
CCL14	GOBP_Divalent_Inorganic_Cation_Homeostasis	Human	Intestine	A8	1.0e-12
CCL14	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Intestine	A8	1.4e-14
CCL14	GOBP_Granulocyte_Chemotaxis	Human	Intestine	A8	8.1e-13
CCL14	GOBP_Granulocyte_Migration	Human	Intestine	A8	1.6e-12
CCL14	GOBP_Ion_Homeostasis	Human	Intestine	A8	6.1e-15
CCL14	GOBP_Leukocyte_Chemotaxis	Human	Intestine	A8	3.7e-14
CCL14	GOBP_Lymphocyte_Migration	Human	Intestine	A8	1.8e-13
CCL14	GOBP_Metal_Ion_Homeostasis	Human	Intestine	A8	2.2e-10
CCL14	GOBP_Monocyte_Chemotaxis	Human	Intestine	A8	1.5e-20
CCL14	GOBP_Mononuclear_Cell_Migration	Human	Intestine	A8	4.0e-13
CCL14	GOBP_Neutrophil_Chemotaxis	Human	Intestine	A8	8.9e-16
CCL14	GOBP_Neutrophil_Migration	Human	Intestine	A8	5.8e-10
CCL14	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
CCL14	GOBP_Response_To_Interleukin_1	Human	Intestine	A8	2.2e-14
CCL14	GOBP_Positive_Regulation_Of_Mapk_Cascade	Human	Pancreas	PDAC-B-st1	1.1e-05
CCL14	GOBP_Regulation_Of_Gtpase_Activity	Human	Pancreas	PDAC-B-st1	9.7e-05
CCL14	GOBP_Lymphocyte_Chemotaxis	Human	Pancreas	PDAC-A-st2	1.9e-05
CCL14	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
CCL14	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
CCL14	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
CCL14	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Uterus	rep_26	2.0e-10
CCL14	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Uterus	rep_26	3.5e-06
CCL14	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
CCL14	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Human	Uterus	rep_26	1.1e-06
CCL14	GOBP_Response_To_Interferon_Gamma	Human	Uterus	rep_26	5.5e-07
CCL14	GOBP_Response_To_Interleukin_1	Human	Uterus	rep_26	1.5e-07
CCL14	GOBP_Response_To_Tumor_Necrosis_Factor	Human	Uterus	rep_26	1.5e-09
CCL14	GOBP_Erk1_And_Erk2_Cascade	Human	Uterus	rep_29	7.0e-08
CCL14	GOBP_Leukocyte_Migration	Human	Uterus	rep_29	1.5e-07
CCL14	GOBP_Lymphocyte_Migration	Human	Uterus	rep_29	2.0e-09
CCL14	GOBP_Mononuclear_Cell_Migration	Human	Uterus	rep_29	3.4e-06
CCL14	GOBP_Neutrophil_Migration	Human	Uterus	rep_29	1.3e-06
CCL14	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Uterus	rep_29	5.5e-06
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Uterus	rep_29	6.6e-10
CCL14	GOBP_Cell_Migration	Human	Breast	rep_1	1.5e-45
CCL14	GOBP_Cellular_Homeostasis	Human	Breast	rep_1	2.8e-10
CCL14	GOBP_Cellular_Ion_Homeostasis	Human	Breast	rep_1	7.6e-24
CCL14	GOBP_Chemical_Homeostasis	Human	Breast	rep_1	4.8e-18
CCL14	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.5e-144
CCL14	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
CCL14	GOBP_Divalent_Inorganic_Cation_Homeostasis	Human	Breast	rep_1	1.2e-25
CCL14	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Breast	rep_1	3.6e-09
CCL14	GOBP_Granulocyte_Chemotaxis	Human	Breast	rep_1	3.7e-93
CCL14	GOBP_Granulocyte_Migration	Human	Breast	rep_1	3.5e-61
CCL14	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
CCL14	GOBP_Inflammatory_Response	Human	Breast	rep_1	3.7e-43
CCL14	GOBP_Ion_Homeostasis	Human	Breast	rep_1	1.4e-53
CCL14	GOBP_Locomotion	Human	Breast	rep_1	4.5e-54
CCL14	GOBP_Lymphocyte_Chemotaxis	Human	Breast	rep_1	8.0e-138
CCL14	GOBP_Lymphocyte_Migration	Human	Breast	rep_1	4.7e-116
CCL14	GOBP_Metal_Ion_Homeostasis	Human	Breast	rep_1	6.8e-70
CCL14	GOBP_Mononuclear_Cell_Migration	Human	Breast	rep_1	1.5e-05
CCL14	GOBP_Neutrophil_Chemotaxis	Human	Breast	rep_1	4.8e-37
CCL14	GOBP_Neutrophil_Migration	Human	Breast	rep_1	9.3e-15
CCL14	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Breast	rep_1	9.2e-11
CCL14	GOBP_Positive_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	1.4e-13
CCL14	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_1	7.8e-04
CCL14	GOBP_Regulation_Of_Gtpase_Activity	Human	Breast	rep_1	9.6e-08
CCL14	GOBP_Response_To_Chemokine	Human	Breast	rep_1	2.5e-22
CCL14	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
CCL14	GOBP_Response_To_Interferon_Gamma	Human	Breast	rep_1	1.1e-10
CCL14	GOBP_Response_To_Interleukin_1	Human	Breast	rep_1	3.2e-51
CCL14	GOBP_Response_To_Tumor_Necrosis_Factor	Human	Breast	rep_1	1.7e-52
CCL14	GOBP_Cell_Chemotaxis	Human	Breast	rep_5	5.7e-10
CCL14	GOBP_Leukocyte_Chemotaxis	Human	Breast	rep_5	5.0e-12
CCL14	GOBP_Leukocyte_Migration	Human	Breast	rep_5	6.0e-14
CCL14	GOBP_Mapk_Cascade	Human	Breast	rep_5	4.6e-17
CCL14	GOBP_Myeloid_Leukocyte_Migration	Human	Breast	rep_5	2.3e-11
CCL14	GOBP_Positive_Regulation_Of_Catalytic_Activity	Human	Breast	rep_5	1.9e-12
CCL14	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Human	Breast	rep_5	4.3e-05
CCL14	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	5.3e-08
CCL14	GOBP_Positive_Regulation_Of_Mapk_Cascade	Human	Breast	rep_5	1.9e-16
CCL14	GOBP_Positive_Regulation_Of_Molecular_Function	Human	Breast	rep_5	7.4e-10
CCL14	GOBP_Positive_Regulation_Of_Signaling	Human	Breast	rep_5	1.3e-06
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Breast	rep_5	3.2e-13
CCL14	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Human	Breast	rep_5	8.7e-11
CCL14	GOBP_Taxis	Human	Breast	rep_5	1.2e-12
CCL14	GOBP_Taxis	Human	Skin	P2_rep2	1.2e-08
CCL14	GOBP_Divalent_Inorganic_Cation_Homeostasis	Human	Skin	P2_rep3	1.3e-08
CCL14	GOBP_Response_To_Chemokine	Human	Skin	P9_rep2	1.9e-09
CCL14	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
CCL14	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
CCL14	GOBP_Inflammatory_Response	Human	Lung	rep_1	1.4e-10
CCL14	GOBP_Ion_Homeostasis	Human	Lung	rep_1	6.1e-07
CCL14	GOBP_Mononuclear_Cell_Migration	Human	Lung	rep_1	2.0e-11
CCL14	GOBP_Neutrophil_Migration	Human	Lung	rep_1	1.0e-07
CCL14	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Lung	rep_1	7.3e-07
CCL14	GOBP_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_1	4.1e-07
CCL14	GOBP_Cellular_Homeostasis	Human	Lung	rep_2	7.3e-07
CCL14	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Human	Lung	rep_2	4.8e-08
CCL14	GOBP_Granulocyte_Chemotaxis	Human	Lung	rep_2	6.1e-07
CCL14	GOBP_Granulocyte_Migration	Human	Lung	rep_2	2.1e-07
CCL14	GOBP_Positive_Regulation_Of_Hydrolase_Activity	Human	Lung	rep_2	7.9e-07
CCL14	GOBP_Taxis	Human	Lung	rep_2	4.0e-07

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CCL14 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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CCL14 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for CCL14 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for CCL14

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CCL14

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source