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Spatial pattern gene: BGN (spascer ID:633) |
Gene summary for BGN |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | BGN | Gene ID | 633 |
| Gene name | biglycan |
| Synonyms | DSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1A |
| Cytomap | Xq28 |
| Type of gene | protein-coding |
| Description | biglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1A |
| Modification date | 20220513 |
| UniProtAcc | P21810 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| BGN | GO:0005615 | extracellular space | 21873635 | Component |
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Spatial pattern events for BGN |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| BGN | Human | Brain | rep_7 | 33558695 | 3.05e-10 |
| BGN | Human | Brain | rep_9 | 33558695 | 2.74e-10 |
| BGN | Human | Brain | rep_10 | 33558695 | 3.23e-15 |
| BGN | Human | Brain | rep_11 | 33558695 | 3.36e-15 |
| BGN | Human | Brain | rep_12 | 33558695 | 1.06e-09 |
| BGN | Human | Prostate | rep_2 | 29925878 | 1.07e-07 |
| BGN | Human | Prostate | rep_7 | 29925878 | 7.83e-06 |
| BGN | Human | Prostate | rep_11 | 29925878 | 9.76e-09 |
| BGN | Human | Bladder | rep_1 | 34385456 | 1.49e-14 |
| BGN | Human | Bladder | rep_2 | 34385456 | 6.29e-15 |
| BGN | Human | Bladder | rep_3 | 34385456 | 6.67e-12 |
| BGN | Human | Liver | rep_1 | 34792289 | 6.55e-08 |
| BGN | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| BGN | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| BGN | Human | Intestine | rep_colon3 | 34417225 | 1.01e-15 |
| BGN | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| BGN | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| BGN | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| BGN | Human | Liver | rep_liver3 | 34417225 | 3.51e-15 |
| BGN | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| BGN | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| BGN | Human | Intestine | A3 | 33406409 | 1.94e-14 |
| BGN | Human | Intestine | A9 | 33406409 | 1.35e-13 |
| BGN | Human | Pancreas | PDAC-A-st1 | 31932730 | 1.11e-14 |
| BGN | Human | Pancreas | PDAC-B-st2 | 31932730 | 3.63e-06 |
| BGN | Human | Pancreas | PDAC-B-st3 | 31932730 | 6.25e-06 |
| BGN | Human | Pancreas | PDAC-D-st1 | 31932730 | 6.89e-14 |
| BGN | Human | Pancreas | PDAC-F-st1 | 31932730 | 4.66e-13 |
| BGN | Human | Pancreas | PDAC-G-st1 | 31932730 | 5.50e-14 |
| BGN | Human | Uterus | rep_1 | 34857954 | 8.62e-06 |
| BGN | Human | Uterus | rep_2 | 34857954 | 2.55e-15 |
| BGN | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| BGN | Human | Uterus | rep_4 | 34857954 | 1.82e-15 |
| BGN | Human | Breast | A6 | 34650042 | 6.67e-07 |
| BGN | Human | Breast | C2 | 34650042 | 7.45e-08 |
| BGN | Human | Breast | C3 | 34650042 | 1.50e-09 |
| BGN | Human | Breast | C4 | 34650042 | 3.15e-13 |
| BGN | Human | Breast | C5 | 34650042 | 3.89e-06 |
| BGN | Human | Breast | D1 | 34650042 | 1.85e-13 |
| BGN | Human | Breast | D2 | 34650042 | 7.14e-14 |
| BGN | Human | Breast | D3 | 34650042 | 1.39e-13 |
| BGN | Human | Breast | D4 | 34650042 | 8.06e-14 |
| BGN | Human | Breast | D5 | 34650042 | 1.07e-13 |
| BGN | Human | Breast | D6 | 34650042 | 1.33e-12 |
| BGN | Human | Breast | E1 | 34650042 | 2.86e-07 |
| BGN | Human | Breast | E2 | 34650042 | 9.80e-07 |
| BGN | Human | Breast | E3 | 34650042 | 2.94e-14 |
| BGN | Human | Breast | F2 | 34650042 | 8.62e-07 |
| BGN | Human | Breast | G1 | 34650042 | 4.83e-12 |
| BGN | Human | Breast | G2 | 34650042 | 1.28e-11 |
| BGN | Human | Breast | G3 | 34650042 | 9.82e-09 |
| BGN | Human | Breast | 1142243F | 34493872 | 2.30e-15 |
| BGN | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| BGN | Human | Breast | CID4290 | 34493872 | 4.68e-15 |
| BGN | Human | Breast | CID4465 | 34493872 | 4.85e-15 |
| BGN | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| BGN | Human | Breast | CID4535 | 34493872 | 6.37e-15 |
| BGN | Human | Heart | w6_s1 | 31835037 | 7.31e-03 |
| BGN | Human | Heart | w6_s3 | 31835037 | 1.35e-13 |
| BGN | Human | Heart | w6_s4 | 31835037 | 1.07e-13 |
| BGN | Human | Heart | w6_s5 | 31835037 | 1.13e-09 |
| BGN | Human | Heart | w6_s6 | 31835037 | 7.20e-04 |
| BGN | Human | Heart | w6_s8 | 31835037 | 2.09e-03 |
| BGN | Human | Heart | w9_s1 | 31835037 | 4.24e-14 |
| BGN | Human | Heart | w9_s2 | 31835037 | 5.38e-14 |
| BGN | Human | Heart | w9_s3 | 31835037 | 4.55e-14 |
| BGN | Human | Heart | w9_s4 | 31835037 | 1.31e-13 |
| BGN | Human | Heart | w9_s5 | 31835037 | 2.40e-14 |
| BGN | Human | Heart | w9_s6 | 31835037 | 2.66e-14 |
| BGN | Human | Skin | P2_rep1 | 32946785 | 5.41e-15 |
| BGN | Human | Skin | P2_rep2 | 32946785 | 5.48e-15 |
| BGN | Human | Skin | P2_rep3 | 32946785 | 9.21e-15 |
| BGN | Human | Skin | P5_rep2 | 32946785 | 1.78e-09 |
| BGN | Human | Skin | P5_rep3 | 32946785 | 3.36e-09 |
| BGN | Human | Skin | P10_rep2 | 32946785 | 1.36e-14 |
| BGN | Human | Skin | mel1_rep1 | 30154148 | 2.81e-14 |
| BGN | Human | Skin | mel1_rep2 | 30154148 | 2.48e-14 |
| BGN | Human | Skin | mel2_rep1 | 30154148 | 2.66e-13 |
| BGN | Human | Skin | mel2_rep2 | 30154148 | 1.83e-10 |
| BGN | Human | Skin | mel3_rep2 | 30154148 | 1.74e-11 |
| BGN | Human | Lung | rep_1 | 35355018 | 4.99e-15 |
| BGN | Human | Lung | rep_2 | 35355018 | 1.83e-14 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_7_H&E  |  |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Brain_rep_11_H&E  |  |
Brain_rep_12_H&E  |  |
Bladder_rep_1_H&E  |  |
Bladder_rep_2_H&E  |  |
Bladder_rep_3_H&E  |  |
Liver_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver3_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A2_H&E  |  |
Intestine_A3_H&E  |  |
Intestine_A9_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Uterus_rep_4_H&E  |  |
Breast_A6_H&E  |  |
Breast_C2_H&E  |  |
Breast_C3_H&E  |  |
Breast_C4_H&E  |  |
Breast_C5_H&E  |  |
Breast_D1_H&E  |  |
Breast_D2_H&E  |  |
Breast_D3_H&E  |  |
Breast_D4_H&E  |  |
Breast_D5_H&E  |  |
Breast_D6_H&E  |  |
Breast_E1_H&E  |  |
Breast_E2_H&E  |  |
Breast_E3_H&E  |  |
Breast_F2_H&E  |  |
Breast_G1_H&E  |  |
Breast_G2_H&E  |  |
Breast_G3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID4290_H&E  |  |
Breast_CID4465_H&E  |  |
Breast_CID44971_H&E  |  |
Breast_CID4535_H&E  |  |
Skin_P2_rep3_H&E  |  |
Skin_P5_rep2_H&E  |  |
Skin_P5_rep3_H&E  |  |
Skin_P10_rep2_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
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Spatial pattern pathway has BGN envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| BGN | GOBP_Bone_Development | Human | Bladder | rep_2 | 1.3e-13 |
| BGN | GOBP_Chondroitin_Sulfate_Proteoglycan_Metabolic_Process | Human | Bladder | rep_2 | 3.1e-05 |
| BGN | GOBP_External_Encapsulating_Structure_Organization | Human | Bladder | rep_2 | 8.7e-05 |
| BGN | GOBP_Mucopolysaccharide_Metabolic_Process | Human | Bladder | rep_2 | 1.6e-11 |
| BGN | GOBP_Proteoglycan_Metabolic_Process | Human | Bladder | rep_2 | 1.1e-15 |
| BGN | GOBP_Skeletal_System_Development | Human | Bladder | rep_2 | 2.5e-15 |
| BGN | GOBP_Carbohydrate_Derivative_Biosynthetic_Process | Human | Bladder | rep_4 | 3.0e-06 |
| BGN | GOBP_Peptide_Cross_Linking_Via_Chondroitin_4_Sulfate_Glycosaminoglycan | Human | Intestine | A1 | 1.7e-19 |
| BGN | GOBP_Carbohydrate_Derivative_Biosynthetic_Process | Human | Intestine | A3 | 1.8e-09 |
| BGN | GOBP_Carbohydrate_Derivative_Metabolic_Process | Human | Intestine | A3 | 3.3e-11 |
| BGN | GOBP_Macromolecule_Catabolic_Process | Human | Intestine | A3 | 2.2e-16 |
| BGN | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Intestine | A3 | 4.5e-13 |
| BGN | GOBP_Peptidyl_Amino_Acid_Modification | Human | Intestine | A3 | 2.7e-09 |
| BGN | GOBP_Peptidyl_Serine_Modification | Human | Intestine | A3 | 9.8e-09 |
| BGN | GOBP_Tissue_Remodeling | Human | Intestine | A3 | 1.3e-11 |
| BGN | GOBP_Aminoglycan_Biosynthetic_Process | Human | Intestine | A8 | 6.2e-18 |
| BGN | GOBP_Aminoglycan_Catabolic_Process | Human | Intestine | A8 | 5.0e-10 |
| BGN | GOBP_Blood_Vessel_Remodeling | Human | Intestine | A8 | 3.7e-07 |
| BGN | GOBP_Bone_Development | Human | Intestine | A8 | 2.9e-07 |
| BGN | GOBP_Carbohydrate_Derivative_Catabolic_Process | Human | Intestine | A8 | 3.2e-10 |
| BGN | GOBP_Chondroitin_Sulfate_Biosynthetic_Process | Human | Intestine | A8 | 3.1e-12 |
| BGN | GOBP_Chondroitin_Sulfate_Proteoglycan_Biosynthetic_Process | Human | Intestine | A8 | 1.2e-24 |
| BGN | GOBP_Connective_Tissue_Development | Human | Intestine | A8 | 1.1e-09 |
| BGN | GOBP_Dermatan_Sulfate_Metabolic_Process | Human | Intestine | A8 | 4.8e-14 |
| BGN | GOBP_Glycoprotein_Biosynthetic_Process | Human | Intestine | A8 | 1.4e-09 |
| BGN | GOBP_Glycoprotein_Metabolic_Process | Human | Intestine | A8 | 5.3e-08 |
| BGN | GOBP_Proteoglycan_Biosynthetic_Process | Human | Intestine | A8 | 1.1e-09 |
| BGN | GOBP_Sulfur_Compound_Biosynthetic_Process | Human | Intestine | A8 | 4.5e-20 |
| BGN | GOBP_Sulfur_Compound_Catabolic_Process | Human | Intestine | A8 | 4.4e-08 |
| BGN | GOBP_Sulfur_Compound_Metabolic_Process | Human | Intestine | A8 | 2.5e-14 |
| BGN | GOBP_Aminoglycan_Biosynthetic_Process | Human | Pancreas | PDAC-A-st2 | 8.4e-06 |
| BGN | GOBP_Chondroitin_Sulfate_Biosynthetic_Process | Human | Pancreas | PDAC-A-st2 | 2.4e-06 |
| BGN | GOBP_Chondroitin_Sulfate_Proteoglycan_Biosynthetic_Process | Human | Pancreas | PDAC-A-st2 | 1.8e-08 |
| BGN | GOBP_Chondroitin_Sulfate_Proteoglycan_Metabolic_Process | Human | Pancreas | PDAC-A-st2 | 4.9e-05 |
| BGN | GOBP_Proteoglycan_Biosynthetic_Process | Human | Pancreas | PDAC-A-st2 | 1.9e-07 |
| BGN | GOBP_Proteoglycan_Metabolic_Process | Human | Pancreas | PDAC-A-st2 | 7.3e-05 |
| BGN | GOBP_Chondroitin_Sulfate_Biosynthetic_Process | Human | Uterus | rep_1 | 3.3e-06 |
| BGN | GOBP_Dermatan_Sulfate_Proteoglycan_Metabolic_Process | Human | Uterus | rep_1 | 3.7e-14 |
| BGN | GOBP_Carbohydrate_Derivative_Biosynthetic_Process | Human | Uterus | rep_26 | 3.5e-11 |
| BGN | GOBP_Carbohydrate_Derivative_Catabolic_Process | Human | Uterus | rep_26 | 5.1e-11 |
| BGN | GOBP_Macromolecule_Catabolic_Process | Human | Uterus | rep_26 | 5.0e-08 |
| BGN | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Uterus | rep_26 | 1.0e-08 |
| BGN | GOBP_Peptidyl_Serine_Modification | Human | Uterus | rep_26 | 1.9e-07 |
| BGN | GOBP_Sulfur_Compound_Metabolic_Process | Human | Uterus | rep_26 | 8.8e-08 |
| BGN | GOBP_Blood_Vessel_Remodeling | Human | Uterus | rep_29 | 6.0e-08 |
| BGN | GOBP_Mucopolysaccharide_Metabolic_Process | Human | Uterus | rep_29 | 7.2e-06 |
| BGN | GOBP_Peptide_Cross_Linking_Via_Chondroitin_4_Sulfate_Glycosaminoglycan | Human | Uterus | rep_29 | 1.4e-11 |
| BGN | GOBP_Aminoglycan_Biosynthetic_Process | Human | Breast | rep_1 | 1.4e-24 |
| BGN | GOBP_Aminoglycan_Metabolic_Process | Human | Breast | rep_1 | 2.4e-24 |
| BGN | GOBP_Blood_Vessel_Remodeling | Human | Breast | rep_1 | 2.5e-36 |
| BGN | GOBP_Carbohydrate_Derivative_Biosynthetic_Process | Human | Breast | rep_1 | 2.1e-06 |
| BGN | GOBP_Cartilage_Development | Human | Breast | rep_1 | 1.9e-101 |
| BGN | GOBP_Chondroitin_Sulfate_Biosynthetic_Process | Human | Breast | rep_1 | 4.2e-163 |
| BGN | GOBP_Chondroitin_Sulfate_Proteoglycan_Biosynthetic_Process | Human | Breast | rep_1 | 9.6e-172 |
| BGN | GOBP_Chondroitin_Sulfate_Proteoglycan_Metabolic_Process | Human | Breast | rep_1 | 1.7e-63 |
| BGN | GOBP_Connective_Tissue_Development | Human | Breast | rep_1 | 1.2e-81 |
| BGN | GOBP_Dermatan_Sulfate_Metabolic_Process | Human | Breast | rep_1 | 3.4e-77 |
| BGN | GOBP_Dermatan_Sulfate_Proteoglycan_Metabolic_Process | Human | Breast | rep_1 | 7.4e-173 |
| BGN | GOBP_External_Encapsulating_Structure_Organization | Human | Breast | rep_1 | 2.8e-108 |
| BGN | GOBP_Mucopolysaccharide_Metabolic_Process | Human | Breast | rep_1 | 7.8e-52 |
| BGN | GOBP_Peptide_Cross_Linking_Via_Chondroitin_4_Sulfate_Glycosaminoglycan | Human | Breast | rep_1 | 5.6e-08 |
| BGN | GOBP_Proteoglycan_Metabolic_Process | Human | Breast | rep_1 | 8.4e-40 |
| BGN | GOBP_Tissue_Remodeling | Human | Breast | rep_1 | 9.1e-41 |
| BGN | GOBP_Bone_Development | Human | Breast | rep_5 | 3.4e-05 |
| BGN | GOBP_Carbohydrate_Derivative_Catabolic_Process | Human | Breast | rep_5 | 1.1e-09 |
| BGN | GOBP_Glycoprotein_Metabolic_Process | Human | Breast | rep_5 | 1.5e-14 |
| BGN | GOBP_Peptidyl_Serine_Modification | Human | Breast | rep_5 | 1.3e-04 |
| BGN | GOBP_Proteoglycan_Biosynthetic_Process | Human | Breast | rep_5 | 3.2e-06 |
| BGN | GOBP_Carbohydrate_Derivative_Metabolic_Process | Human | Breast | rep_6 | 6.1e-07 |
| BGN | GOBP_Glycoprotein_Biosynthetic_Process | Human | Breast | rep_6 | 4.8e-07 |
| BGN | GOBP_Macromolecule_Catabolic_Process | Human | Breast | rep_6 | 1.3e-05 |
| BGN | GOBP_Organonitrogen_Compound_Biosynthetic_Process | Human | Breast | rep_6 | 1.2e-09 |
| BGN | GOBP_Organonitrogen_Compound_Catabolic_Process | Human | Breast | rep_6 | 9.5e-06 |
| BGN | GOBP_Peptidyl_Amino_Acid_Modification | Human | Breast | rep_6 | 3.8e-05 |
| BGN | GOBP_Sulfur_Compound_Biosynthetic_Process | Human | Breast | rep_6 | 1.2e-09 |
| BGN | GOBP_Sulfur_Compound_Catabolic_Process | Human | Breast | rep_6 | 4.7e-11 |
| BGN | GOBP_Sulfur_Compound_Metabolic_Process | Human | Breast | rep_6 | 3.0e-10 |
| BGN | GOBP_Sulfur_Compound_Biosynthetic_Process | Human | Skin | P5_rep1 | 6.9e-17 |
| BGN | GOBP_Cartilage_Development | Human | Skin | P10_rep1 | 2.4e-14 |
| BGN | GOBP_Dermatan_Sulfate_Proteoglycan_Metabolic_Process | Human | Skin | P10_rep1 | 2.3e-17 |
| BGN | GOBP_Peptide_Cross_Linking_Via_Chondroitin_4_Sulfate_Glycosaminoglycan | Human | Skin | P10_rep1 | 2.5e-10 |
| BGN | GOBP_Blood_Vessel_Remodeling | Human | Lung | rep_1 | 1.9e-11 |
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BGN function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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BGN function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication | ||
| BGN | TLR4 | BGN_TLR4 | Breast | F2 | ||
| BGN | TLR1 | BGN_TLR1 | Breast | F2 | ||
| BGN | TLR2 | BGN_TLR2 | Breast | F2 | ||
| BGN | LY96 | BGN_LY96 | Breast | F2 |
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Transcription factor for BGN envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for BGN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BGN |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
