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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: ATXN2 (spascer ID:6311)

Gene summary for ATXN2

Gene summary

Gene information
	Species	Human
	Gene symbol	ATXN2
	Gene ID	6311
	Gene name	ataxin 2
	Synonyms	ATX2\|SCA2\|TNRC13
	Cytomap	12q24.12
	Type of gene	protein-coding
	Description	ataxin-2spinocerebellar ataxia type 2 proteintrinucleotide repeat-containing gene 13 protein
	Modification date	20220513
	UniProtAcc	Q99700

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
ATXN2	GO:0003723	RNA binding	21873635	Function
ATXN2	GO:0010494	cytoplasmic stress granule	21873635	Component
ATXN2	GO:0034063	stress granule assembly	21873635	Process

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Spatial pattern events for ATXN2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
ATXN2	Human	Liver	rep_liver2	34417225	6.98e-16
ATXN2	Human	Breast	CID4290	34493872	9.91e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E
Breast_CID4290_H&E

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Spatial pattern pathway has ATXN2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
ATXN2	GOBP_Endocytosis	Human	Brain	rep_1	7.4e-34
ATXN2	GOBP_Regulation_Of_Transport	Human	Brain	rep_1	3.1e-16
ATXN2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Brain	rep_1	3.1e-16
ATXN2	GOBP_Endocytosis	Human	Liver	rep_1	1.5e-73
ATXN2	GOBP_Regulation_Of_Transport	Human	Liver	rep_1	9.4e-68
ATXN2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Liver	rep_1	3.2e-72
ATXN2	GOBP_Regulation_Of_Transport	Human	Intestine	rep_colon4	1.0e-26
ATXN2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Intestine	rep_colon4	7.4e-22
ATXN2	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
ATXN2	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
ATXN2	GOBP_Endocytosis	Human	Intestine	A3	9.3e-10
ATXN2	GOBP_Establishment_Of_Rna_Localization	Human	Intestine	A3	9.7e-11
ATXN2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	9.1e-10
ATXN2	GOBP_Negative_Regulation_Of_Transport	Human	Intestine	A3	7.4e-09
ATXN2	GOBP_Nucleobase_Containing_Compound_Transport	Human	Intestine	A3	2.5e-11
ATXN2	GOBP_P_Body_Assembly	Human	Intestine	A3	1.3e-08
ATXN2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
ATXN2	GOBP_Receptor_Internalization	Human	Intestine	A3	4.0e-12
ATXN2	GOBP_Receptor_Metabolic_Process	Human	Intestine	A3	1.2e-10
ATXN2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
ATXN2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	8.8e-12
ATXN2	GOBP_Regulation_Of_Organelle_Assembly	Human	Intestine	A3	9.7e-21
ATXN2	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
ATXN2	GOBP_Regulation_Of_Transport	Human	Intestine	A3	4.4e-11
ATXN2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Intestine	A3	1.3e-11
ATXN2	GOBP_Rna_Localization	Human	Intestine	A3	1.4e-08
ATXN2	GOBP_Negative_Regulation_Of_Endocytosis	Human	Intestine	A8	2.0e-10
ATXN2	GOBP_Negative_Regulation_Of_Receptor_Internalization	Human	Intestine	A8	9.0e-08
ATXN2	GOBP_Negative_Regulation_Of_Receptor_Mediated_Endocytosis	Human	Intestine	A8	6.5e-10
ATXN2	GOBP_Receptor_Mediated_Endocytosis	Human	Intestine	A8	6.9e-09
ATXN2	GOBP_Regulation_Of_Cytoplasmic_Mrna_Processing_Body_Assembly	Human	Intestine	A8	6.7e-16
ATXN2	GOBP_Regulation_Of_Endocytosis	Human	Intestine	A8	9.3e-16
ATXN2	GOBP_Regulation_Of_Receptor_Internalization	Human	Intestine	A8	6.2e-19
ATXN2	GOBP_Regulation_Of_Receptor_Mediated_Endocytosis	Human	Intestine	A8	2.8e-13
ATXN2	GOBP_Receptor_Metabolic_Process	Human	Pancreas	PDAC-B-st1	6.8e-05
ATXN2	GOBP_Stress_Granule_Assembly	Human	Pancreas	PDAC-B-st1	4.6e-05
ATXN2	GOBP_Regulation_Of_Cytoplasmic_Mrna_Processing_Body_Assembly	Human	Pancreas	PDAC-A-st2	1.9e-05
ATXN2	GOBP_Regulation_Of_Receptor_Internalization	Human	Uterus	rep_25	6.2e-17
ATXN2	GOBP_Establishment_Of_Rna_Localization	Human	Uterus	rep_26	8.7e-07
ATXN2	GOBP_Negative_Regulation_Of_Transport	Human	Uterus	rep_26	1.0e-12
ATXN2	GOBP_P_Body_Assembly	Human	Uterus	rep_26	1.8e-15
ATXN2	GOBP_Receptor_Internalization	Human	Uterus	rep_26	1.1e-13
ATXN2	GOBP_Receptor_Mediated_Endocytosis	Human	Uterus	rep_26	5.3e-09
ATXN2	GOBP_Receptor_Metabolic_Process	Human	Uterus	rep_26	3.6e-08
ATXN2	GOBP_Regulation_Of_Endocytosis	Human	Uterus	rep_26	1.9e-11
ATXN2	GOBP_Regulation_Of_Organelle_Assembly	Human	Uterus	rep_26	2.0e-06
ATXN2	GOBP_Regulation_Of_Receptor_Mediated_Endocytosis	Human	Uterus	rep_26	3.1e-08
ATXN2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Uterus	rep_26	3.4e-11
ATXN2	GOBP_Rna_Localization	Human	Uterus	rep_26	1.2e-09
ATXN2	GOBP_Stress_Granule_Assembly	Human	Uterus	rep_26	8.3e-08
ATXN2	GOBP_Negative_Regulation_Of_Endocytosis	Human	Uterus	rep_29	3.7e-06
ATXN2	GOBP_Negative_Regulation_Of_Receptor_Mediated_Endocytosis	Human	Uterus	rep_29	8.8e-10
ATXN2	GOBP_Negative_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	7.3e-14
ATXN2	GOBP_Negative_Regulation_Of_Endocytosis	Human	Breast	rep_1	6.4e-74
ATXN2	GOBP_Negative_Regulation_Of_Receptor_Internalization	Human	Breast	rep_1	2.3e-95
ATXN2	GOBP_Negative_Regulation_Of_Receptor_Mediated_Endocytosis	Human	Breast	rep_1	1.4e-34
ATXN2	GOBP_Receptor_Internalization	Human	Breast	rep_1	2.4e-29
ATXN2	GOBP_Receptor_Mediated_Endocytosis	Human	Breast	rep_1	2.7e-84
ATXN2	GOBP_Receptor_Metabolic_Process	Human	Breast	rep_1	8.0e-42
ATXN2	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	4.6e-05
ATXN2	GOBP_Regulation_Of_Endocytosis	Human	Breast	rep_1	2.2e-86
ATXN2	GOBP_Regulation_Of_Organelle_Assembly	Human	Breast	rep_1	1.0e-12
ATXN2	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
ATXN2	GOBP_Regulation_Of_Receptor_Mediated_Endocytosis	Human	Breast	rep_1	9.3e-92
ATXN2	GOBP_Regulation_Of_Transport	Human	Breast	rep_1	3.7e-17
ATXN2	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Breast	rep_1	4.9e-41
ATXN2	GOBP_Negative_Regulation_Of_Transport	Human	Breast	rep_5	5.7e-12
ATXN2	GOBP_Regulation_Of_Cytoplasmic_Mrna_Processing_Body_Assembly	Human	Breast	rep_5	3.4e-08
ATXN2	GOBP_Regulation_Of_Receptor_Internalization	Human	Breast	rep_5	3.8e-06
ATXN2	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
ATXN2	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
ATXN2	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
ATXN2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
ATXN2	GOBP_P_Body_Assembly	Human	Breast	rep_6	2.2e-07
ATXN2	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
ATXN2	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
ATXN2	GOBP_Rna_Localization	Human	Breast	rep_6	7.7e-05
ATXN2	GOBP_Stress_Granule_Assembly	Human	Breast	rep_6	4.3e-06
ATXN2	GOBP_Stress_Granule_Assembly	Human	Skin	P10_rep1	1.2e-09
ATXN2	GOBP_Receptor_Metabolic_Process	Human	Lung	rep_2	1.1e-09

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ATXN2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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ATXN2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for ATXN2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for ATXN2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATXN2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
ATXN2	C0752121	Spinocerebellar Ataxia Type 2	3	CTD_human;GENOMICS_ENGLAND;ORPHANET
ATXN2	C0002736	Amyotrophic Lateral Sclerosis	2	CTD_human;ORPHANET
ATXN2	C0087012	Ataxia, Spinocerebellar	2	CTD_human
ATXN2	C0752120	Spinocerebellar Ataxia Type 1	2	CTD_human
ATXN2	C0752122	Spinocerebellar Ataxia Type 4	2	CTD_human
ATXN2	C0752123	Spinocerebellar Ataxia Type 5	2	CTD_human
ATXN2	C0752124	Spinocerebellar Ataxia Type 6 (disorder)	2	CTD_human
ATXN2	C0752125	Spinocerebellar Ataxia Type 7	2	CTD_human
ATXN2	C0017612	Glaucoma, Open-Angle	1	CTD_human
ATXN2	C0036341	Schizophrenia	1	PSYGENET
ATXN2	C0271148	Secondary Open Angle Glaucoma	1	CTD_human
ATXN2	C0339573	Glaucoma, Primary Open Angle	1	CTD_human
ATXN2	C0393554	Amyotrophic Lateral Sclerosis With Dementia	1	CTD_human
ATXN2	C0543859	Amyotrophic Lateral Sclerosis, Guam Form	1	CTD_human