Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: SC5D (spascer ID:6309)

Gene summary for SC5D

Gene summary

Gene information
	Species	Human
	Gene symbol	SC5D
	Gene ID	6309
	Gene name	sterol-C5-desaturase
	Synonyms	ERG3\|S5DES\|SC5DL
	Cytomap	11q23.3-q24.1
	Type of gene	protein-coding
	Description	lathosterol oxidase3beta-hydroxysteroid-delta5-desaturaseC-5 sterol desaturasedelta(7)-sterol 5(6)-desaturasedelta(7)-sterol 5-desaturasedelta(7)-sterol C5(6)-desaturasefungal ERG3, delta-5-desaturase-likelathosterol 5-desaturaselathosterol dehydr
	Modification date	20220513
	UniProtAcc	O75845

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
SC5D	GO:0000248	C-5 sterol desaturase activity	21873635	Function
SC5D	GO:0005789	endoplasmic reticulum membrane	21873635	Component
SC5D	GO:0016020	membrane	21873635	Component
SC5D	GO:0016126	sterol biosynthetic process	21873635	Process
SC5D	GO:0016491	oxidoreductase activity	21873635	Function
SC5D	GO:0033490	cholesterol biosynthetic process via lathosterol	21873635	Process

Top

Spatial pattern events for SC5D

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
SC5D	Human	Liver	rep_1	34792289	4.48e-13
SC5D	Human	Intestine	rep_colon1	34417225	3.80e-07
SC5D	Human	Liver	rep_liver1	34417225	1.08e-15
SC5D	Human	Liver	rep_liver2	34417225	6.98e-16
SC5D	Human	Liver	rep_liver3	34417225	3.51e-15
SC5D	Human	Liver	rep_liver4	34417225	7.71e-16
SC5D	Human	Intestine	A1	33406409	2.09e-15
SC5D	Human	Intestine	A2	33406409	3.85e-15
SC5D	Human	Uterus	rep_3	34857954	4.51e-09
SC5D	Human	Breast	CID4465	34493872	7.83e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_1_H&E
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Uterus_rep_3_H&E
Breast_CID4465_H&E

Top

Spatial pattern pathway has SC5D envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
SC5D	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
SC5D	GOBP_Regulation_Of_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
SC5D	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SC5D	GOBP_Regulation_Of_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
SC5D	GOBP_Lipid_Biosynthetic_Process	Human	Intestine	A3	5.0e-07
SC5D	GOBP_Alcohol_Biosynthetic_Process	Human	Intestine	A8	5.3e-09
SC5D	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
SC5D	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Intestine	A8	1.2e-10
SC5D	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Intestine	A8	6.4e-10
SC5D	GOBP_Regulation_Of_Alcohol_Biosynthetic_Process	Human	Intestine	A8	6.5e-12
SC5D	GOBP_Regulation_Of_Cholesterol_Biosynthetic_Process	Human	Intestine	A8	3.3e-14
SC5D	GOBP_Regulation_Of_Cholesterol_Metabolic_Process	Human	Intestine	A8	6.7e-10
SC5D	GOBP_Regulation_Of_Lipid_Biosynthetic_Process	Human	Intestine	A8	3.1e-15
SC5D	GOBP_Regulation_Of_Lipid_Metabolic_Process	Human	Intestine	A8	2.1e-17
SC5D	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Human	Intestine	A8	1.7e-14
SC5D	GOBP_Regulation_Of_Steroid_Biosynthetic_Process	Human	Intestine	A8	1.8e-22
SC5D	GOBP_Regulation_Of_Steroid_Metabolic_Process	Human	Intestine	A8	1.1e-16
SC5D	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
SC5D	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
SC5D	GOBP_Steroid_Biosynthetic_Process	Human	Intestine	A8	7.2e-18
SC5D	GOBP_Steroid_Metabolic_Process	Human	Intestine	A8	7.9e-16
SC5D	GOBP_Sterol_Metabolic_Process	Human	Intestine	A8	1.2e-07
SC5D	GOBP_Alcohol_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
SC5D	GOBP_Sterol_Metabolic_Process	Human	Pancreas	PDAC-B-st1	1.9e-05
SC5D	GOBP_Regulation_Of_Cholesterol_Biosynthetic_Process	Human	Pancreas	PDAC-A-st3	4.0e-06
SC5D	GOBP_Alcohol_Biosynthetic_Process	Human	Uterus	rep_26	2.6e-06
SC5D	GOBP_Alcohol_Metabolic_Process	Human	Uterus	rep_26	1.3e-06
SC5D	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Uterus	rep_26	3.2e-10
SC5D	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Uterus	rep_26	2.5e-08
SC5D	GOBP_Regulation_Of_Lipid_Metabolic_Process	Human	Uterus	rep_26	3.4e-09
SC5D	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Human	Uterus	rep_26	2.0e-14
SC5D	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
SC5D	GOBP_Steroid_Biosynthetic_Process	Human	Uterus	rep_26	4.3e-06
SC5D	GOBP_Steroid_Metabolic_Process	Human	Uterus	rep_26	1.0e-07
SC5D	GOBP_Sterol_Biosynthetic_Process	Human	Uterus	rep_26	1.0e-07
SC5D	GOBP_Sterol_Metabolic_Process	Human	Uterus	rep_26	4.7e-08
SC5D	GOBP_Regulation_Of_Lipid_Biosynthetic_Process	Human	Uterus	rep_29	1.7e-06
SC5D	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Breast	rep_1	7.3e-16
SC5D	GOBP_Regulation_Of_Lipid_Biosynthetic_Process	Human	Breast	rep_1	8.8e-14
SC5D	GOBP_Regulation_Of_Lipid_Metabolic_Process	Human	Breast	rep_1	5.0e-06
SC5D	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Human	Breast	rep_1	2.1e-94
SC5D	GOBP_Lipid_Biosynthetic_Process	Human	Breast	rep_5	7.0e-04
SC5D	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
SC5D	GOBP_Regulation_Of_Steroid_Metabolic_Process	Human	Breast	rep_5	6.4e-07
SC5D	GOBP_Alcohol_Biosynthetic_Process	Human	Breast	rep_6	9.0e-04
SC5D	GOBP_Alcohol_Metabolic_Process	Human	Breast	rep_6	1.3e-04
SC5D	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Breast	rep_6	2.5e-06
SC5D	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
SC5D	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
SC5D	GOBP_Steroid_Biosynthetic_Process	Human	Breast	rep_6	2.7e-04
SC5D	GOBP_Steroid_Metabolic_Process	Human	Breast	rep_6	6.6e-05
SC5D	GOBP_Sterol_Metabolic_Process	Human	Breast	rep_6	5.3e-04
SC5D	GOBP_Regulation_Of_Steroid_Metabolic_Process	Human	Skin	P2_rep2	6.9e-13

Top

SC5D function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

SC5D function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for SC5D envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for SC5D

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SC5D

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
SC5D	C1846421	Lathosterolosis	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
SC5D	C3714756	Intellectual Disability	2	CTD_human;GENOMICS_ENGLAND
SC5D	C0020796	Profound Mental Retardation	1	CTD_human
SC5D	C0023895	Liver diseases	1	CTD_human
SC5D	C0025363	Mental Retardation, Psychosocial	1	CTD_human
SC5D	C0086543	Cataract	1	GENOMICS_ENGLAND
SC5D	C0086565	Liver Dysfunction	1	CTD_human
SC5D	C0917816	Mental deficiency	1	CTD_human