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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CFB (spascer ID:629)

Gene summary for CFB

Gene summary

Gene information
	Species	Human
	Gene symbol	CFB
	Gene ID	629
	Gene name	complement factor B
	Synonyms	AHUS4\|ARMD14\|BF\|BFD\|CFAB\|CFBD\|FB\|FBI12\|GBG\|H2-Bf\|PBF2
	Cytomap	6p21.33
	Type of gene	protein-coding
	Description	complement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor B
	Modification date	20220515
	UniProtAcc	P00751

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for CFB

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CFB	Human	Prostate	rep_3	29925878	8.22e-06
CFB	Human	Liver	rep_1	34792289	1.48e-13
CFB	Human	Intestine	rep_colon1	34417225	1.95e-15
CFB	Human	Intestine	rep_colon2	34417225	1.48e-15
CFB	Human	Intestine	rep_colon3	34417225	1.01e-15
CFB	Human	Intestine	rep_colon4	34417225	1.14e-15
CFB	Human	Liver	rep_liver1	34417225	1.89e-15
CFB	Human	Liver	rep_liver2	34417225	1.27e-15
CFB	Human	Liver	rep_liver3	34417225	3.51e-15
CFB	Human	Liver	rep_liver4	34417225	7.71e-16
CFB	Human	Pancreas	PDAC-B-st1	31932730	2.21e-13
CFB	Human	Breast	1160920F	34493872	1.48e-15
CFB	Human	Breast	CID4290	34493872	1.64e-08
CFB	Human	Breast	CID4535	34493872	6.37e-15
CFB	Human	Skin	mel2_rep1	30154148	6.87e-06
CFB	Human	Lung	rep_1	35355018	4.99e-15
CFB	Human	Lung	rep_2	35355018	1.09e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_1_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID4535_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E

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Spatial pattern pathway has CFB envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CFB	GOBP_Activation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
CFB	GOBP_Complement_Activation	Human	Brain	rep_1	8.1e-16
CFB	GOBP_Complement_Activation_Alternative_Pathway	Human	Brain	rep_1	1.1e-26
CFB	GOBP_Humoral_Immune_Response	Human	Brain	rep_1	8.1e-16
CFB	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
CFB	GOBP_Positive_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
CFB	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
CFB	GOBP_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
CFB	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
CFB	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
CFB	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
CFB	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
CFB	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
CFB	GOBP_Activation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
CFB	GOBP_Complement_Activation	Human	Liver	rep_1	2.3e-76
CFB	GOBP_Complement_Activation_Alternative_Pathway	Human	Liver	rep_1	1.3e-69
CFB	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
CFB	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
CFB	GOBP_Humoral_Immune_Response	Human	Liver	rep_1	9.0e-62
CFB	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
CFB	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
CFB	GOBP_Positive_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
CFB	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
CFB	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
CFB	GOBP_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
CFB	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
CFB	GOBP_Activation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
CFB	GOBP_Complement_Activation	Human	Intestine	rep_colon4	7.2e-20
CFB	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
CFB	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
CFB	GOBP_Humoral_Immune_Response	Human	Intestine	rep_colon4	1.3e-27
CFB	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
CFB	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
CFB	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
CFB	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
CFB	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
CFB	GOBP_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
CFB	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
CFB	GOBP_Complement_Activation_Alternative_Pathway	Human	Intestine	rep_liver3	9.5e-14
CFB	GOBP_Activation_Of_Immune_Response	Human	Intestine	A3	5.7e-11
CFB	GOBP_Complement_Activation	Human	Intestine	A3	5.9e-07
CFB	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
CFB	GOBP_Humoral_Immune_Response	Human	Intestine	A3	1.4e-08
CFB	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
CFB	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	A3	2.4e-07
CFB	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	A3	6.8e-15
CFB	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
CFB	GOBP_Regulation_Of_Immune_Response	Human	Intestine	A3	1.6e-12
CFB	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
CFB	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
CFB	GOBP_Regulation_Of_Complement_Activation	Human	Intestine	A8	1.6e-14
CFB	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Intestine	A8	2.6e-12
CFB	GOBP_Regulation_Of_Immune_Effector_Process	Human	Intestine	A8	2.4e-12
CFB	GOBP_Activation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
CFB	GOBP_Complement_Activation	Human	Uterus	rep_4	6.1e-31
CFB	GOBP_Complement_Activation_Alternative_Pathway	Human	Uterus	rep_4	1.0e-36
CFB	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
CFB	GOBP_Humoral_Immune_Response	Human	Uterus	rep_4	2.0e-31
CFB	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
CFB	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
CFB	GOBP_Positive_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
CFB	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
CFB	GOBP_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
CFB	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
CFB	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
CFB	GOBP_Regulation_Of_Immune_Effector_Process	Human	Uterus	rep_28	5.1e-07
CFB	GOBP_Regulation_Of_Complement_Activation	Human	Uterus	rep_29	1.3e-08
CFB	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Uterus	rep_29	3.7e-10
CFB	GOBP_Complement_Activation_Alternative_Pathway	Human	Breast	rep_1	3.0e-236
CFB	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
CFB	GOBP_Regulation_Of_Humoral_Immune_Response	Human	Breast	rep_1	2.0e-67
CFB	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
CFB	GOBP_Regulation_Of_Complement_Activation	Human	Skin	P10_rep1	7.7e-16
CFB	GOBP_Complement_Activation_Alternative_Pathway	Human	Skin	P10_rep2	1.3e-09
CFB	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
CFB	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
CFB	GOBP_Humoral_Immune_Response	Human	Lung	rep_1	1.7e-10
CFB	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	3.1e-08
CFB	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07

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CFB function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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CFB function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for CFB envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for CFB

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CFB

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source