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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: RRM1 (spascer ID:6240)

Gene summary for RRM1

Gene summary

Gene information
	Species	Human
	Gene symbol	RRM1
	Gene ID	6240
	Gene name	ribonucleotide reductase catalytic subunit M1
	Synonyms	R1\|RIR1\|RR1
	Cytomap	11p15.4
	Type of gene	protein-coding
	Description	ribonucleoside-diphosphate reductase large subunitribonucleoside-diphosphate reductase subunit M1ribonucleotide reductase M1 polypeptideribonucleotide reductase, R1 subunit
	Modification date	20220513
	UniProtAcc	P23921

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
RRM1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	21873635	Function
RRM1	GO:0005524	ATP binding	21873635	Function
RRM1	GO:0005971	ribonucleoside-diphosphate reductase complex	21873635	Component
RRM1	GO:0009263	deoxyribonucleotide biosynthetic process	21873635	Process

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Spatial pattern events for RRM1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
RRM1	Human	Bladder	rep_2	34385456	1.67e-06
RRM1	Human	Intestine	rep_colon1	34417225	3.42e-15
RRM1	Human	Liver	rep_liver1	34417225	1.08e-15
RRM1	Human	Liver	rep_liver2	34417225	6.98e-16
RRM1	Human	Intestine	A2	33406409	2.32e-11
RRM1	Human	Uterus	rep_3	34857954	1.66e-15
RRM1	Human	Breast	CID44971	34493872	1.41e-09
RRM1	Human	Lung	rep_1	35355018	6.10e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Intestine_A2_H&E
Uterus_rep_3_H&E
Breast_CID44971_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has RRM1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
RRM1	GOBP_Central_Nervous_System_Development	Human	Brain	rep_1	2.8e-23
RRM1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Bladder	rep_4	3.0e-06
RRM1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Bladder	rep_4	1.4e-09
RRM1	GOBP_Organophosphate_Biosynthetic_Process	Human	Bladder	rep_4	3.2e-09
RRM1	GOBP_Central_Nervous_System_Development	Human	Liver	rep_1	1.0e-70
RRM1	GOBP_Camera_Type_Eye_Development	Human	Intestine	A3	9.7e-08
RRM1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Intestine	A3	1.8e-09
RRM1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Intestine	A3	3.3e-11
RRM1	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
RRM1	GOBP_Central_Nervous_System_Development	Human	Intestine	A3	7.1e-11
RRM1	GOBP_Development_Of_Primary_Sexual_Characteristics	Human	Intestine	A3	5.0e-13
RRM1	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Intestine	A3	2.7e-15
RRM1	GOBP_Dna_Replication	Human	Intestine	A3	2.5e-08
RRM1	GOBP_Head_Development	Human	Intestine	A3	3.8e-09
RRM1	GOBP_Male_Sex_Differentiation	Human	Intestine	A3	2.6e-16
RRM1	GOBP_Mitotic_Cell_Cycle	Human	Intestine	A3	1.8e-12
RRM1	GOBP_Neural_Precursor_Cell_Proliferation	Human	Intestine	A3	8.9e-11
RRM1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Human	Intestine	A3	9.9e-10
RRM1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Intestine	A3	1.6e-10
RRM1	GOBP_Organophosphate_Biosynthetic_Process	Human	Intestine	A3	2.2e-07
RRM1	GOBP_Organophosphate_Metabolic_Process	Human	Intestine	A3	4.4e-13
RRM1	GOBP_Pyrimidine_Containing_Compound_Metabolic_Process	Human	Intestine	A3	9.4e-08
RRM1	GOBP_Reproduction	Human	Intestine	A3	4.6e-19
RRM1	GOBP_Reproductive_System_Development	Human	Intestine	A3	2.9e-14
RRM1	GOBP_Response_To_Abiotic_Stimulus	Human	Intestine	A3	5.3e-18
RRM1	GOBP_Response_To_Radiation	Human	Intestine	A3	6.3e-07
RRM1	GOBP_Retina_Development_In_Camera_Type_Eye	Human	Intestine	A3	1.1e-07
RRM1	GOBP_Sensory_Organ_Development	Human	Intestine	A3	1.3e-12
RRM1	GOBP_Sensory_System_Development	Human	Intestine	A3	8.7e-09
RRM1	GOBP_Sex_Differentiation	Human	Intestine	A3	6.1e-18
RRM1	GOBP_Cell_Proliferation_In_Forebrain	Human	Intestine	A8	8.2e-13
RRM1	GOBP_Nucleobase_Containing_Small_Molecule_Interconversion	Human	Intestine	A8	5.4e-12
RRM1	GOBP_Protein_Heterooligomerization	Human	Intestine	A8	1.4e-09
RRM1	GOBP_Protein_Heterotetramerization	Human	Intestine	A8	4.9e-12
RRM1	GOBP_Protein_Tetramerization	Human	Intestine	A8	2.0e-12
RRM1	GOBP_Response_To_Ionizing_Radiation	Human	Intestine	A8	4.7e-09
RRM1	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
RRM1	GOBP_Camera_Type_Eye_Development	Human	Pancreas	PDAC-B-st1	5.7e-05
RRM1	GOBP_Forebrain_Development	Human	Pancreas	PDAC-B-st1	5.2e-05
RRM1	GOBP_Head_Development	Human	Pancreas	PDAC-B-st1	2.0e-05
RRM1	GOBP_Protein_Complex_Oligomerization	Human	Pancreas	PDAC-B-st1	8.7e-05
RRM1	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Uterus	rep_1	1.6e-06
RRM1	GOBP_Cell_Proliferation_In_Forebrain	Human	Uterus	rep_2	1.3e-06
RRM1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Uterus	rep_26	3.5e-11
RRM1	GOBP_Dna_Replication	Human	Uterus	rep_26	1.5e-09
RRM1	GOBP_Neural_Precursor_Cell_Proliferation	Human	Uterus	rep_26	1.9e-08
RRM1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Human	Uterus	rep_26	2.4e-06
RRM1	GOBP_Nucleobase_Metabolic_Process	Human	Uterus	rep_26	4.3e-08
RRM1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Uterus	rep_26	3.4e-15
RRM1	GOBP_Organophosphate_Biosynthetic_Process	Human	Uterus	rep_26	8.0e-07
RRM1	GOBP_Pyrimidine_Containing_Compound_Metabolic_Process	Human	Uterus	rep_26	2.8e-08
RRM1	GOBP_Deoxyribonucleotide_Biosynthetic_Process	Human	Uterus	rep_29	6.2e-07
RRM1	GOBP_Protein_Tetramerization	Human	Uterus	rep_29	4.3e-07
RRM1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Human	Breast	rep_1	2.1e-06
RRM1	GOBP_Cell_Proliferation_In_Forebrain	Human	Breast	rep_1	2.3e-18
RRM1	GOBP_Central_Nervous_System_Development	Human	Breast	rep_1	5.1e-04
RRM1	GOBP_Head_Development	Human	Breast	rep_1	1.0e-09
RRM1	GOBP_Organophosphate_Biosynthetic_Process	Human	Breast	rep_1	1.4e-07
RRM1	GOBP_Protein_Complex_Oligomerization	Human	Breast	rep_1	1.7e-04
RRM1	GOBP_Protein_Heterooligomerization	Human	Breast	rep_1	5.0e-27
RRM1	GOBP_Response_To_Abiotic_Stimulus	Human	Breast	rep_1	2.6e-19
RRM1	GOBP_Development_Of_Primary_Sexual_Characteristics	Human	Breast	rep_5	3.0e-05
RRM1	GOBP_Developmental_Process_Involved_In_Reproduction	Human	Breast	rep_5	1.5e-12
RRM1	GOBP_Forebrain_Development	Human	Breast	rep_5	8.0e-08
RRM1	GOBP_Pyrimidine_Nucleobase_Metabolic_Process	Human	Breast	rep_5	1.8e-05
RRM1	GOBP_Reproduction	Human	Breast	rep_5	8.1e-06
RRM1	GOBP_Reproductive_System_Development	Human	Breast	rep_5	3.6e-15
RRM1	GOBP_Response_To_Radiation	Human	Breast	rep_5	3.8e-06
RRM1	GOBP_Camera_Type_Eye_Development	Human	Breast	rep_6	9.2e-06
RRM1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Human	Breast	rep_6	6.1e-07
RRM1	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
RRM1	GOBP_Deoxyribonucleotide_Biosynthetic_Process	Human	Breast	rep_6	8.6e-08
RRM1	GOBP_Dna_Replication	Human	Breast	rep_6	3.5e-07
RRM1	GOBP_Male_Sex_Differentiation	Human	Breast	rep_6	2.0e-08
RRM1	GOBP_Mitotic_Cell_Cycle	Human	Breast	rep_6	3.2e-09
RRM1	GOBP_Neural_Precursor_Cell_Proliferation	Human	Breast	rep_6	2.0e-05
RRM1	GOBP_Nucleobase_Containing_Small_Molecule_Interconversion	Human	Breast	rep_6	1.4e-09
RRM1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	1.7e-10
RRM1	GOBP_Nucleobase_Metabolic_Process	Human	Breast	rep_6	2.2e-05
RRM1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Human	Breast	rep_6	6.2e-07
RRM1	GOBP_Organophosphate_Metabolic_Process	Human	Breast	rep_6	1.0e-12
RRM1	GOBP_Pyrimidine_Containing_Compound_Metabolic_Process	Human	Breast	rep_6	6.5e-06
RRM1	GOBP_Response_To_Ionizing_Radiation	Human	Breast	rep_6	1.1e-11
RRM1	GOBP_Sensory_Organ_Development	Human	Breast	rep_6	1.3e-09
RRM1	GOBP_Sensory_System_Development	Human	Breast	rep_6	8.2e-06
RRM1	GOBP_Sex_Differentiation	Human	Breast	rep_6	4.2e-05
RRM1	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
RRM1	GOBP_Cell_Proliferation_In_Forebrain	Human	Skin	P2_rep2	6.9e-11
RRM1	GOBP_Nucleobase_Containing_Small_Molecule_Interconversion	Human	Skin	P5_rep1	9.8e-15

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RRM1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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RRM1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for RRM1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for RRM1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
RRM1	P23921	DB00441	Gemcitabine	Ribonucleoside-diphosphate reductase large subunit	SmallMoleculeDrug	approved
RRM1	P23921	DB01005	Hydroxyurea	Ribonucleoside-diphosphate reductase large subunit	SmallMoleculeDrug	approved
RRM1	P23921	DB01073	Fludarabine	Ribonucleoside-diphosphate reductase large subunit	SmallMoleculeDrug	approved
RRM1	P23921	DB00242	Cladribine	Ribonucleoside-diphosphate reductase large subunit	SmallMoleculeDrug	approved\|investigational
RRM1	P23921	DB00631	Clofarabine	Ribonucleoside-diphosphate reductase large subunit	SmallMoleculeDrug	approved\|investigational

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Related Diseases for RRM1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
RRM1	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
RRM1	C0011999	Diastematomyelia	1	CTD_human
RRM1	C0027794	Neural Tube Defects	1	CTD_human
RRM1	C0027806	Neurenteric Cyst	1	CTD_human
RRM1	C0080218	Tethered Cord Syndrome	1	CTD_human
RRM1	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human
RRM1	C0152234	Iniencephaly	1	CTD_human
RRM1	C0152426	Craniorachischisis	1	CTD_human
RRM1	C0206686	Adrenocortical carcinoma	1	CTD_human
RRM1	C0235874	Disease Exacerbation	1	CTD_human
RRM1	C0266453	Exencephaly	1	CTD_human
RRM1	C0344479	Spinal Cord Myelodysplasia	1	CTD_human
RRM1	C0702169	Acrania	1	CTD_human
RRM1	C2239176	Liver carcinoma	1	CTD_human