Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: RPS21 (spascer ID:6227)

Gene summary for RPS21

Gene summary

Gene information
	Species	Human
	Gene symbol	RPS21
	Gene ID	6227
	Gene name	ribosomal protein S21
	Synonyms	HLDF\|S21
	Cytomap	20q13.33
	Type of gene	protein-coding
	Description	40S ribosomal protein S218.2 kDa differentiation factorhuman leukemia differentiation factorsmall ribosomal subunit protein eS21
	Modification date	20220513
	UniProtAcc	P63220

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
RPS21	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635	Process
RPS21	GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635	Process
RPS21	GO:0003735	structural constituent of ribosome	21873635	Function
RPS21	GO:0022627	cytosolic small ribosomal subunit	21873635	Component

Top

Spatial pattern events for RPS21

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
RPS21	Human	Brain	rep_1	33558695	9.45e-15
RPS21	Human	Brain	rep_2	33558695	5.54e-11
RPS21	Human	Brain	rep_3	33558695	4.93e-15
RPS21	Human	Brain	rep_4	33558695	1.00e-14
RPS21	Human	Brain	rep_5	33558695	2.15e-06
RPS21	Human	Brain	rep_6	33558695	3.39e-14
RPS21	Human	Brain	rep_7	33558695	2.01e-13
RPS21	Human	Brain	rep_8	33558695	8.25e-12
RPS21	Human	Brain	rep_9	33558695	3.01e-15
RPS21	Human	Brain	rep_10	33558695	3.23e-15
RPS21	Human	Brain	rep_11	33558695	6.00e-15
RPS21	Human	Brain	rep_12	33558695	3.65e-15
RPS21	Human	Bladder	rep_2	34385456	6.29e-15
RPS21	Human	Bladder	rep_3	34385456	2.72e-14
RPS21	Human	Liver	rep_1	34792289	2.38e-14
RPS21	Human	Intestine	rep_colon1	34417225	1.95e-15
RPS21	Human	Intestine	rep_colon2	34417225	8.12e-16
RPS21	Human	Intestine	rep_colon3	34417225	1.01e-15
RPS21	Human	Intestine	rep_colon4	34417225	1.14e-15
RPS21	Human	Liver	rep_liver1	34417225	1.89e-15
RPS21	Human	Liver	rep_liver2	34417225	1.27e-15
RPS21	Human	Liver	rep_liver3	34417225	3.51e-15
RPS21	Human	Liver	rep_liver4	34417225	1.39e-15
RPS21	Human	Intestine	A1	33406409	2.09e-15
RPS21	Human	Intestine	A2	33406409	2.47e-15
RPS21	Human	Intestine	A3	33406409	3.28e-14
RPS21	Human	Intestine	A4	33406409	7.35e-15
RPS21	Human	Intestine	A6	33406409	3.71e-08
RPS21	Human	Intestine	A7	33406409	9.86e-11
RPS21	Human	Intestine	A8	33406409	1.37e-13
RPS21	Human	Uterus	rep_1	34857954	8.93e-15
RPS21	Human	Uterus	rep_2	34857954	2.55e-15
RPS21	Human	Uterus	rep_3	34857954	1.66e-15
RPS21	Human	Uterus	rep_4	34857954	1.82e-15
RPS21	Human	Breast	1142243F	34493872	2.30e-15
RPS21	Human	Breast	1160920F	34493872	1.48e-15
RPS21	Human	Breast	CID4290	34493872	4.68e-15
RPS21	Human	Breast	CID4465	34493872	4.85e-15
RPS21	Human	Breast	CID44971	34493872	1.76e-15
RPS21	Human	Breast	CID4535	34493872	6.37e-15
RPS21	Human	Heart	w6_s2	31835037	2.34e-05
RPS21	Human	Heart	w6_s3	31835037	1.73e-05
RPS21	Human	Heart	w6_s4	31835037	5.53e-06
RPS21	Human	Heart	w6_s6	31835037	2.30e-04
RPS21	Human	Skin	P5_rep1	32946785	6.08e-07
RPS21	Human	Skin	P5_rep2	32946785	9.66e-15
RPS21	Human	Skin	P10_rep1	32946785	4.46e-07
RPS21	Human	Skin	mel1_rep1	30154148	4.83e-09
RPS21	Human	Skin	mel1_rep2	30154148	1.29e-07
RPS21	Human	Skin	mel2_rep1	30154148	1.83e-13
RPS21	Human	Skin	mel2_rep2	30154148	2.56e-14
RPS21	Human	Lung	rep_1	35355018	7.55e-15
RPS21	Human	Lung	rep_2	35355018	2.37e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Brain_rep_7_H&E
Brain_rep_8_H&E
Brain_rep_9_H&E
Brain_rep_10_H&E
Brain_rep_11_H&E
Brain_rep_12_H&E
Bladder_rep_2_H&E
Bladder_rep_3_H&E
Liver_rep_1_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver3_H&E
Liver_rep_liver4_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Intestine_A3_H&E
Intestine_A4_H&E
Intestine_A6_H&E
Intestine_A7_H&E
Intestine_A8_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Uterus_rep_4_H&E
Breast_1142243F_H&E
Breast_1160920F_H&E
Breast_CID4290_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E
Breast_CID4535_H&E
Skin_P5_rep1_H&E
Skin_P5_rep2_H&E
Skin_P10_rep1_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E

Top

Spatial pattern pathway has RPS21 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
RPS21	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
RPS21	GOBP_Cytoplasmic_Translation	Human	Intestine	A1	5.4e-14
RPS21	GOBP_Endonucleolytic_Cleavage_In_Its1_To_Separate_Ssu_Rrna_From_5_8s_Rrna_And_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Intestine	A1	7.3e-10
RPS21	GOBP_Endonucleolytic_Cleavage_Involved_In_Rrna_Processing	Human	Intestine	A1	1.7e-13
RPS21	GOBP_Maturation_Of_Ssu_Rrna	Human	Intestine	A1	1.5e-17
RPS21	GOBP_Maturation_Of_Ssu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Intestine	A1	1.8e-31
RPS21	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
RPS21	GOBP_Ribosomal_Small_Subunit_Biogenesis	Human	Intestine	A1	3.0e-16
RPS21	GOBP_Ribosome_Biogenesis	Human	Intestine	A1	6.5e-08
RPS21	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Intestine	A3	3.5e-14
RPS21	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
RPS21	GOBP_Establishment_Of_Protein_Localization	Human	Intestine	A3	5.0e-10
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Intestine	A3	1.0e-07
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Human	Intestine	A3	7.6e-11
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Human	Intestine	A3	3.8e-08
RPS21	GOBP_Intracellular_Protein_Transport	Human	Intestine	A3	4.8e-12
RPS21	GOBP_Intracellular_Transport	Human	Intestine	A3	7.6e-15
RPS21	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
RPS21	GOBP_Mrna_Metabolic_Process	Human	Intestine	A3	7.7e-20
RPS21	GOBP_Ncrna_Metabolic_Process	Human	Intestine	A3	8.6e-07
RPS21	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Intestine	A3	2.8e-10
RPS21	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	1.9e-08
RPS21	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
RPS21	GOBP_Protein_Localization_To_Organelle	Human	Intestine	A3	1.5e-12
RPS21	GOBP_Protein_Targeting	Human	Intestine	A3	6.5e-09
RPS21	GOBP_Protein_Targeting_To_Membrane	Human	Intestine	A3	3.5e-07
RPS21	GOBP_Rna_3_End_Processing	Human	Intestine	A3	9.2e-07
RPS21	GOBP_Rna_Catabolic_Process	Human	Intestine	A3	5.9e-24
RPS21	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	2.3e-07
RPS21	GOBP_Rna_Processing	Human	Intestine	A3	3.9e-09
RPS21	GOBP_Translational_Initiation	Human	Intestine	A3	5.0e-09
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Intestine	A8	4.7e-09
RPS21	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Intestine	A8	1.0e-11
RPS21	GOBP_Viral_Gene_Expression	Human	Intestine	A8	1.8e-23
RPS21	GOBP_Cotranslational_Protein_Targeting_To_Membrane	Human	Pancreas	PDAC-B-st1	6.0e-05
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Pancreas	PDAC-B-st1	9.1e-06
RPS21	GOBP_Mrna_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	9.4e-06
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Pancreas	PDAC-B-st1	6.1e-05
RPS21	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Pancreas	PDAC-B-st1	9.9e-06
RPS21	GOBP_Protein_Targeting	Human	Pancreas	PDAC-B-st1	9.4e-05
RPS21	GOBP_Protein_Targeting_To_Membrane	Human	Pancreas	PDAC-B-st1	8.3e-06
RPS21	GOBP_Rna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	8.0e-05
RPS21	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Pancreas	PDAC-B-st1	3.3e-05
RPS21	GOBP_Endonucleolytic_Cleavage_In_Its1_To_Separate_Ssu_Rrna_From_5_8s_Rrna_And_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Pancreas	PDAC-A-st2	3.6e-05
RPS21	GOBP_Endonucleolytic_Cleavage_Involved_In_Rrna_Processing	Human	Uterus	rep_1	1.9e-06
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Uterus	rep_1	4.6e-06
RPS21	GOBP_Ncrna_Processing	Human	Uterus	rep_1	4.5e-06
RPS21	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Uterus	rep_1	1.2e-09
RPS21	GOBP_Ribosomal_Small_Subunit_Biogenesis	Human	Uterus	rep_1	3.0e-06
RPS21	GOBP_Ribosome_Biogenesis	Human	Uterus	rep_1	9.5e-06
RPS21	GOBP_Rrna_Metabolic_Process	Human	Uterus	rep_1	2.4e-07
RPS21	GOBP_Maturation_Of_5_8s_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Uterus	rep_25	1.3e-10
RPS21	GOBP_Rrna_3_End_Processing	Human	Uterus	rep_25	7.7e-06
RPS21	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Uterus	rep_26	5.9e-08
RPS21	GOBP_Endonucleolytic_Cleavage_In_Its1_To_Separate_Ssu_Rrna_From_5_8s_Rrna_And_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Uterus	rep_26	2.2e-10
RPS21	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
RPS21	GOBP_Maturation_Of_5_8s_Rrna	Human	Uterus	rep_26	9.4e-14
RPS21	GOBP_Maturation_Of_Ssu_Rrna	Human	Uterus	rep_26	1.3e-06
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Uterus	rep_26	8.1e-10
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Uterus	rep_26	3.0e-08
RPS21	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
RPS21	GOBP_Rna_Catabolic_Process	Human	Uterus	rep_26	2.7e-07
RPS21	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Endonucleolytic	Human	Uterus	rep_26	3.6e-07
RPS21	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Breast	rep_1	5.4e-30
RPS21	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
RPS21	GOBP_Establishment_Of_Protein_Localization	Human	Breast	rep_1	7.2e-05
RPS21	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
RPS21	GOBP_Viral_Gene_Expression	Human	Breast	rep_5	4.2e-10
RPS21	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
RPS21	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
RPS21	GOBP_Cleavage_Involved_In_Rrna_Processing	Human	Breast	rep_6	3.4e-05
RPS21	GOBP_Cytoplasmic_Translation	Human	Breast	rep_6	2.4e-06
RPS21	GOBP_Endonucleolytic_Cleavage_In_Its1_To_Separate_Ssu_Rrna_From_5_8s_Rrna_And_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Breast	rep_6	2.9e-04
RPS21	GOBP_Endonucleolytic_Cleavage_Involved_In_Rrna_Processing	Human	Breast	rep_6	3.0e-05
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Breast	rep_6	1.7e-07
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Membrane	Human	Breast	rep_6	3.8e-07
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Organelle	Human	Breast	rep_6	8.5e-11
RPS21	GOBP_Intracellular_Protein_Transport	Human	Breast	rep_6	6.4e-12
RPS21	GOBP_Intracellular_Transport	Human	Breast	rep_6	1.3e-08
RPS21	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
RPS21	GOBP_Maturation_Of_5_8s_Rrna	Human	Breast	rep_6	2.3e-06
RPS21	GOBP_Maturation_Of_5_8s_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Breast	rep_6	7.9e-05
RPS21	GOBP_Maturation_Of_Ssu_Rrna	Human	Breast	rep_6	6.4e-06
RPS21	GOBP_Mrna_Metabolic_Process	Human	Breast	rep_6	3.0e-08
RPS21	GOBP_Ncrna_3_End_Processing	Human	Breast	rep_6	3.6e-04
RPS21	GOBP_Ncrna_Metabolic_Process	Human	Breast	rep_6	1.9e-04
RPS21	GOBP_Ncrna_Processing	Human	Breast	rep_6	1.3e-05
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Breast	rep_6	8.1e-07
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Breast	rep_6	4.8e-06
RPS21	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.6e-05
RPS21	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
RPS21	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
RPS21	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
RPS21	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
RPS21	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Breast	rep_6	2.0e-07
RPS21	GOBP_Protein_Localization_To_Organelle	Human	Breast	rep_6	1.1e-07
RPS21	GOBP_Protein_Targeting	Human	Breast	rep_6	5.5e-10
RPS21	GOBP_Protein_Targeting_To_Membrane	Human	Breast	rep_6	8.6e-10
RPS21	GOBP_Ribonucleoprotein_Complex_Biogenesis	Human	Breast	rep_6	1.3e-07
RPS21	GOBP_Ribosomal_Small_Subunit_Biogenesis	Human	Breast	rep_6	2.8e-07
RPS21	GOBP_Ribosome_Biogenesis	Human	Breast	rep_6	2.0e-06
RPS21	GOBP_Rna_3_End_Processing	Human	Breast	rep_6	1.8e-05
RPS21	GOBP_Rna_Catabolic_Process	Human	Breast	rep_6	3.9e-06
RPS21	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.8e-06
RPS21	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Endonucleolytic	Human	Breast	rep_6	3.0e-08
RPS21	GOBP_Rna_Processing	Human	Breast	rep_6	3.5e-06
RPS21	GOBP_Rrna_3_End_Processing	Human	Breast	rep_6	3.4e-05
RPS21	GOBP_Rrna_Metabolic_Process	Human	Breast	rep_6	4.0e-06
RPS21	GOBP_Translational_Initiation	Human	Breast	rep_6	2.2e-09
RPS21	GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum	Human	Skin	P5_rep1	9.0e-10
RPS21	GOBP_Protein_Localization_To_Endoplasmic_Reticulum	Human	Skin	P5_rep1	1.5e-10
RPS21	GOBP_Mrna_Metabolic_Process	Human	Skin	P5_rep3	1.8e-08
RPS21	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay	Human	Skin	P5_rep3	1.2e-10
RPS21	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Skin	P9_rep2	4.7e-10
RPS21	GOBP_Endonucleolytic_Cleavage_In_Its1_To_Separate_Ssu_Rrna_From_5_8s_Rrna_And_Lsu_Rrna_From_Tricistronic_Rrna_Transcript_Ssu_Rrna_5_8s_Rrna_Lsu_Rrna	Human	Skin	P10_rep1	2.2e-11
RPS21	GOBP_Ncrna_3_End_Processing	Human	Skin	P10_rep1	1.1e-09
RPS21	GOBP_Cleavage_Involved_In_Rrna_Processing	Human	Skin	P10_rep2	1.9e-08
RPS21	GOBP_Rrna_3_End_Processing	Human	Skin	P10_rep2	6.0e-26
RPS21	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Human	Lung	rep_1	2.4e-10
RPS21	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Lung	rep_1	8.8e-08

Top

RPS21 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

RPS21 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for RPS21 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for RPS21

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RPS21

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source