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Spatial pattern gene: RPS18 (spascer ID:6222) |
Gene summary for RPS18 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | RPS18 | Gene ID | 6222 |
| Gene name | ribosomal protein S18 |
| Synonyms | D6S218E|HKE3|KE-3|KE3|S18 |
| Cytomap | 6p21.32 |
| Type of gene | protein-coding |
| Description | 40S ribosomal protein S18rhabdomyosarcoma antigen MU-RMS-40.21small ribosomal subunit protein uS13 |
| Modification date | 20220513 |
| UniProtAcc | P62269 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| RPS18 | GO:0005829 | cytosol | 21873635 | Component |
| RPS18 | GO:0015935 | small ribosomal subunit | 21873635 | Component |
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Spatial pattern events for RPS18 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| RPS18 | Human | Brain | rep_1 | 33558695 | 5.52e-15 |
| RPS18 | Human | Brain | rep_2 | 33558695 | 5.54e-15 |
| RPS18 | Human | Brain | rep_3 | 33558695 | 4.93e-15 |
| RPS18 | Human | Brain | rep_4 | 33558695 | 6.08e-15 |
| RPS18 | Human | Brain | rep_5 | 33558695 | 6.93e-12 |
| RPS18 | Human | Brain | rep_7 | 33558695 | 1.03e-14 |
| RPS18 | Human | Brain | rep_8 | 33558695 | 1.14e-14 |
| RPS18 | Human | Brain | rep_9 | 33558695 | 3.01e-15 |
| RPS18 | Human | Brain | rep_10 | 33558695 | 3.23e-15 |
| RPS18 | Human | Brain | rep_11 | 33558695 | 3.36e-15 |
| RPS18 | Human | Brain | rep_12 | 33558695 | 3.65e-15 |
| RPS18 | Human | Bladder | rep_2 | 34385456 | 6.29e-15 |
| RPS18 | Human | Bladder | rep_3 | 34385456 | 2.40e-14 |
| RPS18 | Human | Bladder | rep_4 | 34385456 | 3.17e-08 |
| RPS18 | Human | Liver | rep_1 | 34792289 | 6.44e-12 |
| RPS18 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| RPS18 | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| RPS18 | Human | Intestine | rep_colon3 | 34417225 | 1.01e-15 |
| RPS18 | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| RPS18 | Human | Liver | rep_liver1 | 34417225 | 1.89e-15 |
| RPS18 | Human | Liver | rep_liver2 | 34417225 | 1.27e-15 |
| RPS18 | Human | Liver | rep_liver3 | 34417225 | 3.51e-15 |
| RPS18 | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| RPS18 | Human | Intestine | A1 | 33406409 | 2.09e-15 |
| RPS18 | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| RPS18 | Human | Intestine | A3 | 33406409 | 1.38e-14 |
| RPS18 | Human | Intestine | A4 | 33406409 | 7.35e-15 |
| RPS18 | Human | Intestine | A6 | 33406409 | 4.59e-12 |
| RPS18 | Human | Intestine | A7 | 33406409 | 1.45e-13 |
| RPS18 | Human | Intestine | A8 | 33406409 | 2.47e-14 |
| RPS18 | Human | Intestine | A9 | 33406409 | 1.19e-11 |
| RPS18 | Human | Uterus | rep_1 | 34857954 | 8.93e-15 |
| RPS18 | Human | Uterus | rep_2 | 34857954 | 2.55e-15 |
| RPS18 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| RPS18 | Human | Uterus | rep_4 | 34857954 | 3.39e-15 |
| RPS18 | Human | Breast | 1142243F | 34493872 | 2.30e-15 |
| RPS18 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| RPS18 | Human | Breast | CID4290 | 34493872 | 4.68e-15 |
| RPS18 | Human | Breast | CID4465 | 34493872 | 4.85e-15 |
| RPS18 | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| RPS18 | Human | Breast | CID4535 | 34493872 | 6.37e-15 |
| RPS18 | Human | Heart | w6_s2 | 31835037 | 1.03e-04 |
| RPS18 | Human | Heart | w6_s3 | 31835037 | 5.57e-06 |
| RPS18 | Human | Heart | w6_s4 | 31835037 | 7.95e-09 |
| RPS18 | Human | Heart | w6_s6 | 31835037 | 8.95e-03 |
| RPS18 | Human | Skin | P2_rep1 | 32946785 | 5.41e-15 |
| RPS18 | Human | Skin | P2_rep2 | 32946785 | 5.48e-15 |
| RPS18 | Human | Skin | P2_rep3 | 32946785 | 9.21e-15 |
| RPS18 | Human | Skin | P5_rep1 | 32946785 | 1.32e-14 |
| RPS18 | Human | Skin | P5_rep2 | 32946785 | 9.66e-15 |
| RPS18 | Human | Skin | P5_rep3 | 32946785 | 7.99e-15 |
| RPS18 | Human | Skin | P10_rep1 | 32946785 | 3.31e-15 |
| RPS18 | Human | Skin | P10_rep2 | 32946785 | 5.10e-15 |
| RPS18 | Human | Skin | P10_rep3 | 32946785 | 6.61e-15 |
| RPS18 | Human | Skin | mel2_rep1 | 30154148 | 3.28e-14 |
| RPS18 | Human | Skin | mel2_rep2 | 30154148 | 2.56e-14 |
| RPS18 | Human | Lung | rep_1 | 35355018 | 4.99e-15 |
| RPS18 | Human | Lung | rep_2 | 35355018 | 1.83e-14 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_7_H&E  |  |
Brain_rep_8_H&E  |  |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Brain_rep_11_H&E  |  |
Brain_rep_12_H&E  |  |
Bladder_rep_2_H&E  |  |
Bladder_rep_3_H&E  |  |
Bladder_rep_4_H&E  |  |
Liver_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver3_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Intestine_A3_H&E  |  |
Intestine_A4_H&E  |  |
Intestine_A6_H&E  |  |
Intestine_A7_H&E  |  |
Intestine_A8_H&E  |  |
Intestine_A9_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Uterus_rep_4_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID4290_H&E  |  |
Breast_CID4465_H&E  |  |
Breast_CID44971_H&E  |  |
Breast_CID4535_H&E  |  |
Skin_P2_rep3_H&E  |  |
Skin_P5_rep1_H&E  |  |
Skin_P5_rep2_H&E  |  |
Skin_P5_rep3_H&E  |  |
Skin_P10_rep1_H&E  |  |
Skin_P10_rep2_H&E  |  |
Skin_P10_rep3_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
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Spatial pattern pathway has RPS18 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| RPS18 | GOBP_Amide_Biosynthetic_Process | Human | Intestine | A1 | 6.4e-07 |
| RPS18 | GOBP_Peptide_Biosynthetic_Process | Human | Intestine | A1 | 4.6e-10 |
| RPS18 | GOBP_Biological_Process_Involved_In_Symbiotic_Interaction | Human | Intestine | A3 | 3.5e-14 |
| RPS18 | GOBP_Cellular_Macromolecule_Localization | Human | Intestine | A3 | 1.7e-09 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization | Human | Intestine | A3 | 5.0e-10 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum | Human | Intestine | A3 | 1.0e-07 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Membrane | Human | Intestine | A3 | 7.6e-11 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Human | Intestine | A3 | 3.8e-08 |
| RPS18 | GOBP_Intracellular_Protein_Transport | Human | Intestine | A3 | 4.8e-12 |
| RPS18 | GOBP_Intracellular_Transport | Human | Intestine | A3 | 7.6e-15 |
| RPS18 | GOBP_Macromolecule_Catabolic_Process | Human | Intestine | A3 | 2.2e-16 |
| RPS18 | GOBP_Mrna_Metabolic_Process | Human | Intestine | A3 | 7.7e-20 |
| RPS18 | GOBP_Negative_Regulation_Of_Gene_Expression | Human | Intestine | A3 | 2.8e-18 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process | Human | Intestine | A3 | 2.8e-10 |
| RPS18 | GOBP_Organic_Cyclic_Compound_Catabolic_Process | Human | Intestine | A3 | 5.9e-24 |
| RPS18 | GOBP_Protein_Localization_To_Organelle | Human | Intestine | A3 | 1.5e-12 |
| RPS18 | GOBP_Protein_Targeting | Human | Intestine | A3 | 6.5e-09 |
| RPS18 | GOBP_Protein_Targeting_To_Membrane | Human | Intestine | A3 | 3.5e-07 |
| RPS18 | GOBP_Rna_Catabolic_Process | Human | Intestine | A3 | 5.9e-24 |
| RPS18 | GOBP_Translational_Initiation | Human | Intestine | A3 | 5.0e-09 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay | Human | Intestine | A8 | 4.7e-09 |
| RPS18 | GOBP_Protein_Localization_To_Endoplasmic_Reticulum | Human | Intestine | A8 | 1.0e-11 |
| RPS18 | GOBP_Viral_Gene_Expression | Human | Intestine | A8 | 1.8e-23 |
| RPS18 | GOBP_Cotranslational_Protein_Targeting_To_Membrane | Human | Pancreas | PDAC-B-st1 | 6.0e-05 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum | Human | Pancreas | PDAC-B-st1 | 9.1e-06 |
| RPS18 | GOBP_Mrna_Metabolic_Process | Human | Pancreas | PDAC-B-st1 | 2.6e-05 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process | Human | Pancreas | PDAC-B-st1 | 9.4e-06 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay | Human | Pancreas | PDAC-B-st1 | 6.1e-05 |
| RPS18 | GOBP_Protein_Localization_To_Endoplasmic_Reticulum | Human | Pancreas | PDAC-B-st1 | 9.9e-06 |
| RPS18 | GOBP_Protein_Targeting | Human | Pancreas | PDAC-B-st1 | 9.4e-05 |
| RPS18 | GOBP_Protein_Targeting_To_Membrane | Human | Pancreas | PDAC-B-st1 | 8.3e-06 |
| RPS18 | GOBP_Rna_Catabolic_Process | Human | Pancreas | PDAC-B-st1 | 8.0e-05 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum | Human | Uterus | rep_1 | 4.6e-06 |
| RPS18 | GOBP_Protein_Localization_To_Endoplasmic_Reticulum | Human | Uterus | rep_1 | 1.2e-09 |
| RPS18 | GOBP_Biological_Process_Involved_In_Symbiotic_Interaction | Human | Uterus | rep_26 | 5.9e-08 |
| RPS18 | GOBP_Macromolecule_Catabolic_Process | Human | Uterus | rep_26 | 5.0e-08 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process | Human | Uterus | rep_26 | 8.1e-10 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay | Human | Uterus | rep_26 | 3.0e-08 |
| RPS18 | GOBP_Organic_Cyclic_Compound_Catabolic_Process | Human | Uterus | rep_26 | 2.6e-06 |
| RPS18 | GOBP_Rna_Catabolic_Process | Human | Uterus | rep_26 | 2.7e-07 |
| RPS18 | GOBP_Biological_Process_Involved_In_Symbiotic_Interaction | Human | Breast | rep_1 | 5.4e-30 |
| RPS18 | GOBP_Cellular_Macromolecule_Localization | Human | Breast | rep_1 | 3.7e-09 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization | Human | Breast | rep_1 | 7.2e-05 |
| RPS18 | GOBP_Negative_Regulation_Of_Gene_Expression | Human | Breast | rep_5 | 5.3e-06 |
| RPS18 | GOBP_Viral_Gene_Expression | Human | Breast | rep_5 | 4.2e-10 |
| RPS18 | GOBP_Amide_Biosynthetic_Process | Human | Breast | rep_6 | 8.7e-05 |
| RPS18 | GOBP_Cellular_Amide_Metabolic_Process | Human | Breast | rep_6 | 5.6e-05 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum | Human | Breast | rep_6 | 1.7e-07 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Membrane | Human | Breast | rep_6 | 3.8e-07 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Organelle | Human | Breast | rep_6 | 8.5e-11 |
| RPS18 | GOBP_Intracellular_Protein_Transport | Human | Breast | rep_6 | 6.4e-12 |
| RPS18 | GOBP_Intracellular_Transport | Human | Breast | rep_6 | 1.3e-08 |
| RPS18 | GOBP_Macromolecule_Catabolic_Process | Human | Breast | rep_6 | 1.3e-05 |
| RPS18 | GOBP_Mrna_Metabolic_Process | Human | Breast | rep_6 | 3.0e-08 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process | Human | Breast | rep_6 | 8.1e-07 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay | Human | Breast | rep_6 | 4.8e-06 |
| RPS18 | GOBP_Organic_Cyclic_Compound_Catabolic_Process | Human | Breast | rep_6 | 7.7e-08 |
| RPS18 | GOBP_Organonitrogen_Compound_Biosynthetic_Process | Human | Breast | rep_6 | 1.2e-09 |
| RPS18 | GOBP_Peptide_Biosynthetic_Process | Human | Breast | rep_6 | 1.6e-05 |
| RPS18 | GOBP_Peptide_Metabolic_Process | Human | Breast | rep_6 | 8.7e-05 |
| RPS18 | GOBP_Protein_Localization_To_Endoplasmic_Reticulum | Human | Breast | rep_6 | 2.0e-07 |
| RPS18 | GOBP_Protein_Localization_To_Organelle | Human | Breast | rep_6 | 1.1e-07 |
| RPS18 | GOBP_Protein_Targeting | Human | Breast | rep_6 | 5.5e-10 |
| RPS18 | GOBP_Protein_Targeting_To_Membrane | Human | Breast | rep_6 | 8.6e-10 |
| RPS18 | GOBP_Rna_Catabolic_Process | Human | Breast | rep_6 | 3.9e-06 |
| RPS18 | GOBP_Translational_Initiation | Human | Breast | rep_6 | 2.2e-09 |
| RPS18 | GOBP_Establishment_Of_Protein_Localization_To_Endoplasmic_Reticulum | Human | Skin | P5_rep1 | 9.0e-10 |
| RPS18 | GOBP_Protein_Localization_To_Endoplasmic_Reticulum | Human | Skin | P5_rep1 | 1.5e-10 |
| RPS18 | GOBP_Mrna_Metabolic_Process | Human | Skin | P5_rep3 | 1.8e-08 |
| RPS18 | GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Nonsense_Mediated_Decay | Human | Skin | P5_rep3 | 1.2e-10 |
| RPS18 | GOBP_Biological_Process_Involved_In_Symbiotic_Interaction | Human | Skin | P9_rep2 | 4.7e-10 |
| RPS18 | GOBP_Biological_Process_Involved_In_Symbiotic_Interaction | Human | Lung | rep_1 | 2.4e-10 |
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RPS18 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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RPS18 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for RPS18 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for RPS18 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RPS18 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
