|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
|
Spatial pattern gene: MRTFA (spascer ID:57591) |
Gene summary for MRTFA |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | MRTFA | Gene ID | 57591 |
| Gene name | myocardin related transcription factor A |
| Synonyms | BSAC|MAL|MKL|MKL1|MRTF-A |
| Cytomap | 22q13.1-q13.2 |
| Type of gene | protein-coding |
| Description | myocardin-related transcription factor AMKL/myocardin-like protein 1alternative protein MKL1basic, SAP and coiled-coil domainmegakaryoblastic leukemia (translocation) 1megakaryoblastic leukemia 1 proteinmegakaryocytic acute leukemia protein |
| Modification date | 20220513 |
| UniProtAcc | Q969V6 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| MRTFA | GO:0003713 | transcription coactivator activity | 21873635 | Function |
| MRTFA | GO:0005634 | nucleus | 21873635 | Component |
| MRTFA | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21873635 | Process |
| MRTFA | GO:0051145 | smooth muscle cell differentiation | 21873635 | Process |
Top |
Spatial pattern events for MRTFA |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| MRTFA | Human | Intestine | rep_colon2 | 34417225 | 2.85e-15 |
| MRTFA | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| MRTFA | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Intestine_rep_colon2_H&E  |  |
Liver_rep_liver1_H&E  |  |
Breast_1160920F_H&E  |  |
Top |
Spatial pattern pathway has MRTFA envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| MRTFA | GOBP_Cell_Migration | Human | Brain | rep_1 | 3.1e-68 |
| MRTFA | GOBP_Locomotion | Human | Brain | rep_1 | 3.1e-68 |
| MRTFA | GOBP_Response_To_Wounding | Human | Brain | rep_1 | 6.9e-125 |
| MRTFA | GOBP_Wound_Healing | Human | Brain | rep_1 | 6.9e-125 |
| MRTFA | GOBP_Wound_Healing | Human | Bladder | rep_2 | 4.6e-05 |
| MRTFA | GOBP_Cell_Migration | Human | Liver | rep_1 | 1.9e-71 |
| MRTFA | GOBP_Locomotion | Human | Liver | rep_1 | 1.9e-71 |
| MRTFA | GOBP_Response_To_Wounding | Human | Liver | rep_1 | 3.1e-62 |
| MRTFA | GOBP_Wound_Healing | Human | Liver | rep_1 | 3.1e-62 |
| MRTFA | GOBP_Response_To_Wounding | Human | Intestine | rep_colon2 | 3.9e-21 |
| MRTFA | GOBP_Wound_Healing | Human | Intestine | rep_colon2 | 3.9e-21 |
| MRTFA | GOBP_Cell_Migration | Human | Intestine | rep_liver2 | 1.0e-64 |
| MRTFA | GOBP_Locomotion | Human | Intestine | rep_liver2 | 1.0e-64 |
| MRTFA | GOBP_Cell_Migration | Human | Intestine | A3 | 1.6e-10 |
| MRTFA | GOBP_Locomotion | Human | Intestine | A3 | 1.9e-08 |
| MRTFA | GOBP_Morphogenesis_Of_An_Epithelial_Sheet | Human | Intestine | A3 | 1.9e-07 |
| MRTFA | GOBP_Morphogenesis_Of_An_Epithelium | Human | Intestine | A3 | 1.5e-09 |
| MRTFA | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Intestine | A3 | 5.1e-13 |
| MRTFA | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Intestine | A3 | 9.4e-13 |
| MRTFA | GOBP_Smooth_Muscle_Cell_Differentiation | Human | Intestine | A3 | 7.5e-10 |
| MRTFA | GOBP_Epiboly | Human | Uterus | rep_29 | 1.2e-06 |
| MRTFA | GOBP_Actin_Filament_Based_Process | Human | Breast | rep_1 | 1.8e-86 |
| MRTFA | GOBP_Cell_Migration | Human | Breast | rep_1 | 1.5e-45 |
| MRTFA | GOBP_Cytoskeleton_Organization | Human | Breast | rep_1 | 1.3e-22 |
| MRTFA | GOBP_Epiboly | Human | Breast | rep_1 | 3.5e-63 |
| MRTFA | GOBP_Epithelium_Development | Human | Breast | rep_1 | 2.0e-22 |
| MRTFA | GOBP_Locomotion | Human | Breast | rep_1 | 4.5e-54 |
| MRTFA | GOBP_Morphogenesis_Of_An_Epithelial_Sheet | Human | Breast | rep_1 | 2.5e-43 |
| MRTFA | GOBP_Morphogenesis_Of_An_Epithelium | Human | Breast | rep_1 | 2.3e-18 |
| MRTFA | GOBP_Muscle_Cell_Differentiation | Human | Breast | rep_1 | 2.9e-50 |
| MRTFA | GOBP_Muscle_Structure_Development | Human | Breast | rep_1 | 6.8e-61 |
| MRTFA | GOBP_Response_To_Wounding | Human | Breast | rep_1 | 4.7e-165 |
| MRTFA | GOBP_Smooth_Muscle_Cell_Differentiation | Human | Breast | rep_1 | 1.7e-14 |
| MRTFA | GOBP_Tissue_Morphogenesis | Human | Breast | rep_1 | 1.4e-30 |
| MRTFA | GOBP_Wound_Healing | Human | Breast | rep_1 | 5.3e-150 |
| MRTFA | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Human | Breast | rep_5 | 8.0e-09 |
| MRTFA | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Human | Breast | rep_6 | 4.2e-06 |
| MRTFA | GOBP_Tissue_Morphogenesis | Human | Skin | P2_rep1 | 2.9e-08 |
| MRTFA | GOBP_Cytoskeleton_Organization | Human | Skin | P9_rep3 | 3.1e-12 |
| MRTFA | GOBP_Epithelium_Development | Human | Skin | P9_rep3 | 4.2e-08 |
| MRTFA | GOBP_Smooth_Muscle_Cell_Differentiation | Human | Lung | rep_1 | 2.6e-09 |
Top |
MRTFA function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
Top |
MRTFA function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
Top |
Transcription factor for MRTFA envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
Top |
Related Drugs for MRTFA |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for MRTFA |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
