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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: KLHL42 (spascer ID:57542)

Gene summary for KLHL42

Gene summary

Gene information
	Species	Human
	Gene symbol	KLHL42
	Gene ID	57542
	Gene name	kelch like family member 42
	Synonyms	Ctb9\|KLHDC5
	Cytomap	12p11.22
	Type of gene	protein-coding
	Description	kelch-like protein 42cullin-3-binding protein 9kelch domain containing 5kelch domain-containing protein 5
	Modification date	20220513
	UniProtAcc	Q9P2K6

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
KLHL42	GO:0000209	protein polyubiquitination	21873635	Process
KLHL42	GO:0032886	regulation of microtubule-based process	21873635	Process
KLHL42	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635	Process

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Spatial pattern events for KLHL42

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
KLHL42	Human	Intestine	rep_colon2	34417225	8.12e-16
KLHL42	Human	Intestine	rep_colon3	34417225	1.82e-15
KLHL42	Human	Liver	rep_liver2	34417225	6.98e-16
KLHL42	Human	Uterus	rep_2	34857954	3.31e-13
KLHL42	Human	Uterus	rep_3	34857954	2.48e-10
KLHL42	Human	Breast	1160920F	34493872	1.48e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon2_H&E
Intestine_rep_colon3_H&E
Liver_rep_liver2_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Breast_1160920F_H&E

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Spatial pattern pathway has KLHL42 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
KLHL42	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
KLHL42	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
KLHL42	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
KLHL42	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
KLHL42	GOBP_Cell_Division	Human	Intestine	A3	2.7e-10
KLHL42	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
KLHL42	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
KLHL42	GOBP_Microtubule_Based_Process	Human	Intestine	A3	3.4e-11
KLHL42	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Intestine	A3	7.7e-11
KLHL42	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
KLHL42	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Intestine	A3	4.6e-13
KLHL42	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
KLHL42	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
KLHL42	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
KLHL42	GOBP_Protein_Polyubiquitination	Human	Intestine	A3	2.1e-10
KLHL42	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
KLHL42	GOBP_Regulation_Of_Microtubule_Based_Process	Human	Intestine	A3	1.2e-12
KLHL42	GOBP_Cell_Division	Human	Pancreas	PDAC-B-st1	5.8e-05
KLHL42	GOBP_Protein_Polyubiquitination	Human	Uterus	rep_25	1.1e-17
KLHL42	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
KLHL42	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
KLHL42	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	1.1e-07
KLHL42	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
KLHL42	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Uterus	rep_26	2.2e-12
KLHL42	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
KLHL42	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
KLHL42	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
KLHL42	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
KLHL42	GOBP_Post_Translational_Protein_Modification	Human	Breast	rep_5	9.8e-05
KLHL42	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
KLHL42	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
KLHL42	GOBP_Cell_Division	Human	Breast	rep_6	8.2e-07
KLHL42	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
KLHL42	GOBP_Microtubule_Based_Process	Human	Breast	rep_6	1.8e-04
KLHL42	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Breast	rep_6	2.2e-09
KLHL42	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
KLHL42	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Breast	rep_6	6.8e-09
KLHL42	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
KLHL42	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
KLHL42	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
KLHL42	GOBP_Protein_Polyubiquitination	Human	Breast	rep_6	6.3e-04
KLHL42	GOBP_Regulation_Of_Microtubule_Based_Process	Human	Breast	rep_6	2.1e-05

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KLHL42 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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KLHL42 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for KLHL42 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for KLHL42

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for KLHL42

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source