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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: MIB1 (spascer ID:57534)

Gene summary for MIB1

Gene summary

Gene information
	Species	Human
	Gene symbol	MIB1
	Gene ID	57534
	Gene name	MIB E3 ubiquitin protein ligase 1
	Synonyms	DIP-1\|DIP1\|LVNC7\|MIB\|ZZANK2\|ZZZ6
	Cytomap	18q11.2
	Type of gene	protein-coding
	Description	E3 ubiquitin-protein ligase MIB1DAPK-interacting protein 1RING-type E3 ubiquitin transferase MIB1mindbomb E3 ubiquitin protein ligase 1ubiquitin ligase mind bombzinc finger ZZ type with ankyrin repeat domain protein 2
	Modification date	20220513
	UniProtAcc	Q86YT6

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
MIB1	GO:0004842	ubiquitin-protein transferase activity	21873635	Function
MIB1	GO:0005737	cytoplasm	21873635	Component
MIB1	GO:0006897	endocytosis	21873635	Process
MIB1	GO:0007219	Notch signaling pathway	21873635	Process
MIB1	GO:0016567	protein ubiquitination	21873635	Process

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Spatial pattern events for MIB1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
MIB1	Human	Liver	rep_liver2	34417225	9.92e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E

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Spatial pattern pathway has MIB1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
MIB1	GOBP_Endocytosis	Human	Brain	rep_1	7.4e-34
MIB1	GOBP_Neurogenesis	Human	Brain	rep_1	7.4e-34
MIB1	GOBP_Neuron_Differentiation	Human	Brain	rep_1	7.4e-34
MIB1	GOBP_Positive_Regulation_Of_Transport	Human	Brain	rep_1	3.1e-16
MIB1	GOBP_Regulation_Of_Transport	Human	Brain	rep_1	3.1e-16
MIB1	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Brain	rep_1	3.1e-16
MIB1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Brain	rep_4	4.1e-17
MIB1	GOBP_Circulatory_System_Development	Human	Brain	rep_4	4.1e-17
MIB1	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
MIB1	GOBP_Tube_Development	Human	Brain	rep_4	4.1e-17
MIB1	GOBP_Tube_Morphogenesis	Human	Brain	rep_4	4.1e-17
MIB1	GOBP_Vasculature_Development	Human	Brain	rep_4	4.1e-17
MIB1	GOBP_Circulatory_System_Development	Human	Bladder	rep_2	1.0e-16
MIB1	GOBP_Vasculature_Development	Human	Bladder	rep_2	2.0e-14
MIB1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Liver	rep_1	6.0e-76
MIB1	GOBP_Circulatory_System_Development	Human	Liver	rep_1	6.0e-76
MIB1	GOBP_Endocytosis	Human	Liver	rep_1	1.5e-73
MIB1	GOBP_Neurogenesis	Human	Liver	rep_1	1.0e-70
MIB1	GOBP_Neuron_Differentiation	Human	Liver	rep_1	1.5e-73
MIB1	GOBP_Positive_Regulation_Of_Transport	Human	Liver	rep_1	9.4e-68
MIB1	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
MIB1	GOBP_Regulation_Of_Transport	Human	Liver	rep_1	9.4e-68
MIB1	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Liver	rep_1	3.2e-72
MIB1	GOBP_Tube_Development	Human	Liver	rep_1	6.0e-76
MIB1	GOBP_Tube_Morphogenesis	Human	Liver	rep_1	6.0e-76
MIB1	GOBP_Vasculature_Development	Human	Liver	rep_1	6.0e-76
MIB1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
MIB1	GOBP_Circulatory_System_Development	Human	Intestine	rep_colon4	1.9e-09
MIB1	GOBP_Positive_Regulation_Of_Transport	Human	Intestine	rep_colon4	1.0e-26
MIB1	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
MIB1	GOBP_Regulation_Of_Transport	Human	Intestine	rep_colon4	1.0e-26
MIB1	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Intestine	rep_colon4	7.4e-22
MIB1	GOBP_Tube_Development	Human	Intestine	rep_colon4	1.9e-09
MIB1	GOBP_Tube_Morphogenesis	Human	Intestine	rep_colon4	1.9e-09
MIB1	GOBP_Vasculature_Development	Human	Intestine	rep_colon4	1.9e-09
MIB1	GOBP_Anterior_Posterior_Pattern_Specification	Human	Intestine	A3	4.1e-08
MIB1	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
MIB1	GOBP_Circulatory_System_Development	Human	Intestine	A3	5.9e-08
MIB1	GOBP_Embryo_Development	Human	Intestine	A3	2.4e-07
MIB1	GOBP_Embryonic_Morphogenesis	Human	Intestine	A3	1.3e-11
MIB1	GOBP_Embryonic_Organ_Development	Human	Intestine	A3	1.4e-10
MIB1	GOBP_Embryonic_Organ_Morphogenesis	Human	Intestine	A3	1.5e-09
MIB1	GOBP_Endocytosis	Human	Intestine	A3	9.3e-10
MIB1	GOBP_Epithelial_Tube_Morphogenesis	Human	Intestine	A3	5.0e-10
MIB1	GOBP_Heart_Development	Human	Intestine	A3	3.2e-07
MIB1	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
MIB1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Intestine	A3	7.7e-11
MIB1	GOBP_Morphogenesis_Of_An_Epithelium	Human	Intestine	A3	1.5e-09
MIB1	GOBP_Negative_Regulation_Of_Cell_Differentiation	Human	Intestine	A3	1.3e-14
MIB1	GOBP_Negative_Regulation_Of_Developmental_Process	Human	Intestine	A3	2.6e-09
MIB1	GOBP_Neurogenesis	Human	Intestine	A3	6.4e-14
MIB1	GOBP_Neuron_Differentiation	Human	Intestine	A3	1.4e-11
MIB1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
MIB1	GOBP_Pattern_Specification_Process	Human	Intestine	A3	4.9e-07
MIB1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	3.8e-12
MIB1	GOBP_Positive_Regulation_Of_Transport	Human	Intestine	A3	9.5e-08
MIB1	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
MIB1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
MIB1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
MIB1	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
MIB1	GOBP_Regionalization	Human	Intestine	A3	1.1e-10
MIB1	GOBP_Regulation_Of_Cell_Differentiation	Human	Intestine	A3	1.7e-10
MIB1	GOBP_Regulation_Of_Transport	Human	Intestine	A3	4.4e-11
MIB1	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Intestine	A3	1.3e-11
MIB1	GOBP_Tube_Development	Human	Intestine	A3	7.6e-08
MIB1	GOBP_Tube_Morphogenesis	Human	Intestine	A3	9.4e-07
MIB1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Intestine	A8	3.3e-08
MIB1	GOBP_Epithelial_Tube_Formation	Human	Intestine	A8	7.2e-07
MIB1	GOBP_Neural_Tube_Development	Human	Intestine	A8	5.7e-09
MIB1	GOBP_Neural_Tube_Formation	Human	Intestine	A8	1.4e-15
MIB1	GOBP_Notch_Signaling_Pathway	Human	Intestine	A8	5.3e-07
MIB1	GOBP_Positive_Regulation_Of_Endocytosis	Human	Intestine	A8	1.3e-07
MIB1	GOBP_Regulation_Of_Endocytosis	Human	Intestine	A8	9.3e-16
MIB1	GOBP_Vasculature_Development	Human	Intestine	A8	9.3e-07
MIB1	GOBP_Embryonic_Heart_Tube_Development	Human	Pancreas	PDAC-B-st1	1.9e-05
MIB1	GOBP_Embryonic_Heart_Tube_Morphogenesis	Human	Pancreas	PDAC-B-st1	9.1e-05
MIB1	GOBP_Segmentation	Human	Pancreas	PDAC-A-st2	6.8e-05
MIB1	GOBP_Positive_Regulation_Of_Endocytosis	Human	Uterus	rep_1	2.7e-10
MIB1	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
MIB1	GOBP_Embryonic_Heart_Tube_Morphogenesis	Human	Uterus	rep_26	7.2e-06
MIB1	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
MIB1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	1.1e-07
MIB1	GOBP_Negative_Regulation_Of_Neuron_Differentiation	Human	Uterus	rep_26	2.5e-07
MIB1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
MIB1	GOBP_Pattern_Specification_Process	Human	Uterus	rep_26	3.6e-06
MIB1	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
MIB1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
MIB1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
MIB1	GOBP_Regionalization	Human	Uterus	rep_26	2.0e-06
MIB1	GOBP_Regulation_Of_Endocytosis	Human	Uterus	rep_26	1.9e-11
MIB1	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Uterus	rep_26	3.4e-11
MIB1	GOBP_Regulation_Of_Cell_Differentiation	Human	Uterus	rep_29	2.8e-06
MIB1	GOBP_Regulation_Of_Neuron_Differentiation	Human	Uterus	rep_29	6.5e-07
MIB1	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Human	Breast	rep_1	1.9e-98
MIB1	GOBP_Animal_Organ_Morphogenesis	Human	Breast	rep_1	5.4e-25
MIB1	GOBP_Circulatory_System_Development	Human	Breast	rep_1	3.8e-70
MIB1	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Human	Breast	rep_1	7.7e-07
MIB1	GOBP_Epithelium_Development	Human	Breast	rep_1	2.0e-22
MIB1	GOBP_Heart_Development	Human	Breast	rep_1	4.1e-08
MIB1	GOBP_Heart_Morphogenesis	Human	Breast	rep_1	3.8e-85
MIB1	GOBP_In_Utero_Embryonic_Development	Human	Breast	rep_1	1.5e-18
MIB1	GOBP_Morphogenesis_Of_An_Epithelium	Human	Breast	rep_1	2.3e-18
MIB1	GOBP_Negative_Regulation_Of_Cell_Differentiation	Human	Breast	rep_1	1.0e-15
MIB1	GOBP_Negative_Regulation_Of_Developmental_Process	Human	Breast	rep_1	1.5e-04
MIB1	GOBP_Negative_Regulation_Of_Neuron_Differentiation	Human	Breast	rep_1	3.9e-19
MIB1	GOBP_Neurogenesis	Human	Breast	rep_1	8.0e-11
MIB1	GOBP_Neuron_Differentiation	Human	Breast	rep_1	1.1e-16
MIB1	GOBP_Notch_Signaling_Pathway	Human	Breast	rep_1	2.7e-27
MIB1	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	1.3e-17
MIB1	GOBP_Positive_Regulation_Of_Endocytosis	Human	Breast	rep_1	1.4e-38
MIB1	GOBP_Positive_Regulation_Of_Transport	Human	Breast	rep_1	3.1e-10
MIB1	GOBP_Regulation_Of_Cell_Differentiation	Human	Breast	rep_1	2.5e-42
MIB1	GOBP_Regulation_Of_Endocytosis	Human	Breast	rep_1	2.2e-86
MIB1	GOBP_Regulation_Of_Neuron_Differentiation	Human	Breast	rep_1	4.2e-29
MIB1	GOBP_Regulation_Of_Transport	Human	Breast	rep_1	3.7e-17
MIB1	GOBP_Regulation_Of_Vesicle_Mediated_Transport	Human	Breast	rep_1	4.9e-41
MIB1	GOBP_Tissue_Morphogenesis	Human	Breast	rep_1	1.4e-30
MIB1	GOBP_Tube_Development	Human	Breast	rep_1	3.8e-32
MIB1	GOBP_Tube_Morphogenesis	Human	Breast	rep_1	2.7e-34
MIB1	GOBP_Vasculature_Development	Human	Breast	rep_1	9.1e-95
MIB1	GOBP_Anterior_Posterior_Pattern_Specification	Human	Breast	rep_5	1.5e-08
MIB1	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
MIB1	GOBP_Embryo_Development	Human	Breast	rep_5	5.5e-08
MIB1	GOBP_Embryonic_Heart_Tube_Morphogenesis	Human	Breast	rep_5	3.1e-04
MIB1	GOBP_Embryonic_Morphogenesis	Human	Breast	rep_5	2.0e-06
MIB1	GOBP_Embryonic_Organ_Development	Human	Breast	rep_5	3.3e-05
MIB1	GOBP_Pattern_Specification_Process	Human	Breast	rep_5	3.7e-14
MIB1	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
MIB1	GOBP_Regionalization	Human	Breast	rep_5	5.8e-16
MIB1	GOBP_Segmentation	Human	Breast	rep_5	4.0e-04
MIB1	GOBP_Somitogenesis	Human	Breast	rep_5	1.7e-05
MIB1	GOBP_Specification_Of_Symmetry	Human	Breast	rep_5	4.1e-08
MIB1	GOBP_Embryonic_Heart_Tube_Development	Human	Breast	rep_6	1.2e-09
MIB1	GOBP_Embryonic_Organ_Morphogenesis	Human	Breast	rep_6	1.8e-08
MIB1	GOBP_Epithelial_Tube_Formation	Human	Breast	rep_6	2.4e-04
MIB1	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
MIB1	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Breast	rep_6	2.2e-09
MIB1	GOBP_Morphogenesis_Of_Embryonic_Epithelium	Human	Breast	rep_6	7.8e-04
MIB1	GOBP_Neural_Tube_Development	Human	Breast	rep_6	5.3e-04
MIB1	GOBP_Neural_Tube_Formation	Human	Breast	rep_6	1.8e-05
MIB1	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
MIB1	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
MIB1	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
MIB1	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
MIB1	GOBP_Tube_Formation	Human	Breast	rep_6	8.9e-04
MIB1	GOBP_Tissue_Morphogenesis	Human	Skin	P2_rep1	2.9e-08
MIB1	GOBP_Epithelium_Development	Human	Skin	P9_rep3	4.2e-08
MIB1	GOBP_Positive_Regulation_Of_Endocytosis	Human	Skin	P10_rep1	7.5e-22
MIB1	GOBP_Negative_Regulation_Of_Neuron_Differentiation	Human	Skin	P10_rep2	4.1e-22
MIB1	GOBP_Negative_Regulation_Of_Cell_Differentiation	Human	Lung	rep_1	5.3e-09
MIB1	GOBP_Negative_Regulation_Of_Developmental_Process	Human	Lung	rep_1	9.2e-08

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MIB1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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MIB1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for MIB1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for MIB1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for MIB1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
MIB1	C0022333	Jacksonian Seizure	1	CTD_human
MIB1	C0036572	Seizures	1	CTD_human
MIB1	C0149958	Complex partial seizures	1	CTD_human
MIB1	C0234533	Generalized seizures	1	CTD_human
MIB1	C0234535	Clonic Seizures	1	CTD_human
MIB1	C0270824	Visual seizure	1	CTD_human
MIB1	C0270844	Tonic Seizures	1	CTD_human
MIB1	C0270846	Epileptic drop attack	1	CTD_human
MIB1	C0422850	Seizures, Somatosensory	1	CTD_human
MIB1	C0422852	Seizures, Auditory	1	CTD_human
MIB1	C0422853	Olfactory seizure	1	CTD_human
MIB1	C0422854	Gustatory seizure	1	CTD_human
MIB1	C0422855	Vertiginous seizure	1	CTD_human
MIB1	C0494475	Tonic - clonic seizures	1	CTD_human
MIB1	C0751056	Non-epileptic convulsion	1	CTD_human
MIB1	C0751110	Single Seizure	1	CTD_human
MIB1	C0751123	Atonic Absence Seizures	1	CTD_human
MIB1	C0751494	Convulsive Seizures	1	CTD_human
MIB1	C0751495	Seizures, Focal	1	CTD_human
MIB1	C0751496	Seizures, Sensory	1	CTD_human
MIB1	C1960469	Left ventricular noncompaction	1	ORPHANET
MIB1	C3495874	Nonepileptic Seizures	1	CTD_human
MIB1	C3554496	LEFT VENTRICULAR NONCOMPACTION 7	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
MIB1	C4048158	Convulsions	1	CTD_human
MIB1	C4316903	Absence Seizures	1	CTD_human
MIB1	C4317109	Epileptic Seizures	1	CTD_human
MIB1	C4317123	Myoclonic Seizures	1	CTD_human
MIB1	C4505436	Generalized Absence Seizures	1	CTD_human