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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: NLN (spascer ID:57486)

Gene summary for NLN

Gene summary

Gene information
	Species	Human
	Gene symbol	NLN
	Gene ID	57486
	Gene name	neurolysin
	Synonyms	AGTBP\|EP24.16\|MEP\|MOP
	Cytomap	5q12.3
	Type of gene	protein-coding
	Description	neurolysin, mitochondrialangiotensin binding proteinendopeptidase 24.16microsomal endopeptidasemitochondrial oligopeptidase Mneurolysin (metallopeptidase M3 family)neurotensin endopeptidase
	Modification date	20220513
	UniProtAcc	Q9BYT8

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
NLN	GO:0004222	metalloendopeptidase activity	21873635	Function
NLN	GO:0005758	mitochondrial intermembrane space	21873635	Component
NLN	GO:0006508	proteolysis	21873635	Process
NLN	GO:0006518	peptide metabolic process	21873635	Process

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Spatial pattern events for NLN

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
NLN	Human	Liver	rep_liver2	34417225	6.98e-16
NLN	Human	Uterus	rep_3	34857954	1.75e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E
Uterus_rep_3_H&E

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Spatial pattern pathway has NLN envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
NLN	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
NLN	GOBP_Regulation_Of_Muscle_Cell_Differentiation	Human	Brain	st	3.1e-32
NLN	GOBP_Regulation_Of_Striated_Muscle_Cell_Differentiation	Human	Brain	st	7.8e-37
NLN	GOBP_Skeletal_Muscle_Fiber_Differentiation	Human	Brain	st	2.4e-14
NLN	GOBP_Skeletal_Muscle_Fiber_Differentiation	Human	Bladder	rep_2	1.1e-12
NLN	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
NLN	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
NLN	GOBP_Carbohydrate_Biosynthetic_Process	Human	Intestine	A3	5.4e-08
NLN	GOBP_Carbohydrate_Metabolic_Process	Human	Intestine	A3	4.1e-08
NLN	GOBP_Cellular_Carbohydrate_Metabolic_Process	Human	Intestine	A3	3.9e-07
NLN	GOBP_Myotube_Differentiation	Human	Intestine	A3	2.0e-10
NLN	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
NLN	GOBP_Regulation_Of_Cell_Differentiation	Human	Intestine	A3	1.7e-10
NLN	GOBP_Glucose_Metabolic_Process	Human	Intestine	A8	1.5e-21
NLN	GOBP_Monosaccharide_Biosynthetic_Process	Human	Intestine	A8	4.0e-16
NLN	GOBP_Monosaccharide_Metabolic_Process	Human	Intestine	A8	4.7e-24
NLN	GOBP_Regulation_Of_Carbohydrate_Biosynthetic_Process	Human	Intestine	A8	3.0e-15
NLN	GOBP_Regulation_Of_Carbohydrate_Metabolic_Process	Human	Intestine	A8	1.8e-17
NLN	GOBP_Regulation_Of_Cellular_Carbohydrate_Metabolic_Process	Human	Intestine	A8	1.7e-16
NLN	GOBP_Regulation_Of_Gluconeogenesis	Human	Intestine	A8	1.3e-11
NLN	GOBP_Regulation_Of_Glucose_Metabolic_Process	Human	Intestine	A8	4.7e-21
NLN	GOBP_Regulation_Of_Muscle_Cell_Differentiation	Human	Intestine	A8	1.5e-11
NLN	GOBP_Regulation_Of_Myotube_Differentiation	Human	Intestine	A8	1.2e-10
NLN	GOBP_Regulation_Of_Skeletal_Muscle_Cell_Differentiation	Human	Intestine	A8	1.9e-08
NLN	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Human	Intestine	A8	1.7e-14
NLN	GOBP_Regulation_Of_Striated_Muscle_Cell_Differentiation	Human	Intestine	A8	1.6e-07
NLN	GOBP_Skeletal_Muscle_Cell_Differentiation	Human	Intestine	A8	1.4e-29
NLN	GOBP_Skeletal_Muscle_Fiber_Differentiation	Human	Intestine	A8	7.3e-07
NLN	GOBP_Skeletal_Muscle_Organ_Development	Human	Intestine	A8	2.2e-39
NLN	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
NLN	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
NLN	GOBP_Regulation_Of_Gluconeogenesis	Human	Pancreas	PDAC-B-st1	5.2e-05
NLN	GOBP_Regulation_Of_Glucose_Metabolic_Process	Human	Pancreas	PDAC-B-st1	8.4e-05
NLN	GOBP_Skeletal_Muscle_Cell_Differentiation	Human	Pancreas	PDAC-B-st1	2.2e-05
NLN	GOBP_Regulation_Of_Skeletal_Muscle_Cell_Differentiation	Human	Pancreas	PDAC-A-st2	1.9e-05
NLN	GOBP_Monosaccharide_Biosynthetic_Process	Human	Uterus	rep_25	6.0e-11
NLN	GOBP_Regulation_Of_Skeletal_Muscle_Cell_Differentiation	Human	Uterus	rep_25	3.6e-16
NLN	GOBP_Regulation_Of_Striated_Muscle_Cell_Differentiation	Human	Uterus	rep_25	1.2e-17
NLN	GOBP_Skeletal_Muscle_Organ_Development	Human	Uterus	rep_25	7.4e-10
NLN	GOBP_Carbohydrate_Biosynthetic_Process	Human	Uterus	rep_26	3.3e-14
NLN	GOBP_Cellular_Carbohydrate_Metabolic_Process	Human	Uterus	rep_26	2.2e-06
NLN	GOBP_Glucose_Metabolic_Process	Human	Uterus	rep_26	1.0e-15
NLN	GOBP_Monosaccharide_Metabolic_Process	Human	Uterus	rep_26	2.7e-11
NLN	GOBP_Muscle_Organ_Development	Human	Uterus	rep_26	6.5e-08
NLN	GOBP_Muscle_Tissue_Development	Human	Uterus	rep_26	1.2e-10
NLN	GOBP_Myotube_Differentiation	Human	Uterus	rep_26	3.3e-12
NLN	GOBP_Regulation_Of_Carbohydrate_Biosynthetic_Process	Human	Uterus	rep_26	1.8e-14
NLN	GOBP_Regulation_Of_Carbohydrate_Metabolic_Process	Human	Uterus	rep_26	7.1e-09
NLN	GOBP_Regulation_Of_Cellular_Carbohydrate_Metabolic_Process	Human	Uterus	rep_26	5.9e-07
NLN	GOBP_Regulation_Of_Gluconeogenesis	Human	Uterus	rep_26	1.0e-12
NLN	GOBP_Regulation_Of_Glucose_Metabolic_Process	Human	Uterus	rep_26	8.7e-07
NLN	GOBP_Regulation_Of_Muscle_Cell_Differentiation	Human	Uterus	rep_26	9.0e-10
NLN	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Human	Uterus	rep_26	2.0e-14
NLN	GOBP_Skeletal_Muscle_Cell_Differentiation	Human	Uterus	rep_26	3.3e-06
NLN	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
NLN	GOBP_Regulation_Of_Cell_Differentiation	Human	Uterus	rep_29	2.8e-06
NLN	GOBP_Skeletal_Muscle_Fiber_Differentiation	Human	Uterus	rep_29	8.9e-06
NLN	GOBP_Muscle_Cell_Differentiation	Human	Breast	rep_1	2.9e-50
NLN	GOBP_Muscle_Organ_Development	Human	Breast	rep_1	1.5e-42
NLN	GOBP_Muscle_Structure_Development	Human	Breast	rep_1	6.8e-61
NLN	GOBP_Muscle_Tissue_Development	Human	Breast	rep_1	1.0e-09
NLN	GOBP_Myotube_Differentiation	Human	Breast	rep_1	9.8e-75
NLN	GOBP_Regulation_Of_Cell_Differentiation	Human	Breast	rep_1	2.5e-42
NLN	GOBP_Regulation_Of_Muscle_Cell_Differentiation	Human	Breast	rep_1	1.3e-15
NLN	GOBP_Regulation_Of_Myotube_Differentiation	Human	Breast	rep_1	1.3e-55
NLN	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Human	Breast	rep_1	2.1e-94
NLN	GOBP_Striated_Muscle_Cell_Differentiation	Human	Breast	rep_1	2.1e-49
NLN	GOBP_Carbohydrate_Metabolic_Process	Human	Breast	rep_5	3.5e-10
NLN	GOBP_Cellular_Carbohydrate_Metabolic_Process	Human	Breast	rep_5	9.4e-08
NLN	GOBP_Glucose_Metabolic_Process	Human	Breast	rep_5	1.3e-09
NLN	GOBP_Monosaccharide_Metabolic_Process	Human	Breast	rep_5	2.9e-08
NLN	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
NLN	GOBP_Regulation_Of_Gluconeogenesis	Human	Breast	rep_5	1.0e-05
NLN	GOBP_Regulation_Of_Striated_Muscle_Cell_Differentiation	Human	Breast	rep_5	2.7e-08
NLN	GOBP_Skeletal_Muscle_Cell_Differentiation	Human	Breast	rep_5	4.2e-04
NLN	GOBP_Skeletal_Muscle_Organ_Development	Human	Breast	rep_5	5.2e-09
NLN	GOBP_Carbohydrate_Biosynthetic_Process	Human	Breast	rep_6	2.3e-09
NLN	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
NLN	GOBP_Monosaccharide_Biosynthetic_Process	Human	Breast	rep_6	1.7e-09
NLN	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
NLN	GOBP_Regulation_Of_Carbohydrate_Biosynthetic_Process	Human	Breast	rep_6	5.3e-09
NLN	GOBP_Regulation_Of_Carbohydrate_Metabolic_Process	Human	Breast	rep_6	4.9e-04
NLN	GOBP_Regulation_Of_Cellular_Carbohydrate_Metabolic_Process	Human	Breast	rep_6	3.9e-06
NLN	GOBP_Regulation_Of_Glucose_Metabolic_Process	Human	Breast	rep_6	3.0e-05
NLN	GOBP_Skeletal_Muscle_Fiber_Differentiation	Human	Breast	rep_6	2.0e-04
NLN	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
NLN	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
NLN	GOBP_Skeletal_Muscle_Organ_Development	Human	Skin	P5_rep1	8.8e-12
NLN	GOBP_Regulation_Of_Skeletal_Muscle_Cell_Differentiation	Human	Skin	P10_rep1	1.5e-08
NLN	GOBP_Skeletal_Muscle_Fiber_Differentiation	Human	Skin	P10_rep2	1.4e-12
NLN	GOBP_Regulation_Of_Muscle_Cell_Differentiation	Human	Lung	rep_1	1.0e-07

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NLN function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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NLN function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for NLN envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for NLN

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NLN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source