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Spatial pattern gene: SHROOM4 (spascer ID:57477) |
Gene summary for SHROOM4 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | SHROOM4 | Gene ID | 57477 |
| Gene name | shroom family member 4 |
| Synonyms | MRXSSDS|SHAP|shrm4 |
| Cytomap | Xp11.22 |
| Type of gene | protein-coding |
| Description | protein Shroom4second homolog of apical protein |
| Modification date | 20220513 |
| UniProtAcc | Q9ULL8 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| SHROOM4 | GO:0005912 | adherens junction | 21873635 | Component |
| SHROOM4 | GO:0007015 | actin filament organization | 21873635 | Process |
| SHROOM4 | GO:0016324 | apical plasma membrane | 21873635 | Component |
| SHROOM4 | GO:0030864 | cortical actin cytoskeleton | 21873635 | Component |
| SHROOM4 | GO:0043296 | apical junction complex | 21873635 | Component |
| SHROOM4 | GO:0051015 | actin filament binding | 21873635 | Function |
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Spatial pattern events for SHROOM4 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| SHROOM4 | Human | Liver | rep_liver1 | 34417225 | 8.81e-07 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
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Spatial pattern pathway has SHROOM4 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| SHROOM4 | GOBP_Central_Nervous_System_Development | Human | Brain | rep_1 | 2.8e-23 |
| SHROOM4 | GOBP_Central_Nervous_System_Development | Human | Liver | rep_1 | 1.0e-70 |
| SHROOM4 | GOBP_Central_Nervous_System_Development | Human | Intestine | A3 | 7.1e-11 |
| SHROOM4 | GOBP_Cognition | Human | Intestine | A3 | 5.7e-09 |
| SHROOM4 | GOBP_Head_Development | Human | Intestine | A3 | 3.8e-09 |
| SHROOM4 | GOBP_Nervous_System_Process | Human | Intestine | A3 | 9.7e-07 |
| SHROOM4 | GOBP_Head_Development | Human | Pancreas | PDAC-B-st1 | 2.0e-05 |
| SHROOM4 | GOBP_Cognition | Human | Uterus | rep_26 | 3.8e-07 |
| SHROOM4 | GOBP_Nervous_System_Process | Human | Uterus | rep_26 | 2.3e-07 |
| SHROOM4 | GOBP_Actin_Filament_Based_Process | Human | Breast | rep_1 | 1.8e-86 |
| SHROOM4 | GOBP_Actin_Filament_Organization | Human | Breast | rep_1 | 4.0e-75 |
| SHROOM4 | GOBP_Central_Nervous_System_Development | Human | Breast | rep_1 | 5.1e-04 |
| SHROOM4 | GOBP_Cytoskeleton_Organization | Human | Breast | rep_1 | 1.3e-22 |
| SHROOM4 | GOBP_Head_Development | Human | Breast | rep_1 | 1.0e-09 |
| SHROOM4 | GOBP_Nervous_System_Process | Human | Breast | rep_1 | 1.2e-04 |
| SHROOM4 | GOBP_Supramolecular_Fiber_Organization | Human | Breast | rep_1 | 2.8e-72 |
| SHROOM4 | GOBP_Cytoskeleton_Organization | Human | Skin | P9_rep3 | 3.1e-12 |
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SHROOM4 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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SHROOM4 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for SHROOM4 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for SHROOM4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SHROOM4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| SHROOM4 | C1845530 | Stocco dos Santos syndrome | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| SHROOM4 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
