Home

Download & Upload

Statistics

Landscape

Help

Contact

	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: CNOT6 (spascer ID:57472)

Gene summary for CNOT6

Gene summary

Gene information
	Species	Human
	Gene symbol	CNOT6
	Gene ID	57472
	Gene name	CCR4-NOT transcription complex subunit 6
	Synonyms	CCR4\|Ccr4a
	Cytomap	5q35.3
	Type of gene	protein-coding
	Description	CCR4-NOT transcription complex subunit 6carbon catabolite repression 4 proteincarbon catabolite repressor protein 4 homologcytoplasmic deadenylase
	Modification date	20220513
	UniProtAcc	Q9ULM6

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
CNOT6	GO:0000175	3'-5'-exoribonuclease activity	21873635	Function
CNOT6	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	21873635	Process
CNOT6	GO:0004535	poly(A)-specific ribonuclease activity	21873635	Function
CNOT6	GO:0005634	nucleus	21873635	Component
CNOT6	GO:0005737	cytoplasm	21873635	Component
CNOT6	GO:0030014	CCR4-NOT complex	21873635	Component

Top

Spatial pattern events for CNOT6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
CNOT6	Human	Liver	rep_liver1	34417225	1.89e-15
CNOT6	Human	Liver	rep_liver2	34417225	6.98e-16
CNOT6	Human	Uterus	rep_3	34857954	2.15e-12
CNOT6	Human	Lung	rep_1	35355018	4.97e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Uterus_rep_3_H&E
Lung_rep_1_H&E

Top

Spatial pattern pathway has CNOT6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
CNOT6	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Brain	rep_1	1.3e-60
CNOT6	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Liver	rep_1	2.0e-49
CNOT6	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Intestine	rep_colon2	2.9e-50
CNOT6	GOBP_Amide_Biosynthetic_Process	Human	Intestine	A1	6.4e-07
CNOT6	GOBP_Peptide_Biosynthetic_Process	Human	Intestine	A1	4.6e-10
CNOT6	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
CNOT6	GOBP_Cell_Cycle_Phase_Transition	Human	Intestine	A3	3.5e-07
CNOT6	GOBP_Cell_Cycle_Process	Human	Intestine	A3	2.7e-14
CNOT6	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Intestine	A3	6.6e-16
CNOT6	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
CNOT6	GOBP_Mitotic_Cell_Cycle	Human	Intestine	A3	1.8e-12
CNOT6	GOBP_Mrna_Metabolic_Process	Human	Intestine	A3	7.7e-20
CNOT6	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Intestine	A3	2.8e-18
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Intestine	A3	2.8e-10
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Intestine	A3	1.5e-09
CNOT6	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	1.9e-08
CNOT6	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Intestine	A3	5.9e-24
CNOT6	GOBP_P_Body_Assembly	Human	Intestine	A3	1.3e-08
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle	Human	Intestine	A3	3.2e-16
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle_Process	Human	Intestine	A3	2.3e-19
CNOT6	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Intestine	A3	3.5e-07
CNOT6	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	1.9e-13
CNOT6	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Intestine	A3	3.8e-12
CNOT6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	5.1e-13
CNOT6	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.7e-13
CNOT6	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Human	Intestine	A3	4.2e-08
CNOT6	GOBP_Regulation_Of_Cell_Cycle	Human	Intestine	A3	1.6e-08
CNOT6	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Intestine	A3	2.6e-08
CNOT6	GOBP_Regulation_Of_Cell_Cycle_Process	Human	Intestine	A3	1.1e-15
CNOT6	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Human	Intestine	A3	2.1e-07
CNOT6	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Intestine	A3	8.8e-12
CNOT6	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Intestine	A3	1.5e-08
CNOT6	GOBP_Regulation_Of_Organelle_Assembly	Human	Intestine	A3	9.7e-21
CNOT6	GOBP_Regulation_Of_Organelle_Organization	Human	Intestine	A3	1.1e-11
CNOT6	GOBP_Rna_Catabolic_Process	Human	Intestine	A3	5.9e-24
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Intestine	A3	2.3e-07
CNOT6	GOBP_Cell_Cycle_G1_S_Phase_Transition	Human	Intestine	A8	8.5e-07
CNOT6	GOBP_Dna_Damage_Response_Signal_Transduction_By_P53_Class_Mediator	Human	Intestine	A8	2.8e-10
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Intestine	A8	3.1e-14
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_G1_S_Phase_Transition	Human	Intestine	A8	2.1e-11
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Intestine	A8	4.4e-08
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Intestine	A8	6.5e-12
CNOT6	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Human	Intestine	A8	5.4e-15
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Intestine	A8	1.9e-13
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Poly_A_Tail_Shortening	Human	Intestine	A8	1.6e-28
CNOT6	GOBP_Regulation_Of_Cytoplasmic_Mrna_Processing_Body_Assembly	Human	Intestine	A8	6.7e-16
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Intestine	A8	6.5e-10
CNOT6	GOBP_Mrna_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	9.4e-06
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Pancreas	PDAC-B-st1	5.2e-05
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Pancreas	PDAC-B-st1	5.0e-05
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle_Process	Human	Pancreas	PDAC-B-st1	4.0e-05
CNOT6	GOBP_Rna_Catabolic_Process	Human	Pancreas	PDAC-B-st1	8.0e-05
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Pancreas	PDAC-B-st1	3.3e-05
CNOT6	GOBP_Regulation_Of_Cytoplasmic_Mrna_Processing_Body_Assembly	Human	Pancreas	PDAC-A-st2	1.9e-05
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Pancreas	PDAC-A-st2	1.4e-05
CNOT6	GOBP_Signal_Transduction_By_P53_Class_Mediator	Human	Uterus	rep_1	3.7e-07
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Poly_A_Tail_Shortening	Human	Uterus	rep_25	4.8e-07
CNOT6	GOBP_Cell_Cycle_Phase_Transition	Human	Uterus	rep_26	1.9e-06
CNOT6	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Uterus	rep_26	2.4e-07
CNOT6	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Uterus	rep_26	1.0e-08
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Uterus	rep_26	8.1e-09
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Uterus	rep_26	2.4e-12
CNOT6	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Human	Uterus	rep_26	1.3e-08
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Uterus	rep_26	8.1e-10
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Uterus	rep_26	2.2e-12
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Uterus	rep_26	1.2e-11
CNOT6	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Uterus	rep_26	2.6e-06
CNOT6	GOBP_P_Body_Assembly	Human	Uterus	rep_26	1.8e-15
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle	Human	Uterus	rep_26	2.1e-09
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle_Process	Human	Uterus	rep_26	1.2e-15
CNOT6	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Uterus	rep_26	1.2e-06
CNOT6	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Uterus	rep_26	9.3e-07
CNOT6	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Uterus	rep_26	2.5e-07
CNOT6	GOBP_Regulation_Of_Organelle_Assembly	Human	Uterus	rep_26	2.0e-06
CNOT6	GOBP_Rna_Catabolic_Process	Human	Uterus	rep_26	2.7e-07
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Uterus	rep_26	9.7e-09
CNOT6	GOBP_Signal_Transduction_In_Response_To_Dna_Damage	Human	Uterus	rep_26	6.1e-08
CNOT6	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Breast	rep_1	9.2e-11
CNOT6	GOBP_Positive_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	3.5e-04
CNOT6	GOBP_Positive_Regulation_Of_Cellular_Component_Organization	Human	Breast	rep_1	1.3e-17
CNOT6	GOBP_Positive_Regulation_Of_Organelle_Assembly	Human	Breast	rep_1	1.4e-54
CNOT6	GOBP_Regulation_Of_Cellular_Component_Biogenesis	Human	Breast	rep_1	4.6e-05
CNOT6	GOBP_Regulation_Of_Organelle_Assembly	Human	Breast	rep_1	1.0e-12
CNOT6	GOBP_Regulation_Of_Organelle_Organization	Human	Breast	rep_1	8.7e-11
CNOT6	GOBP_Negative_Regulation_Of_Gene_Expression	Human	Breast	rep_5	5.3e-06
CNOT6	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_5	8.0e-09
CNOT6	GOBP_Regulation_Of_Cell_Cycle	Human	Breast	rep_5	3.7e-04
CNOT6	GOBP_Regulation_Of_Cytoplasmic_Mrna_Processing_Body_Assembly	Human	Breast	rep_5	3.4e-08
CNOT6	GOBP_Amide_Biosynthetic_Process	Human	Breast	rep_6	8.7e-05
CNOT6	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
CNOT6	GOBP_Cell_Cycle_G1_S_Phase_Transition	Human	Breast	rep_6	3.5e-11
CNOT6	GOBP_Cell_Cycle_Phase_Transition	Human	Breast	rep_6	4.9e-09
CNOT6	GOBP_Cell_Cycle_Process	Human	Breast	rep_6	6.7e-09
CNOT6	GOBP_Cellular_Amide_Metabolic_Process	Human	Breast	rep_6	5.6e-05
CNOT6	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Breast	rep_6	6.0e-06
CNOT6	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
CNOT6	GOBP_Mitotic_Cell_Cycle	Human	Breast	rep_6	3.2e-09
CNOT6	GOBP_Mrna_Metabolic_Process	Human	Breast	rep_6	3.0e-08
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Breast	rep_6	5.3e-11
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_G1_S_Phase_Transition	Human	Breast	rep_6	1.1e-11
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Breast	rep_6	9.1e-12
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Breast	rep_6	2.3e-13
CNOT6	GOBP_Negative_Regulation_Of_Mitotic_Cell_Cycle	Human	Breast	rep_6	1.5e-13
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process	Human	Breast	rep_6	8.1e-07
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Breast	rep_6	1.7e-04
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Exonucleolytic	Human	Breast	rep_6	3.7e-07
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Poly_A_Tail_Shortening	Human	Breast	rep_6	4.1e-04
CNOT6	GOBP_Nucleic_Acid_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.6e-05
CNOT6	GOBP_Organelle_Assembly	Human	Breast	rep_6	2.3e-07
CNOT6	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Human	Breast	rep_6	7.7e-08
CNOT6	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Human	Breast	rep_6	1.2e-09
CNOT6	GOBP_P_Body_Assembly	Human	Breast	rep_6	2.2e-07
CNOT6	GOBP_Peptide_Biosynthetic_Process	Human	Breast	rep_6	1.6e-05
CNOT6	GOBP_Peptide_Metabolic_Process	Human	Breast	rep_6	8.7e-05
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle	Human	Breast	rep_6	7.0e-10
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle_Process	Human	Breast	rep_6	7.5e-09
CNOT6	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Breast	rep_6	7.3e-09
CNOT6	GOBP_Regulation_Of_Cell_Cycle_G1_S_Phase_Transition	Human	Breast	rep_6	2.8e-06
CNOT6	GOBP_Regulation_Of_Cell_Cycle_Phase_Transition	Human	Breast	rep_6	2.7e-07
CNOT6	GOBP_Regulation_Of_Cell_Cycle_Process	Human	Breast	rep_6	6.1e-08
CNOT6	GOBP_Regulation_Of_Mitotic_Cell_Cycle	Human	Breast	rep_6	4.6e-09
CNOT6	GOBP_Rna_Catabolic_Process	Human	Breast	rep_6	3.9e-06
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Breast	rep_6	2.8e-06
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis_Exonucleolytic	Human	Breast	rep_6	3.0e-08
CNOT6	GOBP_Signal_Transduction_By_P53_Class_Mediator	Human	Breast	rep_6	7.7e-05
CNOT6	GOBP_Signal_Transduction_In_Response_To_Dna_Damage	Human	Breast	rep_6	1.7e-07
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Catabolic_Process_Deadenylation_Dependent_Decay	Human	Skin	P5_rep1	4.0e-09
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle	Human	Skin	P5_rep1	7.8e-10
CNOT6	GOBP_Positive_Regulation_Of_Cell_Cycle_Process	Human	Skin	P5_rep1	4.9e-14
CNOT6	GOBP_Mrna_Metabolic_Process	Human	Skin	P5_rep3	1.8e-08
CNOT6	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Human	Skin	P5_rep3	1.1e-11
CNOT6	GOBP_Positive_Regulation_Of_Organelle_Organization	Human	Skin	P5_rep3	4.1e-08
CNOT6	GOBP_Nuclear_Transcribed_Mrna_Poly_A_Tail_Shortening	Human	Skin	P10_rep1	7.2e-08
CNOT6	GOBP_Positive_Regulation_Of_Cell_Population_Proliferation	Human	Lung	rep_1	7.3e-07
CNOT6	GOBP_Rna_Phosphodiester_Bond_Hydrolysis	Human	Lung	rep_1	8.8e-08

Top

CNOT6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

Top

CNOT6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

Top

Transcription factor for CNOT6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

Top

Related Drugs for CNOT6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CNOT6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source