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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: ISY1 (spascer ID:57461)

Gene summary for ISY1

Gene summary

Gene information
	Species	Human
	Gene symbol	ISY1
	Gene ID	57461
	Gene name	ISY1 splicing factor homolog
	Synonyms	FSAP33
	Cytomap	3q21.3
	Type of gene	protein-coding
	Description	pre-mRNA-splicing factor ISY1 homologfunctional spliceosome-associated protein 33
	Modification date	20220513
	UniProtAcc	Q9ULR0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
ISY1	GO:0000350	generation of catalytic spliceosome for second transesterification step	21873635	Process
ISY1	GO:0000389	mRNA 3'-splice site recognition	21873635	Process
ISY1	GO:0000974	Prp19 complex	21873635	Component
ISY1	GO:0071013	catalytic step 2 spliceosome	21873635	Component
ISY1	GO:0071014	post-mRNA release spliceosomal complex	21873635	Component
ISY1	GO:0071020	post-spliceosomal complex	21873635	Component

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Spatial pattern events for ISY1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
ISY1	Human	Liver	rep_liver1	34417225	1.08e-15
ISY1	Human	Liver	rep_liver2	34417225	6.98e-16

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E

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Spatial pattern pathway has ISY1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
ISY1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Intestine	A3	6.6e-16
ISY1	GOBP_Dna_Metabolic_Process	Human	Intestine	A3	1.2e-09
ISY1	GOBP_Dna_Repair	Human	Intestine	A3	4.4e-09
ISY1	GOBP_Mrna_Metabolic_Process	Human	Intestine	A3	7.7e-20
ISY1	GOBP_Mrna_Processing	Human	Intestine	A3	4.9e-17
ISY1	GOBP_Mrna_Splice_Site_Selection	Human	Intestine	A3	6.7e-13
ISY1	GOBP_Nucleotide_Excision_Repair	Human	Intestine	A3	8.1e-09
ISY1	GOBP_Ribonucleoprotein_Complex_Subunit_Organization	Human	Intestine	A3	1.6e-07
ISY1	GOBP_Rna_Processing	Human	Intestine	A3	3.9e-09
ISY1	GOBP_Rna_Splicing	Human	Intestine	A3	3.3e-19
ISY1	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Human	Intestine	A3	2.2e-12
ISY1	GOBP_Spliceosomal_Complex_Assembly	Human	Intestine	A3	8.7e-10
ISY1	GOBP_Mrna_3_Splice_Site_Recognition	Human	Intestine	A8	3.6e-14
ISY1	GOBP_Spliceosomal_Conformational_Changes_To_Generate_Catalytic_Conformation	Human	Intestine	A8	1.0e-07
ISY1	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Intestine	A8	3.5e-07
ISY1	GOBP_Mrna_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
ISY1	GOBP_Rna_Splicing	Human	Pancreas	PDAC-B-st1	1.9e-05
ISY1	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Pancreas	PDAC-B-st1	4.0e-06
ISY1	GOBP_Nucleotide_Excision_Repair	Human	Pancreas	PDAC-A-st2	4.7e-06
ISY1	GOBP_Spliceosomal_Conformational_Changes_To_Generate_Catalytic_Conformation	Human	Uterus	rep_1	7.5e-06
ISY1	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Uterus	rep_1	2.3e-08
ISY1	GOBP_Mrna_3_Splice_Site_Recognition	Human	Uterus	rep_25	1.6e-08
ISY1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Uterus	rep_26	2.4e-07
ISY1	GOBP_Nucleotide_Excision_Repair	Human	Uterus	rep_26	1.3e-07
ISY1	GOBP_Ribonucleoprotein_Complex_Subunit_Organization	Human	Uterus	rep_26	4.6e-06
ISY1	GOBP_Rna_Splicing	Human	Uterus	rep_26	1.0e-05
ISY1	GOBP_Spliceosomal_Complex_Assembly	Human	Uterus	rep_26	5.6e-09
ISY1	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Breast	rep_6	6.0e-06
ISY1	GOBP_Dna_Metabolic_Process	Human	Breast	rep_6	1.4e-10
ISY1	GOBP_Dna_Repair	Human	Breast	rep_6	1.0e-09
ISY1	GOBP_Mrna_Metabolic_Process	Human	Breast	rep_6	3.0e-08
ISY1	GOBP_Mrna_Processing	Human	Breast	rep_6	1.5e-06
ISY1	GOBP_Mrna_Splice_Site_Selection	Human	Breast	rep_6	7.1e-06
ISY1	GOBP_Ribonucleoprotein_Complex_Biogenesis	Human	Breast	rep_6	1.3e-07
ISY1	GOBP_Ribonucleoprotein_Complex_Subunit_Organization	Human	Breast	rep_6	1.4e-08
ISY1	GOBP_Rna_Processing	Human	Breast	rep_6	3.5e-06
ISY1	GOBP_Rna_Splicing	Human	Breast	rep_6	1.1e-09
ISY1	GOBP_Rna_Splicing_Via_Transesterification_Reactions	Human	Breast	rep_6	5.4e-08
ISY1	GOBP_Spliceosomal_Complex_Assembly	Human	Breast	rep_6	2.2e-12
ISY1	GOBP_Spliceosomal_Conformational_Changes_To_Generate_Catalytic_Conformation	Human	Breast	rep_6	1.2e-11
ISY1	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Breast	rep_6	2.3e-11
ISY1	GOBP_Dna_Repair	Human	Skin	P5_rep1	1.7e-08
ISY1	GOBP_Mrna_Metabolic_Process	Human	Skin	P5_rep3	1.8e-08
ISY1	GOBP_Mrna_Processing	Human	Skin	P5_rep3	9.7e-09
ISY1	GOBP_Mrna_3_Splice_Site_Recognition	Human	Skin	P10_rep1	7.6e-14
ISY1	GOBP_Transcription_Coupled_Nucleotide_Excision_Repair	Human	Skin	P10_rep1	1.1e-08
ISY1	GOBP_Mrna_Splice_Site_Selection	Human	Skin	P10_rep2	2.9e-12

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ISY1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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ISY1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for ISY1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for ISY1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ISY1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source