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Spatial pattern gene: NDRG2 (spascer ID:57447) |
Gene summary for NDRG2 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | NDRG2 | Gene ID | 57447 |
| Gene name | NDRG family member 2 |
| Synonyms | SYLD |
| Cytomap | 14q11.2 |
| Type of gene | protein-coding |
| Description | protein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 protein |
| Modification date | 20220515 |
| UniProtAcc | Q9UN36 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| NDRG2 | GO:0005737 | cytoplasm | 21873635 | Component |
| NDRG2 | GO:0007165 | signal transduction | 21873635 | Process |
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Spatial pattern events for NDRG2 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| NDRG2 | Human | Brain | rep_1 | 33558695 | 1.72e-14 |
| NDRG2 | Human | Brain | rep_2 | 33558695 | 9.99e-07 |
| NDRG2 | Human | Brain | rep_3 | 33558695 | 4.38e-13 |
| NDRG2 | Human | Brain | rep_4 | 33558695 | 1.82e-14 |
| NDRG2 | Human | Brain | rep_5 | 33558695 | 3.32e-14 |
| NDRG2 | Human | Brain | rep_6 | 33558695 | 1.97e-14 |
| NDRG2 | Human | Brain | rep_7 | 33558695 | 3.49e-07 |
| NDRG2 | Human | Brain | rep_9 | 33558695 | 3.01e-15 |
| NDRG2 | Human | Brain | rep_10 | 33558695 | 3.15e-10 |
| NDRG2 | Human | Brain | rep_11 | 33558695 | 3.36e-15 |
| NDRG2 | Human | Brain | rep_12 | 33558695 | 3.65e-15 |
| NDRG2 | Human | Bladder | rep_1 | 34385456 | 5.66e-07 |
| NDRG2 | Human | Bladder | rep_3 | 34385456 | 7.46e-13 |
| NDRG2 | Human | Intestine | rep_colon1 | 34417225 | 1.95e-15 |
| NDRG2 | Human | Intestine | rep_colon2 | 34417225 | 8.12e-16 |
| NDRG2 | Human | Intestine | rep_colon3 | 34417225 | 1.01e-15 |
| NDRG2 | Human | Intestine | rep_colon4 | 34417225 | 1.14e-15 |
| NDRG2 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| NDRG2 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| NDRG2 | Human | Liver | rep_liver4 | 34417225 | 7.71e-16 |
| NDRG2 | Human | Intestine | A1 | 33406409 | 2.09e-15 |
| NDRG2 | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| NDRG2 | Human | Uterus | rep_1 | 34857954 | 5.13e-15 |
| NDRG2 | Human | Uterus | rep_2 | 34857954 | 2.55e-15 |
| NDRG2 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| NDRG2 | Human | Uterus | rep_4 | 34857954 | 1.82e-15 |
| NDRG2 | Human | Breast | B1 | 34650042 | 2.89e-08 |
| NDRG2 | Human | Breast | B2 | 34650042 | 1.92e-08 |
| NDRG2 | Human | Breast | B3 | 34650042 | 2.17e-08 |
| NDRG2 | Human | Breast | B4 | 34650042 | 7.28e-13 |
| NDRG2 | Human | Breast | B5 | 34650042 | 4.61e-10 |
| NDRG2 | Human | Breast | B6 | 34650042 | 9.25e-14 |
| NDRG2 | Human | Breast | H1 | 34650042 | 3.39e-14 |
| NDRG2 | Human | Breast | H2 | 34650042 | 3.19e-14 |
| NDRG2 | Human | Breast | H3 | 34650042 | 4.80e-14 |
| NDRG2 | Human | Breast | 1142243F | 34493872 | 4.15e-15 |
| NDRG2 | Human | Breast | 1160920F | 34493872 | 1.48e-15 |
| NDRG2 | Human | Breast | CID4465 | 34493872 | 3.36e-07 |
| NDRG2 | Human | Breast | CID44971 | 34493872 | 1.76e-15 |
| NDRG2 | Human | Skin | P2_rep2 | 32946785 | 5.48e-15 |
| NDRG2 | Human | Lung | rep_1 | 35355018 | 4.99e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_6_H&E  |  |
Brain_rep_7_H&E  |  |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Brain_rep_11_H&E  |  |
Brain_rep_12_H&E  |  |
Bladder_rep_1_H&E  |  |
Bladder_rep_3_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon2_H&E  |  |
Intestine_rep_colon3_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Uterus_rep_4_H&E  |  |
Breast_B1_H&E  |  |
Breast_B2_H&E  |  |
Breast_B3_H&E  |  |
Breast_B4_H&E  |  |
Breast_B5_H&E  |  |
Breast_B6_H&E  |  |
Breast_H1_H&E  |  |
Breast_H2_H&E  |  |
Breast_H3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_1160920F_H&E  |  |
Breast_CID4465_H&E  |  |
Breast_CID44971_H&E  |  |
Lung_rep_1_H&E  |  |
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Spatial pattern pathway has NDRG2 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| NDRG2 | GOBP_Central_Nervous_System_Development | Human | Brain | rep_1 | 2.8e-23 |
| NDRG2 | GOBP_Regulation_Of_Intracellular_Signal_Transduction | Human | Brain | rep_1 | 1.2e-64 |
| NDRG2 | GOBP_Cytokine_Production | Human | Brain | rep_4 | 4.1e-17 |
| NDRG2 | GOBP_Vascular_Endothelial_Growth_Factor_Production | Human | Bladder | rep_2 | 4.3e-05 |
| NDRG2 | GOBP_Central_Nervous_System_Development | Human | Liver | rep_1 | 1.0e-70 |
| NDRG2 | GOBP_Cytokine_Production | Human | Liver | rep_1 | 1.0e-70 |
| NDRG2 | GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process | Human | Liver | rep_1 | 2.8e-53 |
| NDRG2 | GOBP_Negative_Regulation_Of_Response_To_Stimulus | Human | Liver | rep_1 | 2.8e-53 |
| NDRG2 | GOBP_Regulation_Of_Intracellular_Signal_Transduction | Human | Liver | rep_1 | 6.9e-47 |
| NDRG2 | GOBP_Regulation_Of_Intracellular_Signal_Transduction | Human | Intestine | rep_colon2 | 2.4e-25 |
| NDRG2 | GOBP_Cytokine_Production | Human | Intestine | rep_colon4 | 9.0e-12 |
| NDRG2 | GOBP_Cell_Cell_Signaling | Human | Intestine | A3 | 6.4e-08 |
| NDRG2 | GOBP_Cell_Cell_Signaling_By_Wnt | Human | Intestine | A3 | 3.1e-07 |
| NDRG2 | GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling | Human | Intestine | A3 | 7.0e-07 |
| NDRG2 | GOBP_Central_Nervous_System_Development | Human | Intestine | A3 | 7.1e-11 |
| NDRG2 | GOBP_Cytokine_Production | Human | Intestine | A3 | 8.9e-12 |
| NDRG2 | GOBP_Erk1_And_Erk2_Cascade | Human | Intestine | A3 | 2.6e-07 |
| NDRG2 | GOBP_Head_Development | Human | Intestine | A3 | 3.8e-09 |
| NDRG2 | GOBP_Mapk_Cascade | Human | Intestine | A3 | 1.1e-12 |
| NDRG2 | GOBP_Muscle_Cell_Proliferation | Human | Intestine | A3 | 4.4e-07 |
| NDRG2 | GOBP_Negative_Regulation_Of_Cell_Population_Proliferation | Human | Intestine | A3 | 5.4e-19 |
| NDRG2 | GOBP_Negative_Regulation_Of_Erk1_And_Erk2_Cascade | Human | Intestine | A3 | 7.7e-09 |
| NDRG2 | GOBP_Negative_Regulation_Of_Gene_Expression | Human | Intestine | A3 | 2.8e-18 |
| NDRG2 | GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction | Human | Intestine | A3 | 2.6e-18 |
| NDRG2 | GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process | Human | Intestine | A3 | 6.2e-10 |
| NDRG2 | GOBP_Negative_Regulation_Of_Response_To_Stimulus | Human | Intestine | A3 | 6.0e-11 |
| NDRG2 | GOBP_Negative_Regulation_Of_Signaling | Human | Intestine | A3 | 4.9e-15 |
| NDRG2 | GOBP_Negative_Regulation_Of_Smooth_Muscle_Cell_Proliferation | Human | Intestine | A3 | 5.4e-08 |
| NDRG2 | GOBP_Regulation_Of_Intracellular_Signal_Transduction | Human | Intestine | A3 | 7.5e-12 |
| NDRG2 | GOBP_Negative_Regulation_Of_Cytokine_Production | Human | Intestine | A8 | 6.2e-16 |
| NDRG2 | GOBP_Negative_Regulation_Of_Mapk_Cascade | Human | Intestine | A8 | 1.2e-15 |
| NDRG2 | GOBP_Smooth_Muscle_Cell_Proliferation | Human | Intestine | A8 | 2.0e-16 |
| NDRG2 | GOBP_Vascular_Endothelial_Growth_Factor_Production | Human | Intestine | A8 | 1.1e-09 |
| NDRG2 | GOBP_Head_Development | Human | Pancreas | PDAC-B-st1 | 2.0e-05 |
| NDRG2 | GOBP_Negative_Regulation_Of_Signaling | Human | Pancreas | PDAC-B-st1 | 1.7e-05 |
| NDRG2 | GOBP_Midbrain_Development | Human | Uterus | rep_25 | 1.4e-06 |
| NDRG2 | GOBP_Neural_Nucleus_Development | Human | Uterus | rep_25 | 1.0e-08 |
| NDRG2 | GOBP_Cell_Cell_Signaling_By_Wnt | Human | Uterus | rep_26 | 5.5e-06 |
| NDRG2 | GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling | Human | Uterus | rep_26 | 9.2e-08 |
| NDRG2 | GOBP_Negative_Regulation_Of_Cytokine_Production | Human | Uterus | rep_26 | 6.8e-07 |
| NDRG2 | GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction | Human | Uterus | rep_26 | 2.7e-06 |
| NDRG2 | GOBP_Substantia_Nigra_Development | Human | Uterus | rep_26 | 4.1e-08 |
| NDRG2 | GOBP_Erk1_And_Erk2_Cascade | Human | Uterus | rep_29 | 7.0e-08 |
| NDRG2 | GOBP_Muscle_Cell_Proliferation | Human | Uterus | rep_29 | 6.5e-09 |
| NDRG2 | GOBP_Negative_Regulation_Of_Response_To_Stimulus | Human | Uterus | rep_29 | 1.2e-06 |
| NDRG2 | GOBP_Negative_Regulation_Of_Signaling | Human | Uterus | rep_29 | 5.3e-06 |
| NDRG2 | GOBP_Smooth_Muscle_Cell_Proliferation | Human | Uterus | rep_29 | 1.1e-07 |
| NDRG2 | GOBP_Central_Nervous_System_Development | Human | Breast | rep_1 | 5.1e-04 |
| NDRG2 | GOBP_Cytokine_Production | Human | Breast | rep_1 | 6.5e-12 |
| NDRG2 | GOBP_Head_Development | Human | Breast | rep_1 | 1.0e-09 |
| NDRG2 | GOBP_Midbrain_Development | Human | Breast | rep_1 | 7.5e-13 |
| NDRG2 | GOBP_Muscle_Cell_Proliferation | Human | Breast | rep_1 | 9.1e-68 |
| NDRG2 | GOBP_Negative_Regulation_Of_Cell_Population_Proliferation | Human | Breast | rep_1 | 1.3e-54 |
| NDRG2 | GOBP_Negative_Regulation_Of_Cytokine_Production | Human | Breast | rep_1 | 1.3e-70 |
| NDRG2 | GOBP_Negative_Regulation_Of_Erk1_And_Erk2_Cascade | Human | Breast | rep_1 | 5.7e-07 |
| NDRG2 | GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction | Human | Breast | rep_1 | 3.6e-04 |
| NDRG2 | GOBP_Negative_Regulation_Of_Multicellular_Organismal_Process | Human | Breast | rep_1 | 8.3e-12 |
| NDRG2 | GOBP_Negative_Regulation_Of_Response_To_Stimulus | Human | Breast | rep_1 | 2.4e-07 |
| NDRG2 | GOBP_Negative_Regulation_Of_Smooth_Muscle_Cell_Proliferation | Human | Breast | rep_1 | 6.0e-58 |
| NDRG2 | GOBP_Neural_Nucleus_Development | Human | Breast | rep_1 | 1.0e-30 |
| NDRG2 | GOBP_Smooth_Muscle_Cell_Proliferation | Human | Breast | rep_1 | 3.6e-75 |
| NDRG2 | GOBP_Substantia_Nigra_Development | Human | Breast | rep_1 | 6.4e-40 |
| NDRG2 | GOBP_Vascular_Endothelial_Growth_Factor_Production | Human | Breast | rep_1 | 8.8e-77 |
| NDRG2 | GOBP_Mapk_Cascade | Human | Breast | rep_5 | 4.6e-17 |
| NDRG2 | GOBP_Negative_Regulation_Of_Gene_Expression | Human | Breast | rep_5 | 5.3e-06 |
| NDRG2 | GOBP_Negative_Regulation_Of_Signaling | Human | Breast | rep_5 | 8.6e-14 |
| NDRG2 | GOBP_Regulation_Of_Intracellular_Signal_Transduction | Human | Breast | rep_5 | 8.7e-11 |
| NDRG2 | GOBP_Cell_Cell_Signaling | Human | Breast | rep_6 | 5.0e-05 |
| NDRG2 | GOBP_Cell_Cell_Signaling_By_Wnt | Human | Breast | rep_6 | 4.2e-06 |
| NDRG2 | GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling | Human | Breast | rep_6 | 1.5e-06 |
| NDRG2 | GOBP_Negative_Regulation_Of_Mapk_Cascade | Human | Breast | rep_6 | 4.5e-09 |
| NDRG2 | GOBP_Midbrain_Development | Human | Skin | P5_rep3 | 2.2e-08 |
| NDRG2 | GOBP_Negative_Regulation_Of_Erk1_And_Erk2_Cascade | Human | Skin | P10_rep1 | 7.6e-16 |
| NDRG2 | GOBP_Vascular_Endothelial_Growth_Factor_Production | Human | Skin | P10_rep2 | 4.9e-16 |
| NDRG2 | GOBP_Negative_Regulation_Of_Cytokine_Production | Human | Lung | rep_1 | 8.4e-07 |
| NDRG2 | GOBP_Muscle_Cell_Proliferation | Human | Lung | rep_2 | 6.4e-07 |
| NDRG2 | GOBP_Smooth_Muscle_Cell_Proliferation | Human | Lung | rep_2 | 1.8e-08 |
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NDRG2 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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NDRG2 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for NDRG2 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for NDRG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NDRG2 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| NDRG2 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| NDRG2 | C0007787 | Transient Ischemic Attack | 1 | CTD_human |
| NDRG2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| NDRG2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| NDRG2 | C0086543 | Cataract | 1 | CTD_human |
| NDRG2 | C0472381 | Posterior Circulation Transient Ischemic Attack | 1 | CTD_human |
| NDRG2 | C0524524 | Pseudoaphakia | 1 | CTD_human |
| NDRG2 | C0751019 | Carotid Circulation Transient Ischemic Attack | 1 | CTD_human |
| NDRG2 | C0751020 | Transient Ischemic Attack, Vertebrobasilar Circulation | 1 | CTD_human |
| NDRG2 | C0751021 | Crescendo Transient Ischemic Attacks | 1 | CTD_human |
| NDRG2 | C0751022 | Brain Stem Ischemia, Transient | 1 | CTD_human |
| NDRG2 | C0917805 | Transient Cerebral Ischemia | 1 | CTD_human |
| NDRG2 | C1510497 | Lens Opacities | 1 | CTD_human |
| NDRG2 | C1527335 | Transient Ischemic Attack, Anterior Circulation | 1 | CTD_human |
