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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: SCYL1 (spascer ID:57410)

Gene summary for SCYL1

Gene summary

Gene information
	Species	Human
	Gene symbol	SCYL1
	Gene ID	57410
	Gene name	SCY1 like pseudokinase 1
	Synonyms	GKLP\|HT019\|NKTL\|NTKL\|P105\|SCAR21\|TAPK\|TEIF\|TRAP
	Cytomap	11q13.1
	Type of gene	protein-coding
	Description	N-terminal kinase-like proteinSCY1-like protein 1SCY1-like, kinase-like 1coated vesicle-associated kinase of 90 kDalikely ortholog of mouse N-terminal kinase-like proteintelomerase regulation-associated proteintelomerase transcriptional elements-int
	Modification date	20220513
	UniProtAcc	Q96KG9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for SCYL1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
SCYL1	Human	Liver	rep_liver2	34417225	4.34e-06
SCYL1	Human	Intestine	A1	33406409	6.40e-08
SCYL1	Human	Intestine	A2	33406409	3.45e-07
SCYL1	Human	Uterus	rep_2	34857954	2.55e-15
SCYL1	Human	Uterus	rep_3	34857954	1.66e-15
SCYL1	Human	Breast	1160920F	34493872	7.83e-14
SCYL1	Human	Breast	CID44971	34493872	5.17e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_liver2_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Uterus_rep_2_H&E
Uterus_rep_3_H&E
Breast_1160920F_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has SCYL1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
SCYL1	GOBP_Central_Nervous_System_Development	Human	Brain	rep_1	2.8e-23
SCYL1	GOBP_Neurogenesis	Human	Brain	rep_1	7.4e-34
SCYL1	GOBP_Neuron_Development	Human	Brain	rep_1	7.4e-34
SCYL1	GOBP_Neuron_Differentiation	Human	Brain	rep_1	7.4e-34
SCYL1	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
SCYL1	GOBP_Inflammatory_Response	Human	Brain	rep_4	5.6e-28
SCYL1	GOBP_Central_Nervous_System_Development	Human	Liver	rep_1	1.0e-70
SCYL1	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
SCYL1	GOBP_Inflammatory_Response	Human	Liver	rep_1	1.1e-67
SCYL1	GOBP_Neurogenesis	Human	Liver	rep_1	1.0e-70
SCYL1	GOBP_Neuron_Development	Human	Liver	rep_1	1.5e-73
SCYL1	GOBP_Neuron_Differentiation	Human	Liver	rep_1	1.5e-73
SCYL1	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
SCYL1	GOBP_Inflammatory_Response	Human	Intestine	rep_colon4	3.1e-51
SCYL1	GOBP_Cellular_Macromolecule_Localization	Human	Intestine	A3	1.7e-09
SCYL1	GOBP_Central_Nervous_System_Development	Human	Intestine	A3	7.1e-11
SCYL1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Intestine	A3	8.6e-07
SCYL1	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
SCYL1	GOBP_Golgi_Vesicle_Transport	Human	Intestine	A3	9.2e-10
SCYL1	GOBP_Inflammatory_Response	Human	Intestine	A3	2.9e-09
SCYL1	GOBP_Neurogenesis	Human	Intestine	A3	6.4e-14
SCYL1	GOBP_Neuron_Development	Human	Intestine	A3	1.3e-12
SCYL1	GOBP_Neuron_Differentiation	Human	Intestine	A3	1.4e-11
SCYL1	GOBP_Peptidyl_Amino_Acid_Modification	Human	Intestine	A3	2.7e-09
SCYL1	GOBP_Peptidyl_Tyrosine_Modification	Human	Intestine	A8	2.2e-17
SCYL1	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Human	Intestine	A8	8.6e-10
SCYL1	GOBP_Spinal_Cord_Development	Human	Pancreas	PDAC-A-st2	4.9e-07
SCYL1	GOBP_Spinal_Cord_Motor_Neuron_Differentiation	Human	Pancreas	PDAC-A-st2	5.0e-06
SCYL1	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
SCYL1	GOBP_Ventral_Spinal_Cord_Development	Human	Uterus	rep_1	2.8e-06
SCYL1	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Human	Uterus	rep_25	8.7e-07
SCYL1	GOBP_Spinal_Cord_Motor_Neuron_Differentiation	Human	Uterus	rep_25	6.9e-08
SCYL1	GOBP_Cell_Differentiation_In_Spinal_Cord	Human	Uterus	rep_26	1.5e-06
SCYL1	GOBP_Golgi_Vesicle_Transport	Human	Uterus	rep_26	3.4e-14
SCYL1	GOBP_Spinal_Cord_Development	Human	Uterus	rep_26	3.8e-08
SCYL1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Uterus	rep_29	2.3e-07
SCYL1	GOBP_Peptidyl_Tyrosine_Modification	Human	Uterus	rep_29	8.2e-10
SCYL1	GOBP_Cellular_Macromolecule_Localization	Human	Breast	rep_1	3.7e-09
SCYL1	GOBP_Central_Nervous_System_Development	Human	Breast	rep_1	5.1e-04
SCYL1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Breast	rep_1	6.0e-26
SCYL1	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
SCYL1	GOBP_Inflammatory_Response	Human	Breast	rep_1	3.7e-43
SCYL1	GOBP_Neurogenesis	Human	Breast	rep_1	8.0e-11
SCYL1	GOBP_Neuron_Development	Human	Breast	rep_1	2.5e-26
SCYL1	GOBP_Neuron_Differentiation	Human	Breast	rep_1	1.1e-16
SCYL1	GOBP_Retrograde_Vesicle_Mediated_Transport_Golgi_To_Endoplasmic_Reticulum	Human	Breast	rep_1	4.7e-76
SCYL1	GOBP_Peptidyl_Tyrosine_Modification	Human	Breast	rep_5	3.3e-18
SCYL1	GOBP_Cell_Differentiation_In_Spinal_Cord	Human	Breast	rep_6	3.0e-08
SCYL1	GOBP_Golgi_Vesicle_Transport	Human	Breast	rep_6	2.0e-08
SCYL1	GOBP_Peptidyl_Amino_Acid_Modification	Human	Breast	rep_6	3.8e-05
SCYL1	GOBP_Spinal_Cord_Development	Human	Breast	rep_6	3.8e-05
SCYL1	GOBP_Cell_Differentiation_In_Spinal_Cord	Human	Skin	P10_rep1	4.2e-12
SCYL1	GOBP_Central_Nervous_System_Neuron_Differentiation	Human	Skin	P10_rep1	5.0e-08
SCYL1	GOBP_Spinal_Cord_Motor_Neuron_Differentiation	Human	Skin	P10_rep1	8.5e-09
SCYL1	GOBP_Ventral_Spinal_Cord_Development	Human	Skin	P10_rep1	1.1e-08
SCYL1	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
SCYL1	GOBP_Inflammatory_Response	Human	Lung	rep_1	1.4e-10

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SCYL1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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SCYL1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for SCYL1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for SCYL1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SCYL1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
SCYL1	C4225236	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 21	2	GENOMICS_ENGLAND;ORPHANET