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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: LRRC8A (spascer ID:56262)

Gene summary for LRRC8A

Gene summary

Gene information
	Species	Human
	Gene symbol	LRRC8A
	Gene ID	56262
	Gene name	leucine rich repeat containing 8 VRAC subunit A
	Synonyms	AGM5\|HsLRRC8A\|LRRC8\|SWELL1
	Cytomap	9q34.11
	Type of gene	protein-coding
	Description	volume-regulated anion channel subunit LRRC8Aleucine rich repeat containing 8 family member Aleucine-rich repeat-containing protein 8Aswelling protein 1
	Modification date	20220513
	UniProtAcc	Q8IWT6

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for LRRC8A

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
LRRC8A	Human	Brain	rep_4	33558695	2.65e-06
LRRC8A	Human	Liver	rep_liver1	34417225	7.78e-08
LRRC8A	Human	Liver	rep_liver2	34417225	6.93e-06
LRRC8A	Human	Uterus	rep_1	34857954	7.82e-10
LRRC8A	Human	Uterus	rep_2	34857954	2.55e-15
LRRC8A	Human	Uterus	rep_4	34857954	1.82e-15
LRRC8A	Human	Breast	1142243F	34493872	2.30e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Uterus_rep_1_H&E
Uterus_rep_2_H&E
Uterus_rep_4_H&E
Breast_1142243F_H&E

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Spatial pattern pathway has LRRC8A envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
LRRC8A	GOBP_Transmembrane_Transport	Human	Brain	rep_1	2.8e-23
LRRC8A	GOBP_Sulfur_Compound_Transport	Human	Bladder	rep_4	2.4e-04
LRRC8A	GOBP_Transmembrane_Transport	Human	Liver	rep_1	1.0e-70
LRRC8A	GOBP_Amino_Acid_Transport	Human	Intestine	A3	1.3e-07
LRRC8A	GOBP_B_Cell_Activation	Human	Intestine	A3	1.4e-11
LRRC8A	GOBP_B_Cell_Differentiation	Human	Intestine	A3	1.3e-17
LRRC8A	GOBP_Cell_Activation	Human	Intestine	A3	6.2e-08
LRRC8A	GOBP_Homeostatic_Process	Human	Intestine	A3	8.7e-10
LRRC8A	GOBP_Immature_B_Cell_Differentiation	Human	Intestine	A3	7.7e-09
LRRC8A	GOBP_Immune_System_Development	Human	Intestine	A3	4.3e-10
LRRC8A	GOBP_Leukocyte_Differentiation	Human	Intestine	A3	2.0e-07
LRRC8A	GOBP_Lymphocyte_Activation	Human	Intestine	A3	1.8e-09
LRRC8A	GOBP_Mononuclear_Cell_Differentiation	Human	Intestine	A3	5.6e-08
LRRC8A	GOBP_Regulation_Of_Cell_Size	Human	Intestine	A3	1.3e-17
LRRC8A	GOBP_Regulation_Of_Cellular_Component_Size	Human	Intestine	A3	3.0e-07
LRRC8A	GOBP_Response_To_Abiotic_Stimulus	Human	Intestine	A3	5.3e-18
LRRC8A	GOBP_Transmembrane_Transport	Human	Intestine	A3	1.4e-10
LRRC8A	GOBP_Acidic_Amino_Acid_Transport	Human	Intestine	A8	6.2e-22
LRRC8A	GOBP_Amino_Acid_Transmembrane_Transport	Human	Intestine	A8	6.6e-18
LRRC8A	GOBP_Anion_Transmembrane_Transport	Human	Intestine	A8	1.2e-13
LRRC8A	GOBP_Aspartate_Transmembrane_Transport	Human	Intestine	A8	4.1e-07
LRRC8A	GOBP_C4_Dicarboxylate_Transport	Human	Intestine	A8	3.8e-11
LRRC8A	GOBP_Carboxylic_Acid_Transport	Human	Intestine	A8	4.8e-16
LRRC8A	GOBP_Cell_Volume_Homeostasis	Human	Intestine	A8	1.2e-13
LRRC8A	GOBP_Cellular_Homeostasis	Human	Intestine	A8	2.1e-11
LRRC8A	GOBP_Dicarboxylic_Acid_Transport	Human	Intestine	A8	1.1e-15
LRRC8A	GOBP_Inorganic_Anion_Transport	Human	Intestine	A8	1.6e-11
LRRC8A	GOBP_Lipid_Localization	Human	Intestine	A8	2.5e-15
LRRC8A	GOBP_Monocarboxylic_Acid_Transport	Human	Intestine	A8	7.2e-16
LRRC8A	GOBP_Organic_Acid_Transmembrane_Transport	Human	Intestine	A8	3.8e-16
LRRC8A	GOBP_Organic_Acid_Transport	Human	Intestine	A8	1.5e-15
LRRC8A	GOBP_Organic_Anion_Transport	Human	Intestine	A8	3.5e-15
LRRC8A	GOBP_Protein_Hexamerization	Human	Intestine	A8	2.1e-10
LRRC8A	GOBP_Regulation_Of_Anatomical_Structure_Size	Human	Intestine	A8	3.3e-07
LRRC8A	GOBP_Sulfur_Compound_Transport	Human	Intestine	A8	1.2e-08
LRRC8A	GOBP_Taurine_Transport	Human	Intestine	A8	7.1e-12
LRRC8A	GOBP_Xenobiotic_Transport	Human	Intestine	A8	9.4e-18
LRRC8A	GOBP_Acidic_Amino_Acid_Transport	Human	Pancreas	PDAC-B-st1	2.9e-05
LRRC8A	GOBP_Amino_Acid_Transmembrane_Transport	Human	Pancreas	PDAC-B-st1	3.2e-07
LRRC8A	GOBP_Amino_Acid_Transport	Human	Pancreas	PDAC-B-st1	3.8e-07
LRRC8A	GOBP_Dicarboxylic_Acid_Transport	Human	Pancreas	PDAC-B-st1	4.8e-08
LRRC8A	GOBP_Protein_Complex_Oligomerization	Human	Pancreas	PDAC-B-st1	8.7e-05
LRRC8A	GOBP_Response_To_Osmotic_Stress	Human	Pancreas	PDAC-B-st1	5.0e-05
LRRC8A	GOBP_Acidic_Amino_Acid_Transport	Human	Uterus	rep_25	3.9e-07
LRRC8A	GOBP_Amino_Acid_Transport	Human	Uterus	rep_25	3.6e-06
LRRC8A	GOBP_Aspartate_Transmembrane_Transport	Human	Uterus	rep_25	1.4e-24
LRRC8A	GOBP_C4_Dicarboxylate_Transport	Human	Uterus	rep_25	2.8e-09
LRRC8A	GOBP_Dicarboxylic_Acid_Transport	Human	Uterus	rep_25	1.3e-06
LRRC8A	GOBP_Protein_Hexamerization	Human	Uterus	rep_25	3.8e-14
LRRC8A	GOBP_Taurine_Transport	Human	Uterus	rep_25	3.1e-08
LRRC8A	GOBP_B_Cell_Differentiation	Human	Uterus	rep_26	1.8e-09
LRRC8A	GOBP_Carboxylic_Acid_Transport	Human	Uterus	rep_26	9.1e-08
LRRC8A	GOBP_Cell_Volume_Homeostasis	Human	Uterus	rep_26	1.3e-06
LRRC8A	GOBP_Homeostatic_Process	Human	Uterus	rep_26	1.9e-07
LRRC8A	GOBP_Immature_B_Cell_Differentiation	Human	Uterus	rep_26	1.0e-06
LRRC8A	GOBP_Immune_System_Development	Human	Uterus	rep_26	1.0e-06
LRRC8A	GOBP_Inorganic_Anion_Transport	Human	Uterus	rep_26	1.1e-08
LRRC8A	GOBP_Leukocyte_Differentiation	Human	Uterus	rep_26	1.4e-08
LRRC8A	GOBP_Lipid_Localization	Human	Uterus	rep_26	3.7e-10
LRRC8A	GOBP_Mononuclear_Cell_Differentiation	Human	Uterus	rep_26	2.1e-10
LRRC8A	GOBP_Xenobiotic_Transport	Human	Uterus	rep_26	1.6e-06
LRRC8A	GOBP_Cell_Activation	Human	Uterus	rep_28	2.5e-06
LRRC8A	GOBP_Lymphocyte_Activation	Human	Uterus	rep_28	6.6e-07
LRRC8A	GOBP_Amino_Acid_Transmembrane_Transport	Human	Breast	rep_1	3.4e-84
LRRC8A	GOBP_Aspartate_Transmembrane_Transport	Human	Breast	rep_1	9.1e-86
LRRC8A	GOBP_B_Cell_Differentiation	Human	Breast	rep_1	1.7e-73
LRRC8A	GOBP_Cellular_Homeostasis	Human	Breast	rep_1	2.8e-10
LRRC8A	GOBP_Homeostatic_Process	Human	Breast	rep_1	9.0e-53
LRRC8A	GOBP_Immune_System_Development	Human	Breast	rep_1	1.0e-31
LRRC8A	GOBP_Inorganic_Anion_Transport	Human	Breast	rep_1	6.6e-04
LRRC8A	GOBP_Organic_Acid_Transmembrane_Transport	Human	Breast	rep_1	3.1e-21
LRRC8A	GOBP_Protein_Complex_Oligomerization	Human	Breast	rep_1	1.7e-04
LRRC8A	GOBP_Protein_Hexamerization	Human	Breast	rep_1	1.9e-81
LRRC8A	GOBP_Regulation_Of_Anatomical_Structure_Size	Human	Breast	rep_1	1.1e-84
LRRC8A	GOBP_Regulation_Of_Cell_Size	Human	Breast	rep_1	7.8e-23
LRRC8A	GOBP_Regulation_Of_Cellular_Component_Size	Human	Breast	rep_1	8.6e-78
LRRC8A	GOBP_Response_To_Abiotic_Stimulus	Human	Breast	rep_1	2.6e-19
LRRC8A	GOBP_Taurine_Transport	Human	Breast	rep_1	2.6e-105
LRRC8A	GOBP_Transmembrane_Transport	Human	Breast	rep_1	3.2e-56
LRRC8A	GOBP_Acidic_Amino_Acid_Transport	Human	Breast	rep_5	2.0e-13
LRRC8A	GOBP_Amino_Acid_Transport	Human	Breast	rep_5	1.8e-19
LRRC8A	GOBP_Anion_Transmembrane_Transport	Human	Breast	rep_5	2.6e-06
LRRC8A	GOBP_C4_Dicarboxylate_Transport	Human	Breast	rep_5	2.0e-18
LRRC8A	GOBP_Carboxylic_Acid_Transport	Human	Breast	rep_5	5.4e-12
LRRC8A	GOBP_Cell_Volume_Homeostasis	Human	Breast	rep_5	7.4e-15
LRRC8A	GOBP_Dicarboxylic_Acid_Transport	Human	Breast	rep_5	2.9e-10
LRRC8A	GOBP_Immature_B_Cell_Differentiation	Human	Breast	rep_5	4.3e-10
LRRC8A	GOBP_Lipid_Localization	Human	Breast	rep_5	1.4e-06
LRRC8A	GOBP_Organic_Anion_Transport	Human	Breast	rep_5	9.5e-10
LRRC8A	GOBP_Response_To_Osmotic_Stress	Human	Breast	rep_5	6.5e-08
LRRC8A	GOBP_Xenobiotic_Transport	Human	Breast	rep_5	3.0e-14
LRRC8A	GOBP_Monocarboxylic_Acid_Transport	Human	Breast	rep_6	1.9e-12
LRRC8A	GOBP_Organic_Acid_Transport	Human	Breast	rep_6	9.3e-09
LRRC8A	GOBP_Sulfur_Compound_Transport	Human	Breast	rep_6	6.1e-13
LRRC8A	GOBP_Protein_Hexamerization	Human	Skin	P2_rep2	5.4e-23
LRRC8A	GOBP_Regulation_Of_Cell_Size	Human	Skin	P2_rep2	7.1e-08
LRRC8A	GOBP_Carboxylic_Acid_Transport	Human	Skin	P5_rep1	3.2e-08
LRRC8A	GOBP_Organic_Acid_Transmembrane_Transport	Human	Skin	P5_rep2	4.4e-08
LRRC8A	GOBP_C4_Dicarboxylate_Transport	Human	Skin	P10_rep2	2.1e-08
LRRC8A	GOBP_Mononuclear_Cell_Differentiation	Human	Skin	P10_rep3	6.1e-09
LRRC8A	GOBP_B_Cell_Differentiation	Human	Lung	rep_1	1.1e-09
LRRC8A	GOBP_C4_Dicarboxylate_Transport	Human	Lung	rep_1	5.8e-09
LRRC8A	GOBP_Cell_Activation	Human	Lung	rep_1	2.1e-08
LRRC8A	GOBP_Dicarboxylic_Acid_Transport	Human	Lung	rep_1	8.0e-07
LRRC8A	GOBP_Leukocyte_Differentiation	Human	Lung	rep_1	9.7e-07
LRRC8A	GOBP_Cellular_Homeostasis	Human	Lung	rep_2	7.3e-07
LRRC8A	GOBP_Immune_System_Development	Human	Lung	rep_2	7.9e-07
LRRC8A	GOBP_Mononuclear_Cell_Differentiation	Human	Lung	rep_2	2.5e-07

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LRRC8A function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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LRRC8A function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for LRRC8A envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for LRRC8A

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for LRRC8A

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
LRRC8A	C1832241	Agammaglobulinemia, non-Bruton type	1	ORPHANET