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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: IP6K2 (spascer ID:51447)

Gene summary for IP6K2

Gene summary

Gene information
	Species	Human
	Gene symbol	IP6K2
	Gene ID	51447
	Gene name	inositol hexakisphosphate kinase 2
	Synonyms	IHPK2\|InsP6K2\|PIUS
	Cytomap	3p21.31
	Type of gene	protein-coding
	Description	inositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulator
	Modification date	20220513
	UniProtAcc	Q9UHH9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
IP6K2	GO:0000828	inositol hexakisphosphate kinase activity	21873635	Function
IP6K2	GO:0005634	nucleus	21873635	Component
IP6K2	GO:0005737	cytoplasm	21873635	Component
IP6K2	GO:0016301	kinase activity	21873635	Function
IP6K2	GO:0032958	inositol phosphate biosynthetic process	21873635	Process
IP6K2	GO:0046854	phosphatidylinositol phosphate biosynthetic process	21873635	Process

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Spatial pattern events for IP6K2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
IP6K2	Human	Bladder	rep_2	34385456	4.88e-07
IP6K2	Human	Intestine	rep_colon1	34417225	1.95e-15
IP6K2	Human	Intestine	rep_colon2	34417225	8.12e-16
IP6K2	Human	Liver	rep_liver1	34417225	1.08e-15
IP6K2	Human	Liver	rep_liver2	34417225	6.98e-16
IP6K2	Human	Liver	rep_liver4	34417225	1.39e-15
IP6K2	Human	Intestine	A1	33406409	2.48e-14
IP6K2	Human	Intestine	A2	33406409	5.70e-11
IP6K2	Human	Uterus	rep_3	34857954	1.13e-10
IP6K2	Human	Breast	1160920F	34493872	9.21e-09
IP6K2	Human	Lung	rep_1	35355018	2.89e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon1_H&E
Intestine_rep_colon2_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Intestine_A1_H&E
Intestine_A2_H&E
Uterus_rep_3_H&E
Breast_1160920F_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has IP6K2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
IP6K2	GOBP_Lipid_Metabolic_Process	Human	Brain	rep_1	2.8e-23
IP6K2	GOBP_Cell_Growth	Human	Brain	rep_4	1.0e-14
IP6K2	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
IP6K2	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
IP6K2	GOBP_Growth	Human	Brain	rep_4	1.0e-14
IP6K2	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
IP6K2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Brain	rep_10	5.3e-26
IP6K2	GOBP_Lipid_Phosphorylation	Human	Bladder	rep_2	5.9e-05
IP6K2	GOBP_Organophosphate_Biosynthetic_Process	Human	Bladder	rep_4	3.2e-09
IP6K2	GOBP_Cell_Growth	Human	Liver	rep_1	2.1e-52
IP6K2	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
IP6K2	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
IP6K2	GOBP_Growth	Human	Liver	rep_1	2.1e-52
IP6K2	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
IP6K2	GOBP_Lipid_Metabolic_Process	Human	Liver	rep_1	1.0e-70
IP6K2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Liver	rep_1	1.5e-74
IP6K2	GOBP_Cell_Growth	Human	Intestine	rep_colon2	1.5e-57
IP6K2	GOBP_Growth	Human	Intestine	rep_colon2	1.5e-57
IP6K2	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
IP6K2	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
IP6K2	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
IP6K2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	rep_liver2	3.3e-10
IP6K2	GOBP_Cell_Growth	Human	Intestine	A3	1.3e-16
IP6K2	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Intestine	A3	2.6e-09
IP6K2	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
IP6K2	GOBP_Glycerophospholipid_Metabolic_Process	Human	Intestine	A3	7.7e-12
IP6K2	GOBP_Growth	Human	Intestine	A3	3.3e-16
IP6K2	GOBP_Negative_Regulation_Of_Cell_Growth	Human	Intestine	A3	2.6e-16
IP6K2	GOBP_Organophosphate_Biosynthetic_Process	Human	Intestine	A3	2.2e-07
IP6K2	GOBP_Organophosphate_Metabolic_Process	Human	Intestine	A3	4.4e-13
IP6K2	GOBP_Phospholipid_Metabolic_Process	Human	Intestine	A3	3.0e-11
IP6K2	GOBP_Positive_Regulation_Of_Cell_Death	Human	Intestine	A3	4.5e-11
IP6K2	GOBP_Regulation_Of_Cell_Death	Human	Intestine	A3	7.1e-10
IP6K2	GOBP_Regulation_Of_Growth	Human	Intestine	A3	3.6e-10
IP6K2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Intestine	A3	8.2e-08
IP6K2	GOBP_Alcohol_Biosynthetic_Process	Human	Intestine	A8	5.3e-09
IP6K2	GOBP_Cellular_Lipid_Metabolic_Process	Human	Intestine	A8	3.8e-13
IP6K2	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Intestine	A8	1.4e-09
IP6K2	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
IP6K2	GOBP_Glycerolipid_Metabolic_Process	Human	Intestine	A8	1.2e-09
IP6K2	GOBP_Inorganic_Anion_Transport	Human	Intestine	A8	1.6e-11
IP6K2	GOBP_Inositol_Phosphate_Biosynthetic_Process	Human	Intestine	A8	4.3e-11
IP6K2	GOBP_Inositol_Phosphate_Metabolic_Process	Human	Intestine	A8	3.1e-11
IP6K2	GOBP_Lipid_Metabolic_Process	Human	Intestine	A8	1.1e-11
IP6K2	GOBP_Lipid_Modification	Human	Intestine	A8	2.7e-13
IP6K2	GOBP_Negative_Regulation_Of_Growth	Human	Intestine	A8	3.4e-21
IP6K2	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Intestine	A8	1.2e-10
IP6K2	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Intestine	A8	6.4e-10
IP6K2	GOBP_Phosphate_Ion_Transport	Human	Intestine	A8	1.3e-12
IP6K2	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Intestine	A8	1.1e-15
IP6K2	GOBP_Polyol_Biosynthetic_Process	Human	Intestine	A8	1.3e-18
IP6K2	GOBP_Polyol_Metabolic_Process	Human	Intestine	A8	6.2e-14
IP6K2	GOBP_Response_To_Cytokine	Human	Intestine	A8	1.6e-08
IP6K2	GOBP_Response_To_Type_I_Interferon	Human	Intestine	A8	5.3e-09
IP6K2	GOBP_Small_Molecule_Biosynthetic_Process	Human	Intestine	A8	1.0e-14
IP6K2	GOBP_Small_Molecule_Metabolic_Process	Human	Intestine	A8	2.1e-15
IP6K2	GOBP_Alcohol_Metabolic_Process	Human	Pancreas	PDAC-B-st1	2.6e-05
IP6K2	GOBP_Polyol_Metabolic_Process	Human	Pancreas	PDAC-B-st1	9.8e-06
IP6K2	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
IP6K2	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
IP6K2	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
IP6K2	GOBP_Lipid_Modification	Human	Uterus	rep_1	1.8e-07
IP6K2	GOBP_Lipid_Phosphorylation	Human	Uterus	rep_25	3.7e-07
IP6K2	GOBP_Phosphate_Ion_Transport	Human	Uterus	rep_25	2.5e-08
IP6K2	GOBP_Alcohol_Biosynthetic_Process	Human	Uterus	rep_26	2.6e-06
IP6K2	GOBP_Alcohol_Metabolic_Process	Human	Uterus	rep_26	1.3e-06
IP6K2	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Uterus	rep_26	2.0e-10
IP6K2	GOBP_Inorganic_Anion_Transport	Human	Uterus	rep_26	1.1e-08
IP6K2	GOBP_Inositol_Phosphate_Metabolic_Process	Human	Uterus	rep_26	1.1e-15
IP6K2	GOBP_Negative_Regulation_Of_Cell_Growth	Human	Uterus	rep_26	3.0e-09
IP6K2	GOBP_Negative_Regulation_Of_Growth	Human	Uterus	rep_26	2.4e-09
IP6K2	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Uterus	rep_26	3.2e-10
IP6K2	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Uterus	rep_26	2.5e-08
IP6K2	GOBP_Organophosphate_Biosynthetic_Process	Human	Uterus	rep_26	8.0e-07
IP6K2	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Uterus	rep_26	6.7e-06
IP6K2	GOBP_Small_Molecule_Biosynthetic_Process	Human	Uterus	rep_26	5.8e-09
IP6K2	GOBP_Glycerolipid_Metabolic_Process	Human	Uterus	rep_29	5.7e-07
IP6K2	GOBP_Cell_Growth	Human	Breast	rep_1	6.0e-15
IP6K2	GOBP_Cytokine_Mediated_Signaling_Pathway	Human	Breast	rep_1	1.5e-144
IP6K2	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
IP6K2	GOBP_Inorganic_Anion_Transport	Human	Breast	rep_1	6.6e-04
IP6K2	GOBP_Lipid_Phosphorylation	Human	Breast	rep_1	2.6e-42
IP6K2	GOBP_Organic_Hydroxy_Compound_Metabolic_Process	Human	Breast	rep_1	7.3e-16
IP6K2	GOBP_Organophosphate_Biosynthetic_Process	Human	Breast	rep_1	1.4e-07
IP6K2	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Breast	rep_1	1.8e-27
IP6K2	GOBP_Positive_Regulation_Of_Cell_Death	Human	Breast	rep_1	2.2e-15
IP6K2	GOBP_Regulation_Of_Growth	Human	Breast	rep_1	2.3e-04
IP6K2	GOBP_Response_To_Cytokine	Human	Breast	rep_1	2.5e-24
IP6K2	GOBP_Response_To_Type_I_Interferon	Human	Breast	rep_1	9.9e-33
IP6K2	GOBP_Cellular_Lipid_Metabolic_Process	Human	Breast	rep_5	2.6e-07
IP6K2	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.9e-11
IP6K2	GOBP_Growth	Human	Breast	rep_5	5.4e-12
IP6K2	GOBP_Inositol_Phosphate_Biosynthetic_Process	Human	Breast	rep_5	3.2e-08
IP6K2	GOBP_Lipid_Metabolic_Process	Human	Breast	rep_5	2.9e-06
IP6K2	GOBP_Polyol_Biosynthetic_Process	Human	Breast	rep_5	2.7e-07
IP6K2	GOBP_Regulation_Of_Cell_Death	Human	Breast	rep_5	9.8e-08
IP6K2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Breast	rep_5	4.2e-13
IP6K2	GOBP_Alcohol_Biosynthetic_Process	Human	Breast	rep_6	9.0e-04
IP6K2	GOBP_Alcohol_Metabolic_Process	Human	Breast	rep_6	1.3e-04
IP6K2	GOBP_Glycerolipid_Metabolic_Process	Human	Breast	rep_6	9.2e-09
IP6K2	GOBP_Glycerophospholipid_Metabolic_Process	Human	Breast	rep_6	3.2e-05
IP6K2	GOBP_Lipid_Modification	Human	Breast	rep_6	8.0e-04
IP6K2	GOBP_Organic_Hydroxy_Compound_Biosynthetic_Process	Human	Breast	rep_6	2.5e-06
IP6K2	GOBP_Organophosphate_Metabolic_Process	Human	Breast	rep_6	1.0e-12
IP6K2	GOBP_Phosphate_Ion_Transport	Human	Breast	rep_6	3.4e-05
IP6K2	GOBP_Phospholipid_Metabolic_Process	Human	Breast	rep_6	4.1e-09
IP6K2	GOBP_Polyol_Metabolic_Process	Human	Breast	rep_6	2.9e-05
IP6K2	GOBP_Small_Molecule_Biosynthetic_Process	Human	Breast	rep_6	1.0e-06
IP6K2	GOBP_Small_Molecule_Metabolic_Process	Human	Breast	rep_6	5.5e-09
IP6K2	GOBP_Phosphatidylinositol_Metabolic_Process	Human	Skin	P5_rep1	2.8e-09
IP6K2	GOBP_Cell_Growth	Human	Skin	P9_rep3	4.1e-08
IP6K2	GOBP_Lipid_Phosphorylation	Human	Skin	P10_rep1	2.6e-29
IP6K2	GOBP_Inositol_Phosphate_Biosynthetic_Process	Human	Skin	P10_rep2	8.2e-08
IP6K2	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
IP6K2	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
IP6K2	GOBP_Response_To_Oxygen_Containing_Compound	Human	Lung	rep_1	7.8e-08
IP6K2	GOBP_Positive_Regulation_Of_Cell_Death	Human	Lung	rep_2	3.0e-07

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IP6K2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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IP6K2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for IP6K2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for IP6K2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IP6K2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
IP6K2	C0020179	Huntington Disease	1	CTD_human
IP6K2	C0393574	Huntington Disease, Late Onset	1	CTD_human
IP6K2	C0751207	Akinetic-Rigid Variant of Huntington Disease	1	CTD_human
IP6K2	C0751208	Juvenile Huntington Disease	1	CTD_human