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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: WAC (spascer ID:51322)

Gene summary for WAC

Gene summary

Gene information
	Species	Human
	Gene symbol	WAC
	Gene ID	51322
	Gene name	WW domain containing adaptor with coiled-coil
	Synonyms	BM-016\|DESSH\|PRO1741\|Wwp4
	Cytomap	10p12.1\|10p12.1-p11.2
	Type of gene	protein-coding
	Description	WW domain-containing adapter protein with coiled-coil
	Modification date	20220513
	UniProtAcc	Q9BTA9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
WAC	GO:0000993	RNA polymerase II complex binding	21873635	Function
WAC	GO:0003682	chromatin binding	21873635	Function
WAC	GO:0005634	nucleus	21873635	Component
WAC	GO:0010390	histone monoubiquitination	21873635	Process
WAC	GO:0010506	regulation of autophagy	21873635	Process
WAC	GO:1904263	positive regulation of TORC1 signaling	21873635	Process

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Spatial pattern events for WAC

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
WAC	Human	Bladder	rep_2	34385456	7.17e-10
WAC	Human	Intestine	rep_colon4	34417225	2.77e-08
WAC	Human	Liver	rep_liver1	34417225	1.08e-15
WAC	Human	Liver	rep_liver2	34417225	6.98e-16
WAC	Human	Liver	rep_liver4	34417225	7.91e-06
WAC	Human	Breast	E3	34650042	1.70e-06
WAC	Human	Breast	CID4290	34493872	3.04e-07
WAC	Human	Breast	CID4465	34493872	5.09e-07
WAC	Human	Breast	CID44971	34493872	1.76e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Bladder_rep_2_H&E
Intestine_rep_colon4_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Liver_rep_liver4_H&E
Breast_E3_H&E
Breast_CID4290_H&E
Breast_CID4465_H&E
Breast_CID44971_H&E

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Spatial pattern pathway has WAC envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
WAC	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Brain	rep_1	7.4e-34
WAC	GOBP_Negative_Regulation_Of_Proteolysis	Human	Brain	rep_1	2.8e-23
WAC	GOBP_Regulation_Of_Proteolysis	Human	Brain	rep_1	4.4e-07
WAC	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
WAC	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Liver	rep_1	1.0e-70
WAC	GOBP_Negative_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.0e-70
WAC	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
WAC	GOBP_Regulation_Of_Proteolysis	Human	Liver	rep_1	1.1e-67
WAC	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
WAC	GOBP_Regulation_Of_Proteolysis	Human	Intestine	rep_colon4	1.2e-51
WAC	GOBP_Cell_Cycle	Human	Intestine	A3	2.7e-11
WAC	GOBP_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-12
WAC	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Intestine	A3	6.6e-16
WAC	GOBP_Chromatin_Organization	Human	Intestine	A3	3.2e-11
WAC	GOBP_Chromosome_Organization	Human	Intestine	A3	2.5e-13
WAC	GOBP_Histone_Ubiquitination	Human	Intestine	A3	1.9e-07
WAC	GOBP_Macroautophagy	Human	Intestine	A3	2.3e-07
WAC	GOBP_Macromolecule_Catabolic_Process	Human	Intestine	A3	2.2e-16
WAC	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Intestine	A3	7.7e-11
WAC	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Intestine	A3	5.0e-10
WAC	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Intestine	A3	9.0e-12
WAC	GOBP_Negative_Regulation_Of_Protein_Catabolic_Process	Human	Intestine	A3	3.2e-07
WAC	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Intestine	A3	7.8e-11
WAC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Intestine	A3	4.5e-13
WAC	GOBP_Positive_Regulation_Of_Catabolic_Process	Human	Intestine	A3	2.8e-16
WAC	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Intestine	A3	5.1e-13
WAC	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Intestine	A3	4.7e-11
WAC	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Intestine	A3	4.6e-13
WAC	GOBP_Protein_Catabolic_Process	Human	Intestine	A3	2.9e-14
WAC	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Intestine	A3	1.2e-13
WAC	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Intestine	A3	1.8e-12
WAC	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
WAC	GOBP_Regulation_Of_Autophagy	Human	Intestine	A3	1.5e-09
WAC	GOBP_Regulation_Of_Catabolic_Process	Human	Intestine	A3	3.5e-16
WAC	GOBP_Regulation_Of_Cell_Cycle	Human	Intestine	A3	1.6e-08
WAC	GOBP_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Intestine	A3	7.2e-15
WAC	GOBP_Regulation_Of_Proteasomal_Protein_Catabolic_Process	Human	Intestine	A3	1.4e-18
WAC	GOBP_Regulation_Of_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Intestine	A3	4.3e-16
WAC	GOBP_Regulation_Of_Protein_Catabolic_Process	Human	Intestine	A3	1.2e-14
WAC	GOBP_Regulation_Of_Proteolysis	Human	Intestine	A3	9.5e-13
WAC	GOBP_Regulation_Of_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Intestine	A3	6.9e-14
WAC	GOBP_Histone_H2b_Ubiquitination	Human	Intestine	A8	1.0e-07
WAC	GOBP_Histone_Monoubiquitination	Human	Intestine	A8	3.2e-09
WAC	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Intestine	A8	3.1e-14
WAC	GOBP_Negative_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Intestine	A8	1.5e-10
WAC	GOBP_Negative_Regulation_Of_Proteolysis	Human	Intestine	A8	8.9e-12
WAC	GOBP_Negative_Regulation_Of_Proteolysis_Involved_In_Cellular_Protein_Catabolic_Process	Human	Intestine	A8	7.2e-07
WAC	GOBP_Protein_Monoubiquitination	Human	Intestine	A8	9.4e-12
WAC	GOBP_Histone_Monoubiquitination	Human	Pancreas	PDAC-B-st1	2.4e-06
WAC	GOBP_Positive_Regulation_Of_Autophagy	Human	Pancreas	PDAC-B-st1	1.8e-05
WAC	GOBP_Chromatin_Organization	Human	Uterus	rep_1	1.9e-06
WAC	GOBP_Histone_H2b_Ubiquitination	Human	Uterus	rep_25	1.3e-07
WAC	GOBP_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	8.2e-11
WAC	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Uterus	rep_26	2.4e-07
WAC	GOBP_Chromosome_Organization	Human	Uterus	rep_26	1.2e-09
WAC	GOBP_Histone_Monoubiquitination	Human	Uterus	rep_26	5.9e-09
WAC	GOBP_Histone_Ubiquitination	Human	Uterus	rep_26	8.7e-07
WAC	GOBP_Macroautophagy	Human	Uterus	rep_26	1.7e-06
WAC	GOBP_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	5.0e-08
WAC	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Uterus	rep_26	1.1e-07
WAC	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Uterus	rep_26	4.0e-09
WAC	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Uterus	rep_26	1.0e-08
WAC	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Uterus	rep_26	4.4e-10
WAC	GOBP_Negative_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	9.6e-19
WAC	GOBP_Negative_Regulation_Of_Proteasomal_Protein_Catabolic_Process	Human	Uterus	rep_26	5.2e-09
WAC	GOBP_Negative_Regulation_Of_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Uterus	rep_26	8.5e-14
WAC	GOBP_Negative_Regulation_Of_Protein_Catabolic_Process	Human	Uterus	rep_26	1.3e-06
WAC	GOBP_Negative_Regulation_Of_Proteolysis_Involved_In_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	7.9e-15
WAC	GOBP_Negative_Regulation_Of_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Uterus	rep_26	2.6e-15
WAC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Uterus	rep_26	1.0e-08
WAC	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Uterus	rep_26	2.2e-12
WAC	GOBP_Protein_Catabolic_Process	Human	Uterus	rep_26	3.6e-10
WAC	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Uterus	rep_26	2.1e-08
WAC	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Uterus	rep_26	5.7e-08
WAC	GOBP_Protein_Monoubiquitination	Human	Uterus	rep_26	5.5e-08
WAC	GOBP_Regulation_Of_Autophagy	Human	Uterus	rep_26	3.2e-06
WAC	GOBP_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Uterus	rep_26	2.7e-10
WAC	GOBP_Regulation_Of_Macroautophagy	Human	Uterus	rep_26	9.2e-09
WAC	GOBP_Regulation_Of_Proteasomal_Protein_Catabolic_Process	Human	Uterus	rep_26	3.7e-07
WAC	GOBP_Regulation_Of_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Uterus	rep_26	8.7e-10
WAC	GOBP_Regulation_Of_Protein_Catabolic_Process	Human	Uterus	rep_26	7.3e-06
WAC	GOBP_Regulation_Of_Proteolysis	Human	Uterus	rep_26	2.1e-07
WAC	GOBP_Regulation_Of_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Uterus	rep_26	1.2e-10
WAC	GOBP_Regulation_Of_Proteolysis	Human	Breast	rep_1	6.4e-05
WAC	GOBP_Cellular_Protein_Catabolic_Process	Human	Breast	rep_5	4.4e-04
WAC	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Human	Breast	rep_5	4.3e-05
WAC	GOBP_Negative_Regulation_Of_Proteolysis	Human	Breast	rep_5	2.0e-06
WAC	GOBP_Positive_Regulation_Of_Autophagy	Human	Breast	rep_5	1.7e-07
WAC	GOBP_Positive_Regulation_Of_Macroautophagy	Human	Breast	rep_5	5.7e-17
WAC	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Human	Breast	rep_5	8.0e-09
WAC	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
WAC	GOBP_Regulation_Of_Cell_Cycle	Human	Breast	rep_5	3.7e-04
WAC	GOBP_Cell_Cycle	Human	Breast	rep_6	3.4e-09
WAC	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Human	Breast	rep_6	6.0e-06
WAC	GOBP_Chromatin_Organization	Human	Breast	rep_6	4.3e-07
WAC	GOBP_Chromosome_Organization	Human	Breast	rep_6	1.1e-06
WAC	GOBP_Histone_H2b_Ubiquitination	Human	Breast	rep_6	5.8e-05
WAC	GOBP_Histone_Monoubiquitination	Human	Breast	rep_6	5.1e-06
WAC	GOBP_Histone_Ubiquitination	Human	Breast	rep_6	3.5e-07
WAC	GOBP_Macroautophagy	Human	Breast	rep_6	6.1e-10
WAC	GOBP_Macromolecule_Catabolic_Process	Human	Breast	rep_6	1.3e-05
WAC	GOBP_Modification_Dependent_Macromolecule_Catabolic_Process	Human	Breast	rep_6	2.2e-09
WAC	GOBP_Negative_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	2.0e-06
WAC	GOBP_Negative_Regulation_Of_Cell_Cycle	Human	Breast	rep_6	5.3e-11
WAC	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Breast	rep_6	1.0e-06
WAC	GOBP_Negative_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Breast	rep_6	4.8e-10
WAC	GOBP_Negative_Regulation_Of_Proteasomal_Protein_Catabolic_Process	Human	Breast	rep_6	4.1e-12
WAC	GOBP_Negative_Regulation_Of_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Breast	rep_6	6.5e-14
WAC	GOBP_Negative_Regulation_Of_Protein_Catabolic_Process	Human	Breast	rep_6	1.3e-04
WAC	GOBP_Negative_Regulation_Of_Proteolysis_Involved_In_Cellular_Protein_Catabolic_Process	Human	Breast	rep_6	4.0e-10
WAC	GOBP_Negative_Regulation_Of_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Breast	rep_6	6.2e-09
WAC	GOBP_Organonitrogen_Compound_Catabolic_Process	Human	Breast	rep_6	9.5e-06
WAC	GOBP_Positive_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	9.2e-08
WAC	GOBP_Process_Utilizing_Autophagic_Mechanism	Human	Breast	rep_6	1.9e-08
WAC	GOBP_Proteasomal_Protein_Catabolic_Process	Human	Breast	rep_6	6.8e-09
WAC	GOBP_Protein_Catabolic_Process	Human	Breast	rep_6	5.3e-06
WAC	GOBP_Protein_Modification_By_Small_Protein_Conjugation	Human	Breast	rep_6	3.6e-10
WAC	GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_Removal	Human	Breast	rep_6	2.7e-09
WAC	GOBP_Protein_Monoubiquitination	Human	Breast	rep_6	2.7e-05
WAC	GOBP_Regulation_Of_Autophagy	Human	Breast	rep_6	7.8e-04
WAC	GOBP_Regulation_Of_Catabolic_Process	Human	Breast	rep_6	3.3e-04
WAC	GOBP_Regulation_Of_Cellular_Protein_Catabolic_Process	Human	Breast	rep_6	6.2e-07
WAC	GOBP_Regulation_Of_Macroautophagy	Human	Breast	rep_6	3.2e-07
WAC	GOBP_Regulation_Of_Proteasomal_Protein_Catabolic_Process	Human	Breast	rep_6	4.3e-07
WAC	GOBP_Regulation_Of_Proteasomal_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Breast	rep_6	3.4e-07
WAC	GOBP_Regulation_Of_Protein_Catabolic_Process	Human	Breast	rep_6	4.3e-04
WAC	GOBP_Regulation_Of_Ubiquitin_Dependent_Protein_Catabolic_Process	Human	Breast	rep_6	5.9e-07
WAC	GOBP_Negative_Regulation_Of_Proteolysis	Human	Lung	rep_1	5.7e-10
WAC	GOBP_Regulation_Of_Proteolysis	Human	Lung	rep_1	3.2e-08
WAC	GOBP_Negative_Regulation_Of_Cellular_Catabolic_Process	Human	Lung	rep_2	3.4e-07

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WAC function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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WAC function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for WAC envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for WAC

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for WAC

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
WAC	C0033578	Prostatic Neoplasms	1	CTD_human
WAC	C0376358	Malignant neoplasm of prostate	1	CTD_human
WAC	C1535926	Neurodevelopmental Disorders	1	CTD_human
WAC	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
WAC	C4225239	DESANTO-SHINAWI SYNDROME	1	CTD_human;ORPHANET
WAC	C4225431	CHROMOSOME 10p12-p11 DELETION SYNDROME	1	ORPHANET