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Spatial pattern gene: ECSIT (spascer ID:51295) |
Gene summary for ECSIT |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | ECSIT | Gene ID | 51295 |
| Gene name | ECSIT signaling integrator |
| Synonyms | SITPEC |
| Cytomap | 19p13.2 |
| Type of gene | protein-coding |
| Description | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT homologECSIT signalling integratorlikely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved |
| Modification date | 20220513 |
| UniProtAcc | Q9BQ95 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| ECSIT | GO:0005739 | mitochondrion | 21873635 | Component |
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Spatial pattern events for ECSIT |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| ECSIT | Human | Liver | rep_liver1 | 34417225 | 1.91e-09 |
| ECSIT | Human | Liver | rep_liver2 | 34417225 | 1.60e-06 |
| ECSIT | Human | Intestine | A1 | 33406409 | 2.09e-15 |
| ECSIT | Human | Intestine | A2 | 33406409 | 2.47e-15 |
| ECSIT | Human | Uterus | rep_2 | 34857954 | 2.55e-15 |
| ECSIT | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| ECSIT | Human | Breast | 1160920F | 34493872 | 1.46e-08 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Intestine_A1_H&E  |  |
Intestine_A2_H&E  |  |
Uterus_rep_2_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1160920F_H&E  |  |
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Spatial pattern pathway has ECSIT envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| ECSIT | GOBP_Defense_Response | Human | Brain | rep_4 | 2.2e-20 |
| ECSIT | GOBP_Defense_Response_To_Other_Organism | Human | Brain | rep_4 | 1.2e-64 |
| ECSIT | GOBP_Innate_Immune_Response | Human | Brain | rep_4 | 1.2e-64 |
| ECSIT | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Bladder | rep_4 | 1.8e-09 |
| ECSIT | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Human | Bladder | rep_4 | 1.1e-14 |
| ECSIT | GOBP_Defense_Response | Human | Liver | rep_1 | 1.3e-59 |
| ECSIT | GOBP_Defense_Response_To_Other_Organism | Human | Liver | rep_1 | 4.3e-69 |
| ECSIT | GOBP_Innate_Immune_Response | Human | Liver | rep_1 | 7.3e-68 |
| ECSIT | GOBP_Defense_Response | Human | Intestine | rep_colon4 | 2.5e-86 |
| ECSIT | GOBP_Defense_Response_To_Other_Organism | Human | Intestine | rep_colon4 | 1.2e-82 |
| ECSIT | GOBP_Innate_Immune_Response | Human | Intestine | rep_colon4 | 3.4e-69 |
| ECSIT | GOBP_Defense_Response | Human | Intestine | A3 | 6.3e-13 |
| ECSIT | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Intestine | A3 | 1.5e-07 |
| ECSIT | GOBP_Mitochondrion_Organization | Human | Intestine | A3 | 2.3e-19 |
| ECSIT | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Human | Intestine | A3 | 3.9e-07 |
| ECSIT | GOBP_Defense_Response_To_Other_Organism | Human | Intestine | A8 | 5.3e-08 |
| ECSIT | GOBP_Regulation_Of_Oxidoreductase_Activity | Human | Intestine | A8 | 3.9e-08 |
| ECSIT | GOBP_Regulation_Of_Protein_Complex_Stability | Human | Intestine | A8 | 7.8e-24 |
| ECSIT | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Pancreas | PDAC-B-st1 | 9.9e-05 |
| ECSIT | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Human | Pancreas | PDAC-B-st1 | 4.6e-05 |
| ECSIT | GOBP_Defense_Response_To_Other_Organism | Human | Uterus | rep_4 | 2.0e-31 |
| ECSIT | GOBP_Innate_Immune_Response | Human | Uterus | rep_4 | 6.1e-31 |
| ECSIT | GOBP_Defense_Response | Human | Uterus | rep_1 | 3.0e-06 |
| ECSIT | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Uterus | rep_26 | 2.3e-06 |
| ECSIT | GOBP_Nadh_Dehydrogenase_Complex_Assembly | Human | Uterus | rep_26 | 9.9e-07 |
| ECSIT | GOBP_Regulation_Of_Protein_Complex_Stability | Human | Uterus | rep_29 | 2.6e-10 |
| ECSIT | GOBP_Defense_Response | Human | Breast | rep_1 | 1.0e-09 |
| ECSIT | GOBP_Regulation_Of_Protein_Complex_Stability | Human | Breast | rep_1 | 5.1e-05 |
| ECSIT | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Breast | rep_6 | 3.3e-04 |
| ECSIT | GOBP_Mitochondrion_Organization | Human | Breast | rep_6 | 2.0e-05 |
| ECSIT | GOBP_Regulation_Of_Oxidoreductase_Activity | Human | Breast | rep_6 | 4.3e-04 |
| ECSIT | GOBP_Defense_Response | Human | Lung | rep_1 | 9.9e-12 |
| ECSIT | GOBP_Defense_Response_To_Other_Organism | Human | Lung | rep_1 | 1.5e-09 |
| ECSIT | GOBP_Regulation_Of_Oxidoreductase_Activity | Human | Lung | rep_2 | 6.1e-07 |
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ECSIT function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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ECSIT function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for ECSIT envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for ECSIT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ECSIT |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| ECSIT | C3495676 | Anorectal Malformations | 1 | GENOMICS_ENGLAND |
