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Spatial pattern gene: COA4 (spascer ID:51287) |
Gene summary for COA4 |
 Gene summary |
| Gene information | |
| Species | Human | Gene symbol | COA4 | Gene ID | 51287 |
| Gene name | cytochrome c oxidase assembly factor 4 homolog |
| Synonyms | CHCHD8|CMC3|E2IG2 |
| Cytomap | 11q13.4 |
| Type of gene | protein-coding |
| Description | cytochrome c oxidase assembly factor 4 homolog, mitochondrialE2-induced gene 2 proteincoiled-coil-helix-coiled-coil-helix domain containing 8coiled-coil-helix-coiled-coil-helix domain-containing protein 8 |
| Modification date | 20220513 |
| UniProtAcc | Q9NYJ1 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| COA4 | GO:0005758 | mitochondrial intermembrane space | 21873635 | Component |
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Spatial pattern events for COA4 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| COA4 | Human | Brain | rep_9 | 33558695 | 9.20e-13 |
| COA4 | Human | Brain | rep_10 | 33558695 | 8.88e-10 |
| COA4 | Human | Brain | rep_11 | 33558695 | 4.39e-14 |
| COA4 | Human | Bladder | rep_1 | 34385456 | 5.88e-13 |
| COA4 | Human | Intestine | rep_colon1 | 34417225 | 6.48e-15 |
| COA4 | Human | Intestine | rep_colon4 | 34417225 | 2.06e-15 |
| COA4 | Human | Liver | rep_liver1 | 34417225 | 1.08e-15 |
| COA4 | Human | Liver | rep_liver2 | 34417225 | 6.98e-16 |
| COA4 | Human | Liver | rep_liver4 | 34417225 | 1.39e-15 |
| COA4 | Human | Uterus | rep_1 | 34857954 | 8.43e-06 |
| COA4 | Human | Uterus | rep_3 | 34857954 | 1.66e-15 |
| COA4 | Human | Breast | 1142243F | 34493872 | 2.30e-15 |
| COA4 | Human | Breast | CID4465 | 34493872 | 3.38e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_9_H&E  |  |
Brain_rep_10_H&E  |  |
Brain_rep_11_H&E  |  |
Bladder_rep_1_H&E  |  |
Intestine_rep_colon1_H&E  |  |
Intestine_rep_colon4_H&E  |  |
Liver_rep_liver1_H&E  |  |
Liver_rep_liver2_H&E  |  |
Liver_rep_liver4_H&E  |  |
Uterus_rep_1_H&E  |  |
Uterus_rep_3_H&E  |  |
Breast_1142243F_H&E  |  |
Breast_CID4465_H&E  |  |
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Spatial pattern pathway has COA4 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| COA4 | GOBP_Cytochrome_Complex_Assembly | Human | Bladder | rep_4 | 6.0e-26 |
| COA4 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Bladder | rep_4 | 1.8e-09 |
| COA4 | GOBP_Respiratory_Chain_Complex_Iv_Assembly | Human | Bladder | rep_4 | 4.0e-22 |
| COA4 | GOBP_Cytochrome_Complex_Assembly | Human | Intestine | A3 | 3.5e-09 |
| COA4 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Intestine | A3 | 1.5e-07 |
| COA4 | GOBP_Mitochondrion_Organization | Human | Intestine | A3 | 2.3e-19 |
| COA4 | GOBP_Respiratory_Chain_Complex_Iv_Assembly | Human | Intestine | A3 | 9.2e-08 |
| COA4 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Pancreas | PDAC-B-st1 | 9.9e-05 |
| COA4 | GOBP_Mitochondrial_Cytochrome_C_Oxidase_Assembly | Human | Uterus | rep_25 | 9.6e-09 |
| COA4 | GOBP_Respiratory_Chain_Complex_Iv_Assembly | Human | Uterus | rep_25 | 1.7e-10 |
| COA4 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Uterus | rep_26 | 2.3e-06 |
| COA4 | GOBP_Cytochrome_Complex_Assembly | Human | Breast | rep_1 | 1.3e-184 |
| COA4 | GOBP_Respiratory_Chain_Complex_Iv_Assembly | Human | Breast | rep_1 | 3.1e-179 |
| COA4 | GOBP_Mitochondrial_Cytochrome_C_Oxidase_Assembly | Human | Breast | rep_6 | 2.7e-05 |
| COA4 | GOBP_Mitochondrial_Respiratory_Chain_Complex_Assembly | Human | Breast | rep_6 | 3.3e-04 |
| COA4 | GOBP_Mitochondrion_Organization | Human | Breast | rep_6 | 2.0e-05 |
| COA4 | GOBP_Mitochondrial_Cytochrome_C_Oxidase_Assembly | Human | Skin | P5_rep1 | 1.8e-09 |
| COA4 | GOBP_Respiratory_Chain_Complex_Iv_Assembly | Human | Skin | P9_rep2 | 7.3e-09 |
| COA4 | GOBP_Cytochrome_Complex_Assembly | Human | Skin | P10_rep1 | 2.7e-21 |
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COA4 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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COA4 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for COA4 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for COA4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COA4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
