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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: C1RL (spascer ID:51279)

Gene summary for C1RL

Gene summary

Gene information
	Species	Human
	Gene symbol	C1RL
	Gene ID	51279
	Gene name	complement C1r subcomponent like
	Synonyms	C1RL1\|C1RLP\|C1r-LP\|CLSPa
	Cytomap	12p13.31
	Type of gene	protein-coding
	Description	complement C1r subcomponent-like proteinC1r-like proteinC1r-like serine protease analog proteincomplement C1r-like proteinasecomplement component 1, r subcomponent-like
	Modification date	20220513
	UniProtAcc	Q9NZP8

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
C1RL	GO:0004252	serine-type endopeptidase activity	21873635	Function
C1RL	GO:0005615	extracellular space	21873635	Component
C1RL	GO:0031638	zymogen activation	21873635	Process
C1RL	GO:0072562	blood microparticle	21873635	Component

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Spatial pattern events for C1RL

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
C1RL	Human	Intestine	rep_colon2	34417225	8.12e-16
C1RL	Human	Liver	rep_liver1	34417225	1.08e-15
C1RL	Human	Liver	rep_liver2	34417225	6.98e-16
C1RL	Human	Uterus	rep_2	34857954	2.55e-15
C1RL	Human	Uterus	rep_4	34857954	1.82e-15
C1RL	Human	Breast	1160920F	34493872	1.59e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Intestine_rep_colon2_H&E
Liver_rep_liver1_H&E
Liver_rep_liver2_H&E
Uterus_rep_2_H&E
Uterus_rep_4_H&E
Breast_1160920F_H&E

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Spatial pattern pathway has C1RL envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
C1RL	GOBP_Activation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Adaptive_Immune_Response	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_B_Cell_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Complement_Activation	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Humoral_Immune_Response	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Immune_Effector_Process	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Leukocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Lymphocyte_Mediated_Immunity	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Positive_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
C1RL	GOBP_Protein_Maturation	Human	Brain	rep_1	1.3e-161
C1RL	GOBP_Protein_Processing	Human	Brain	rep_1	1.3e-161
C1RL	GOBP_Regulation_Of_Immune_Response	Human	Brain	rep_1	8.1e-16
C1RL	GOBP_Regulation_Of_Immune_System_Process	Human	Brain	rep_1	1.1e-18
C1RL	GOBP_Defense_Response	Human	Brain	rep_4	2.2e-20
C1RL	GOBP_Defense_Response_To_Other_Organism	Human	Brain	rep_4	1.2e-64
C1RL	GOBP_Innate_Immune_Response	Human	Brain	rep_4	1.2e-64
C1RL	GOBP_Proteolysis	Human	Brain	rep_4	1.6e-22
C1RL	GOBP_Zymogen_Activation	Human	Bladder	rep_2	8.2e-04
C1RL	GOBP_Activation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Adaptive_Immune_Response	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_B_Cell_Mediated_Immunity	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Complement_Activation	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Defense_Response	Human	Liver	rep_1	1.3e-59
C1RL	GOBP_Defense_Response_To_Other_Organism	Human	Liver	rep_1	4.3e-69
C1RL	GOBP_Humoral_Immune_Response	Human	Liver	rep_1	9.0e-62
C1RL	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Immune_Effector_Process	Human	Liver	rep_1	9.0e-62
C1RL	GOBP_Innate_Immune_Response	Human	Liver	rep_1	7.3e-68
C1RL	GOBP_Leukocyte_Mediated_Immunity	Human	Liver	rep_1	9.0e-62
C1RL	GOBP_Lymphocyte_Mediated_Immunity	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Positive_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
C1RL	GOBP_Protein_Maturation	Human	Liver	rep_1	4.6e-81
C1RL	GOBP_Protein_Processing	Human	Liver	rep_1	6.7e-84
C1RL	GOBP_Proteolysis	Human	Liver	rep_1	4.2e-73
C1RL	GOBP_Regulation_Of_Immune_Response	Human	Liver	rep_1	2.3e-76
C1RL	GOBP_Regulation_Of_Immune_System_Process	Human	Liver	rep_1	1.4e-67
C1RL	GOBP_Zymogen_Activation	Human	Liver	rep_1	7.7e-79
C1RL	GOBP_Protein_Maturation	Human	Intestine	rep_colon2	7.9e-42
C1RL	GOBP_Protein_Processing	Human	Intestine	rep_colon2	1.2e-19
C1RL	GOBP_Activation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Adaptive_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_B_Cell_Mediated_Immunity	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Complement_Activation	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Defense_Response	Human	Intestine	rep_colon4	2.5e-86
C1RL	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	rep_colon4	1.2e-82
C1RL	GOBP_Humoral_Immune_Response	Human	Intestine	rep_colon4	1.3e-27
C1RL	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Immune_Effector_Process	Human	Intestine	rep_colon4	1.3e-27
C1RL	GOBP_Innate_Immune_Response	Human	Intestine	rep_colon4	3.4e-69
C1RL	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	rep_colon4	1.3e-27
C1RL	GOBP_Lymphocyte_Mediated_Immunity	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
C1RL	GOBP_Proteolysis	Human	Intestine	rep_colon4	2.4e-90
C1RL	GOBP_Regulation_Of_Immune_Response	Human	Intestine	rep_colon4	7.2e-20
C1RL	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	rep_colon4	4.8e-23
C1RL	GOBP_Activation_Of_Immune_Response	Human	Intestine	A3	5.7e-11
C1RL	GOBP_Complement_Activation	Human	Intestine	A3	5.9e-07
C1RL	GOBP_Defense_Response	Human	Intestine	A3	6.3e-13
C1RL	GOBP_Humoral_Immune_Response	Human	Intestine	A3	1.4e-08
C1RL	GOBP_Immune_Effector_Process	Human	Intestine	A3	3.9e-14
C1RL	GOBP_Leukocyte_Mediated_Immunity	Human	Intestine	A3	8.2e-10
C1RL	GOBP_Positive_Regulation_Of_Immune_Response	Human	Intestine	A3	2.4e-07
C1RL	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Intestine	A3	6.8e-15
C1RL	GOBP_Proteolysis	Human	Intestine	A3	7.3e-12
C1RL	GOBP_Regulation_Of_Immune_Response	Human	Intestine	A3	1.6e-12
C1RL	GOBP_Regulation_Of_Immune_System_Process	Human	Intestine	A3	1.5e-15
C1RL	GOBP_Adaptive_Immune_Response	Human	Intestine	A8	2.4e-10
C1RL	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Intestine	A8	1.3e-09
C1RL	GOBP_B_Cell_Mediated_Immunity	Human	Intestine	A8	9.3e-10
C1RL	GOBP_Defense_Response_To_Other_Organism	Human	Intestine	A8	5.3e-08
C1RL	GOBP_Protein_Maturation	Human	Intestine	A8	1.1e-12
C1RL	GOBP_Protein_Processing	Human	Intestine	A8	4.1e-18
C1RL	GOBP_Zymogen_Activation	Human	Intestine	A8	4.1e-11
C1RL	GOBP_Activation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Adaptive_Immune_Response	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Adaptive_Immune_Response_Based_On_Somatic_Recombination_Of_Immune_Receptors_Built_From_Immunoglobulin_Superfamily_Domains	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_B_Cell_Mediated_Immunity	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Complement_Activation	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Defense_Response_To_Other_Organism	Human	Uterus	rep_4	2.0e-31
C1RL	GOBP_Humoral_Immune_Response	Human	Uterus	rep_4	2.0e-31
C1RL	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Immune_Effector_Process	Human	Uterus	rep_4	2.0e-31
C1RL	GOBP_Innate_Immune_Response	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Leukocyte_Mediated_Immunity	Human	Uterus	rep_4	2.0e-31
C1RL	GOBP_Lymphocyte_Mediated_Immunity	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Positive_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
C1RL	GOBP_Regulation_Of_Immune_Response	Human	Uterus	rep_4	6.1e-31
C1RL	GOBP_Regulation_Of_Immune_System_Process	Human	Uterus	rep_4	5.1e-31
C1RL	GOBP_Defense_Response	Human	Uterus	rep_1	3.0e-06
C1RL	GOBP_Defense_Response	Human	Breast	rep_1	1.0e-09
C1RL	GOBP_Protein_Maturation	Human	Breast	rep_1	4.1e-23
C1RL	GOBP_Protein_Processing	Human	Breast	rep_1	4.4e-37
C1RL	GOBP_Zymogen_Activation	Human	Breast	rep_1	1.6e-17
C1RL	GOBP_Proteolysis	Human	Breast	rep_5	1.8e-07
C1RL	GOBP_Humoral_Immune_Response_Mediated_By_Circulating_Immunoglobulin	Human	Skin	P10_rep1	3.5e-08
C1RL	GOBP_Defense_Response	Human	Lung	rep_1	9.9e-12
C1RL	GOBP_Defense_Response_To_Other_Organism	Human	Lung	rep_1	1.5e-09
C1RL	GOBP_Humoral_Immune_Response	Human	Lung	rep_1	1.7e-10
C1RL	GOBP_Positive_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	3.1e-08
C1RL	GOBP_Regulation_Of_Immune_System_Process	Human	Lung	rep_1	5.9e-07
C1RL	GOBP_Lymphocyte_Mediated_Immunity	Human	Lung	rep_2	3.7e-07

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C1RL function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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C1RL function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for C1RL envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for C1RL

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for C1RL

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source